If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Dipropylene glycol
CASRN: ="25265-71-8"
Study Number: C88031
Exposure Route: DOSED WATER
TDMS Number: 8803103
Sex: Female
Strain and Species: F 344/N Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver 8.0 % 10 23 231 95 1 Atypical Focus Mild Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 13 183 95 1 Developmental Malformation Mild, Focal Terminal Sacrifice
Alimentary System Liver 8.0 % 10 23 231 95 1 Fatty Change Moderate Terminal Sacrifice
Alimentary System Liver 8.0 % 10 23 232 95 1 Fatty Change Mild Terminal Sacrifice
Alimentary System Liver 8.0 % 10 23 233 95 1 Fatty Change Mild Terminal Sacrifice
Alimentary System Liver 8.0 % 10 23 234 95 1 Fatty Change Moderate Terminal Sacrifice
Alimentary System Liver 8.0 % 10 23 235 95 1 Fatty Change Mild Terminal Sacrifice
Alimentary System Liver 8.0 % 10 24 236 95 1 Fatty Change Mild Terminal Sacrifice
Alimentary System Liver 8.0 % 10 24 237 95 1 Fatty Change Mild Terminal Sacrifice
Alimentary System Liver 8.0 % 10 24 238 95 1 Fatty Change Mild Terminal Sacrifice
Alimentary System Liver 8.0 % 10 24 239 95 1 Fatty Change Minimal Terminal Sacrifice
Alimentary System Liver 8.0 % 10 24 240 95 1 Fatty Change Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 14 188 95 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 1.0 % 1 17 205 95 Multiple Hepatodiaphragmatic Nodule Moderate Terminal Sacrifice
Alimentary System Liver 2.0 % 3 19 211 95 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 2.0 % 3 20 219 95 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 4.0 % 10 21 223 95 1 Hepatodiaphragmatic Nodule Moderate Terminal Sacrifice
Alimentary System Liver 8.0 % 10 23 234 95 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 10 13 183 95 1 Atrophy Mild, Focal Terminal Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 10 13 185 95 1 Atrophy Minimal, Focal Terminal Sacrifice
Alimentary System Pancreas Acinus 8.0 % 10 23 234 95 1 Atrophy Mild, Focal Terminal Sacrifice
Alimentary System Pancreas 8.0 % 10 23 235 95 1 Ectopic Liver Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 8.0 % 10 24 238 95 1 Cardiomyopathy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Vehicle Control 10 13 181 95 1 Hyperplasia Mild, Focal Terminal Sacrifice
Endocrine System Adrenal Cortex 0.5 % 10 15 191 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 0.5 % 10 15 192 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 0.5 % 10 15 195 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 0.5 % 10 16 196 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 0.5 % 10 16 197 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 0.5 % 10 16 198 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 0.5 % 10 16 199 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 0.5 % 10 16 200 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 1.0 % 10 17 201 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 1.0 % 10 17 202 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 1.0 % 10 17 203 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 1.0 % 10 17 204 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 1.0 % 10 17 205 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 1.0 % 10 18 206 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 1.0 % 10 18 207 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 1.0 % 10 18 208 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 1.0 % 10 18 209 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 1.0 % 10 18 210 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 2.0 % 10 19 211 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 2.0 % 10 19 212 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 2.0 % 10 19 213 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 2.0 % 10 19 214 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 2.0 % 10 19 215 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 2.0 % 10 20 216 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 2.0 % 10 20 217 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 2.0 % 10 20 218 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 2.0 % 10 20 219 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 2.0 % 10 20 220 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 4.0 % 10 21 221 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 4.0 % 10 21 222 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 4.0 % 10 21 223 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 4.0 % 10 21 224 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 4.0 % 10 21 225 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 4.0 % 10 22 226 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 4.0 % 10 22 227 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 4.0 % 10 22 228 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 4.0 % 10 22 229 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 4.0 % 10 22 230 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 8.0 % 10 23 231 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 8.0 % 10 23 233 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 8.0 % 10 23 234 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 8.0 % 10 23 235 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 8.0 % 10 24 236 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 8.0 % 10 24 237 95 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Adrenal Cortex 8.0 % 10 24 238 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 8.0 % 10 24 239 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 8.0 % 10 24 240 95 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1.0 % 1 17 204 95 1 Hyperplasia Mild, Focal Terminal Sacrifice
Genital System Ovary 4.0 % 1 21 222 95 1 Cyst Moderate Terminal Sacrifice
Genital System Uterus 8.0 % 10 23 232 95 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus 8.0 % 10 23 234 95 1 Atrophy Mild Terminal Sacrifice
Genital System Uterus Vehicle Control 10 13 181 95 1 Dilatation Moderate Terminal Sacrifice
Genital System Uterus 0.5 % 1 16 196 95 1 Dilatation Moderate Terminal Sacrifice
Genital System Uterus 1.0 % 1 18 206 95 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus 2.0 % 3 19 213 95 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus 2.0 % 3 19 215 95 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus 2.0 % 3 20 218 95 1 Dilatation Minimal Terminal Sacrifice
Genital System Uterus 4.0 % 3 21 221 95 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus 4.0 % 3 22 228 95 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus 8.0 % 10 23 231 95 1 Dilatation Moderate Terminal Sacrifice
Hematopoietic System Lymph Node Bronchial Vehicle Control 10 14 189 95 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular Vehicle Control 10 14 189 95 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular Vehicle Control 10 14 190 95 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 1.0 % 2 17 204 95 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 2.0 % 3 19 213 95 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 2.0 % 3 20 218 95 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mandibular 8.0 % 10 23 231 95 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 1.0 % 2 17 202 95 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 2.0 % 3 19 213 95 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 2.0 % 3 20 217 95 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Renal 4.0 % 1 21 225 95 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Spleen 8.0 % 10 24 236 95 1 Ectopic Tissue Terminal Sacrifice
Hematopoietic System Thymus Vehicle Control 10 14 190 95 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Thymus 1.0 % 1 18 210 95 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 14 186 95 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 14 189 95 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 14 190 95 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung 8.0 % 10 24 238 95 1 Hemorrhage Minimal, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 13 184 95 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 14 189 95 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 14 187 95 1 Inflammation Minimal, Focal, Subacute Terminal Sacrifice
Respiratory System Nose Olfactory Epi 8.0 % 10 23 231 95 1 Degeneration Moderate, Focal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 8.0 % 10 23 232 95 1 Degeneration Moderate, Focal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 8.0 % 10 23 233 95 1 Degeneration Moderate, Focal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 8.0 % 10 23 234 95 1 Degeneration Moderate, Focal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 8.0 % 10 23 235 95 1 Degeneration Marked, Focal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 8.0 % 10 24 236 95 1 Degeneration Moderate, Focal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 8.0 % 10 24 237 95 1 Degeneration Moderate, Focal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 8.0 % 10 24 238 95 1 Degeneration Moderate, Focal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 8.0 % 10 24 239 95 1 Degeneration Moderate, Focal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 8.0 % 10 24 240 95 1 Degeneration Moderate, Focal Terminal Sacrifice
Respiratory System Nose Respirat Epith 8.0 % 10 23 231 95 1 Degeneration Mild, Focal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 23 231 95 1 Casts Protein Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 23 232 95 1 Casts Protein Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 23 235 95 1 Casts Protein Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 24 236 95 1 Casts Protein Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 24 237 95 1 Casts Protein Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 24 238 95 1 Casts Protein Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 24 239 95 1 Casts Protein Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 24 240 95 1 Casts Protein Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 23 232 95 1 Regeneration Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 23 235 95 1 Regeneration Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 24 237 95 1 Regeneration Minimal Terminal Sacrifice
Urinary System Kidney Renal Tubule 8.0 % 10 24 239 95 1 Regeneration Minimal Terminal Sacrifice
Urinary System Kidney 8.0 % 10 23 232 95 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Kidney 8.0 % 10 23 235 95 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice