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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Milk thistle extract
CASRN: ="84604-20-6"
Study Number: C20008
Exposure Route:
TDMS Number: 2000802
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Untreated Control 10 62 69 93 1 Depletion Glycogen Mild Terminal Sacrifice
Alimentary System Liver Untreated Control 10 61 61 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 61 65 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver Untreated Control 10 62 67 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 63 71 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 63 72 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 63 73 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 63 74 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 63 75 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 64 76 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 64 77 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 64 78 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 64 79 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 3125 PPM 10 64 80 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 65 81 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 65 82 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 65 83 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 65 84 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 66 86 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 66 87 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 66 88 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 66 89 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 6250 PPM 10 66 90 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 67 91 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 67 92 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 67 93 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 67 94 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 67 95 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 68 96 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 68 97 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 68 98 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 12500 PPM 10 68 99 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 69 101 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 69 102 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 69 103 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 69 104 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 69 105 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 70 106 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 70 107 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 25000 PPM 10 70 108 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 71 111 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 71 112 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 71 113 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 71 114 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 71 115 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 72 116 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 72 117 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 72 118 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 72 119 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Liver 50000 PPM 10 72 120 93 1 Inflammation Minimal, Focal, Chronic Terminal Sacrifice
Alimentary System Pancreas 3125 PPM 1 63 73 93 1 Cyst Mild Terminal Sacrifice
Alimentary System Stomach Forestomach 25000 PPM 10 69 101 93 1 Hyperplasia Minimal, Focal, Squamous Terminal Sacrifice
Alimentary System Stomach Forestomach 25000 PPM 10 70 108 93 1 Hyperplasia Minimal, Focal, Squamous Terminal Sacrifice
Alimentary System Stomach Forestomach 50000 PPM 10 71 111 93 1 Hyperplasia Mild, Focal, Squamous Terminal Sacrifice
Alimentary System Stomach Forestomach 50000 PPM 10 71 115 93 1 Hyperplasia Mild, Focal, Squamous Terminal Sacrifice
Alimentary System Stomach Forestomach 50000 PPM 10 71 115 93 1 Ulcer Minimal, Focal Terminal Sacrifice
Alimentary System Stomach Glandular Untreated Control 10 61 64 93 1 Cyst Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex 50000 PPM 10 71 114 93 1 Accessory Adrenal Cortical Nodule Terminal Sacrifice
Endocrine System Adrenal Cortex Untreated Control 10 61 65 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Untreated Control 10 62 67 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Untreated Control 10 62 69 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Untreated Control 10 61 61 93 1 Ectopic Thymus Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric Untreated Control 10 62 70 93 1 Degeneration Minimal, Diffuse, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 50000 PPM 10 72 117 93 1 Degeneration Minimal, Diffuse, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 50000 PPM 10 72 118 93 1 Degeneration Minimal, Diffuse, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mesenteric 50000 PPM 10 72 119 93 1 Degeneration Mild, Diffuse, Lymphoid Terminal Sacrifice
Hematopoietic System Thymus Untreated Control 10 62 70 93 1 Degeneration Minimal, Diffuse, Lymphoid Terminal Sacrifice
Respiratory System Lung 50000 PPM 10 72 119 93 1 Infiltration Cellular Minimal, Focal, Lymphocyte Terminal Sacrifice
Special Senses System Eye Retrobulbar Untreated Control 10 62 70 93 1 Inflammation Mild, Focal, Acute Terminal Sacrifice
Urinary System Kidney Renal Tubule 50000 PPM 10 72 117 93 1 Regeneration Minimal, Focal Terminal Sacrifice
Urinary System Kidney 50000 PPM 10 72 118 93 1 Hydronephrosis Marked Terminal Sacrifice