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Short-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine
CASRN: ="AZTDDCCOMB"
Study Number: C89007
Exposure Route: GAVAGE
TDMS Number: 8900702
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
73 Vehicle Control Opacity 08/28/1989 08/21/89 8.00 No
73 Vehicle Control Opacity 09/05/1989 08/21/89 16.00 No
73 Vehicle Control Opacity 09/11/1989 08/21/89 22.00 No
73 Vehicle Control Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
73 Vehicle Control Micro-Ophthalmia 09/18/1989 08/21/89 29.00 Yes
73 Vehicle Control Opacity 09/18/1989 08/21/89 29.00 Yes
79 Vehicle Control Opacity 08/28/1989 08/21/89 8.00 No
79 Vehicle Control Opacity 09/05/1989 08/21/89 16.00 No
79 Vehicle Control Opacity 09/11/1989 08/21/89 22.00 No
79 Vehicle Control Opacity 09/18/1989 08/21/89 29.00 Yes
91 500 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
91 500 MG/KG Opacity 09/05/1989 08/21/89 16.00 No
91 500 MG/KG Opacity 09/11/1989 08/21/89 22.00 No
91 500 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
91 500 MG/KG Opacity 09/18/1989 08/21/89 29.00 Yes
91 500 MG/KG Micro-Ophthalmia 09/18/1989 08/21/89 29.00 Yes
95 500 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
95 500 MG/KG Opacity 09/05/1989 08/21/89 16.00 No
95 500 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
95 500 MG/KG Opacity 09/11/1989 08/21/89 22.00 No
95 500 MG/KG Micro-Ophthalmia 09/18/1989 08/21/89 29.00 Yes
95 500 MG/KG Opacity 09/18/1989 08/21/89 29.00 Yes
99 500 MG/KG Dehydrated 08/21/1989 08/21/89 1.00 No
99 500 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
99 500 MG/KG Opacity 09/05/1989 08/21/89 16.00 No
99 500 MG/KG Opacity 09/11/1989 08/21/89 22.00 No
99 500 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
99 500 MG/KG Opacity 09/18/1989 08/21/89 29.00 Yes
99 500 MG/KG Micro-Ophthalmia 09/18/1989 08/21/89 29.00 Yes
105 500 MG/KG, 10 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
105 500 MG/KG, 10 MG/KG Opacity 09/05/1989 08/21/89 16.00 No
105 500 MG/KG, 10 MG/KG Opacity 09/11/1989 08/21/89 22.00 No
105 500 MG/KG, 10 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
105 500 MG/KG, 10 MG/KG Micro-Ophthalmia 09/18/1989 08/21/89 29.00 Yes
105 500 MG/KG, 10 MG/KG Opacity 09/18/1989 08/21/89 29.00 Yes
108 500 MG/KG, 10 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
108 500 MG/KG, 10 MG/KG Opacity 09/05/1989 08/21/89 16.00 No
108 500 MG/KG, 10 MG/KG Opacity 09/11/1989 08/21/89 22.00 No
108 500 MG/KG, 10 MG/KG Opacity 09/18/1989 08/21/89 29.00 Yes
108 500 MG/KG, 10 MG/KG Micro-Ophthalmia 09/18/1989 08/21/89 29.00 Yes
111 500 MG/KG, 100 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
111 500 MG/KG, 100 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
113 500 MG/KG, 100 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
113 500 MG/KG, 100 MG/KG Opacity 09/05/1989 08/21/89 16.00 No
113 500 MG/KG, 100 MG/KG Opacity 09/11/1989 08/21/89 22.00 No
113 500 MG/KG, 100 MG/KG Opacity 09/18/1989 08/21/89 29.00 Yes
116 500 MG/KG, 100 MG/KG Micro-Ophthalmia 08/28/1989 08/21/89 8.00 No
116 500 MG/KG, 100 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
116 500 MG/KG, 100 MG/KG Micro-Ophthalmia 09/05/1989 08/21/89 16.00 No
116 500 MG/KG, 100 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
116 500 MG/KG, 100 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
116 500 MG/KG, 100 MG/KG Opacity 09/11/1989 08/21/89 22.00 No
116 500 MG/KG, 100 MG/KG Pallor 09/15/1989 08/21/89 26.00 Yes
116 500 MG/KG, 100 MG/KG Dehydrated 09/15/1989 08/21/89 26.00 Yes
116 500 MG/KG, 100 MG/KG Hypoactivity 09/15/1989 08/21/89 26.00 Yes
116 500 MG/KG, 100 MG/KG Micro-Ophthalmia 09/15/1989 08/21/89 26.00 Yes
116 500 MG/KG, 100 MG/KG Emaciated 09/15/1989 08/21/89 26.00 Yes
118 500 MG/KG, 100 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
118 500 MG/KG, 100 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
119 500 MG/KG, 100 MG/KG Micro-Ophthalmia 08/28/1989 08/21/89 8.00 No
119 500 MG/KG, 100 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
119 500 MG/KG, 100 MG/KG Micro-Ophthalmia 09/05/1989 08/21/89 16.00 No
119 500 MG/KG, 100 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
119 500 MG/KG, 100 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
119 500 MG/KG, 100 MG/KG Micro-Ophthalmia 09/18/1989 08/21/89 29.00 Yes
121 500 MG/KG, 500 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
121 500 MG/KG, 500 MG/KG Micro-Ophthalmia 09/05/1989 08/21/89 16.00 No
121 500 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
121 500 MG/KG, 500 MG/KG Hypoactivity 09/05/1989 08/21/89 16.00 No
121 500 MG/KG, 500 MG/KG Hypoactivity 09/11/1989 08/21/89 22.00 Yes
121 500 MG/KG, 500 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
121 500 MG/KG, 500 MG/KG Opacity 09/11/1989 08/21/89 22.00 Yes
121 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
121 500 MG/KG, 500 MG/KG Emaciated 09/11/1989 08/21/89 22.00 Yes
121 500 MG/KG, 500 MG/KG Opacity 09/11/1989 08/21/89 22.00 No
121 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 Yes
122 500 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
122 500 MG/KG, 500 MG/KG Pallor 09/15/1989 08/21/89 26.00 Yes
122 500 MG/KG, 500 MG/KG Hypoactivity 09/15/1989 08/21/89 26.00 Yes
122 500 MG/KG, 500 MG/KG Emaciated 09/15/1989 08/21/89 26.00 Yes
122 500 MG/KG, 500 MG/KG Hypothermia 09/15/1989 08/21/89 26.00 Yes
122 500 MG/KG, 500 MG/KG Dehydrated 09/15/1989 08/21/89 26.00 Yes
123 500 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
123 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
123 500 MG/KG, 500 MG/KG Dehydrated 09/15/1989 08/21/89 26.00 Yes
123 500 MG/KG, 500 MG/KG Pallor 09/15/1989 08/21/89 26.00 Yes
123 500 MG/KG, 500 MG/KG Hypothermia 09/15/1989 08/21/89 26.00 Yes
123 500 MG/KG, 500 MG/KG Hypoactivity 09/15/1989 08/21/89 26.00 Yes
124 500 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
124 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
124 500 MG/KG, 500 MG/KG Dehydrated 09/15/1989 08/21/89 26.00 Yes
124 500 MG/KG, 500 MG/KG Hypothermia 09/15/1989 08/21/89 26.00 Yes
124 500 MG/KG, 500 MG/KG Pallor 09/15/1989 08/21/89 26.00 Yes
124 500 MG/KG, 500 MG/KG Hypoactivity 09/15/1989 08/21/89 26.00 Yes
124 500 MG/KG, 500 MG/KG Emaciated 09/15/1989 08/21/89 26.00 Yes
125 500 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
125 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
126 500 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
126 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
126 500 MG/KG, 500 MG/KG Emaciated 09/13/1989 08/21/89 24.00 Yes
126 500 MG/KG, 500 MG/KG Micro-Ophthalmia 09/13/1989 08/21/89 24.00 Yes
126 500 MG/KG, 500 MG/KG Hypothermia 09/13/1989 08/21/89 24.00 Yes
126 500 MG/KG, 500 MG/KG Pallor 09/13/1989 08/21/89 24.00 Yes
126 500 MG/KG, 500 MG/KG Hypoactivity 09/13/1989 08/21/89 24.00 Yes
127 500 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
127 500 MG/KG, 500 MG/KG Hypoactivity 09/05/1989 08/21/89 16.00 No
127 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
127 500 MG/KG, 500 MG/KG Hypoactivity 09/11/1989 08/21/89 22.00 No
127 500 MG/KG, 500 MG/KG Pallor 09/13/1989 08/21/89 24.00 Yes
127 500 MG/KG, 500 MG/KG Emaciated 09/13/1989 08/21/89 24.00 Yes
127 500 MG/KG, 500 MG/KG Hypoactivity 09/13/1989 08/21/89 24.00 Yes
128 500 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
128 500 MG/KG, 500 MG/KG Hypoactivity 09/05/1989 08/21/89 16.00 No
128 500 MG/KG, 500 MG/KG Hypoactivity 09/11/1989 08/21/89 22.00 No
128 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
128 500 MG/KG, 500 MG/KG Pallor 09/15/1989 08/21/89 26.00 Yes
128 500 MG/KG, 500 MG/KG Hypoactivity 09/15/1989 08/21/89 26.00 Yes
128 500 MG/KG, 500 MG/KG Emaciated 09/15/1989 08/21/89 26.00 Yes
128 500 MG/KG, 500 MG/KG Hypothermia 09/15/1989 08/21/89 26.00 Yes
128 500 MG/KG, 500 MG/KG Dehydrated 09/15/1989 08/21/89 26.00 Yes
129 500 MG/KG, 500 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
129 500 MG/KG, 500 MG/KG Micro-Ophthalmia 08/28/1989 08/21/89 8.00 No
129 500 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
129 500 MG/KG, 500 MG/KG Opacity 09/05/1989 08/21/89 16.00 No
129 500 MG/KG, 500 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 Yes
129 500 MG/KG, 500 MG/KG Hypoactivity 09/11/1989 08/21/89 22.00 Yes
129 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
129 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 Yes
129 500 MG/KG, 500 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
129 500 MG/KG, 500 MG/KG Opacity 09/11/1989 08/21/89 22.00 Yes
129 500 MG/KG, 500 MG/KG Opacity 09/11/1989 08/21/89 22.00 No
130 500 MG/KG, 500 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
130 500 MG/KG, 500 MG/KG Micro-Ophthalmia 08/28/1989 08/21/89 8.00 No
130 500 MG/KG, 500 MG/KG Micro-Ophthalmia 09/05/1989 08/21/89 16.00 No
130 500 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
130 500 MG/KG, 500 MG/KG Hypoactivity 09/05/1989 08/21/89 16.00 No
130 500 MG/KG, 500 MG/KG Hypoactivity 09/11/1989 08/21/89 22.00 No
130 500 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
130 500 MG/KG, 500 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
130 500 MG/KG, 500 MG/KG Dehydrated 09/12/1989 08/21/89 23.00 Yes
130 500 MG/KG, 500 MG/KG Micro-Ophthalmia 09/12/1989 08/21/89 23.00 Yes
130 500 MG/KG, 500 MG/KG Pallor 09/12/1989 08/21/89 23.00 Yes
130 500 MG/KG, 500 MG/KG Emaciated 09/12/1989 08/21/89 23.00 Yes
130 500 MG/KG, 500 MG/KG Hypoactivity 09/12/1989 08/21/89 23.00 Yes
130 500 MG/KG, 500 MG/KG Hypothermia 09/12/1989 08/21/89 23.00 Yes
131 1000 MG/KG, 500 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
131 1000 MG/KG, 500 MG/KG Emaciated 09/05/1989 08/21/89 16.00 No
131 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 09/05/1989 08/21/89 16.00 No
131 1000 MG/KG, 500 MG/KG Hypoactivity 09/05/1989 08/21/89 16.00 No
131 1000 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
131 1000 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
131 1000 MG/KG, 500 MG/KG Hypoactivity 09/11/1989 08/21/89 22.00 No
131 1000 MG/KG, 500 MG/KG Emaciated 09/11/1989 08/21/89 22.00 No
131 1000 MG/KG, 500 MG/KG Opacity 09/11/1989 08/21/89 22.00 No
132 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 08/28/1989 08/21/89 8.00 No
132 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 09/05/1989 08/21/89 16.00 No
132 1000 MG/KG, 500 MG/KG Hypoactivity 09/05/1989 08/21/89 16.00 No
132 1000 MG/KG, 500 MG/KG Emaciated 09/05/1989 08/21/89 16.00 No
132 1000 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
133 1000 MG/KG, 500 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
133 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 08/28/1989 08/21/89 8.00 No
133 1000 MG/KG, 500 MG/KG Hypoactivity 09/05/1989 08/21/89 16.00 No
133 1000 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
133 1000 MG/KG, 500 MG/KG Emaciated 09/05/1989 08/21/89 16.00 No
133 1000 MG/KG, 500 MG/KG Opacity 09/05/1989 08/21/89 16.00 No
133 1000 MG/KG, 500 MG/KG Hypoactivity 09/08/1989 08/21/89 19.00 Yes
133 1000 MG/KG, 500 MG/KG Opacity 09/08/1989 08/21/89 19.00 Yes
133 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 09/08/1989 08/21/89 19.00 Yes
133 1000 MG/KG, 500 MG/KG Dehydrated 09/08/1989 08/21/89 19.00 Yes
133 1000 MG/KG, 500 MG/KG Emaciated 09/08/1989 08/21/89 19.00 Yes
133 1000 MG/KG, 500 MG/KG Hypothermia 09/08/1989 08/21/89 19.00 Yes
133 1000 MG/KG, 500 MG/KG Pallor 09/08/1989 08/21/89 19.00 Yes
134 1000 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
135 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 09/05/1989 08/21/89 16.00 No
135 1000 MG/KG, 500 MG/KG Hypoactivity 09/05/1989 08/21/89 16.00 No
135 1000 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
135 1000 MG/KG, 500 MG/KG Emaciated 09/05/1989 08/21/89 16.00 No
135 1000 MG/KG, 500 MG/KG Hypoactivity 09/11/1989 08/21/89 22.00 No
135 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 09/11/1989 08/21/89 22.00 No
135 1000 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
135 1000 MG/KG, 500 MG/KG Hypoactivity 09/11/1989 08/21/89 22.00 Yes
135 1000 MG/KG, 500 MG/KG Emaciated 09/11/1989 08/21/89 22.00 Yes
135 1000 MG/KG, 500 MG/KG Emaciated 09/11/1989 08/21/89 22.00 No
135 1000 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 Yes
136 1000 MG/KG, 500 MG/KG Hypoactivity 08/31/1989 08/21/89 11.00 Yes
136 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 08/31/1989 08/21/89 11.00 Yes
136 1000 MG/KG, 500 MG/KG Emaciated 08/31/1989 08/21/89 11.00 Yes
136 1000 MG/KG, 500 MG/KG Pallor 08/31/1989 08/21/89 11.00 Yes
136 1000 MG/KG, 500 MG/KG Hypothermia 08/31/1989 08/21/89 11.00 Yes
137 1000 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No
137 1000 MG/KG, 500 MG/KG Pallor 09/11/1989 08/21/89 22.00 No
137 1000 MG/KG, 500 MG/KG Emaciated 09/13/1989 08/21/89 24.00 Yes
137 1000 MG/KG, 500 MG/KG Pallor 09/13/1989 08/21/89 24.00 Yes
137 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 09/13/1989 08/21/89 24.00 Yes
137 1000 MG/KG, 500 MG/KG Hypoactivity 09/13/1989 08/21/89 24.00 Yes
138 1000 MG/KG, 500 MG/KG Emaciated 08/28/1989 08/21/89 8.00 No
138 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 08/28/1989 08/21/89 8.00 No
138 1000 MG/KG, 500 MG/KG Opacity 08/28/1989 08/21/89 8.00 No
138 1000 MG/KG, 500 MG/KG Hypothermia 08/31/1989 08/21/89 11.00 Yes
138 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 08/31/1989 08/21/89 11.00 Yes
138 1000 MG/KG, 500 MG/KG Opacity 08/31/1989 08/21/89 11.00 Yes
138 1000 MG/KG, 500 MG/KG Pallor 08/31/1989 08/21/89 11.00 Yes
138 1000 MG/KG, 500 MG/KG Hypoactivity 08/31/1989 08/21/89 11.00 Yes
138 1000 MG/KG, 500 MG/KG Emaciated 08/31/1989 08/21/89 11.00 Yes
139 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 08/28/1989 08/21/89 8.00 No
139 1000 MG/KG, 500 MG/KG Emaciated 08/28/1989 08/21/89 8.00 No
139 1000 MG/KG, 500 MG/KG Hypothermia 09/05/1989 08/21/89 16.00 Yes
139 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 09/05/1989 08/21/89 16.00 Yes
139 1000 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 Yes
139 1000 MG/KG, 500 MG/KG Hypoactivity 09/05/1989 08/21/89 16.00 Yes
139 1000 MG/KG, 500 MG/KG Emaciated 09/05/1989 08/21/89 16.00 Yes
140 1000 MG/KG, 500 MG/KG Pallor 09/05/1989 08/21/89 16.00 No