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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: alpha/beta Thujone mixture
CASRN: ="76231-76-0"
Study Number: C99037B
Exposure Route: GAVAGE
TDMS Number: 9903704
Sex: Male
Strain and Species: B6C3F1 Mice

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Vehicle Control 10 3 3 93 1 Depletion Glycogen Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 4 4 93 1 Depletion Glycogen Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 7 7 93 1 Depletion Glycogen Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 8 8 93 1 Depletion Glycogen Minimal Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 9 9 93 1 Depletion Glycogen Mild Terminal Sacrifice
Alimentary System Liver 25 MG/KG 10 32 32 93 1 Depletion Glycogen Mild Terminal Sacrifice
Alimentary System Liver 25 MG/KG 10 34 34 93 1 Depletion Glycogen Mild Terminal Sacrifice
Alimentary System Liver 25 MG/KG 10 35 35 93 1 Depletion Glycogen Minimal Terminal Sacrifice
Alimentary System Liver 25 MG/KG 10 38 38 93 1 Depletion Glycogen Minimal Terminal Sacrifice
Alimentary System Liver 25 MG/KG 10 40 40 93 1 Depletion Glycogen Mild Terminal Sacrifice
Alimentary System Liver 50 MG/KG 10 44 44 93 1 Depletion Glycogen Mild Terminal Sacrifice
Alimentary System Liver 25 MG/KG 10 31 31 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 25 MG/KG 10 32 32 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 50 MG/KG 10 45 45 55 1 Hematopoietic Cell Proliferation Minimal Natural Death
Alimentary System Liver 75 MG/KG 10 55 55 49 1 Hematopoietic Cell Proliferation Minimal Natural Death
Alimentary System Liver 75 MG/KG 10 59 59 42 1 Hematopoietic Cell Proliferation Minimal Natural Death
Alimentary System Liver Vehicle Control 10 3 3 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Alimentary System Stomach Glandular Vehicle Control 10 6 6 93 1 Cyst Terminal Sacrifice
Alimentary System Stomach Glandular Vehicle Control 10 8 8 93 1 Cyst Terminal Sacrifice
Alimentary System Stomach Glandular Vehicle Control 10 9 9 93 1 Cyst Terminal Sacrifice
Alimentary System Stomach Glandular 25 MG/KG 10 32 32 93 1 Cyst Terminal Sacrifice
Alimentary System Stomach Glandular 25 MG/KG 10 37 37 93 1 Cyst Terminal Sacrifice
Alimentary System Stomach Glandular 25 MG/KG 10 32 32 93 1 Edema Mild Terminal Sacrifice
Alimentary System Stomach Glandular 25 MG/KG 10 32 32 93 1 Infiltration Cellular Mild, Eosinophil Terminal Sacrifice
Endocrine System Parathyroid Gland Vehicle Control 10 4 4 93 1 Cyst Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 50 MG/KG 10 41 41 42 1 Cyst Natural Death
Genital System Preputial Gland 50 MG/KG 10 44 44 93 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 5 5 93 1 Hyperplasia Mild, Lymphoid Terminal Sacrifice
Hematopoietic System Spleen Vehicle Control 10 5 5 93 1 Pigmentation Minimal, Focal, Hemosiderin Terminal Sacrifice
Nervous System Spinal Cord 50 MG/KG 10 46 46 55 1 Congestion Mild Natural Death
Nervous System Spinal Cord 75 MG/KG 10 56 56 51 1 Congestion Mild Natural Death
Respiratory System Lung 50 MG/KG 10 46 46 55 1 Congestion Mild Natural Death
Respiratory System Lung 75 MG/KG 10 51 51 35 1 Congestion Minimal Natural Death
Respiratory System Lung 75 MG/KG 10 52 52 42 1 Congestion Mild Natural Death
Respiratory System Lung 75 MG/KG 10 54 54 43 1 Congestion Mild Natural Death
Respiratory System Lung 75 MG/KG 10 55 55 49 1 Congestion Mild Natural Death
Respiratory System Lung 75 MG/KG 10 57 57 38 1 Congestion Mild Natural Death
Respiratory System Lung 50 MG/KG 10 41 41 42 1 Hemorrhage Mild Natural Death
Respiratory System Lung 50 MG/KG 10 42 42 63 1 Hemorrhage Mild Natural Death
Respiratory System Lung 50 MG/KG 10 43 43 87 1 Hemorrhage Mild Natural Death
Respiratory System Lung 50 MG/KG 10 49 49 55 1 Hemorrhage Minimal Natural Death
Respiratory System Lung 50 MG/KG 10 50 50 76 1 Hemorrhage Mild Natural Death
Respiratory System Lung 75 MG/KG 10 58 58 38 1 Hemorrhage Minimal Natural Death
Special Senses System Eye 25 MG/KG 10 35 35 93 1 Inflammation Minimal, Acute Terminal Sacrifice
Special Senses System Harderian Gland 25 MG/KG 10 31 31 93 1 Hyperplasia Mild, Focal Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 9 9 93 1 Inflammation Mild, Acute Terminal Sacrifice
Special Senses System Harderian Gland 25 MG/KG 10 35 35 93 1 Inflammation Minimal, Acute Terminal Sacrifice
Special Senses System Harderian Gland 25 MG/KG 10 40 40 93 1 Inflammation Minimal, Acute Terminal Sacrifice
Urinary System Kidney Renal Tubule 75 MG/KG 10 56 56 51 1 Mineralization Minimal Natural Death
Urinary System Kidney 25 MG/KG 10 39 39 93 1 Cyst Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 2 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 25 MG/KG 10 31 31 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 25 MG/KG 10 32 32 93 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 50 MG/KG 10 43 43 87 1 Nephropathy Minimal Natural Death
Urinary System Kidney 50 MG/KG 10 49 49 55 1 Nephropathy Minimal Natural Death
Urinary System Kidney 75 MG/KG 10 59 59 42 1 Nephropathy Minimal Natural Death