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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 3,3',4,4'-Tetrachloroazoxybenzene
CASRN: ="21232-47-3"
Study Number: C88149
Exposure Route: GAVAGE
TDMS Number: 8814903
Sex: Male
Strain and Species: F 344/N Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Large Rectum, Epithelium 10 MG/KG 10 10 47 92 1 Hemorrhage Mild Accidentally Killed
Alimentary System Liver Bile Duct 30 MG/KG 10 11 51 46 1 Hyperplasia Minimal Moribund Sacrifice
Alimentary System Liver Bile Duct 30 MG/KG 10 11 53 45 1 Hyperplasia Minimal Moribund Sacrifice
Alimentary System Liver Bile Duct 30 MG/KG 10 12 58 50 1 Hyperplasia Minimal Moribund Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 10 46 92 1 Degeneration Mild Accidentally Killed
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 10 47 92 1 Degeneration Minimal Accidentally Killed
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 10 48 92 1 Degeneration Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 9 41 92 1 Degeneration Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 9 42 92 1 Degeneration Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 11 51 46 1 Degeneration Mild Moribund Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 11 52 45 1 Degeneration Marked Moribund Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 11 53 45 1 Degeneration Moderate Moribund Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 11 54 58 1 Degeneration Minimal Moribund Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 11 55 45 1 Degeneration Marked Moribund Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 12 58 50 1 Degeneration Marked Moribund Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 12 59 57 1 Degeneration Marked Moribund Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 12 56 50 1 Degeneration Marked Natural Death
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 12 57 42 1 Degeneration Marked Natural Death
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 12 60 45 1 Degeneration Moderate Natural Death
Alimentary System Liver Hepatocyte 10 MG/KG 10 10 50 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte, Periportal 10 MG/KG 10 9 41 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver 30 MG/KG 10 11 51 46 1 Hematopoietic Cell Proliferation Minimal Moribund Sacrifice
Alimentary System Liver 30 MG/KG 10 11 52 45 1 Hematopoietic Cell Proliferation Moderate Moribund Sacrifice
Alimentary System Liver 30 MG/KG 10 11 53 45 1 Hematopoietic Cell Proliferation Minimal Moribund Sacrifice
Alimentary System Liver 30 MG/KG 10 11 55 45 1 Hematopoietic Cell Proliferation Minimal Moribund Sacrifice
Alimentary System Liver 30 MG/KG 10 12 58 50 1 Hematopoietic Cell Proliferation Minimal Moribund Sacrifice
Alimentary System Liver 30 MG/KG 10 12 56 50 1 Hematopoietic Cell Proliferation Minimal Natural Death
Alimentary System Liver 0.1 MG/KG 10 3 14 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 0.1 MG/KG 10 4 20 92 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Mesentery Fat Vehicle Control 1 1 3 92 1 Necrosis Mild Terminal Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 10 1 4 92 1 Atrophy Mild, Focal Terminal Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 10 2 10 92 1 Atrophy Mild, Focal Terminal Sacrifice
Alimentary System Pancreas Acinus 10 MG/KG 10 10 48 92 1 Atrophy Minimal, Focal Terminal Sacrifice
Alimentary System Pancreas 10 MG/KG 10 9 44 92 1 Atrophy Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 1 MG/KG 10 5 24 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 7 31 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 7 32 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 7 35 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 8 38 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 8 39 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 8 40 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 10 46 92 1 Hyperplasia Minimal, Focal Accidentally Killed
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 10 47 92 1 Hyperplasia Mild, Focal Accidentally Killed
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 10 48 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 10 49 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 9 41 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 9 42 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 9 43 92 1 Hyperplasia Mild, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 9 44 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 11 51 46 1 Hyperplasia Moderate, Focal Moribund Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 11 52 45 1 Hyperplasia Minimal, Focal Moribund Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 11 53 45 1 Hyperplasia Moderate, Focal Moribund Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 11 54 58 1 Hyperplasia Minimal, Focal Moribund Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 11 55 45 1 Hyperplasia Mild, Focal Moribund Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 12 58 50 1 Hyperplasia Minimal, Focal Moribund Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 12 59 57 1 Hyperplasia Minimal, Focal Moribund Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 12 56 50 1 Hyperplasia Mild, Focal Natural Death
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 12 60 45 1 Hyperplasia Mild, Focal Natural Death
Alimentary System Stomach Glandular, Epithelium Vehicle Control 10 1 5 92 1 Inflammation Minimal, Acute Terminal Sacrifice
Cardiovascular System Heart Atrium, Epicardium 30 MG/KG 10 12 59 57 1 Hemorrhage Mild Moribund Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 1 1 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 1 2 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 1 3 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 1 4 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 1 5 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 2 10 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 2 6 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 2 7 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 2 8 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 2 9 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 0.1 MG/KG 9 3 11 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 0.1 MG/KG 9 3 12 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 0.1 MG/KG 9 3 13 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 0.1 MG/KG 9 3 14 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 0.1 MG/KG 9 3 15 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 0.1 MG/KG 9 4 17 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 0.1 MG/KG 9 4 18 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 0.1 MG/KG 9 4 19 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 0.1 MG/KG 9 4 20 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 1 MG/KG 10 5 21 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1 MG/KG 10 5 22 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 1 MG/KG 10 5 23 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1 MG/KG 10 5 25 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1 MG/KG 10 6 26 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1 MG/KG 10 6 27 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1 MG/KG 10 6 28 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 1 MG/KG 10 6 29 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 1 MG/KG 10 6 30 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 3 MG/KG 10 7 32 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 3 MG/KG 10 7 33 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 3 MG/KG 10 7 34 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 3 MG/KG 10 7 35 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 3 MG/KG 10 8 36 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 3 MG/KG 10 8 37 92 1 Cardiomyopathy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium 3 MG/KG 10 8 39 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 3 MG/KG 10 8 40 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 10 MG/KG 10 10 46 92 1 Cardiomyopathy Mild Accidentally Killed
Cardiovascular System Heart Myocardium 10 MG/KG 10 10 47 92 1 Cardiomyopathy Mild Accidentally Killed
Cardiovascular System Heart Myocardium 10 MG/KG 10 10 48 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 10 MG/KG 10 10 49 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 10 MG/KG 10 9 41 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 10 MG/KG 10 9 44 92 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 30 MG/KG 10 11 51 46 1 Cardiomyopathy Moderate Moribund Sacrifice
Cardiovascular System Heart Myocardium 30 MG/KG 10 11 52 45 1 Cardiomyopathy Moderate Moribund Sacrifice
Cardiovascular System Heart Myocardium 30 MG/KG 10 11 53 45 1 Cardiomyopathy Moderate Moribund Sacrifice
Cardiovascular System Heart Myocardium 30 MG/KG 10 11 54 58 1 Cardiomyopathy Mild Moribund Sacrifice
Cardiovascular System Heart Myocardium 30 MG/KG 10 11 55 45 1 Cardiomyopathy Moderate Moribund Sacrifice
Cardiovascular System Heart Myocardium 30 MG/KG 10 12 58 50 1 Cardiomyopathy Moderate Moribund Sacrifice
Cardiovascular System Heart Myocardium 30 MG/KG 10 12 59 57 1 Cardiomyopathy Moderate Moribund Sacrifice
Cardiovascular System Heart Myocardium 30 MG/KG 10 12 56 50 1 Cardiomyopathy Mild Natural Death
Cardiovascular System Heart Myocardium 30 MG/KG 10 12 57 42 1 Cardiomyopathy Mild Natural Death
Cardiovascular System Heart Myocardium 30 MG/KG 10 12 60 45 1 Cardiomyopathy Moderate Natural Death
Cardiovascular System Heart Vehicle Control 10 2 8 92 1 Hemorrhage Mild, Focal Terminal Sacrifice
Endocrine System Adrenal Cortex 30 MG/KG 10 12 58 50 1 Vacuolization Cytoplasmic Mild, Focal Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 10 MG/KG 10 9 44 92 1 Cyst Minimal, Focal Terminal Sacrifice
Endocrine System Thyroid Gland Vehicle Control 10 1 1 92 1 Ultimobranchial Cyst Mild, Focal Terminal Sacrifice
Endocrine System Thyroid Gland Vehicle Control 10 1 3 92 1 Ultimobranchial Cyst Minimal, Focal Terminal Sacrifice
Endocrine System Thyroid Gland Vehicle Control 10 2 6 92 1 Ultimobranchial Cyst Minimal, Focal Terminal Sacrifice
Endocrine System Thyroid Gland 10 MG/KG 10 10 48 92 1 Ultimobranchial Cyst Mild, Focal Terminal Sacrifice
Endocrine System Thyroid Gland 10 MG/KG 10 10 49 92 1 Ultimobranchial Cyst Mild, Focal Terminal Sacrifice
Endocrine System Thyroid Gland 10 MG/KG 10 9 45 92 1 Ultimobranchial Cyst Minimal, Focal Terminal Sacrifice
Endocrine System Thyroid Gland 30 MG/KG 10 11 52 45 1 Ultimobranchial Cyst Mild, Focal Moribund Sacrifice
Endocrine System Thyroid Gland 30 MG/KG 10 12 58 50 1 Ultimobranchial Cyst Minimal, Focal Moribund Sacrifice
Endocrine System Thyroid Gland 30 MG/KG 10 12 59 57 1 Ultimobranchial Cyst Minimal, Focal Moribund Sacrifice
Endocrine System Thyroid Gland 30 MG/KG 10 12 56 50 1 Ultimobranchial Cyst Minimal, Focal Natural Death
Genital System Preputial Gland 30 MG/KG 10 11 51 46 1 Atrophy Mild Moribund Sacrifice
Genital System Preputial Gland 30 MG/KG 10 11 52 45 1 Atrophy Mild Moribund Sacrifice
Genital System Preputial Gland 30 MG/KG 10 11 53 45 1 Atrophy Mild Moribund Sacrifice
Genital System Preputial Gland 30 MG/KG 10 11 54 58 1 Atrophy Minimal Moribund Sacrifice
Genital System Preputial Gland 30 MG/KG 10 11 55 45 1 Atrophy Minimal Moribund Sacrifice
Genital System Preputial Gland 30 MG/KG 10 12 58 50 1 Atrophy Mild Moribund Sacrifice
Genital System Preputial Gland 30 MG/KG 10 12 59 57 1 Atrophy Minimal Moribund Sacrifice
Genital System Preputial Gland 30 MG/KG 10 12 56 50 1 Atrophy Mild Natural Death
Genital System Preputial Gland 30 MG/KG 10 12 57 42 1 Atrophy Mild Natural Death
Genital System Preputial Gland 30 MG/KG 10 12 60 45 1 Atrophy Mild Natural Death
Genital System Preputial Gland Vehicle Control 10 1 3 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Preputial Gland Vehicle Control 10 2 10 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Genital System Preputial Gland Vehicle Control 10 2 6 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Preputial Gland Vehicle Control 10 2 7 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Preputial Gland 10 MG/KG 10 10 50 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Genital System Seminal Vesicle 30 MG/KG 10 11 51 46 1 Atrophy Minimal Moribund Sacrifice
Genital System Seminal Vesicle 30 MG/KG 10 11 52 45 1 Atrophy Mild Moribund Sacrifice
Genital System Seminal Vesicle 30 MG/KG 10 11 53 45 1 Atrophy Mild Moribund Sacrifice
Genital System Seminal Vesicle 30 MG/KG 10 11 54 58 1 Atrophy Minimal Moribund Sacrifice
Genital System Seminal Vesicle 30 MG/KG 10 11 55 45 1 Atrophy Minimal Moribund Sacrifice
Genital System Seminal Vesicle 30 MG/KG 10 12 58 50 1 Atrophy Minimal Moribund Sacrifice
Genital System Seminal Vesicle 30 MG/KG 10 12 59 57 1 Atrophy Minimal Moribund Sacrifice
Genital System Seminal Vesicle 30 MG/KG 10 12 56 50 1 Atrophy Minimal Natural Death
Genital System Seminal Vesicle 30 MG/KG 10 12 57 42 1 Atrophy Moderate Natural Death
Genital System Seminal Vesicle 30 MG/KG 10 12 60 45 1 Atrophy Mild Natural Death
Genital System Testes Bilateral, Germinal Epith 30 MG/KG 10 11 52 45 1 Degeneration Mild Moribund Sacrifice
Genital System Testes Germinal Epith 10 MG/KG 10 9 41 92 1 Atrophy Marked Terminal Sacrifice
Genital System Testes 10 MG/KG 10 9 41 92 1 Inflammation Moderate, Granulomatous Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 10 MG/KG 10 10 48 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 10 MG/KG 10 10 49 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 30 MG/KG 10 12 56 50 1 Atrophy Minimal Natural Death
Hematopoietic System Lymph Node Mandibular Vehicle Control 10 2 8 92 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 1 MG/KG 10 6 27 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 3 MG/KG 10 7 31 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 3 MG/KG 10 8 36 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 1 MG/KG 10 6 28 92 1 Hyperplasia Minimal, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 1 MG/KG 10 6 29 92 1 Hyperplasia Minimal, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 3 MG/KG 10 8 36 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 1 MG/KG 10 5 23 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 3 MG/KG 10 7 31 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 10 MG/KG 10 10 49 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 10 MG/KG 10 9 45 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 30 MG/KG 10 12 56 50 1 Atrophy Minimal Natural Death
Hematopoietic System Lymph Node Mesenteric 3 MG/KG 10 8 36 92 1 Hyperplasia Minimal, Histiocytic Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 10 MG/KG 10 9 41 92 1 Inflammation Minimal, Focal, Granulomatous Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 10 MG/KG 10 9 42 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Hematopoietic System Spleen 0.1 MG/KG 10 4 19 92 1 Accessory Spleen Terminal Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 11 51 46 1 Hematopoietic Cell Proliferation Mild Moribund Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 11 52 45 1 Hematopoietic Cell Proliferation Minimal Moribund Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 11 53 45 1 Hematopoietic Cell Proliferation Mild Moribund Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 11 54 58 1 Hematopoietic Cell Proliferation Mild Moribund Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 11 55 45 1 Hematopoietic Cell Proliferation Mild Moribund Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 12 58 50 1 Hematopoietic Cell Proliferation Minimal Moribund Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 12 59 57 1 Hematopoietic Cell Proliferation Mild Moribund Sacrifice
Hematopoietic System Spleen 30 MG/KG 10 12 56 50 1 Hematopoietic Cell Proliferation Mild Natural Death
Hematopoietic System Spleen 30 MG/KG 10 12 60 45 1 Hematopoietic Cell Proliferation Minimal Natural Death
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 7 31 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 7 32 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 7 33 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 7 34 92 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 7 35 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 8 36 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 8 37 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 8 38 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 8 39 92 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 10 46 92 1 Atrophy Marked Accidentally Killed
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 10 47 92 1 Atrophy Marked Accidentally Killed
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 10 48 92 1 Atrophy Marked Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 10 49 92 1 Atrophy Moderate Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 10 50 92 1 Atrophy Moderate Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 9 41 92 1 Atrophy Moderate Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 9 42 92 1 Atrophy Marked Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 9 43 92 1 Atrophy Marked Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 9 44 92 1 Atrophy Moderate Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 9 45 92 1 Atrophy Marked Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 11 51 46 1 Atrophy Moderate Moribund Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 11 52 45 1 Atrophy Marked Moribund Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 11 53 45 1 Atrophy Marked Moribund Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 11 54 58 1 Atrophy Marked Moribund Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 11 55 45 1 Atrophy Moderate Moribund Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 12 58 50 1 Atrophy Marked Moribund Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 12 59 57 1 Atrophy Moderate Moribund Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 12 56 50 1 Atrophy Marked Natural Death
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 12 57 42 1 Atrophy Marked Natural Death
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 12 60 45 1 Atrophy Marked Natural Death
Hematopoietic System Thymus Vehicle Control 10 2 7 92 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Thymus Vehicle Control 10 2 9 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Thymus 0.1 MG/KG 10 4 19 92 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 12 56 50 1 Hemorrhage Mild Natural Death
Hematopoietic System Thymus 30 MG/KG 10 12 57 42 1 Hemorrhage Mild Natural Death
Hematopoietic System Thymus 30 MG/KG 10 12 60 45 1 Hemorrhage Marked Natural Death
Integumentary System Mammary Gland Duct 10 MG/KG 10 10 48 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Artery 10 MG/KG 10 10 46 92 1 Inflammation Mild, Chronic Active Accidentally Killed
Respiratory System Lung Artery 10 MG/KG 10 10 47 92 1 Inflammation Mild, Chronic Active Accidentally Killed
Respiratory System Lung Artery 10 MG/KG 10 10 48 92 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung Artery 10 MG/KG 10 9 42 92 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Lung Artery 30 MG/KG 10 11 51 46 1 Inflammation Mild, Chronic Active Moribund Sacrifice
Respiratory System Lung Artery 30 MG/KG 10 11 52 45 1 Inflammation Moderate, Chronic Active Moribund Sacrifice
Respiratory System Lung Artery 30 MG/KG 10 11 53 45 1 Inflammation Moderate, Chronic Active Moribund Sacrifice
Respiratory System Lung Artery 30 MG/KG 10 11 54 58 1 Inflammation Mild, Chronic Active Moribund Sacrifice
Respiratory System Lung Artery 30 MG/KG 10 11 55 45 1 Inflammation Mild, Chronic Active Moribund Sacrifice
Respiratory System Lung Artery 30 MG/KG 10 12 58 50 1 Inflammation Mild, Chronic Active Moribund Sacrifice
Respiratory System Lung Artery 30 MG/KG 10 12 59 57 1 Inflammation Mild, Chronic Active Moribund Sacrifice
Respiratory System Lung Artery 30 MG/KG 10 12 56 50 1 Inflammation Mild, Chronic Active Natural Death
Respiratory System Lung Artery 30 MG/KG 10 12 57 42 1 Inflammation Moderate, Chronic Active Natural Death
Respiratory System Lung Artery 30 MG/KG 10 12 60 45 1 Inflammation Mild, Chronic Active Natural Death
Respiratory System Lung Bronchus 10 MG/KG 10 10 48 92 1 Necrosis Moderate Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 1 1 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 1 2 92 1 Inflammation Moderate, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 1 3 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 1 4 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 1 5 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 2 10 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 2 6 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 2 7 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 2 8 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 2 9 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 0.1 MG/KG 10 3 11 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 0.1 MG/KG 10 3 12 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 0.1 MG/KG 10 3 13 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 0.1 MG/KG 10 3 14 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 0.1 MG/KG 10 3 15 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 0.1 MG/KG 10 4 16 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 0.1 MG/KG 10 4 17 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 0.1 MG/KG 10 4 18 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 0.1 MG/KG 10 4 19 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 0.1 MG/KG 10 4 20 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 1 MG/KG 10 5 21 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 1 MG/KG 10 5 22 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 1 MG/KG 10 5 23 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 1 MG/KG 10 5 24 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 1 MG/KG 10 5 25 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 1 MG/KG 10 6 26 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 1 MG/KG 10 6 27 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 1 MG/KG 10 6 28 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 1 MG/KG 10 6 29 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 1 MG/KG 10 6 30 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 3 MG/KG 10 7 31 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 3 MG/KG 10 7 32 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 3 MG/KG 10 7 33 92 1 Inflammation Moderate, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 3 MG/KG 10 7 34 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 3 MG/KG 10 7 35 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 3 MG/KG 10 8 36 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 3 MG/KG 10 8 37 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 3 MG/KG 10 8 38 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 3 MG/KG 10 8 39 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 3 MG/KG 10 8 40 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/KG 10 10 46 92 1 Inflammation Mild, Chronic Accidentally Killed
Respiratory System Lung Interstitium 10 MG/KG 10 10 47 92 1 Inflammation Moderate, Chronic Accidentally Killed
Respiratory System Lung Interstitium 10 MG/KG 10 10 48 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/KG 10 10 49 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/KG 10 10 50 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/KG 10 9 41 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/KG 10 9 42 92 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/KG 10 9 45 92 1 Inflammation Mild, Chronic Terminal Sacrifice
Respiratory System Lung Interstitium 30 MG/KG 10 11 51 46 1 Inflammation Mild, Chronic Moribund Sacrifice
Respiratory System Lung Interstitium 30 MG/KG 10 11 52 45 1 Inflammation Mild, Chronic Moribund Sacrifice
Respiratory System Lung Interstitium 30 MG/KG 10 11 53 45 1 Inflammation Mild, Chronic Moribund Sacrifice
Respiratory System Lung Interstitium 30 MG/KG 10 11 54 58 1 Inflammation Mild, Chronic Moribund Sacrifice
Respiratory System Lung Interstitium 30 MG/KG 10 11 55 45 1 Inflammation Mild, Chronic Moribund Sacrifice
Respiratory System Lung Interstitium 30 MG/KG 10 12 59 57 1 Inflammation Mild, Chronic Moribund Sacrifice
Respiratory System Lung Interstitium 30 MG/KG 10 12 56 50 1 Inflammation Mild, Chronic Natural Death
Respiratory System Lung Interstitium 30 MG/KG 10 12 57 42 1 Inflammation Moderate, Chronic Natural Death
Respiratory System Lung Interstitium 30 MG/KG 10 12 60 45 1 Inflammation Moderate, Chronic Natural Death
Respiratory System Lung Vehicle Control 10 1 5 92 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung 1 MG/KG 10 6 30 92 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Lung 3 MG/KG 10 8 36 92 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung 3 MG/KG 10 8 40 92 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung 10 MG/KG 10 9 43 92 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung 10 MG/KG 10 9 44 92 1 Hemorrhage Mild, Focal Terminal Sacrifice
Respiratory System Lung 10 MG/KG 10 9 45 92 1 Hemorrhage Mild, Focal Terminal Sacrifice
Respiratory System Trachea Epithelium 10 MG/KG 10 9 42 92 1 Hyperplasia Minimal Terminal Sacrifice
Respiratory System Trachea 10 MG/KG 10 9 42 92 1 Inflammation Minimal, Acute Terminal Sacrifice
Urinary System Kidney Pelvis 30 MG/KG 10 12 59 57 1 Dilatation Minimal Moribund Sacrifice
Urinary System Kidney Pelvis, Transit Epithe 10 MG/KG 10 10 47 92 1 Hyperplasia Minimal Accidentally Killed
Urinary System Kidney Pelvis, Transit Epithe 10 MG/KG 10 10 50 92 1 Hyperplasia Minimal Terminal Sacrifice
Urinary System Kidney 30 MG/KG 10 11 54 58 1 Hemorrhage Mild, Focal Moribund Sacrifice
Urinary System Kidney Vehicle Control 10 1 1 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 2 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 3 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 4 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 5 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 10 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 6 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 7 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 8 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 9 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 0.1 MG/KG 10 3 11 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 0.1 MG/KG 10 3 12 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 0.1 MG/KG 10 3 13 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 0.1 MG/KG 10 3 14 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 0.1 MG/KG 10 3 15 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 0.1 MG/KG 10 4 16 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 0.1 MG/KG 10 4 17 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 0.1 MG/KG 10 4 18 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 0.1 MG/KG 10 4 19 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 0.1 MG/KG 10 4 20 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1 MG/KG 10 5 21 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1 MG/KG 10 5 22 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1 MG/KG 10 5 23 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1 MG/KG 10 5 24 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 1 MG/KG 10 5 25 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 1 MG/KG 10 6 26 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 1 MG/KG 10 6 27 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1 MG/KG 10 6 28 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1 MG/KG 10 6 29 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 1 MG/KG 10 6 30 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 MG/KG 10 7 31 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 3 MG/KG 10 7 32 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 3 MG/KG 10 7 33 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 3 MG/KG 10 7 34 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 MG/KG 10 7 35 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 MG/KG 10 8 36 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 MG/KG 10 8 37 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 MG/KG 10 8 38 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 3 MG/KG 10 8 39 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 3 MG/KG 10 8 40 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 10 MG/KG 10 10 46 92 1 Nephropathy Mild Accidentally Killed
Urinary System Kidney 10 MG/KG 10 10 47 92 1 Nephropathy Mild Accidentally Killed
Urinary System Kidney 10 MG/KG 10 10 48 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 10 MG/KG 10 10 49 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 10 MG/KG 10 10 50 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 10 MG/KG 10 9 41 92 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 10 MG/KG 10 9 42 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 10 MG/KG 10 9 43 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 10 MG/KG 10 9 44 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 10 MG/KG 10 9 45 92 1 Nephropathy Mild Terminal Sacrifice
Urinary System Kidney 30 MG/KG 10 11 51 46 1 Nephropathy Mild Moribund Sacrifice
Urinary System Kidney 30 MG/KG 10 11 52 45 1 Nephropathy Moderate Moribund Sacrifice
Urinary System Kidney 30 MG/KG 10 11 53 45 1 Nephropathy Moderate Moribund Sacrifice
Urinary System Kidney 30 MG/KG 10 11 54 58 1 Nephropathy Mild Moribund Sacrifice
Urinary System Kidney 30 MG/KG 10 11 55 45 1 Nephropathy Moderate Moribund Sacrifice
Urinary System Kidney 30 MG/KG 10 12 58 50 1 Nephropathy Moderate Moribund Sacrifice
Urinary System Kidney 30 MG/KG 10 12 59 57 1 Nephropathy Moderate Moribund Sacrifice
Urinary System Kidney 30 MG/KG 10 12 56 50 1 Nephropathy Moderate Natural Death
Urinary System Kidney 30 MG/KG 10 12 60 45 1 Nephropathy Moderate Natural Death