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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Benzyltrimethyl ammonium chloride
CASRN: ="56-93-9"
Study Number: C88139C
Exposure Route: GAVAGE
TDMS Number: 8813905
Sex: Female
Strain and Species: F 344/N Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Centrilobular, Hepatocyte 25.0 MG/KG 1 16 76 83 1 Vacuolization Cytoplasmic Mild Dosing Accident
Alimentary System Liver Vehicle Control 10 11 51 92 1 Inflammation Mild, Focal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 12 57 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 12 58 92 1 Inflammation Mild, Focal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 12 59 92 1 Inflammation Mild, Focal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 12 60 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 10 19 91 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 10 19 93 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 10 19 94 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 10 20 98 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Mesentery Fat Vehicle Control 1 12 57 92 1 Necrosis Moderate Terminal Sacrifice
Alimentary System Mesentery Fat 25.0 MG/KG 1 15 75 92 1 Necrosis Moderate Terminal Sacrifice
Alimentary System Pancreas Acinus 100.0 MG/KG 10 19 91 92 1 Atrophy Minimal Terminal Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 10 12 58 92 1 Degeneration Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 11 51 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 11 52 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 11 55 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 12 56 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 12 59 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 25.0 MG/KG 1 16 76 83 1 Inflammation Minimal, Focal Dosing Accident
Cardiovascular System Heart 100.0 MG/KG 10 19 92 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 100.0 MG/KG 10 19 94 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 100.0 MG/KG 10 19 95 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 100.0 MG/KG 10 20 96 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 100.0 MG/KG 10 20 96 92 1 Cyst Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle Vehicle Control 10 11 51 92 1 Cyst Minimal Terminal Sacrifice
Genital System Uterus Bilateral 12.5 MG/KG 2 14 67 92 1 Cyst Mild Terminal Sacrifice
Genital System Uterus Bilateral 12.5 MG/KG 2 14 70 92 1 Cyst Mild Terminal Sacrifice
Genital System Uterus Bilateral 50.0 MG/KG 1 18 88 92 1 Cyst Mild Terminal Sacrifice
Genital System Uterus Bilateral Vehicle Control 10 11 51 92 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus Bilateral Vehicle Control 10 11 52 92 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus Bilateral 100.0 MG/KG 10 19 94 92 1 Dilatation Moderate Terminal Sacrifice
Genital System Uterus Bilateral 100.0 MG/KG 10 20 99 92 1 Dilatation Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 11 53 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 25.0 MG/KG 1 16 76 83 1 Hematopoietic Cell Proliferation Minimal Dosing Accident
Respiratory System Lung 100.0 MG/KG 10 20 97 83 1 Congestion Moderate Natural Death
Respiratory System Lung Vehicle Control 10 11 51 92 1 Inflammation Mild, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 11 53 92 1 Inflammation Mild, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 12 58 92 1 Inflammation Mild, Focal Terminal Sacrifice
Respiratory System Lung 25.0 MG/KG 1 16 76 83 1 Inflammation Minimal, Focal Dosing Accident
Respiratory System Lung 50.0 MG/KG 10 17 84 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 50.0 MG/KG 10 18 86 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 50.0 MG/KG 10 18 90 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 10 20 100 70 1 Inflammation Moderate, Focal Natural Death
Respiratory System Lung 100.0 MG/KG 10 20 97 83 1 Inflammation Moderate, Focal Natural Death
Respiratory System Lung 100.0 MG/KG 10 19 94 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 10 20 96 92 1 Inflammation Moderate, Focal Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 10 20 98 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 10 20 99 92 1 Inflammation Mild, Focal Terminal Sacrifice
Respiratory System Nose Vehicle Control 10 12 60 92 1 Inflammation Mild, Chronic Active Terminal Sacrifice