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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 5-(Hydroxymethyl)-2-furfural
CASRN: ="67-47-0"
Study Number: C95011
Exposure Route: GAVAGE
TDMS Number: 9501103
Sex: Male
Strain and Species: F 344/N Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus Muscularis 1500 MG/KG 10 12 58 16 1 Degeneration Minimal Dosing Accident
Alimentary System Esophagus Muscularis 1500 MG/KG 10 12 57 94 1 Degeneration Minimal Terminal Sacrifice
Alimentary System Esophagus Muscularis 1500 MG/KG 10 12 60 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Intestine Large Colon Vehicle Control 10 1 5 94 1 Parasite Metazoan Terminal Sacrifice
Alimentary System Intestine Large Rectum Vehicle Control 10 1 2 94 1 Parasite Metazoan Terminal Sacrifice
Alimentary System Intestine Large Rectum 1500 MG/KG 10 12 57 94 1 Parasite Metazoan Terminal Sacrifice
Alimentary System Liver Centrilobular 1500 MG/KG 10 12 58 16 1 Fatty Change Mild Dosing Accident
Alimentary System Liver 94 MG/KG 1 4 17 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 188 MG/KG 2 5 23 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 188 MG/KG 2 6 27 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 375 MG/KG 1 8 37 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 750 MG/KG 2 10 47 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 750 MG/KG 2 10 49 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Pancreas Acinus 1500 MG/KG 10 11 53 94 1 Atrophy Minimal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 1 1 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 1 2 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 1 4 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 1 5 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 2 6 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 2 8 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 2 9 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1500 MG/KG 10 11 52 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1500 MG/KG 10 11 53 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1500 MG/KG 10 11 54 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1500 MG/KG 10 11 55 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Myocardium 1500 MG/KG 10 12 57 94 1 Degeneration Minimal, Focal Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1500 MG/KG 10 11 54 94 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Nervous System Brain 1500 MG/KG 10 12 58 16 1 Congestion Mild Dosing Accident
Respiratory System Lung Alveolus 1500 MG/KG 10 11 54 94 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 1500 MG/KG 10 12 58 16 1 Congestion Moderate Dosing Accident
Respiratory System Lung 1500 MG/KG 10 11 52 94 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Respiratory System Lung 1500 MG/KG 10 11 51 94 1 Hemorrhage Minimal, Acute Terminal Sacrifice
Respiratory System Lung 1500 MG/KG 10 11 54 94 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Lung 1500 MG/KG 10 11 55 94 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Nose 1500 MG/KG 10 11 53 94 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose 1500 MG/KG 10 11 54 94 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Nose 1500 MG/KG 10 12 56 94 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Respiratory System Trachea 1500 MG/KG 10 12 58 16 1 Fibrosis Moderate Dosing Accident
Respiratory System Trachea 1500 MG/KG 10 11 52 94 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Trachea 1500 MG/KG 10 12 58 16 1 Inflammation Moderate, Chronic Dosing Accident
Respiratory System Trachea 1500 MG/KG 10 11 52 94 1 Inflammation Minimal, Chronic Terminal Sacrifice