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Short-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative)
CASRN: ="INTAZTCOMB"
Study Number: C89006
Exposure Route: SUBCUTANEOUS
TDMS Number: 8900601
Sex: Male
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
1 Vehicle Control Micro-Ophthalmia 03/14/1990 02/20/90 23.00 No
1 Vehicle Control Opacity 03/14/1990 02/20/90 23.00 No
1 Vehicle Control Micro-Ophthalmia 03/20/1990 02/20/90 29.00 Yes
1 Vehicle Control Opacity 03/20/1990 02/20/90 29.00 Yes
26 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
27 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
28 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
29 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
30 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
31 500 500 U 0 Micro-Ophthalmia 03/07/1990 02/20/90 16.00 No
31 500 500 U 0 Opacity 03/07/1990 02/20/90 16.00 No
31 500 500 U 0 Opacity 03/14/1990 02/20/90 23.00 No
31 500 500 U 0 Micro-Ophthalmia 03/14/1990 02/20/90 23.00 No
31 500 500 U 0 Opacity 03/20/1990 02/20/90 29.00 Yes
31 500 500 U 0 Micro-Ophthalmia 03/20/1990 02/20/90 29.00 Yes
51 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
52 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
53 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
54 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
56 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
57 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
58 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
59 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
60 500 500 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
60 500 500 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
72 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
73 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
74 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
75 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
76 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
77 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
78 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
79 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
80 5000 5000 U 0, 500 0 U 500 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
81 5000 5000 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
82 5000 5000 U 0, 1 0 U 1 Micro-Ophthalmia 03/07/1990 02/20/90 15.00 No
82 5000 5000 U 0, 1 0 U 1 Opacity 03/07/1990 02/20/90 15.00 No
82 5000 5000 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
82 5000 5000 U 0, 1 0 U 1 Opacity 03/14/1990 02/20/90 22.00 No
82 5000 5000 U 0, 1 0 U 1 Micro-Ophthalmia 03/14/1990 02/20/90 22.00 No
82 5000 5000 U 0, 1 0 U 1 Opacity 03/21/1990 02/20/90 29.00 Yes
82 5000 5000 U 0, 1 0 U 1 Micro-Ophthalmia 03/21/1990 02/20/90 29.00 Yes
82 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
83 5000 5000 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
83 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
84 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
85 5000 5000 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
85 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
86 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
87 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
88 5000 5000 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
88 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
89 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
90 5000 5000 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
92 50 U 0 Micro-Ophthalmia 03/07/1990 02/20/90 16.00 No
92 50 U 0 Opacity 03/07/1990 02/20/90 16.00 No
92 50 U 0 Micro-Ophthalmia 03/14/1990 02/20/90 23.00 No
92 50 U 0 Opacity 03/14/1990 02/20/90 23.00 No
92 50 U 0 Micro-Ophthalmia 03/20/1990 02/20/90 29.00 Yes
92 50 U 0 Opacity 03/20/1990 02/20/90 29.00 Yes
94 50 U 0 Malocclusion 03/14/1990 02/20/90 23.00 No
94 50 U 0 Malocclusion 03/20/1990 02/20/90 29.00 Yes
102 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
103 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
104 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
105 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
106 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
107 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
108 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
109 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
110 500 0 U 500, 50 U 0 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
111 50 U 0, 1 0 U 1 Opacity 03/07/1990 02/20/90 15.00 No
111 50 U 0, 1 0 U 1 Micro-Ophthalmia 03/07/1990 02/20/90 15.00 No
111 50 U 0, 1 0 U 1 Opacity 03/14/1990 02/20/90 22.00 No
111 50 U 0, 1 0 U 1 Micro-Ophthalmia 03/14/1990 02/20/90 22.00 No
111 50 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
111 50 U 0, 1 0 U 1 Opacity 03/21/1990 02/20/90 29.00 Yes
111 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
111 50 U 0, 1 0 U 1 Micro-Ophthalmia 03/21/1990 02/20/90 29.00 Yes
112 50 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
112 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
113 50 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
113 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
114 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
115 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
116 50 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
116 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
117 50 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
117 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
118 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
119 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
120 50 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
120 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
123 50 U 0 Opacity 03/07/1990 02/20/90 16.00 No
123 50 U 0 Micro-Ophthalmia 03/07/1990 02/20/90 16.00 No
123 50 U 0 Micro-Ophthalmia 03/14/1990 02/20/90 23.00 No
123 50 U 0 Micro-Ophthalmia 03/20/1990 02/20/90 29.00 Yes
124 50 U 0 Opacity 03/14/1990 02/20/90 23.00 No
124 50 U 0 Micro-Ophthalmia 03/14/1990 02/20/90 23.00 No
124 50 U 0 Micro-Ophthalmia 03/20/1990 02/20/90 29.00 Yes
124 50 U 0 Opacity 03/20/1990 02/20/90 29.00 Yes
131 50 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
131 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
132 50 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
132 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
133 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
134 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
135 50 U 0, 1 0 U 1 Pallor 03/14/1990 02/20/90 22.00 No
135 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
136 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
137 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
138 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
139 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes
140 50 U 0, 1 0 U 1 Discoloration Tail, Black 03/21/1990 02/20/90 29.00 Yes