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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 3,3',4,4'-Tetrachloroazoxybenzene
CASRN: ="21232-47-3"
Study Number: C88149
Exposure Route: GAVAGE
TDMS Number: 8814904
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Centrilobular, Hepatocyte 3 MG/KG 10 68 96 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 69 101 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 69 102 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 69 103 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 69 105 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 71 111 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 71 112 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 71 113 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 71 114 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 71 115 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 72 118 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 3 MG/KG 10 67 95 92 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 3 MG/KG 10 67 93 92 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 70 108 92 1 Hyperplasia Mild Accidentally Killed
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 70 106 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 70 110 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 71 111 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 71 112 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 71 115 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 72 117 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 72 118 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 72 119 92 1 Hyperplasia Moderate Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 72 120 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Glandular 3 MG/KG 10 67 95 92 1 Fibrosis Mild Terminal Sacrifice
Cardiovascular System Heart Pericardium 30 MG/KG 10 72 116 28 1 Inflammation Moderate, Diffuse, Chronic Dosing Accident
Endocrine System Adrenal Cortex Vehicle Control 10 62 68 92 1 Hemorrhage Mild, Acute Terminal Sacrifice
Endocrine System Parathyroid Gland Vehicle Control 10 61 62 92 1 Infiltration Cellular Moderate, Lymphocyte Terminal Sacrifice
Endocrine System Parathyroid Gland Vehicle Control 10 61 63 92 1 Inflammation Mild, Focal, Granulomatous Terminal Sacrifice
General Body System Tissue NOS Mediastinum 10 MG/KG 1 69 104 8 1 Inflammation Marked Dosing Accident
Hematopoietic System Bone Marrow Myeloid Cell 10 MG/KG 1 69 104 8 1 Hyperplasia Moderate Dosing Accident
Hematopoietic System Bone Marrow Myeloid Cell 30 MG/KG 10 72 116 28 1 Hyperplasia Moderate Dosing Accident
Hematopoietic System Spleen Red Pulp Vehicle Control 10 62 67 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 62 70 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 63 75 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 63 71 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 63 72 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 63 73 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 63 74 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 64 80 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 65 83 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 65 81 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 65 82 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 65 84 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 66 86 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 66 89 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 67 93 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 67 94 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 67 95 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 68 100 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 70 108 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 69 104 8 1 Hematopoietic Cell Proliferation Mild, Diffuse Dosing Accident
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 69 102 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 69 105 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 70 106 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 70 107 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 70 109 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 71 111 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 71 112 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 71 113 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 71 114 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 71 115 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 72 117 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 72 118 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 72 119 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 72 120 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 61 61 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 61 62 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 61 63 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 61 64 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 61 65 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 62 66 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 62 67 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 62 68 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 62 69 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 62 70 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 63 75 92 1 Pigmentation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 63 71 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 63 72 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 63 73 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 63 74 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 64 76 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 64 77 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 64 78 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 64 79 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 64 80 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 65 83 92 1 Pigmentation Mild, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 65 81 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 65 82 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 65 84 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 65 85 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 66 86 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 66 87 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 66 88 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 66 89 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 66 90 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 68 97 92 1 Pigmentation Mild, Diffuse Natural Death
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 67 91 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 67 92 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 67 93 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 67 94 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 67 95 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 68 100 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 68 96 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 68 98 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 68 99 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 70 108 92 1 Pigmentation Moderate, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 69 101 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 69 102 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 69 103 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 69 105 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 70 106 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 70 107 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 70 109 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 70 110 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 71 111 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 71 112 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 71 113 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 71 114 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 71 115 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 72 117 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 72 118 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 72 119 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 72 120 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Thymus Thymocyte Vehicle Control 10 62 69 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 0.1 MG/KG 10 64 77 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 67 91 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 3 MG/KG 10 68 100 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 69 103 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 69 105 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 70 107 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 70 109 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 70 110 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 71 111 92 1 Necrosis Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 71 112 92 1 Necrosis Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 71 113 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 71 114 92 1 Necrosis Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 72 117 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 72 118 92 1 Necrosis Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 72 119 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 72 120 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus 10 MG/KG 10 69 104 8 1 Atrophy Marked, Diffuse Dosing Accident
Integumentary System Skin Hair Follicle 10 MG/KG 10 70 106 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 71 112 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 71 113 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 71 114 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 71 115 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 72 117 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 72 118 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 72 119 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 72 120 92 1 Dilatation Minimal Terminal Sacrifice
Respiratory System Lung Perivascular 30 MG/KG 10 71 112 92 1 Inflammation Minimal Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 71 111 92 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung 30 MG/KG 10 72 120 92 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Respiratory System Lung 10 MG/KG 1 69 104 8 1 Inflammation Marked, Focal Dosing Accident
Respiratory System Lung 30 MG/KG 10 72 116 28 1 Inflammation Marked, Focal Dosing Accident