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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Milk thistle extract
CASRN: ="84604-20-6"
Study Number: C20008
Exposure Route: DOSED FEED
TDMS Number: 2000801
Sex: Male
Strain and Species: F 344/N Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Large Colon 50000 PPM 10 12 57 93 1 Intussusception Moderate Terminal Sacrifice
Alimentary System Intestine Large Rectum 50000 PPM 10 12 57 93 1 Intussusception Moderate Terminal Sacrifice
Alimentary System Liver 3125 PPM 1 3 14 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 6 27 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 8 40 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 11 54 93 1 Hepatodiaphragmatic Nodule Mild Terminal Sacrifice
Alimentary System Liver Untreated Control 10 1 3 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 1 5 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 2 6 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 2 7 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 2 8 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 2 9 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 5 21 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 5 22 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 5 23 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 5 25 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 6 26 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 6 27 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 6 28 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 6 29 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 6 30 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 7 31 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 7 32 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 7 33 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 7 34 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 7 35 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 8 36 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 8 37 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 8 38 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 8 39 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 8 40 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 10 46 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 10 49 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 11 53 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 12 57 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 12 58 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 2 10 93 1 Vacuolization Cytoplasmic Minimal, Focal Terminal Sacrifice
Alimentary System Liver Untreated Control 10 2 6 93 1 Vacuolization Cytoplasmic Minimal, Focal Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 12 57 93 1 Vacuolization Cytoplasmic Minimal, Focal Terminal Sacrifice
Alimentary System Pancreas Acinus Untreated Control 10 1 3 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Pancreas Interstitium Untreated Control 10 2 7 93 1 Fibrosis Minimal, Focal Terminal Sacrifice
Alimentary System Pancreas 50000 PPM 10 11 54 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Pancreas Untreated Control 10 1 3 93 1 Fibrosis Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl Untreated Control 10 1 2 93 Multiple Basophilic Focus Mild Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl Untreated Control 10 1 3 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl Untreated Control 10 1 4 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl Untreated Control 10 1 5 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl Untreated Control 10 2 6 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl Untreated Control 10 2 7 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl Untreated Control 10 2 8 93 1 Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl Untreated Control 10 2 9 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 11 51 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 11 53 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 11 54 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 11 55 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 12 56 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 12 57 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 12 59 93 Multiple Basophilic Focus Minimal Terminal Sacrifice
Alimentary System Salivary Glands Parotid Gl 50000 PPM 10 12 60 93 Multiple Basophilic Focus Mild Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 1 1 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 1 2 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 1 3 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 1 4 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 1 5 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 2 10 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 2 6 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 2 7 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 2 8 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Untreated Control 10 2 9 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 3125 PPM 10 3 11 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 3125 PPM 10 3 12 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 3125 PPM 10 3 13 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 3125 PPM 10 3 14 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 3125 PPM 10 3 15 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 3125 PPM 10 4 16 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 3125 PPM 10 4 17 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 3125 PPM 10 4 18 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 3125 PPM 10 4 19 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 3125 PPM 10 4 20 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 6250 PPM 10 5 21 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 6250 PPM 10 5 22 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 6250 PPM 10 5 23 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 6250 PPM 10 5 24 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 6250 PPM 10 5 25 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 6250 PPM 10 6 26 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 6250 PPM 10 6 27 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 6250 PPM 10 6 28 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 6250 PPM 10 6 29 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 6250 PPM 10 6 30 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 12500 PPM 10 7 31 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 12500 PPM 10 7 32 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 12500 PPM 10 7 33 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 12500 PPM 10 7 34 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 12500 PPM 10 7 35 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 12500 PPM 10 8 36 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 12500 PPM 10 8 37 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 12500 PPM 10 8 38 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 12500 PPM 10 8 39 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 12500 PPM 10 8 40 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 25000 PPM 10 10 46 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 25000 PPM 10 10 47 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 25000 PPM 10 10 48 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 25000 PPM 10 10 49 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 25000 PPM 10 10 50 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 25000 PPM 10 9 41 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 25000 PPM 10 9 43 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 25000 PPM 10 9 44 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 25000 PPM 10 9 45 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 11 51 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 11 52 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 11 53 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 11 54 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 11 55 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 12 56 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 12 57 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 12 58 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 12 59 93 1 Cardiomyopathy Mild, Focal Terminal Sacrifice
Cardiovascular System Heart 50000 PPM 10 12 60 93 1 Cardiomyopathy Minimal, Focal Terminal Sacrifice
Endocrine System Adrenal Cortex Untreated Control 10 2 6 93 1 Accessory Adrenal Cortical Nodule Terminal Sacrifice
Endocrine System Adrenal Cortex Untreated Control 10 2 7 93 1 Accessory Adrenal Cortical Nodule Terminal Sacrifice
Endocrine System Adrenal Cortex 50000 PPM 10 12 56 93 1 Accessory Adrenal Cortical Nodule Terminal Sacrifice
Endocrine System Adrenal Cortex 50000 PPM 10 12 60 93 1 Accessory Adrenal Cortical Nodule Minimal Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Untreated Control 10 2 7 93 1 Cyst Minimal Terminal Sacrifice
Endocrine System Pituitary Gland Pars Nervosa 50000 PPM 10 11 54 93 1 Cyst Minimal Terminal Sacrifice
Endocrine System Thyroid Gland 50000 PPM 10 12 59 93 1 Ultimobranchial Cyst Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow Myeloid Cell 50000 PPM 10 12 60 93 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Untreated Control 10 2 10 93 1 Inflammation Minimal, Focal, Histiocytic Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 50000 PPM 10 11 53 93 1 Inflammation Minimal, Focal, Histiocytic Terminal Sacrifice
Hematopoietic System Lymph Node Pancreatic Untreated Control 10 2 8 93 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Pancreatic 50000 PPM 10 11 52 93 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Thymus 50000 PPM 10 11 54 93 1 Hemorrhage Minimal Terminal Sacrifice
Integumentary System Skin Lip 6250 PPM 1 5 21 93 1 Hemorrhage Mild, Focal Terminal Sacrifice
Respiratory System Lung Untreated Control 10 2 8 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Respiratory System Lung Untreated Control 10 2 9 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Respiratory System Lung 50000 PPM 10 11 52 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Respiratory System Lung 50000 PPM 10 12 57 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Urinary System Kidney Untreated Control 10 1 2 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Untreated Control 10 1 4 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Untreated Control 10 2 8 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Untreated Control 10 2 9 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 6250 PPM 10 5 22 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 6250 PPM 10 5 23 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 6250 PPM 10 6 27 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 12500 PPM 10 7 31 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 12500 PPM 10 7 34 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 12500 PPM 10 7 35 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 25000 PPM 10 10 47 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 25000 PPM 10 9 41 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 25000 PPM 10 9 42 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 25000 PPM 10 9 44 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 25000 PPM 10 9 45 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 50000 PPM 10 11 51 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 50000 PPM 10 11 53 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 50000 PPM 10 12 56 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 50000 PPM 10 12 57 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 50000 PPM 10 12 58 93 1 Nephropathy Minimal, Focal Terminal Sacrifice
Urinary System Kidney 50000 PPM 10 12 59 93 1 Nephropathy Minimal Terminal Sacrifice