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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Water disinfection model (Dichloroacetic acid)
CASRN: ="79-43-6"
Study Number: C97013D
Exposure Route: SKIN APPLICATION
TDMS Number: 9701312
Sex: Male
Strain and Species: FVB/N Mice

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Centrilobular 125 MG/KG 5 17 17 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 125 MG/KG 5 19 19 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 125 MG/KG 5 20 20 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 250 MG/KG 5 21 21 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 250 MG/KG 5 22 22 17 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Centrilobular 250 MG/KG 5 23 23 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 500 MG/KG 5 26 26 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 500 MG/KG 5 27 27 17 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Centrilobular 500 MG/KG 5 28 28 17 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Centrilobular 500 MG/KG 5 29 29 17 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Centrilobular 500 MG/KG 5 30 30 17 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver 62.5 MG/KG 5 14 14 17 1 Inflammation Minimal Terminal Sacrifice
Alimentary System Liver 250 MG/KG 5 22 22 17 1 Inflammation Minimal Terminal Sacrifice
Alimentary System Liver 500 MG/KG 5 28 28 17 1 Inflammation Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 5 1 1 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 31.25 MG/KG 5 7 7 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 31.25 MG/KG 5 8 8 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 62.5 MG/KG 5 13 13 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 62.5 MG/KG 5 14 14 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 62.5 MG/KG 5 15 15 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 250 MG/KG 5 21 21 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 250 MG/KG 5 23 23 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 250 MG/KG 5 24 24 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 250 MG/KG 5 25 25 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 500 MG/KG 5 29 29 17 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver 500 MG/KG 5 29 29 17 1 Pigmentation Minimal, Focal Terminal Sacrifice
Integumentary System Skin SOA 125 MG/KG 5 18 18 17 1 Hyperkeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 21 21 17 1 Hyperkeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 23 23 17 1 Hyperkeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 24 24 17 1 Hyperkeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 250 MG/KG 5 25 25 17 1 Hyperkeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 26 26 17 1 Hyperkeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 27 27 17 1 Hyperkeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 28 28 17 1 Hyperkeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 29 29 17 1 Hyperkeratosis Minimal Terminal Sacrifice
Integumentary System Skin SOA 500 MG/KG 5 30 30 17 1 Hyperkeratosis Minimal Terminal Sacrifice
Respiratory System Lung 125 MG/KG 5 19 19 17 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Urinary System Kidney 250 MG/KG 5 21 21 17 1 Cyst Minimal, Focal Terminal Sacrifice