If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Methyl ethyl ketoxime
CASRN: ="96-29-7"
Study Number: C88009
Exposure Route: DOSED WATER
TDMS Number: 8800904
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Centrilobular 10000 PPM 10 112 112 93 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Centrilobular 10000 PPM 10 113 113 93 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 10000 PPM 10 115 115 93 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 10000 PPM 10 116 116 93 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Centrilobular 10000 PPM 10 117 117 93 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 111 111 93 1 Erythrophagocytosis Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 112 112 93 1 Erythrophagocytosis Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 113 113 93 1 Erythrophagocytosis Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 114 114 93 1 Erythrophagocytosis Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 115 115 93 1 Erythrophagocytosis Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 116 116 93 1 Erythrophagocytosis Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 117 117 93 1 Erythrophagocytosis Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 118 118 93 1 Erythrophagocytosis Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 111 111 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 112 112 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 113 113 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 114 114 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 115 115 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 116 116 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 117 117 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 118 118 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 119 119 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 10000 PPM 10 120 120 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver 10000 PPM 10 112 112 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Alimentary System Liver 10000 PPM 10 113 113 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Alimentary System Liver 10000 PPM 10 114 114 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Alimentary System Liver 10000 PPM 10 116 116 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Alimentary System Liver 10000 PPM 10 118 118 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Alimentary System Liver 10000 PPM 10 119 119 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Alimentary System Liver 10000 PPM 10 118 118 93 1 Necrosis Minimal, Focal Terminal Sacrifice
Alimentary System Salivary Glands Vehicle Control 10 61 61 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Alimentary System Salivary Glands Vehicle Control 10 65 65 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Alimentary System Stomach Glandular 10000 PPM 10 116 116 93 1 Inflammation Mild, Focal, Chronic Active Terminal Sacrifice
Endocrine System Adrenal Cortex Subcapsular Vehicle Control 10 61 61 93 1 Hyperplasia Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Subcapsular Vehicle Control 10 62 62 93 1 Hyperplasia Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Subcapsular Vehicle Control 10 64 64 93 1 Hyperplasia Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Subcapsular Vehicle Control 10 66 66 93 1 Hyperplasia Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Subcapsular 10000 PPM 10 115 115 93 1 Hyperplasia Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Subcapsular 10000 PPM 10 116 116 93 1 Hyperplasia Mild Terminal Sacrifice
Endocrine System Adrenal Cortex Subcapsular 10000 PPM 10 119 119 93 1 Hyperplasia Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 10000 PPM 10 116 116 93 1 Congestion Mild Terminal Sacrifice
Endocrine System Thyroid Gland Vehicle Control 10 65 65 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Hematopoietic System Bone Marrow 10000 PPM 10 111 111 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 10000 PPM 10 112 112 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 10000 PPM 10 113 113 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 10000 PPM 10 114 114 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 10000 PPM 10 115 115 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 10000 PPM 10 116 116 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 10000 PPM 10 117 117 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 10000 PPM 10 118 118 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 10000 PPM 10 119 119 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 10000 PPM 10 120 120 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 2500 PPM 10 100 100 93 1 Hyperplasia Minimal Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 10 101 101 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 10 102 102 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 10 103 103 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 10 104 104 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 10 105 105 93 1 Hyperplasia Mild, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 10 106 106 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 10 107 107 93 1 Hyperplasia Mild, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 10 108 108 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 10 109 109 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 5000 PPM 10 110 110 93 1 Hyperplasia Minimal, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 111 111 93 1 Hyperplasia Mild, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 112 112 93 1 Hyperplasia Moderate, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 113 113 93 1 Hyperplasia Moderate, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 114 114 93 1 Hyperplasia Moderate, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 115 115 93 1 Hyperplasia Moderate, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 116 116 93 1 Hyperplasia Moderate, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 117 117 93 1 Hyperplasia Moderate, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 118 118 93 1 Hyperplasia Moderate, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 119 119 93 1 Hyperplasia Moderate, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 120 120 93 1 Hyperplasia Mild, Erythrocyte Terminal Sacrifice
Hematopoietic System Spleen 2500 PPM 10 100 100 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 2500 PPM 10 95 95 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 2500 PPM 10 98 98 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 111 111 93 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 112 112 93 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 113 113 93 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 114 114 93 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 115 115 93 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 116 116 93 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 117 117 93 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 118 118 93 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 119 119 93 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Spleen 10000 PPM 10 120 120 93 1 Pigmentation Minimal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 70 70 93 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Lung 1250 PPM 1 89 89 93 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Lung 10000 PPM 10 113 113 93 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Lung 10000 PPM 10 115 115 93 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2500 PPM 10 91 91 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2500 PPM 10 94 94 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2500 PPM 10 98 98 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2500 PPM 10 99 99 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5000 PPM 10 101 101 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5000 PPM 10 102 102 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5000 PPM 10 103 103 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5000 PPM 10 104 104 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5000 PPM 10 105 105 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5000 PPM 10 106 106 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5000 PPM 10 107 107 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5000 PPM 10 108 108 93 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5000 PPM 10 109 109 93 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5000 PPM 10 110 110 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10000 PPM 10 111 111 93 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10000 PPM 10 112 112 93 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10000 PPM 10 113 113 93 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10000 PPM 10 114 114 93 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10000 PPM 10 115 115 93 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10000 PPM 10 116 116 93 1 Degeneration Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10000 PPM 10 117 117 93 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10000 PPM 10 118 118 93 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10000 PPM 10 119 119 93 1 Degeneration Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10000 PPM 10 120 120 93 1 Degeneration Moderate Terminal Sacrifice
Urinary System Kidney Interstitium Vehicle Control 10 63 63 93 1 Inflammation Minimal, Focal, Subacute Terminal Sacrifice
Urinary System Kidney Renal Tubule Vehicle Control 10 70 70 93 1 Regeneration Mild, Focal Terminal Sacrifice
Urinary System Kidney Renal Tubule 10000 PPM 10 118 118 93 1 Regeneration Minimal, Focal Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe 2500 PPM 10 92 92 93 1 Hyperplasia Mild Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe 2500 PPM 10 96 96 93 1 Hyperplasia Minimal Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe 2500 PPM 10 98 98 93 1 Hyperplasia Minimal Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe 5000 PPM 10 107 107 93 1 Hyperplasia Mild Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe 5000 PPM 10 110 110 93 1 Hyperplasia Mild Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe 10000 PPM 10 111 111 93 1 Hyperplasia Minimal Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe 10000 PPM 10 113 113 93 1 Hyperplasia Minimal Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe 10000 PPM 10 117 117 93 1 Hyperplasia Mild Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe 10000 PPM 10 118 118 93 1 Hyperplasia Minimal Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe 10000 PPM 10 119 119 93 1 Hyperplasia Minimal Terminal Sacrifice
Urinary System Urinary Bladder Vehicle Control 10 62 62 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 1250 PPM 10 83 83 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 2500 PPM 10 92 92 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 2500 PPM 10 93 93 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 2500 PPM 10 95 95 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 2500 PPM 10 96 96 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 2500 PPM 10 98 98 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 2500 PPM 10 99 99 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 5000 PPM 10 101 101 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 5000 PPM 10 102 102 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 5000 PPM 10 103 103 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 5000 PPM 10 104 104 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 5000 PPM 10 105 105 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 5000 PPM 10 106 106 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 5000 PPM 10 107 107 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 5000 PPM 10 108 108 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 5000 PPM 10 109 109 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 5000 PPM 10 110 110 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 10000 PPM 10 111 111 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 10000 PPM 10 112 112 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 10000 PPM 10 114 114 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 10000 PPM 10 116 116 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 10000 PPM 10 117 117 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 10000 PPM 10 118 118 93 1 Infiltration Cellular Mild, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 10000 PPM 10 119 119 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Urinary System Urinary Bladder 10000 PPM 10 120 120 93 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice