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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 3,3',4,4'-Tetrachloroazoxybenzene
CASRN: ="21232-47-3"
Study Number: C88149
Exposure Route: GAVAGE
TDMS Number: 8814904
Sex: Male
Strain and Species: B6C3F1 Mice

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Centrilobular, Hepatocyte 3 MG/KG 10 36 36 92 1 Hypertrophy Minimal Accidentally Killed
Alimentary System Liver Centrilobular, Hepatocyte 3 MG/KG 10 32 32 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 3 MG/KG 10 37 37 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 41 41 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 43 43 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 44 44 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 45 45 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 48 48 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 10 MG/KG 10 50 50 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 56 56 92 1 Hypertrophy Minimal Accidentally Killed
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 51 51 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 52 52 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 53 53 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 54 54 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 55 55 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 57 57 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 58 58 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 59 59 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular, Hepatocyte 30 MG/KG 10 60 60 92 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 1 MG/KG 10 27 27 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 3 MG/KG 10 35 35 92 1 Hyperplasia Minimal Accidentally Killed
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 42 42 92 1 Hyperplasia Minimal Accidentally Killed
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 41 41 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 43 43 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 44 44 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 46 46 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 48 48 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 10 MG/KG 10 50 50 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 56 56 92 1 Hyperplasia Minimal Accidentally Killed
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 51 51 92 1 Hyperplasia Minimal Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 52 52 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 53 53 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 54 54 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 55 55 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 57 57 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 58 58 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 59 59 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Forestomach, Epithelium 30 MG/KG 10 60 60 92 1 Hyperplasia Mild Terminal Sacrifice
Alimentary System Stomach Glandular, Epithelium Vehicle Control 10 2 2 92 1 Cyst Minimal, Focal Terminal Sacrifice
Endocrine System Thyroid Gland Vehicle Control 10 2 2 92 1 Ectopic Thymus Terminal Sacrifice
Genital System Preputial Gland 30 MG/KG 10 59 59 92 1 Cyst Minimal Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 10 10 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp Vehicle Control 10 3 3 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 11 11 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 20 20 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 27 27 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 28 28 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 35 35 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 31 31 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 38 38 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 40 40 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 41 41 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 43 43 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 44 44 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 45 45 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 48 48 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 50 50 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 56 56 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 52 52 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 53 53 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 55 55 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 57 57 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 58 58 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 59 59 92 1 Hematopoietic Cell Proliferation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 60 60 92 1 Hematopoietic Cell Proliferation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 11 11 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 14 14 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 17 17 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 0.1 MG/KG 10 20 20 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 23 23 92 1 Pigmentation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 24 24 92 1 Pigmentation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 26 26 92 1 Pigmentation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 21 21 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 22 22 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 25 25 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 27 27 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 28 28 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 1 MG/KG 10 30 30 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 33 33 92 1 Pigmentation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 35 35 92 1 Pigmentation Mild, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 36 36 92 1 Pigmentation Mild, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 39 39 92 1 Pigmentation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 31 31 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 32 32 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 34 34 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 37 37 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 38 38 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 3 MG/KG 10 40 40 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 42 42 92 1 Pigmentation Minimal, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 47 47 92 1 Pigmentation Mild, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 49 49 92 1 Pigmentation Mild, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 41 41 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 43 43 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 44 44 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 45 45 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 46 46 92 1 Pigmentation Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 48 48 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 10 MG/KG 10 50 50 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 56 56 92 1 Pigmentation Mild, Diffuse Accidentally Killed
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 51 51 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 52 52 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 53 53 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 54 54 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 55 55 92 1 Pigmentation Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 57 57 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 58 58 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 59 59 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Spleen Red Pulp 30 MG/KG 10 60 60 92 1 Pigmentation Mild, Diffuse Terminal Sacrifice
Hematopoietic System Thymus Thymocyte Vehicle Control 10 4 4 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte Vehicle Control 10 6 6 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 47 47 92 1 Necrosis Minimal Accidentally Killed
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 49 49 92 1 Necrosis Minimal Accidentally Killed
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 41 41 92 1 Necrosis Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 43 43 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 44 44 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 46 46 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 48 48 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 10 MG/KG 10 50 50 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 56 56 92 1 Necrosis Minimal Accidentally Killed
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 51 51 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 53 53 92 1 Necrosis Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 54 54 92 1 Necrosis Mild Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 57 57 92 1 Necrosis Minimal Terminal Sacrifice
Hematopoietic System Thymus Thymocyte 30 MG/KG 10 60 60 92 1 Necrosis Mild Terminal Sacrifice
Hematopoietic System Thymus 3 MG/KG 10 40 40 92 1 Atrophy Minimal, Diffuse Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 52 52 92 1 Atrophy Moderate, Diffuse Terminal Sacrifice
Hematopoietic System Thymus 30 MG/KG 10 59 59 92 1 Atrophy Minimal, Diffuse Terminal Sacrifice
Integumentary System Skin Hair Follicle 0.1 MG/KG 10 14 14 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 1 MG/KG 10 22 22 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 3 MG/KG 10 32 32 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 3 MG/KG 10 37 37 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 3 MG/KG 10 38 38 92 1 Dilatation Mild Terminal Sacrifice
Integumentary System Skin Hair Follicle 10 MG/KG 10 42 42 92 1 Dilatation Minimal Accidentally Killed
Integumentary System Skin Hair Follicle 10 MG/KG 10 47 47 92 1 Dilatation Minimal Accidentally Killed
Integumentary System Skin Hair Follicle 10 MG/KG 10 49 49 92 1 Dilatation Minimal Accidentally Killed
Integumentary System Skin Hair Follicle 10 MG/KG 10 41 41 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 10 MG/KG 10 43 43 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 10 MG/KG 10 44 44 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 10 MG/KG 10 45 45 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 10 MG/KG 10 46 46 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 10 MG/KG 10 48 48 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 10 MG/KG 10 50 50 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 56 56 92 1 Dilatation Mild Accidentally Killed
Integumentary System Skin Hair Follicle 30 MG/KG 10 51 51 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 52 52 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 53 53 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 54 54 92 1 Dilatation Mild Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 55 55 92 1 Dilatation Mild Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 57 57 92 1 Dilatation Mild Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 58 58 92 1 Dilatation Mild Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 59 59 92 1 Dilatation Minimal Terminal Sacrifice
Integumentary System Skin Hair Follicle 30 MG/KG 10 60 60 92 1 Dilatation Mild Terminal Sacrifice
Respiratory System Lung Alveolar Epith Vehicle Control 10 5 5 92 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 6 6 92 1 Hydronephrosis Mild Terminal Sacrifice