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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: 3'-Azido-3'-deoxythymidine (AIDS)
CASRN: ="30516-87-1"
Study Number: C88072
Exposure Route: GAVAGE
TDMS Number: 8900606
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
203 Vehicle Control Lethargic 03/06/1992 07/09/90 607.00 Yes
203 Vehicle Control Abnormal Breathing 03/06/1992 07/09/90 607.00 Yes
205 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 07/10/1992 07/09/90 733.00 Yes
216 Vehicle Control Mass Head, Small (1mm-5mm) 1 07/10/1992 07/09/90 733.00 Yes
219 Vehicle Control Abnormal Breathing 06/30/1992 07/09/90 723.00 Yes
219 Vehicle Control Abnormal Posture 06/30/1992 07/09/90 723.00 Yes
226 Vehicle Control Mass Appendage, Medium (6mm-15mm) 1 06/30/1992 07/09/90 723.00 Yes
227 Vehicle Control Lethargic 05/03/1992 07/09/90 665.00 Yes
227 Vehicle Control Tremors 05/03/1992 07/09/90 665.00 Yes
227 Vehicle Control Abnormal Posture 05/03/1992 07/09/90 665.00 Yes
229 Vehicle Control Nasal/Eye Discharge 09/06/1991 07/09/90 425.00 No
229 Vehicle Control Nasal/Eye Discharge 10/04/1991 07/09/90 453.00 No
229 Vehicle Control Mass Head, Small (1mm-5mm) 1 04/17/1992 07/09/90 649.00 No
229 Vehicle Control Mass Head, Medium (6mm-15mm) 1 05/15/1992 07/09/90 677.00 No
229 Vehicle Control Mass Head, Small (1mm-5mm) 1 06/12/1992 07/09/90 705.00 No
229 Vehicle Control Mass Head, Medium (6mm-15mm) 1 07/10/1992 07/09/90 733.00 Yes
234 Vehicle Control Mass Head, Small (1mm-5mm) 1 04/17/1992 07/09/90 649.00 No
234 Vehicle Control Mass Head, Medium (6mm-15mm) 1 05/15/1992 07/09/90 677.00 No
234 Vehicle Control Mass Head, Medium (6mm-15mm) 1 06/12/1992 07/09/90 705.00 No
234 Vehicle Control Mass Head, Medium (6mm-15mm) 1 07/08/1992 07/09/90 731.00 Yes
235 Vehicle Control Hyperactive 12/13/1991 07/09/90 523.00 Yes
237 Vehicle Control Abnormal Breathing 12/03/1991 07/09/90 513.00 Yes
237 Vehicle Control Lethargic 12/03/1991 07/09/90 513.00 Yes
241 Vehicle Control Nasal/Eye Discharge 08/22/1991 07/09/90 410.00 Yes
259 30 MG/KG Lethargic 03/16/1992 07/09/90 617.00 Yes
259 30 MG/KG Abnormal Breathing 03/16/1992 07/09/90 617.00 Yes
259 30 MG/KG Abnormal Posture 03/16/1992 07/09/90 617.00 Yes
261 30 MG/KG Thin 07/09/1992 07/09/90 732.00 Yes
265 30 MG/KG Mass Head, Small (1mm-5mm) 1 04/17/1992 07/09/90 649.00 No
265 30 MG/KG Mass Head, Small (1mm-5mm) 1 05/15/1992 07/09/90 677.00 No
265 30 MG/KG Mass Head, Small (1mm-5mm) 1 06/12/1992 07/09/90 705.00 No
265 30 MG/KG Mass Head, Medium (6mm-15mm) 1 07/09/1992 07/09/90 732.00 Yes
269 30 MG/KG Abnormal Breathing 12/15/1991 07/09/90 525.00 Yes
269 30 MG/KG Ataxia 12/15/1991 07/09/90 525.00 Yes
269 30 MG/KG Tremors 12/15/1991 07/09/90 525.00 Yes
275 30 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 07/09/1992 07/09/90 732.00 Yes
278 30 MG/KG Abnormal Breathing 02/17/1992 07/09/90 589.00 Yes
278 30 MG/KG Abnormal Posture 02/17/1992 07/09/90 589.00 Yes
293 30 MG/KG Lethargic 05/12/1992 07/09/90 674.00 Yes
293 30 MG/KG Abnormal Posture 05/12/1992 07/09/90 674.00 Yes
293 30 MG/KG Abnormal Breathing 05/12/1992 07/09/90 674.00 Yes
300 30 MG/KG Thin 07/08/1992 07/09/90 731.00 Yes
302 60 MG/KG Lethargic 11/13/1991 07/09/90 493.00 Yes
302 60 MG/KG Abnormal Posture 11/13/1991 07/09/90 493.00 Yes
302 60 MG/KG Abnormal Breathing 11/13/1991 07/09/90 493.00 Yes
308 60 MG/KG Abnormal Breathing 12/13/1991 07/09/90 523.00 Yes
308 60 MG/KG Abnormal Posture 12/13/1991 07/09/90 523.00 Yes
309 60 MG/KG Lethargic 07/11/1990 07/09/90 3.00 Yes
309 60 MG/KG Discharge Head, White 07/11/1990 07/09/90 3.00 Yes
310 60 MG/KG Abnormal Breathing 01/15/1992 07/09/90 556.00 Yes
310 60 MG/KG Lethargic 01/15/1992 07/09/90 556.00 Yes
310 60 MG/KG Abnormal Posture 01/15/1992 07/09/90 556.00 Yes
310 60 MG/KG Nasal/Eye Discharge 01/15/1992 07/09/90 556.00 Yes
310 60 MG/KG Diarrhea 01/15/1992 07/09/90 556.00 Yes
317 60 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 07/09/1992 07/09/90 732.00 Yes
318 60 MG/KG Abnormal Posture 04/30/1991 07/09/90 296.00 Yes
319 60 MG/KG Mass Torso/Dorsal, Small (1mm-5mm) 1 06/12/1992 07/09/90 705.00 No
319 60 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 07/09/1992 07/09/90 732.00 Yes
321 60 MG/KG Thin 07/09/1992 07/09/90 732.00 Yes
332 60 MG/KG Abnormal Breathing 03/19/1992 07/09/90 620.00 Yes
332 60 MG/KG Abnormal Posture 03/19/1992 07/09/90 620.00 Yes
333 60 MG/KG Mass Torso/Ventral, Medium (6mm-15mm) 1 05/15/1992 07/09/90 677.00 No
333 60 MG/KG Abnormal Posture 05/28/1992 07/09/90 690.00 Yes
333 60 MG/KG Mass Torso/Ventral, Large (16mm And Larger) 1 05/28/1992 07/09/90 690.00 Yes
333 60 MG/KG Ulcer/Abscess Torso/Ventral 05/28/1992 07/09/90 690.00 Yes
334 60 MG/KG Mass Head, Small (1mm-5mm) 1 04/17/1992 07/09/90 649.00 No
334 60 MG/KG Mass Head, Small (1mm-5mm) 1 05/15/1992 07/09/90 677.00 No
334 60 MG/KG Mass Head, Medium (6mm-15mm) 1 05/27/1992 07/09/90 689.00 Yes
346 60 MG/KG Ataxia 05/12/1992 07/09/90 674.00 Yes
346 60 MG/KG Abnormal Breathing 05/12/1992 07/09/90 674.00 Yes
356 120 MG/KG Tremors 06/29/1992 07/09/90 722.00 Yes
356 120 MG/KG Hyperactive 06/29/1992 07/09/90 722.00 Yes
356 120 MG/KG Abnormal Breathing 06/29/1992 07/09/90 722.00 Yes
359 120 MG/KG Mass Torso/Ventral, Medium (6mm-15mm) 1 03/03/1992 07/09/90 604.00 Yes
364 120 MG/KG Abnormal Breathing 06/02/1992 07/09/90 695.00 Yes
364 120 MG/KG Abnormal Posture 06/02/1992 07/09/90 695.00 Yes
365 120 MG/KG Ulcer/Abscess Torso/Ventral 05/15/1992 07/09/90 677.00 No
365 120 MG/KG Mass Torso/Lateral, Large (16mm And Larger) 1 05/15/1992 07/09/90 677.00 No
365 120 MG/KG Mass Torso/Lateral, Large (16mm And Larger) 1 06/12/1992 07/09/90 705.00 No
365 120 MG/KG Ulcer/Abscess Torso/Ventral 06/12/1992 07/09/90 705.00 No
365 120 MG/KG Mass Torso/Ventral, Large (16mm And Larger) 1 06/16/1992 07/09/90 709.00 Yes
370 120 MG/KG Lethargic 02/29/1992 07/09/90 601.00 Yes
370 120 MG/KG Ulcer/Abscess Torso/Dorsal 02/29/1992 07/09/90 601.00 Yes
371 120 MG/KG Abnormal Breathing 06/17/1992 07/09/90 710.00 Yes
373 120 MG/KG Hyperactive 07/09/1992 07/09/90 732.00 Yes
373 120 MG/KG Abnormal Breathing 07/09/1992 07/09/90 732.00 Yes
380 120 MG/KG Mass Head, Small (1mm-5mm) 1 07/09/1992 07/09/90 732.00 Yes
382 120 MG/KG Nasal/Eye Discharge 09/06/1991 07/09/90 425.00 No
382 120 MG/KG Mass Head, Small (1mm-5mm) 1 04/17/1992 07/09/90 649.00 No
382 120 MG/KG Mass Head, Small (1mm-5mm) 1 05/15/1992 07/09/90 677.00 No
382 120 MG/KG Mass Head, Medium (6mm-15mm) 1 07/09/1992 07/09/90 732.00 Yes
396 120 MG/KG Lethargic 07/10/1990 07/09/90 2.00 Yes
398 120 MG/KG Abnormal Breathing 06/17/1992 07/09/90 710.00 Yes
398 120 MG/KG Abnormal Posture 06/17/1992 07/09/90 710.00 Yes
398 120 MG/KG Thin 06/17/1992 07/09/90 710.00 Yes
400 120 MG/KG Lethargic 06/02/1992 07/09/90 695.00 Yes
400 120 MG/KG Abnormal Breathing 06/02/1992 07/09/90 695.00 Yes