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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Benzyltrimethyl ammonium chloride
CASRN: ="56-93-9"
Study Number: C88139C
Exposure Route: GAVAGE
TDMS Number: 8813905
Sex: Male
Strain and Species: F 344/N Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Centrilobular, Hepatocyte 100.0 MG/KG 10 9 41 92 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 3 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 5 92 1 Inflammation Mild, Focal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 10 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 2 8 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 10 10 49 92 1 Inflammation Mild, Focal Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 10 10 50 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 10 9 41 92 1 Inflammation Mild, Focal Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 10 9 43 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Alimentary System Liver 100.0 MG/KG 10 9 45 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 1 92 1 Inflammation Mild, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 2 92 1 Inflammation Mild, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 3 92 1 Inflammation Moderate, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 4 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 5 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 6 92 1 Inflammation Mild, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 8 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 9 92 1 Inflammation Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 100.0 MG/KG 10 10 46 92 1 Inflammation Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 100.0 MG/KG 10 10 49 92 1 Inflammation Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 100.0 MG/KG 10 9 41 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 100.0 MG/KG 10 9 43 92 1 Inflammation Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 100.0 MG/KG 10 9 45 92 1 Inflammation Mild, Focal Terminal Sacrifice
Endocrine System Pituitary Gland Vehicle Control 10 2 7 92 1 Cyst Minimal Terminal Sacrifice
Endocrine System Pituitary Gland 100.0 MG/KG 10 10 50 92 1 Cyst Mild Terminal Sacrifice
Endocrine System Thyroid Gland Follicle Vehicle Control 10 1 4 92 1 Cyst Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle Vehicle Control 10 1 5 92 1 Cyst Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 100.0 MG/KG 10 10 48 92 1 Cyst Mild Terminal Sacrifice
Genital System Epididymis 25.0 MG/KG 1 6 26 92 1 Inflammation Moderate, Focal, Granulomatous Terminal Sacrifice
Genital System Prostate Vehicle Control 10 2 6 92 1 Infiltration Cellular Mild, Focal, Lymphocyte Terminal Sacrifice
Genital System Prostate 100.0 MG/KG 10 9 41 92 1 Inflammation Minimal Terminal Sacrifice
Genital System Testes 25.0 MG/KG 1 6 26 92 1 Atrophy Moderate Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 1 2 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 2 10 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 2 9 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 100.0 MG/KG 10 10 49 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 100.0 MG/KG 10 9 42 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 100.0 MG/KG 10 9 43 92 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 100.0 MG/KG 10 9 45 92 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 1 92 1 Inflammation Mild, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 2 92 1 Inflammation Mild, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 3 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 4 92 1 Inflammation Mild, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 5 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 10 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 50.0 MG/KG 10 7 34 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 10 10 46 92 1 Inflammation Mild, Focal Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 10 10 47 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 10 10 49 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 10 10 50 92 1 Inflammation Mild, Focal Terminal Sacrifice
Respiratory System Lung 100.0 MG/KG 10 9 42 92 1 Inflammation Minimal, Focal Terminal Sacrifice
Respiratory System Nose Vehicle Control 10 1 5 92 1 Inflammation Minimal Terminal Sacrifice
Respiratory System Nose Vehicle Control 10 2 9 92 1 Inflammation Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule Vehicle Control 10 2 6 92 1 Hemorrhage Mild, Focal Terminal Sacrifice