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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Methacrylonitrile
CASRN: ="126-98-7"
Study Number: C88050
Exposure Route: GAVAGE
TDMS Number: 8805004
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus Muscularis Vehicle Control 10 133 183 32 1 Inflammation Mild, Chronic Active Scheduled Sacrifice
Alimentary System Esophagus Muscularis 1.5 MG/KG 2 138 209 4 1 Inflammation Marked, Suppurative, Acute Dosing Accident
Alimentary System Esophagus 1.5 MG/KG 2 138 209 4 1 Perforation Dosing Accident
Alimentary System Liver Vehicle Control 10 61 65 95 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Alimentary System Liver 12 MG/KG 10 144 237 32 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Alimentary System Liver 12.0 MG/KG 10 71 112 95 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Cardiovascular System Heart 1.5 MG/KG 2 138 209 4 1 Inflammation Moderate, Suppurative, Acute Dosing Accident
Genital System Ovary 3.0 MG/KG 1 68 99 95 1 Cyst Mild Terminal Sacrifice
Hematopoietic System Spleen 12.0 MG/KG 10 71 111 53 1 Hematopoietic Cell Proliferation Moderate Natural Death
Hematopoietic System Thymus Thymocyte 12.0 MG/KG 10 72 120 2 1 Necrosis Moderate Dosing Accident
Hematopoietic System Thymus 1.5 MG/KG 2 138 209 4 1 Inflammation Moderate, Suppurative, Acute Dosing Accident
Respiratory System Lung Mediastinum 1.5 MG/KG 2 138 209 4 1 Inflammation Moderate, Suppurative, Acute Dosing Accident
Respiratory System Lung Mediastinum 1.5 MG/KG 2 138 210 3 1 Inflammation Moderate, Suppurative, Acute Dosing Accident
Respiratory System Lung Mediastinum 12.0 MG/KG 10 72 120 2 1 Inflammation Moderate, Suppurative, Acute Dosing Accident
Respiratory System Nose Vehicle Control 10 134 187 32 1 Inflammation Minimal Scheduled Sacrifice
Respiratory System Nose Vehicle Control 10 134 189 32 1 Inflammation Minimal Scheduled Sacrifice
Respiratory System Nose Vehicle Control 10 134 190 32 1 Inflammation Minimal Scheduled Sacrifice
Respiratory System Pleura 1.5 MG/KG 1 138 209 4 1 Inflammation Moderate, Suppurative, Acute Dosing Accident
Respiratory System Trachea 1.5 MG/KG 2 138 209 4 1 Inflammation Moderate, Suppurative, Acute Dosing Accident
Urinary System Kidney 12.0 MG/KG 10 71 114 95 1 Hydronephrosis Moderate Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 134 188 32 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Urinary System Kidney Vehicle Control 10 61 62 95 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Urinary System Kidney 12 MG/KG 10 144 240 32 1 Inflammation Minimal, Chronic Active Scheduled Sacrifice
Urinary System Urinary Bladder 12.0 MG/KG 10 72 119 95 1 Inflammation Mild, Focal, Granulomatous, Chronic Terminal Sacrifice
Urinary System Urinary Bladder 12.0 MG/KG 10 72 119 95 1 Mineralization Mild, Focal, Chronic Terminal Sacrifice