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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 5-(Hydroxymethyl)-2-furfural
CASRN: ="67-47-0"
Study Number: C95011
Exposure Route: GAVAGE
TDMS Number: 9501103
Sex: Female
Strain and Species: F 344/N Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus Muscularis Vehicle Control 10 13 61 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Esophagus Muscularis Vehicle Control 10 14 70 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Intestine Large Colon Vehicle Control 10 14 66 94 1 Parasite Metazoan Terminal Sacrifice
Alimentary System Intestine Large Colon 1500 MG/KG 10 23 113 92 1 Ulcer Minimal Natural Death
Alimentary System Liver Vehicle Control 10 13 64 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 14 67 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 94 MG/KG 5 15 71 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 94 MG/KG 5 15 72 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 94 MG/KG 5 15 73 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 94 MG/KG 5 16 76 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 94 MG/KG 5 16 78 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 188 MG/KG 2 17 82 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 188 MG/KG 2 18 87 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 375 MG/KG 2 20 100 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 375 MG/KG 2 20 99 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 750 MG/KG 1 21 102 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 1500 MG/KG 10 23 111 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 1500 MG/KG 10 24 117 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 13 61 94 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 13 62 94 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 13 64 94 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 13 65 94 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Alimentary System Mesentery Fat Vehicle Control 1 14 67 94 1 Necrosis Mild Terminal Sacrifice
Alimentary System Mesentery Fat 188 MG/KG 1 17 85 94 1 Necrosis Mild Terminal Sacrifice
Alimentary System Mesentery Fat 750 MG/KG 1 21 105 94 1 Necrosis Mild Terminal Sacrifice
Alimentary System Salivary Glands 1500 MG/KG 10 23 113 92 1 Necrosis Mild Natural Death
Alimentary System Stomach Glandular 1500 MG/KG 10 23 113 92 1 Ulcer Moderate Natural Death
Cardiovascular System Heart Myocardium Vehicle Control 10 14 68 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 14 69 94 1 Degeneration Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1500 MG/KG 10 23 113 92 1 Degeneration Minimal, Focal Natural Death
Endocrine System Pituitary Gland 1500 MG/KG 10 23 113 92 1 Necrosis Marked, Acute Natural Death
Hematopoietic System Lymph Node Mesenteric 1500 MG/KG 10 23 112 4 1 Atrophy Moderate Natural Death
Hematopoietic System Lymph Node Mesenteric 94 MG/KG 1 16 76 94 1 Hyperplasia Moderate, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 188 MG/KG 1 18 87 94 1 Hyperplasia Marked, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 94 MG/KG 1 16 76 94 1 Infiltration Cellular Moderate, Histiocyte Terminal Sacrifice
Hematopoietic System Spleen Lymph Follic 1500 MG/KG 10 23 112 4 1 Atrophy Marked Natural Death
Hematopoietic System Spleen Lymph Follic 1500 MG/KG 10 23 113 92 1 Atrophy Moderate Natural Death
Hematopoietic System Spleen Lymph Follic 1500 MG/KG 10 23 114 29 1 Atrophy Mild Natural Death
Hematopoietic System Spleen 1500 MG/KG 10 23 114 29 1 Congestion Marked Natural Death
Hematopoietic System Spleen 94 MG/KG 1 16 80 94 1 Hyperplasia Marked, Stromal Terminal Sacrifice
Nervous System Brain 1500 MG/KG 10 23 113 92 1 Congestion Moderate Natural Death
Nervous System Brain 1500 MG/KG 10 23 114 29 1 Congestion Mild Natural Death
Respiratory System Lung Alveolus 1500 MG/KG 10 24 120 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung 1500 MG/KG 10 23 112 4 1 Congestion Mild Natural Death
Respiratory System Lung 1500 MG/KG 10 23 114 29 1 Congestion Mild Natural Death
Respiratory System Lung 1500 MG/KG 10 23 114 29 1 Hemorrhage Minimal Natural Death
Respiratory System Nose 1500 MG/KG 10 23 114 29 1 Congestion Moderate Natural Death
Respiratory System Nose Vehicle Control 10 13 65 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Nose 1500 MG/KG 10 23 114 29 1 Inflammation Minimal, Suppurative Natural Death
Respiratory System Nose 1500 MG/KG 10 23 115 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Nose 1500 MG/KG 10 24 116 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Trachea 1500 MG/KG 10 23 114 29 1 Fibrosis Minimal Natural Death
Respiratory System Trachea 1500 MG/KG 10 23 114 29 1 Inflammation Minimal, Chronic Natural Death
Urinary System Kidney Renal Tubule 1500 MG/KG 10 23 112 4 1 Necrosis Moderate, Focal, Acute Natural Death
Urinary System Kidney 1500 MG/KG 10 23 112 4 1 Congestion Moderate Natural Death
Urinary System Kidney 1500 MG/KG 10 23 114 29 1 Hemorrhage Mild, Focal, Acute Natural Death