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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: m-Chloroaniline
CASRN: ="108-42-9"
Study Number: C61529B
Exposure Route: GAVAGE
TDMS Number: 6152902
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus Vehicle Control 10 63 63 7 1 Hemorrhage Mild Dosing Accident
Alimentary System Esophagus 40 MG/KG 2 99 99 8 1 Ulcer Marked Dosing Accident
Alimentary System Liver Kupffer Cell 80 MG/KG 9 101 101 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 80 MG/KG 9 103 103 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 80 MG/KG 9 104 104 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 80 MG/KG 9 105 105 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 80 MG/KG 9 106 106 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 80 MG/KG 9 107 107 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 80 MG/KG 9 108 108 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 80 MG/KG 9 109 109 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 80 MG/KG 9 110 110 93 1 Pigmentation Minimal Terminal Sacrifice
Alimentary System Liver Kupffer Cell 160 MG/KG 10 111 111 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 160 MG/KG 10 112 112 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 160 MG/KG 10 113 113 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 160 MG/KG 10 114 114 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 160 MG/KG 10 115 115 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 160 MG/KG 10 116 116 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 160 MG/KG 10 117 117 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 160 MG/KG 10 118 118 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver Kupffer Cell 160 MG/KG 10 119 119 93 1 Pigmentation Mild Terminal Sacrifice
Alimentary System Liver 80 MG/KG 9 101 101 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 160 MG/KG 10 111 111 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 160 MG/KG 10 112 112 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 160 MG/KG 10 113 113 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 160 MG/KG 10 114 114 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 160 MG/KG 10 116 116 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 160 MG/KG 10 118 118 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 160 MG/KG 10 119 119 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Alimentary System Liver 160 MG/KG 10 113 113 93 1 Necrosis Minimal, Focal Terminal Sacrifice
Cardiovascular System Heart Pericardium 10 MG/KG 1 79 79 7 1 Inflammation Mild, Suppurative Dosing Accident
Cardiovascular System Heart Pericardium 40 MG/KG 2 94 94 7 1 Inflammation Marked, Suppurative Dosing Accident
Genital System Ovary 20 MG/KG 1 81 81 93 1 Cyst Mild Terminal Sacrifice
Hematopoietic System Bone Marrow Erythroid Cell 160 MG/KG 10 111 111 93 1 Hyperplasia Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow Erythroid Cell 160 MG/KG 10 115 115 93 1 Hyperplasia Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow Myeloid Cell 40 MG/KG 10 94 94 7 1 Hyperplasia Moderate, Diffuse Dosing Accident
Hematopoietic System Bone Marrow 10 MG/KG 10 71 71 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 10 MG/KG 10 72 72 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 10 MG/KG 10 73 73 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 10 MG/KG 10 78 78 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 20 MG/KG 10 81 81 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 20 MG/KG 10 82 82 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 20 MG/KG 10 83 83 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 20 MG/KG 10 84 84 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 20 MG/KG 10 87 87 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 20 MG/KG 10 88 88 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 20 MG/KG 10 89 89 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 20 MG/KG 10 90 90 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 40 MG/KG 10 100 100 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 40 MG/KG 10 91 91 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 40 MG/KG 10 92 92 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 40 MG/KG 10 93 93 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 40 MG/KG 10 96 96 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 40 MG/KG 10 97 97 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 40 MG/KG 10 98 98 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 80 MG/KG 10 101 101 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 80 MG/KG 10 102 102 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 80 MG/KG 10 103 103 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 80 MG/KG 10 104 104 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 80 MG/KG 10 105 105 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 80 MG/KG 10 106 106 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 80 MG/KG 10 107 107 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 80 MG/KG 10 108 108 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 80 MG/KG 10 109 109 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 80 MG/KG 10 110 110 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 160 MG/KG 10 111 111 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 160 MG/KG 10 112 112 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 160 MG/KG 10 113 113 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 160 MG/KG 10 114 114 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 160 MG/KG 10 115 115 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 160 MG/KG 10 116 116 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 160 MG/KG 10 117 117 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 160 MG/KG 10 118 118 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Bone Marrow 160 MG/KG 10 119 119 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 73 73 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 75 75 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 81 81 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 82 82 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 83 83 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 84 84 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 87 87 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 89 89 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 90 90 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 100 100 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 91 91 93 1 Hematopoietic Cell Proliferation Minimal Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 92 92 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 93 93 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 95 95 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 96 96 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 97 97 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 101 101 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 102 102 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 103 103 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 104 104 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 105 105 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 106 106 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 107 107 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 108 108 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 109 109 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 110 110 93 1 Hematopoietic Cell Proliferation Mild Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 111 111 93 1 Hematopoietic Cell Proliferation Marked Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 112 112 93 1 Hematopoietic Cell Proliferation Marked Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 113 113 93 1 Hematopoietic Cell Proliferation Marked Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 114 114 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 115 115 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 116 116 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 117 117 93 1 Hematopoietic Cell Proliferation Marked Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 118 118 93 1 Hematopoietic Cell Proliferation Moderate Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 119 119 93 1 Hematopoietic Cell Proliferation Marked Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 71 71 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 72 72 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 73 73 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 74 74 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 75 75 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 76 76 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 77 77 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 78 78 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 10 MG/KG 10 80 80 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 81 81 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 82 82 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 83 83 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 84 84 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 85 85 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 86 86 93 1 Pigmentation Minimal, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 87 87 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 88 88 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 89 89 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 20 MG/KG 10 90 90 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 100 100 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 91 91 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 92 92 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 93 93 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 95 95 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 96 96 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 97 97 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 40 MG/KG 10 98 98 93 1 Pigmentation Mild, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 101 101 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 102 102 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 103 103 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 104 104 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 105 105 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 106 106 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 107 107 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 108 108 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 109 109 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 80 MG/KG 10 110 110 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 111 111 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 112 112 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 113 113 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 114 114 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 115 115 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 116 116 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 117 117 93 1 Pigmentation Moderate, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 118 118 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Spleen 160 MG/KG 10 119 119 93 1 Pigmentation Marked, Hemosiderin Terminal Sacrifice
Hematopoietic System Thymus 40 MG/KG 2 99 99 8 1 Atrophy Marked Dosing Accident
Respiratory System Lung Serosa 10 MG/KG 1 79 79 7 1 Inflammation Moderate, Suppurative Dosing Accident
Respiratory System Lung Serosa 40 MG/KG 2 94 94 7 1 Inflammation Moderate, Suppurative Dosing Accident
Respiratory System Lung Serosa 40 MG/KG 2 99 99 8 1 Inflammation Marked, Suppurative Dosing Accident
Respiratory System Lung Serosa 160 MG/KG 10 120 120 7 1 Inflammation Moderate, Suppurative Dosing Accident
Respiratory System Lung 40 MG/KG 2 94 94 7 1 Foreign Body Dosing Accident
Respiratory System Lung 40 MG/KG 2 99 99 8 1 Foreign Body Dosing Accident
Respiratory System Lung 160 MG/KG 10 120 120 7 1 Foreign Body Dosing Accident
Respiratory System Lung Vehicle Control 10 63 63 7 1 Hemorrhage Moderate Dosing Accident
Urinary System Kidney Vehicle Control 10 61 61 93 1 Hyperplasia Mild, Lymphoid Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 61 61 93 1 Infarct Minimal Terminal Sacrifice
Urinary System Kidney 160 MG/KG 10 114 114 93 1 Pigmentation Minimal Terminal Sacrifice
Urinary System Kidney 160 MG/KG 10 115 115 93 1 Pigmentation Minimal Terminal Sacrifice
Urinary System Kidney 160 MG/KG 10 116 116 93 1 Pigmentation Minimal Terminal Sacrifice
Urinary System Kidney 160 MG/KG 10 117 117 93 1 Pigmentation Minimal Terminal Sacrifice
Urinary System Kidney 160 MG/KG 10 118 118 93 1 Pigmentation Minimal Terminal Sacrifice
Urinary System Kidney 160 MG/KG 10 119 119 93 1 Pigmentation Minimal Terminal Sacrifice