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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 3,3',4,4'-Tetrachloroazoxybenzene
CASRN: ="21232-47-3"
Study Number: C88149
Exposure Route: GAVAGE
TDMS Number: 8814901
Sex: Female
Strain and Species: F 344/N Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Hepatocyte 32 MG/KG 5 9 41 17 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 32 MG/KG 5 9 42 17 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 32 MG/KG 5 9 43 17 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 80 MG/KG 5 10 46 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 80 MG/KG 5 10 47 17 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 80 MG/KG 5 10 48 17 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 80 MG/KG 5 10 49 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 80 MG/KG 5 10 50 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 200 MG/KG 5 11 51 17 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 200 MG/KG 5 11 52 17 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 200 MG/KG 5 11 53 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 200 MG/KG 5 11 54 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 200 MG/KG 5 11 55 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 5 12 56 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 5 12 57 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 5 12 58 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 5 12 59 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 5 12 60 17 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver 12.5 MG/KG 5 8 36 17 1 Inflammation Minimal, Focal Terminal Sacrifice
Hematopoietic System Spleen 500 MG/KG 5 12 60 17 1 Congestion Minimal Terminal Sacrifice
Hematopoietic System Spleen 12.5 MG/KG 5 8 38 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 12.5 MG/KG 5 8 39 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 32 MG/KG 5 9 41 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 32 MG/KG 5 9 42 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 32 MG/KG 5 9 43 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 32 MG/KG 5 9 44 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 32 MG/KG 5 9 45 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 5 10 46 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 5 10 47 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 5 10 48 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 5 10 49 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 5 10 50 17 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 200 MG/KG 5 11 51 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 200 MG/KG 5 11 52 17 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 200 MG/KG 5 11 53 17 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 200 MG/KG 5 11 54 17 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 200 MG/KG 5 11 55 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 500 MG/KG 5 12 56 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 500 MG/KG 5 12 57 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 500 MG/KG 5 12 58 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 500 MG/KG 5 12 60 17 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 32 MG/KG 5 9 43 17 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 32 MG/KG 5 9 44 17 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 32 MG/KG 5 9 45 17 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 80 MG/KG 5 10 46 17 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 80 MG/KG 5 10 47 17 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 80 MG/KG 5 10 48 17 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 80 MG/KG 5 10 50 17 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 200 MG/KG 5 11 51 17 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 200 MG/KG 5 11 52 17 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 200 MG/KG 5 11 53 17 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 200 MG/KG 5 11 54 17 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 200 MG/KG 5 11 55 17 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 500 MG/KG 5 12 56 17 1 Atrophy Moderate Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 500 MG/KG 5 12 57 17 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 500 MG/KG 5 12 58 17 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 500 MG/KG 5 12 59 17 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 500 MG/KG 5 12 60 17 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Vehicle Control 5 7 34 17 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Thymus 12.5 MG/KG 5 8 39 17 1 Hemorrhage Minimal Terminal Sacrifice
Urinary System Kidney Cortex 12.5 MG/KG 5 8 36 17 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Urinary System Kidney Vehicle Control 5 7 31 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 5 7 32 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 5 7 33 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 5 7 34 17 1 Mineralization Mild Terminal Sacrifice
Urinary System Kidney Vehicle Control 5 7 35 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 12.5 MG/KG 5 8 36 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 12.5 MG/KG 5 8 37 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 12.5 MG/KG 5 8 38 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 12.5 MG/KG 5 8 39 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 12.5 MG/KG 5 8 40 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 32 MG/KG 5 9 41 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 32 MG/KG 5 9 42 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 32 MG/KG 5 9 43 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 32 MG/KG 5 9 45 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 80 MG/KG 5 10 46 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 80 MG/KG 5 10 47 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 80 MG/KG 5 10 48 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 80 MG/KG 5 10 49 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 80 MG/KG 5 10 50 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200 MG/KG 5 11 53 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200 MG/KG 5 11 54 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200 MG/KG 5 11 55 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 500 MG/KG 5 12 56 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 500 MG/KG 5 12 58 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 500 MG/KG 5 12 59 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 500 MG/KG 5 12 60 17 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 5 7 33 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney Vehicle Control 5 7 34 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney Vehicle Control 5 7 35 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 12.5 MG/KG 5 8 37 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 12.5 MG/KG 5 8 38 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 32 MG/KG 5 9 43 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 32 MG/KG 5 9 44 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 32 MG/KG 5 9 45 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 80 MG/KG 5 10 46 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 80 MG/KG 5 10 47 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 80 MG/KG 5 10 49 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 200 MG/KG 5 11 51 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 200 MG/KG 5 11 53 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 200 MG/KG 5 11 54 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 200 MG/KG 5 11 55 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 500 MG/KG 5 12 56 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 500 MG/KG 5 12 57 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 500 MG/KG 5 12 58 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 500 MG/KG 5 12 59 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice
Urinary System Kidney 500 MG/KG 5 12 60 17 1 Nephropathy Minimal, Chronic Terminal Sacrifice