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Short-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine
CASRN: ="AZTDDCCOMB"
Study Number: C89007
Exposure Route: GAVAGE
TDMS Number: 8900702
Sex: Male
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
1 Vehicle Control Opacity 08/24/1989 08/17/89 8.00 No
1 Vehicle Control Opacity 08/31/1989 08/17/89 15.00 No
1 Vehicle Control Opacity 09/07/1989 08/17/89 22.00 No
1 Vehicle Control Opacity 09/14/1989 08/17/89 29.00 Yes
1 Vehicle Control Micro-Ophthalmia 09/14/1989 08/17/89 29.00 Yes
19 500 MG/KG Prolapse 09/07/1989 08/17/89 22.00 No
25 500 MG/KG Alopecia 08/17/1989 08/17/89 1.00 No
36 500 MG/KG, 10 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
51 500 MG/KG, 500 MG/KG Emaciated 09/07/1989 08/17/89 22.00 No
51 500 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
51 500 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
51 500 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
51 500 MG/KG, 500 MG/KG Emaciated 09/14/1989 08/17/89 29.00 Yes
51 500 MG/KG, 500 MG/KG Hypoactivity 09/14/1989 08/17/89 29.00 Yes
52 500 MG/KG, 500 MG/KG Opacity 08/24/1989 08/17/89 8.00 No
52 500 MG/KG, 500 MG/KG Micro-Ophthalmia 08/24/1989 08/17/89 8.00 No
52 500 MG/KG, 500 MG/KG Opacity 08/31/1989 08/17/89 15.00 No
52 500 MG/KG, 500 MG/KG Emaciated 09/07/1989 08/17/89 22.00 No
52 500 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
52 500 MG/KG, 500 MG/KG Opacity 09/07/1989 08/17/89 22.00 No
52 500 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
52 500 MG/KG, 500 MG/KG Opacity 09/14/1989 08/17/89 29.00 Yes
52 500 MG/KG, 500 MG/KG Emaciated 09/14/1989 08/17/89 29.00 Yes
52 500 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
52 500 MG/KG, 500 MG/KG Hypothermia 09/14/1989 08/17/89 29.00 Yes
52 500 MG/KG, 500 MG/KG Hypoactivity 09/14/1989 08/17/89 29.00 Yes
53 500 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
53 500 MG/KG, 500 MG/KG Emaciated 09/07/1989 08/17/89 22.00 No
53 500 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
53 500 MG/KG, 500 MG/KG Emaciated 09/14/1989 08/17/89 29.00 Yes
53 500 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
53 500 MG/KG, 500 MG/KG Hypoactivity 09/14/1989 08/17/89 29.00 Yes
54 500 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
54 500 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
54 500 MG/KG, 500 MG/KG Hypoactivity 09/14/1989 08/17/89 29.00 Yes
54 500 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
55 500 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
55 500 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
55 500 MG/KG, 500 MG/KG Hypothermia 09/14/1989 08/17/89 29.00 Yes
55 500 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
55 500 MG/KG, 500 MG/KG Hypoactivity 09/14/1989 08/17/89 29.00 Yes
56 500 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
56 500 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
56 500 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
57 500 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
57 500 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
58 500 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
58 500 MG/KG, 500 MG/KG Hypoactivity 09/14/1989 08/17/89 29.00 Yes
58 500 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
59 500 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
60 500 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
60 500 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
60 500 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
60 500 MG/KG, 500 MG/KG Hypothermia 09/14/1989 08/17/89 29.00 Yes
60 500 MG/KG, 500 MG/KG Hypoactivity 09/14/1989 08/17/89 29.00 Yes
60 500 MG/KG, 500 MG/KG Emaciated 09/14/1989 08/17/89 29.00 Yes
61 1000 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
61 1000 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
61 1000 MG/KG, 500 MG/KG Pallor 09/13/1989 08/17/89 28.00 Yes
63 1000 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
63 1000 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
63 1000 MG/KG, 500 MG/KG Emaciated 09/07/1989 08/17/89 22.00 No
63 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 09/12/1989 08/17/89 27.00 Yes
63 1000 MG/KG, 500 MG/KG Hypothermia 09/12/1989 08/17/89 27.00 Yes
63 1000 MG/KG, 500 MG/KG Emaciated 09/12/1989 08/17/89 27.00 Yes
63 1000 MG/KG, 500 MG/KG Pallor 09/12/1989 08/17/89 27.00 Yes
63 1000 MG/KG, 500 MG/KG Hypoactivity 09/12/1989 08/17/89 27.00 Yes
64 1000 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
64 1000 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
64 1000 MG/KG, 500 MG/KG Emaciated 09/07/1989 08/17/89 22.00 No
65 1000 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
65 1000 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
65 1000 MG/KG, 500 MG/KG Emaciated 09/07/1989 08/17/89 22.00 No
65 1000 MG/KG, 500 MG/KG Hypoactivity 09/12/1989 08/17/89 27.00 Yes
65 1000 MG/KG, 500 MG/KG Emaciated 09/12/1989 08/17/89 27.00 Yes
65 1000 MG/KG, 500 MG/KG Pallor 09/12/1989 08/17/89 27.00 Yes
65 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 09/12/1989 08/17/89 27.00 Yes
65 1000 MG/KG, 500 MG/KG Dehydrated 09/12/1989 08/17/89 27.00 Yes
65 1000 MG/KG, 500 MG/KG Hypothermia 09/12/1989 08/17/89 27.00 Yes
66 1000 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
66 1000 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
66 1000 MG/KG, 500 MG/KG Pallor 09/13/1989 08/17/89 28.00 Yes
66 1000 MG/KG, 500 MG/KG Micro-Ophthalmia 09/13/1989 08/17/89 28.00 Yes
66 1000 MG/KG, 500 MG/KG Emaciated 09/13/1989 08/17/89 28.00 Yes
66 1000 MG/KG, 500 MG/KG Hypoactivity 09/13/1989 08/17/89 28.00 Yes
67 1000 MG/KG, 500 MG/KG Emaciated 09/07/1989 08/17/89 22.00 No
67 1000 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
67 1000 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
67 1000 MG/KG, 500 MG/KG Hypothermia 09/14/1989 08/17/89 29.00 Yes
67 1000 MG/KG, 500 MG/KG Hypoactivity 09/14/1989 08/17/89 29.00 Yes
67 1000 MG/KG, 500 MG/KG Emaciated 09/14/1989 08/17/89 29.00 Yes
67 1000 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
68 1000 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
68 1000 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
68 1000 MG/KG, 500 MG/KG Emaciated 09/07/1989 08/17/89 22.00 No
68 1000 MG/KG, 500 MG/KG Hypothermia 09/14/1989 08/17/89 29.00 Yes
68 1000 MG/KG, 500 MG/KG Emaciated 09/14/1989 08/17/89 29.00 Yes
68 1000 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
68 1000 MG/KG, 500 MG/KG Hypoactivity 09/14/1989 08/17/89 29.00 Yes
69 1000 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
69 1000 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
69 1000 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes
70 1000 MG/KG, 500 MG/KG Pallor 09/07/1989 08/17/89 22.00 No
70 1000 MG/KG, 500 MG/KG Hypoactivity 09/07/1989 08/17/89 22.00 No
70 1000 MG/KG, 500 MG/KG Pallor 09/14/1989 08/17/89 29.00 Yes