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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Water disinfection model (Dichloroacetic acid)
CASRN: ="79-43-6"
Study Number: C97013D
Exposure Route: SKIN APPLICATION
TDMS Number: 9701302
Sex: Female
Strain and Species: FVB/N Mice

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Centrilobular Vehicle Control 5 31 31 18 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular Vehicle Control 5 32 32 18 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular Vehicle Control 5 33 33 18 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular Vehicle Control 5 34 34 18 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular Vehicle Control 5 35 35 18 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 31.25 MG/KG 5 36 36 18 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 31.25 MG/KG 5 37 37 18 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 31.25 MG/KG 5 38 38 18 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 31.25 MG/KG 5 39 39 18 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 31.25 MG/KG 5 40 40 18 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 62.5 MG/KG 5 41 41 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 62.5 MG/KG 5 42 42 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 62.5 MG/KG 5 43 43 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 62.5 MG/KG 5 44 44 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 62.5 MG/KG 5 45 45 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 125 MG/KG 5 46 46 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 125 MG/KG 5 47 47 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 125 MG/KG 5 48 48 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 125 MG/KG 5 49 49 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 125 MG/KG 5 50 50 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 250 MG/KG 5 51 51 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 250 MG/KG 5 52 52 18 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Centrilobular 250 MG/KG 5 53 53 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 250 MG/KG 5 54 54 18 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Centrilobular 250 MG/KG 5 55 55 18 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 500 MG/KG 5 56 56 18 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Centrilobular 500 MG/KG 5 57 57 18 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Centrilobular 500 MG/KG 5 58 58 18 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Centrilobular 500 MG/KG 5 59 59 18 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Centrilobular 500 MG/KG 5 60 60 18 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Integumentary System Skin Control 500 MG/KG 5 58 58 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin Control, Epidermis 500 MG/KG 5 58 58 18 1 Hyperplasia Mild Terminal Sacrifice
Integumentary System Skin Dermis, SOA 125 MG/KG 5 46 46 18 1 Fibrosis Mild Terminal Sacrifice
Integumentary System Skin Dermis, SOA 125 MG/KG 5 48 48 18 1 Fibrosis Minimal Terminal Sacrifice
Integumentary System Skin Dermis, SOA 125 MG/KG 5 49 49 18 1 Fibrosis Mild Terminal Sacrifice
Integumentary System Skin Dermis, SOA 125 MG/KG 5 50 50 18 1 Fibrosis Minimal Terminal Sacrifice
Integumentary System Skin Dermis, SOA 250 MG/KG 5 51 51 18 1 Fibrosis Mild Terminal Sacrifice
Integumentary System Skin Dermis, SOA 250 MG/KG 5 52 52 18 1 Fibrosis Mild Terminal Sacrifice
Integumentary System Skin Dermis, SOA 250 MG/KG 5 53 53 18 1 Fibrosis Moderate Terminal Sacrifice
Integumentary System Skin Dermis, SOA 250 MG/KG 5 54 54 18 1 Fibrosis Marked Terminal Sacrifice
Integumentary System Skin Dermis, SOA 250 MG/KG 5 55 55 18 1 Fibrosis Moderate Terminal Sacrifice
Integumentary System Skin Dermis, SOA 500 MG/KG 5 56 56 18 1 Fibrosis Marked Terminal Sacrifice
Integumentary System Skin Dermis, SOA 500 MG/KG 5 57 57 18 1 Fibrosis Marked Terminal Sacrifice
Integumentary System Skin Dermis, SOA 500 MG/KG 5 58 58 18 1 Fibrosis Marked Terminal Sacrifice
Integumentary System Skin Dermis, SOA 500 MG/KG 5 59 59 18 1 Fibrosis Moderate Terminal Sacrifice
Integumentary System Skin Dermis, SOA 500 MG/KG 5 60 60 18 1 Fibrosis Marked Terminal Sacrifice
Integumentary System Skin Dermis, SOA 62.5 MG/KG 5 42 42 18 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 62.5 MG/KG 5 43 43 18 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 125 MG/KG 5 46 46 18 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 125 MG/KG 5 47 47 18 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 125 MG/KG 5 48 48 18 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 125 MG/KG 5 49 49 18 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 125 MG/KG 5 50 50 18 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 250 MG/KG 5 51 51 18 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 250 MG/KG 5 52 52 18 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 250 MG/KG 5 53 53 18 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 250 MG/KG 5 54 54 18 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 250 MG/KG 5 55 55 18 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 500 MG/KG 5 56 56 18 1 Inflammation Marked, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 500 MG/KG 5 57 57 18 1 Inflammation Marked, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 500 MG/KG 5 58 58 18 1 Inflammation Marked, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 500 MG/KG 5 59 59 18 1 Inflammation Marked, Chronic Active Terminal Sacrifice
Integumentary System Skin Dermis, SOA 500 MG/KG 5 60 60 18 1 Inflammation Marked, Chronic Active Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 62.5 MG/KG 5 41 41 18 1 Hyperplasia Minimal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 62.5 MG/KG 5 42 42 18 1 Hyperplasia Minimal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 62.5 MG/KG 5 43 43 18 1 Hyperplasia Minimal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 62.5 MG/KG 5 44 44 18 1 Hyperplasia Minimal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 62.5 MG/KG 5 45 45 18 1 Hyperplasia Minimal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 125 MG/KG 5 46 46 18 1 Hyperplasia Mild Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 125 MG/KG 5 47 47 18 1 Hyperplasia Mild Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 125 MG/KG 5 48 48 18 1 Hyperplasia Mild Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 125 MG/KG 5 49 49 18 1 Hyperplasia Mild Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 125 MG/KG 5 50 50 18 1 Hyperplasia Mild Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 51 51 18 1 Hyperplasia Moderate Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 52 52 18 1 Hyperplasia Moderate Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 53 53 18 1 Hyperplasia Marked Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 54 54 18 1 Hyperplasia Moderate Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 55 55 18 1 Hyperplasia Marked Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 56 56 18 1 Hyperplasia Minimal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 57 57 18 1 Hyperplasia Minimal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 58 58 18 1 Hyperplasia Mild Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 59 59 18 1 Hyperplasia Mild Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 125 MG/KG 5 49 49 18 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 52 52 18 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 54 54 18 1 Inflammation Moderate, Suppurative Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 55 55 18 1 Inflammation Minimal, Suppurative Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 56 56 18 1 Inflammation Marked, Suppurative Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 57 57 18 1 Inflammation Marked, Suppurative Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 58 58 18 1 Inflammation Marked, Suppurative Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 59 59 18 1 Inflammation Marked, Suppurative Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 60 60 18 1 Inflammation Marked, Suppurative Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 62.5 MG/KG 5 44 44 18 1 Necrosis Minimal, Focal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 125 MG/KG 5 47 47 18 1 Necrosis Minimal, Focal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 125 MG/KG 5 48 48 18 1 Necrosis Minimal, Focal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 125 MG/KG 5 49 49 18 1 Necrosis Minimal, Focal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 51 51 18 1 Necrosis Minimal, Focal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 52 52 18 1 Necrosis Mild, Focal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 54 54 18 1 Necrosis Minimal, Focal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 250 MG/KG 5 55 55 18 1 Necrosis Moderate, Focal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 58 58 18 1 Necrosis Marked, Focal Terminal Sacrifice
Integumentary System Skin Epidermis, SOA 500 MG/KG 5 59 59 18 1 Necrosis Moderate, Focal Terminal Sacrifice
Integumentary System Skin SOA 62.5 MG/KG 5 41 41 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 62.5 MG/KG 5 42 42 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 62.5 MG/KG 5 43 43 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 62.5 MG/KG 5 44 44 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 62.5 MG/KG 5 45 45 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 46 46 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 47 47 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 48 48 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 49 49 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 50 50 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 51 51 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 52 52 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 53 53 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 54 54 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 55 55 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 56 56 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 57 57 18 1 Hyperkeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 58 58 18 1 Hyperkeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 59 59 18 1 Hyperkeratosis Moderate Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 46 46 18 1 Parakeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 47 47 18 1 Parakeratosis Moderate Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 48 48 18 1 Parakeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 49 49 18 1 Parakeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 51 51 18 1 Parakeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 52 52 18 1 Parakeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 53 53 18 1 Parakeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 54 54 18 1 Parakeratosis Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 55 55 18 1 Parakeratosis Moderate Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 57 57 18 1 Parakeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 48 48 18 1 Ulcer Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 51 51 18 1 Ulcer Mild Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 52 52 18 1 Ulcer Moderate Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 54 54 18 1 Ulcer Moderate Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 55 55 18 1 Ulcer Minimal Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 56 56 18 1 Ulcer Marked Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 57 57 18 1 Ulcer Marked Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 58 58 18 1 Ulcer Marked Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 59 59 18 1 Ulcer Marked Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 60 60 18 1 Ulcer Marked Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 250 MG/KG 5 51 51 18 1 Fibrosis Minimal Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 250 MG/KG 5 52 52 18 1 Fibrosis Minimal Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 250 MG/KG 5 53 53 18 1 Fibrosis Mild Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 250 MG/KG 5 54 54 18 1 Fibrosis Moderate Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 250 MG/KG 5 55 55 18 1 Fibrosis Mild Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 500 MG/KG 5 56 56 18 1 Fibrosis Marked Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 500 MG/KG 5 57 57 18 1 Fibrosis Marked Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 500 MG/KG 5 58 58 18 1 Fibrosis Marked Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 500 MG/KG 5 59 59 18 1 Fibrosis Moderate Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 500 MG/KG 5 60 60 18 1 Fibrosis Marked Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 250 MG/KG 5 51 51 18 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 250 MG/KG 5 52 52 18 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 250 MG/KG 5 53 53 18 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 250 MG/KG 5 54 54 18 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 250 MG/KG 5 55 55 18 1 Inflammation Mild, Chronic Active Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 500 MG/KG 5 56 56 18 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 500 MG/KG 5 57 57 18 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 500 MG/KG 5 58 58 18 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 500 MG/KG 5 59 59 18 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Integumentary System Skin SOA, Subcut Tiss 500 MG/KG 5 60 60 18 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Respiratory System Lung Serosa 500 MG/KG 5 60 60 18 1 Fibrosis Minimal, Focal Terminal Sacrifice