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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Milk thistle extract
CASRN: ="84604-20-6"
Study Number: C20008
Exposure Route: DOSED FEED
TDMS Number: 2000801
Sex: Female
Strain and Species: F 344/N Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Large Colon 50000 PPM 10 24 118 93 1 Intussusception Moderate Terminal Sacrifice
Alimentary System Intestine Large Rectum 50000 PPM 10 24 118 93 1 Intussusception Moderate Terminal Sacrifice
Alimentary System Liver Untreated Control 10 13 65 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 15 72 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 16 76 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 18 87 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 18 88 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 19 95 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 21 103 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 23 115 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver Untreated Control 10 13 61 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 13 62 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 13 63 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 13 65 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 14 67 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 14 68 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 14 69 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 15 71 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 15 72 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 15 73 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 15 74 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 15 75 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 16 76 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 16 77 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 16 78 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 16 79 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 16 80 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 17 81 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 17 82 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 17 83 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 17 84 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 17 85 93 1 Inflammation Mild, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 18 88 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 18 89 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 18 90 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 19 91 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 19 92 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 19 93 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 19 95 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 20 100 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 20 96 93 1 Inflammation Mild, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 20 97 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 20 98 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 20 99 93 1 Inflammation Mild, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 21 101 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 21 102 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 21 103 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 21 104 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 21 105 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 22 106 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 22 107 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 22 108 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 22 109 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 22 110 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 23 111 93 1 Inflammation Mild, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 23 112 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 23 113 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 23 115 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 24 116 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 24 117 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 24 118 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 24 119 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 24 120 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Pancreas Acinus Untreated Control 10 14 66 93 1 Atrophy Minimal, Focal Terminal Sacrifice
Alimentary System Pancreas Interstitium 50000 PPM 10 23 113 93 1 Fibrosis Minimal, Focal Terminal Sacrifice
Alimentary System Salivary Glands Duct, Parotid Gl 12500 PPM 10 20 98 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Salivary Glands Duct, Parotid Gl 50000 PPM 10 24 118 93 1 Proliferation Minimal, Focal Terminal Sacrifice
Alimentary System Salivary Glands Interstitium 50000 PPM 10 24 116 93 1 Fibrosis Minimal, Focal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl Untreated Control 10 14 68 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl Untreated Control 10 14 70 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 3125 PPM 10 15 71 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 3125 PPM 10 15 72 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 3125 PPM 10 15 73 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 3125 PPM 10 15 74 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 3125 PPM 10 16 76 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 3125 PPM 10 16 77 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 3125 PPM 10 16 78 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 6250 PPM 10 17 83 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 6250 PPM 10 18 86 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 6250 PPM 10 18 88 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 6250 PPM 10 18 90 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 12500 PPM 10 19 91 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 12500 PPM 10 19 92 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 12500 PPM 10 19 95 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 12500 PPM 10 20 99 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 25000 PPM 7 21 102 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 25000 PPM 7 21 104 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 25000 PPM 7 22 106 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 25000 PPM 7 22 108 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 25000 PPM 7 22 109 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 25000 PPM 7 22 110 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 23 112 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 23 114 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 24 116 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 24 117 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 24 118 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 24 119 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 24 120 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Tooth Pulp Untreated Control 1 13 64 93 1 Dysplasia Mild Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 13 63 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 14 67 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 23 113 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 24 117 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Endocrine System Adrenal Cortex Untreated Control 10 13 62 93 1 Accessory Adrenal Cortical Nodule Minimal Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 50000 PPM 10 23 112 93 1 Cyst Minimal Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 50000 PPM 10 23 115 93 1 Cyst Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Untreated Control 10 13 64 93 1 Ultimobranchial Cyst Minimal Terminal Sacrifice
Endocrine System Thyroid Gland 50000 PPM 10 24 119 93 1 Ultimobranchial Cyst Minimal Terminal Sacrifice
Genital System Clitoral Gland 12500 PPM 1 19 95 93 1 Cyst Mild Terminal Sacrifice
Genital System Uterus Untreated Control 10 13 64 93 1 Hydrometra Mild Terminal Sacrifice
Genital System Uterus 3125 PPM 1 15 75 93 1 Hydrometra Minimal Terminal Sacrifice
Genital System Uterus 12500 PPM 2 20 96 93 1 Hydrometra Mild Terminal Sacrifice
Genital System Uterus 12500 PPM 2 20 99 93 1 Hydrometra Mild Terminal Sacrifice
Genital System Uterus 50000 PPM 10 24 116 93 1 Hydrometra Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal Untreated Control 10 13 64 93 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Untreated Control 10 13 62 93 1 Hyperplasia Mild, Histiocytic Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Untreated Control 10 14 70 93 1 Hyperplasia Minimal, Histiocytic Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 50000 PPM 10 23 111 93 1 Hyperplasia Minimal, Histiocytic Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 50000 PPM 10 23 112 93 1 Hyperplasia Minimal, Histiocytic Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 50000 PPM 10 23 115 93 1 Hyperplasia Minimal, Histiocytic Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 50000 PPM 10 24 117 93 1 Hyperplasia Minimal, Histiocytic Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 50000 PPM 10 24 118 93 1 Hyperplasia Minimal, Histiocytic Terminal Sacrifice
Hematopoietic System Lymph Node Pancreatic 6250 PPM 2 17 84 93 1 Hyperplasia Moderate, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Pancreatic 6250 PPM 2 17 85 93 1 Hyperplasia Mild, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Pancreatic 12500 PPM 1 20 96 93 1 Hyperplasia Mild, Lymphoid Terminal Sacrifice
Respiratory System Lung Untreated Control 10 13 62 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Urinary System Kidney Pelvis 50000 PPM 10 23 113 93 1 Inflammation Mild Terminal Sacrifice
Urinary System Kidney Untreated Control 10 13 61 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Untreated Control 10 13 63 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 50000 PPM 10 23 112 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 50000 PPM 10 24 120 93 1 Nephropathy Minimal Terminal Sacrifice