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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: 3'-Azido-3'-deoxythymidine (AIDS)
CASRN: ="30516-87-1"
Study Number: C88072
Exposure Route: GAVAGE
TDMS Number: 8900606
Sex: Male
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
4 Vehicle Control Abnormal Breathing 03/05/1992 07/09/90 606.00 Yes
4 Vehicle Control Abnormal Posture 03/05/1992 07/09/90 606.00 Yes
7 Vehicle Control Abnormal Posture 06/17/1992 07/09/90 710.00 Yes
7 Vehicle Control Abnormal Breathing 06/17/1992 07/09/90 710.00 Yes
7 Vehicle Control Thin 06/17/1992 07/09/90 710.00 Yes
7 Vehicle Control Lethargic 06/17/1992 07/09/90 710.00 Yes
18 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 06/11/1992 07/09/90 704.00 No
18 Vehicle Control Abnormal Breathing 06/29/1992 07/09/90 722.00 Yes
18 Vehicle Control Mass Torso/Dorsal, Large (16mm And Larger) 1 06/29/1992 07/09/90 722.00 Yes
18 Vehicle Control Abnormal Posture 06/29/1992 07/09/90 722.00 Yes
37 Vehicle Control Abnormal Breathing 10/09/1991 07/09/90 458.00 Yes
46 Vehicle Control Mass Torso/Lateral, 16-20 Mm 05/29/1991 07/09/90 325.00 Yes
47 Vehicle Control Lethargic 03/31/1992 07/09/90 632.00 Yes
47 Vehicle Control Abnormal Breathing 03/31/1992 07/09/90 632.00 Yes
54 30 MG/KG Abnormal Breathing 05/09/1992 07/09/90 671.00 Yes
54 30 MG/KG Lethargic 05/09/1992 07/09/90 671.00 Yes
66 30 MG/KG Mass Head, Medium (6mm-15mm) 1 10/03/1991 07/09/90 452.00 No
66 30 MG/KG Mass Head, Large (16mm And Larger) 1 10/09/1991 07/09/90 458.00 Yes
66 30 MG/KG Ulcer/Abscess Head 10/09/1991 07/09/90 458.00 Yes
66 30 MG/KG Thin 10/09/1991 07/09/90 458.00 Yes
67 30 MG/KG Thin 04/20/1992 07/09/90 652.00 Yes
67 30 MG/KG Lethargic 04/20/1992 07/09/90 652.00 Yes
67 30 MG/KG Abnormal Posture 04/20/1992 07/09/90 652.00 Yes
67 30 MG/KG Tremors 04/20/1992 07/09/90 652.00 Yes
67 30 MG/KG Abnormal Breathing 04/20/1992 07/09/90 652.00 Yes
68 30 MG/KG Thin 07/07/1992 07/09/90 730.00 Yes
70 30 MG/KG Thin 07/07/1992 07/09/90 730.00 Yes
70 30 MG/KG Lethargic 07/07/1992 07/09/90 730.00 Yes
70 30 MG/KG Abnormal Posture 07/07/1992 07/09/90 730.00 Yes
70 30 MG/KG Abnormal Breathing 07/07/1992 07/09/90 730.00 Yes
72 30 MG/KG Thin 03/22/1991 07/09/90 257.00 Yes
72 30 MG/KG Abnormal Posture 03/22/1991 07/09/90 257.00 Yes
72 30 MG/KG Abnormal Breathing 03/22/1991 07/09/90 257.00 Yes
73 30 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 01/27/1992 07/09/90 568.00 Yes
75 30 MG/KG Thin 07/07/1992 07/09/90 730.00 Yes
78 30 MG/KG Mass Head, Small (1mm-5mm) 1 05/14/1992 07/09/90 676.00 No
78 30 MG/KG Mass Head, Small (1mm-5mm) 1 06/11/1992 07/09/90 704.00 No
78 30 MG/KG Mass Head, Small (1mm-5mm) 1 07/07/1992 07/09/90 730.00 Yes
78 30 MG/KG Mass Torso/Ventral, Large (16mm And Larger) 1 07/07/1992 07/09/90 730.00 Yes
85 30 MG/KG Lethargic 06/29/1992 07/09/90 722.00 Yes
85 30 MG/KG Abnormal Posture 06/29/1992 07/09/90 722.00 Yes
85 30 MG/KG Abnormal Breathing 06/29/1992 07/09/90 722.00 Yes
87 30 MG/KG Abnormal Breathing 06/29/1992 07/09/90 722.00 Yes
87 30 MG/KG Lethargic 06/29/1992 07/09/90 722.00 Yes
88 30 MG/KG Mass Torso/Ventral, Large (16mm And Larger) 1 07/06/1992 07/09/90 729.00 Yes
90 30 MG/KG Lethargic 05/03/1992 07/09/90 665.00 Yes
90 30 MG/KG Tremors 05/03/1992 07/09/90 665.00 Yes
90 30 MG/KG Abnormal Posture 05/03/1992 07/09/90 665.00 Yes
92 30 MG/KG Abnormal Posture 04/02/1992 07/09/90 634.00 Yes
92 30 MG/KG Thin 04/02/1992 07/09/90 634.00 Yes
92 30 MG/KG Mass Torso/Lateral, Medium (6mm-15mm) 1 04/02/1992 07/09/90 634.00 Yes
92 30 MG/KG Ulcer/Abscess Torso/Lateral 04/02/1992 07/09/90 634.00 Yes
99 30 MG/KG Mass Head, Small (1mm-5mm) 1 04/16/1992 07/09/90 648.00 No
99 30 MG/KG Mass Head, Small (1mm-5mm) 1 05/14/1992 07/09/90 676.00 No
99 30 MG/KG Mass Head, Small (1mm-5mm) 1 06/11/1992 07/09/90 704.00 No
99 30 MG/KG Mass Head, Small (1mm-5mm) 1 07/08/1992 07/09/90 731.00 Yes
101 60 MG/KG Lethargic 07/12/1990 07/09/90 4.00 Yes
101 60 MG/KG Abnormal Posture 07/12/1990 07/09/90 4.00 Yes
107 60 MG/KG Thin 05/15/1992 07/09/90 677.00 Yes
107 60 MG/KG Abnormal Breathing 05/15/1992 07/09/90 677.00 Yes
108 60 MG/KG Abnormal Breathing 11/21/1991 07/09/90 501.00 Yes
108 60 MG/KG Lethargic 11/21/1991 07/09/90 501.00 Yes
114 60 MG/KG Abnormal Breathing 07/07/1992 07/09/90 730.00 Yes
114 60 MG/KG Mass Torso/Ventral, Large (16mm And Larger) 1 07/07/1992 07/09/90 730.00 Yes
115 60 MG/KG Thin 07/07/1992 07/09/90 730.00 Yes
118 60 MG/KG Diarrhea 06/29/1992 07/09/90 722.00 Yes
118 60 MG/KG Abnormal Breathing 06/29/1992 07/09/90 722.00 Yes
118 60 MG/KG Lethargic 06/29/1992 07/09/90 722.00 Yes
121 60 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 04/16/1992 07/09/90 648.00 No
121 60 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 05/05/1992 07/09/90 667.00 Yes
124 60 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 07/07/1992 07/09/90 730.00 Yes
129 60 MG/KG Abnormal Breathing 10/24/1991 07/09/90 473.00 Yes
129 60 MG/KG Lethargic 10/24/1991 07/09/90 473.00 Yes
131 60 MG/KG Abnormal Posture 05/14/1991 07/09/90 310.00 Yes
135 60 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 09/03/1991 07/09/90 422.00 Yes
142 60 MG/KG Abnormal Breathing 01/23/1992 07/09/90 564.00 Yes
142 60 MG/KG Abnormal Posture 01/23/1992 07/09/90 564.00 Yes
142 60 MG/KG Lethargic 01/23/1992 07/09/90 564.00 Yes
144 60 MG/KG Abnormal Posture 04/15/1992 07/09/90 647.00 Yes
144 60 MG/KG Abnormal Breathing 04/15/1992 07/09/90 647.00 Yes
144 60 MG/KG Lethargic 04/15/1992 07/09/90 647.00 Yes
145 60 MG/KG Lethargic 07/25/1991 07/09/90 382.00 Yes
145 60 MG/KG Abnormal Posture 07/25/1991 07/09/90 382.00 Yes
145 60 MG/KG Abnormal Breathing 07/25/1991 07/09/90 382.00 Yes
154 120 MG/KG Mass Head, Small (1mm-5mm) 1 06/11/1992 07/09/90 704.00 No
154 120 MG/KG Mass Head, Small (1mm-5mm) 1 07/07/1992 07/09/90 730.00 Yes
155 120 MG/KG Abnormal Posture 01/06/1992 07/09/90 547.00 Yes
155 120 MG/KG Abnormal Breathing 01/06/1992 07/09/90 547.00 Yes
159 120 MG/KG Mass Head, Small (1mm-5mm) 1 06/11/1992 07/09/90 704.00 No
159 120 MG/KG Mass Head, Small (1mm-5mm) 1 07/07/1992 07/09/90 730.00 Yes
160 120 MG/KG Nasal/Eye Discharge 06/01/1992 07/09/90 694.00 Yes
166 120 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 07/07/1992 07/09/90 730.00 Yes
167 120 MG/KG Mass Head, Small (1mm-5mm) 1 07/07/1992 07/09/90 730.00 Yes
169 120 MG/KG Mass Head, Small (1mm-5mm) 1 04/16/1992 07/09/90 648.00 No
169 120 MG/KG Mass Head, Small (1mm-5mm) 1 05/14/1992 07/09/90 676.00 No
169 120 MG/KG Mass Head, Small (1mm-5mm) 1 06/11/1992 07/09/90 704.00 No
169 120 MG/KG Mass Head, Medium (6mm-15mm) 1 07/07/1992 07/09/90 730.00 Yes
174 120 MG/KG Abnormal Breathing 12/30/1991 07/09/90 540.00 Yes
174 120 MG/KG Lethargic 12/30/1991 07/09/90 540.00 Yes
179 120 MG/KG Abnormal Posture 06/02/1992 07/09/90 695.00 Yes
179 120 MG/KG Thin 06/02/1992 07/09/90 695.00 Yes
179 120 MG/KG Ruffled Fur 06/02/1992 07/09/90 695.00 Yes
181 120 MG/KG Thin 07/06/1992 07/09/90 729.00 Yes
184 120 MG/KG Mass Torso/Ventral, Medium (6mm-15mm) 1 07/06/1992 07/09/90 729.00 Yes
186 120 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 07/06/1992 07/09/90 729.00 Yes
189 120 MG/KG Mass Head, Small (1mm-5mm) 1 05/14/1992 07/09/90 676.00 No
189 120 MG/KG Mass Head, Small (1mm-5mm) 1 06/11/1992 07/09/90 704.00 No
189 120 MG/KG Mass Head, Small (1mm-5mm) 1 07/06/1992 07/09/90 729.00 Yes
199 120 MG/KG Mass Head, Medium (6mm-15mm) 1 04/16/1992 07/09/90 648.00 No
199 120 MG/KG Mass Head, Medium (6mm-15mm) 1 05/14/1992 07/09/90 676.00 No
199 120 MG/KG Mass Head, Medium (6mm-15mm) 1 06/11/1992 07/09/90 704.00 No
199 120 MG/KG Mass Head, Medium (6mm-15mm) 1 07/08/1992 07/09/90 731.00 Yes