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Short-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative)
CASRN: ="INTAZTCOMB"
Study Number: C89006
Exposure Route: SUBCUTANEOUS
TDMS Number: 8900601
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
145 Vehicle Control Opacity 03/15/1990 02/22/90 22.00 No
145 Vehicle Control Micro-Ophthalmia 03/15/1990 02/22/90 22.00 No
145 Vehicle Control Opacity 03/22/1990 02/22/90 29.00 Yes
145 Vehicle Control Micro-Ophthalmia 03/22/1990 02/22/90 29.00 Yes
161 1 0 U 1 Pallor 03/15/1990 02/22/90 21.00 No
161 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
162 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
163 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
164 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
165 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
166 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
167 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
168 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
169 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
170 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
182 500 0 U 500, 500 500 U 0 Opacity 03/08/1990 02/22/90 15.00 No
182 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/08/1990 02/22/90 15.00 No
182 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/15/1990 02/22/90 22.00 No
182 500 0 U 500, 500 500 U 0 Opacity 03/15/1990 02/22/90 22.00 No
182 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/22/1990 02/22/90 29.00 Yes
182 500 0 U 500, 500 500 U 0 Opacity 03/22/1990 02/22/90 29.00 Yes
183 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/08/1990 02/22/90 15.00 No
183 500 0 U 500, 500 500 U 0 Opacity 03/08/1990 02/22/90 15.00 No
183 500 0 U 500, 500 500 U 0 Opacity 03/15/1990 02/22/90 22.00 No
183 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/15/1990 02/22/90 22.00 No
183 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/22/1990 02/22/90 29.00 Yes
183 500 0 U 500, 500 500 U 0 Opacity 03/22/1990 02/22/90 29.00 Yes
184 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/08/1990 02/22/90 15.00 No
184 500 0 U 500, 500 500 U 0 Opacity 03/08/1990 02/22/90 15.00 No
184 500 0 U 500, 500 500 U 0 Opacity 03/15/1990 02/22/90 22.00 No
184 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/15/1990 02/22/90 22.00 No
184 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/22/1990 02/22/90 29.00 Yes
184 500 0 U 500, 500 500 U 0 Opacity 03/22/1990 02/22/90 29.00 Yes
185 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/08/1990 02/22/90 15.00 No
185 500 0 U 500, 500 500 U 0 Opacity 03/08/1990 02/22/90 15.00 No
185 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/15/1990 02/22/90 22.00 No
185 500 0 U 500, 500 500 U 0 Opacity 03/15/1990 02/22/90 22.00 No
185 500 0 U 500, 500 500 U 0 Micro-Ophthalmia 03/22/1990 02/22/90 29.00 Yes
185 500 0 U 500, 500 500 U 0 Opacity 03/22/1990 02/22/90 29.00 Yes
191 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
192 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
193 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
194 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
195 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
196 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
197 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
198 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
199 500 500 U 0, 1 0 U 1 Hyperactive 03/08/1990 02/22/90 14.00 No
199 500 500 U 0, 1 0 U 1 Hyperactive 03/15/1990 02/22/90 21.00 No
199 500 500 U 0, 1 0 U 1 Hyperactive 03/23/1990 02/22/90 29.00 Yes
199 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
200 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
211 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
212 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
213 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
214 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
215 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
216 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
217 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
218 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
219 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
220 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
221 5000 5000 U 0, 1 0 U 1 Pallor 03/15/1990 02/22/90 21.00 No
221 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
222 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
223 5000 5000 U 0, 1 0 U 1 Pallor 03/15/1990 02/22/90 21.00 No
223 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
224 5000 5000 U 0, 1 0 U 1 Pallor 03/15/1990 02/22/90 21.00 No
224 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
225 5000 5000 U 0, 1 0 U 1 Pallor 03/15/1990 02/22/90 21.00 No
225 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
226 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
227 5000 5000 U 0, 1 0 U 1 Pallor 03/15/1990 02/22/90 21.00 No
227 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
228 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
229 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
230 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
241 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
242 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
243 500 0 U 500, 50 U 0 Opacity 03/08/1990 02/22/90 14.00 No
243 500 0 U 500, 50 U 0 Micro-Ophthalmia 03/08/1990 02/22/90 14.00 No
243 500 0 U 500, 50 U 0 Opacity 03/15/1990 02/22/90 21.00 No
243 500 0 U 500, 50 U 0 Micro-Ophthalmia 03/23/1990 02/22/90 29.00 Yes
243 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
244 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
245 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
246 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
247 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
248 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
249 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
251 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
252 50 U 0, 1 0 U 1 Hyperactive 03/15/1990 02/22/90 21.00 No
252 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
253 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
254 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
255 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
256 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
257 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
258 50 U 0, 1 0 U 1 Pallor 03/15/1990 02/22/90 21.00 No
258 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
259 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
260 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
271 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
272 50 U 0, 1 0 U 1 Opacity 03/08/1990 02/22/90 14.00 No
272 50 U 0, 1 0 U 1 Micro-Ophthalmia 03/08/1990 02/22/90 14.00 No
272 50 U 0, 1 0 U 1 Micro-Ophthalmia 03/15/1990 02/22/90 21.00 No
272 50 U 0, 1 0 U 1 Opacity 03/15/1990 02/22/90 21.00 No
272 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
273 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
274 50 U 0, 1 0 U 1 Opacity 03/15/1990 02/22/90 21.00 No
274 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
274 50 U 0, 1 0 U 1 Opacity 03/23/1990 02/22/90 29.00 Yes
275 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
276 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
277 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
278 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
279 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes
280 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/23/1990 02/22/90 29.00 Yes