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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative)
CASRN: ="INTAZTCOMB"
Study Number: C89006
Exposure Route: GAVAGE
TDMS Number: 8900602
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
2206 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 02/28/1991 10/08/90 144.00 No
2206 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 03/28/1991 10/08/90 172.00 No
2206 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 06/20/1991 10/08/90 256.00 No
2206 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 07/18/1991 10/08/90 284.00 No
2206 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 08/15/1991 10/08/90 312.00 No
2207 Vehicle Control Tremors 01/17/1992 10/08/90 467.00 Yes
2207 Vehicle Control Lethargic 01/17/1992 10/08/90 467.00 Yes
2207 Vehicle Control Abnormal Posture 01/17/1992 10/08/90 467.00 Yes
2207 Vehicle Control Abnormal Breathing 01/17/1992 10/08/90 467.00 Yes
2209 Vehicle Control Abnormal Breathing 09/11/1992 10/08/90 705.00 Yes
2209 Vehicle Control Abnormal Posture 09/11/1992 10/08/90 705.00 Yes
2209 Vehicle Control Thin 09/11/1992 10/08/90 705.00 Yes
2214 Vehicle Control Abnormal Posture 06/08/1992 10/08/90 610.00 Yes
2214 Vehicle Control Ataxia 06/08/1992 10/08/90 610.00 Yes
2214 Vehicle Control Abnormal Breathing 06/08/1992 10/08/90 610.00 Yes
2214 Vehicle Control Lethargic 06/08/1992 10/08/90 610.00 Yes
2215 Vehicle Control Lethargic 09/13/1992 10/08/90 707.00 Yes
2215 Vehicle Control Abnormal Breathing 09/13/1992 10/08/90 707.00 Yes
2215 Vehicle Control Abnormal Posture 09/13/1992 10/08/90 707.00 Yes
2216 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 09/16/1992 10/08/90 710.00 Yes
2216 Vehicle Control Thin 09/16/1992 10/08/90 710.00 Yes
2220 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 07/16/1992 10/08/90 648.00 No
2220 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 08/13/1992 10/08/90 676.00 No
2220 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 08/25/1992 10/08/90 688.00 Yes
2222 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 10/05/1992 10/08/90 729.00 Yes
2227 Vehicle Control Thin 09/11/1992 10/08/90 705.00 Yes
2227 Vehicle Control Abnormal Posture 09/11/1992 10/08/90 705.00 Yes
2228 Vehicle Control Ataxia 03/20/1992 10/08/90 530.00 Yes
2228 Vehicle Control Abnormal Posture 03/20/1992 10/08/90 530.00 Yes
2228 Vehicle Control Abnormal Breathing 03/20/1992 10/08/90 530.00 Yes
2236 Vehicle Control Abnormal Posture 10/10/1990 10/08/90 3.00 Yes
2236 Vehicle Control Abnormal Breathing 10/10/1990 10/08/90 3.00 Yes
2246 Vehicle Control Mass Torso/Lateral, Medium (6mm-15mm) 1 04/23/1992 10/08/90 564.00 No
2248 Vehicle Control Thin 11/02/1990 10/08/90 26.00 Yes
2248 Vehicle Control Ruffled Fur 11/02/1990 10/08/90 26.00 Yes
2252 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 06/20/1991 10/08/90 256.00 No
2252 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 07/18/1991 10/08/90 284.00 No
2252 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 08/15/1991 10/08/90 312.00 No
2252 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 12/05/1991 10/08/90 424.00 No
2252 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 01/02/1992 10/08/90 452.00 No
2257 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 10/06/1992 10/08/90 730.00 Yes
2258 500 MG/KG, 30 MG/KG Mass Torso/Lateral, Large (16mm And Larger) 1 10/05/1992 10/08/90 729.00 Yes
2262 500 MG/KG, 30 MG/KG Abnormal Breathing 03/16/1992 10/08/90 526.00 Yes
2262 500 MG/KG, 30 MG/KG Abnormal Posture 03/16/1992 10/08/90 526.00 Yes
2262 500 MG/KG, 30 MG/KG Ataxia 03/16/1992 10/08/90 526.00 Yes
2262 500 MG/KG, 30 MG/KG Lethargic 03/16/1992 10/08/90 526.00 Yes
2263 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 06/20/1991 10/08/90 256.00 No
2263 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 07/18/1991 10/08/90 284.00 No
2263 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 08/15/1991 10/08/90 312.00 No
2263 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 10/10/1991 10/08/90 368.00 No
2263 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 11/07/1991 10/08/90 396.00 No
2263 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 12/05/1991 10/08/90 424.00 No
2263 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 01/02/1992 10/08/90 452.00 No
2265 500 MG/KG, 30 MG/KG Lethargic 06/29/1992 10/08/90 631.00 Yes
2265 500 MG/KG, 30 MG/KG Abnormal Posture 06/29/1992 10/08/90 631.00 Yes
2265 500 MG/KG, 30 MG/KG Tremors 06/29/1992 10/08/90 631.00 Yes
2265 500 MG/KG, 30 MG/KG Abnormal Breathing 06/29/1992 10/08/90 631.00 Yes
2268 500 MG/KG, 30 MG/KG Lethargic 09/08/1992 10/08/90 702.00 Yes
2268 500 MG/KG, 30 MG/KG Abnormal Posture 09/08/1992 10/08/90 702.00 Yes
2268 500 MG/KG, 30 MG/KG Abnormal Breathing 09/08/1992 10/08/90 702.00 Yes
2271 500 MG/KG, 30 MG/KG Abnormal Posture 06/01/1992 10/08/90 603.00 Yes
2271 500 MG/KG, 30 MG/KG Abnormal Breathing 06/01/1992 10/08/90 603.00 Yes
2271 500 MG/KG, 30 MG/KG Lethargic 06/01/1992 10/08/90 603.00 Yes
2280 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Small (1mm-5mm) 1 10/05/1992 10/08/90 729.00 Yes
2288 500 MG/KG, 30 MG/KG Lethargic 10/06/1992 10/08/90 730.00 Yes
2288 500 MG/KG, 30 MG/KG Abnormal Posture 10/06/1992 10/08/90 730.00 Yes
2289 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 06/18/1992 10/08/90 620.00 No
2289 500 MG/KG, 30 MG/KG Ulcer/Abscess Torso/Dorsal 06/18/1992 10/08/90 620.00 No
2289 500 MG/KG, 30 MG/KG Ulcer/Abscess Torso/Dorsal 07/06/1992 10/08/90 638.00 Yes
2289 500 MG/KG, 30 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 07/06/1992 10/08/90 638.00 Yes
2289 500 MG/KG, 30 MG/KG Abnormal Posture 07/06/1992 10/08/90 638.00 Yes
2290 500 MG/KG, 30 MG/KG Lethargic 04/20/1992 10/08/90 561.00 Yes
2290 500 MG/KG, 30 MG/KG Abnormal Posture 04/20/1992 10/08/90 561.00 Yes
2290 500 MG/KG, 30 MG/KG Abnormal Breathing 04/20/1992 10/08/90 561.00 Yes
2294 500 MG/KG, 30 MG/KG Mass Torso/Ventral, Medium (6mm-15mm) 1 10/05/1992 10/08/90 729.00 Yes
2294 500 MG/KG, 30 MG/KG Ulcer/Abscess Torso/Ventral 10/05/1992 10/08/90 729.00 Yes
2295 500 MG/KG, 30 MG/KG Nasal/Eye Discharge 10/06/1992 10/08/90 730.00 Yes
2297 500 MG/KG, 30 MG/KG Abnormal Posture 01/17/1992 10/08/90 467.00 Yes
2297 500 MG/KG, 30 MG/KG Ulcer/Abscess Torso/Dorsal 01/17/1992 10/08/90 467.00 Yes
2299 500 MG/KG, 30 MG/KG Abnormal Breathing 03/17/1992 10/08/90 527.00 Yes
2299 500 MG/KG, 30 MG/KG Ataxia 03/17/1992 10/08/90 527.00 Yes
2299 500 MG/KG, 30 MG/KG Abnormal Posture 03/17/1992 10/08/90 527.00 Yes
2302 500 MG/KG, 60 MG/KG Abnormal Breathing 06/12/1992 10/08/90 614.00 Yes
2302 500 MG/KG, 60 MG/KG Abnormal Posture 06/12/1992 10/08/90 614.00 Yes
2304 500 MG/KG, 60 MG/KG Ulcer/Abscess Torso/Dorsal 12/17/1991 10/08/90 436.00 Yes
2305 500 MG/KG, 60 MG/KG Abnormal Breathing 03/04/1992 10/08/90 514.00 Yes
2305 500 MG/KG, 60 MG/KG Ataxia 03/04/1992 10/08/90 514.00 Yes
2305 500 MG/KG, 60 MG/KG Abnormal Posture 03/04/1992 10/08/90 514.00 Yes
2305 500 MG/KG, 60 MG/KG Lethargic 03/04/1992 10/08/90 514.00 Yes
2316 500 MG/KG, 60 MG/KG Lethargic 05/27/1992 10/08/90 598.00 Yes
2316 500 MG/KG, 60 MG/KG Abnormal Breathing 05/27/1992 10/08/90 598.00 Yes
2316 500 MG/KG, 60 MG/KG Abnormal Posture 05/27/1992 10/08/90 598.00 Yes
2316 500 MG/KG, 60 MG/KG Ataxia 05/27/1992 10/08/90 598.00 Yes
2317 500 MG/KG, 60 MG/KG Ulcer/Abscess Torso/Dorsal 07/16/1992 10/08/90 648.00 No
2317 500 MG/KG, 60 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 07/16/1992 10/08/90 648.00 No
2317 500 MG/KG, 60 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 07/24/1992 10/08/90 656.00 Yes
2317 500 MG/KG, 60 MG/KG Ulcer/Abscess Torso/Dorsal 07/24/1992 10/08/90 656.00 Yes
2318 500 MG/KG, 60 MG/KG Mass Torso/Ventral, Small (1mm-5mm) 1 10/05/1992 10/08/90 729.00 Yes
2326 500 MG/KG, 60 MG/KG Tremors 05/26/1992 10/08/90 597.00 Yes
2326 500 MG/KG, 60 MG/KG Ataxia 05/26/1992 10/08/90 597.00 Yes
2326 500 MG/KG, 60 MG/KG Abnormal Breathing 05/26/1992 10/08/90 597.00 Yes
2326 500 MG/KG, 60 MG/KG Thin 05/26/1992 10/08/90 597.00 Yes
2326 500 MG/KG, 60 MG/KG Abnormal Posture 05/26/1992 10/08/90 597.00 Yes
2328 500 MG/KG, 60 MG/KG Mass Torso/Lateral, Medium (6mm-15mm) 1 09/10/1992 10/08/90 704.00 No
2328 500 MG/KG, 60 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 10/05/1992 10/08/90 729.00 Yes
2332 500 MG/KG, 60 MG/KG Mass Torso/Ventral, Small (1mm-5mm) 1 10/05/1992 10/08/90 729.00 Yes
2333 500 MG/KG, 60 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 08/26/1992 10/08/90 689.00 Yes
2333 500 MG/KG, 60 MG/KG Abnormal Posture 08/26/1992 10/08/90 689.00 Yes
2333 500 MG/KG, 60 MG/KG Abnormal Breathing 08/26/1992 10/08/90 689.00 Yes
2333 500 MG/KG, 60 MG/KG Lethargic 08/26/1992 10/08/90 689.00 Yes
2336 500 MG/KG, 60 MG/KG Abnormal Posture 07/28/1992 10/08/90 660.00 Yes
2336 500 MG/KG, 60 MG/KG Abnormal Breathing 07/28/1992 10/08/90 660.00 Yes
2339 500 MG/KG, 60 MG/KG Abnormal Posture 08/19/1992 10/08/90 682.00 Yes
2339 500 MG/KG, 60 MG/KG Abnormal Breathing 08/19/1992 10/08/90 682.00 Yes
2341 500 MG/KG, 60 MG/KG Abnormal Posture 07/15/1992 10/08/90 647.00 Yes
2341 500 MG/KG, 60 MG/KG Abnormal Breathing 07/15/1992 10/08/90 647.00 Yes
2341 500 MG/KG, 60 MG/KG Lethargic 07/15/1992 10/08/90 647.00 Yes
2341 500 MG/KG, 60 MG/KG Tremors 07/15/1992 10/08/90 647.00 Yes
2348 500 MG/KG, 60 MG/KG Hyperactive 06/12/1992 10/08/90 614.00 Yes
2348 500 MG/KG, 60 MG/KG Ataxia 06/12/1992 10/08/90 614.00 Yes
2349 500 MG/KG, 60 MG/KG Nasal/Eye Discharge 10/06/1992 10/08/90 730.00 Yes
2352 500 MG/KG, 120 MG/KG Nasal/Eye Discharge 05/18/1992 10/08/90 589.00 Yes
2353 500 MG/KG, 120 MG/KG Abnormal Breathing 09/05/1992 10/08/90 699.00 Yes
2353 500 MG/KG, 120 MG/KG Thin 09/05/1992 10/08/90 699.00 Yes
2353 500 MG/KG, 120 MG/KG Abnormal Posture 09/05/1992 10/08/90 699.00 Yes
2354 500 MG/KG, 120 MG/KG Lethargic 06/15/1992 10/08/90 617.00 Yes
2354 500 MG/KG, 120 MG/KG Abnormal Breathing 06/15/1992 10/08/90 617.00 Yes
2358 500 MG/KG, 120 MG/KG Thin 11/01/1990 10/08/90 25.00 Yes
2358 500 MG/KG, 120 MG/KG Ruffled Fur 11/01/1990 10/08/90 25.00 Yes
2358 500 MG/KG, 120 MG/KG Tremors 11/01/1990 10/08/90 25.00 Yes
2359 500 MG/KG, 120 MG/KG Mass Torso/Ventral, Medium (6mm-15mm) 1 03/26/1992 10/08/90 536.00 No
2359 500 MG/KG, 120 MG/KG Mass Torso/Lateral, Medium (6mm-15mm) 1 03/26/1992 10/08/90 536.00 No
2359 500 MG/KG, 120 MG/KG Abnormal Posture 06/02/1992 10/08/90 604.00 Yes
2359 500 MG/KG, 120 MG/KG Abnormal Breathing 06/02/1992 10/08/90 604.00 Yes
2359 500 MG/KG, 120 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 06/02/1992 10/08/90 604.00 Yes
2362 500 MG/KG, 120 MG/KG Abnormal Breathing 08/10/1992 10/08/90 673.00 Yes
2362 500 MG/KG, 120 MG/KG Lethargic 08/10/1992 10/08/90 673.00 Yes
2365 500 MG/KG, 120 MG/KG Abnormal Posture 07/30/1992 10/08/90 662.00 Yes
2365 500 MG/KG, 120 MG/KG Lethargic 07/30/1992 10/08/90 662.00 Yes
2367 500 MG/KG, 120 MG/KG Abnormal Posture 05/06/1992 10/08/90 577.00 Yes
2367 500 MG/KG, 120 MG/KG Abnormal Breathing 05/06/1992 10/08/90 577.00 Yes
2367 500 MG/KG, 120 MG/KG Lethargic 05/06/1992 10/08/90 577.00 Yes
2367 500 MG/KG, 120 MG/KG Tremors 05/06/1992 10/08/90 577.00 Yes
2373 500 MG/KG, 120 MG/KG Mass Torso/Ventral, Small (1mm-5mm) 1 10/07/1992 10/08/90 731.00 Yes
2377 500 MG/KG, 120 MG/KG Mass Torso/Lateral, Large (16mm And Larger) 1 10/06/1992 10/08/90 730.00 Yes
2381 500 MG/KG, 120 MG/KG Abnormal Posture 12/11/1991 10/08/90 430.00 Yes
2381 500 MG/KG, 120 MG/KG Abnormal Breathing 12/11/1991 10/08/90 430.00 Yes
2381 500 MG/KG, 120 MG/KG Nasal/Eye Discharge 12/11/1991 10/08/90 430.00 Yes
2381 500 MG/KG, 120 MG/KG Lethargic 12/11/1991 10/08/90 430.00 Yes
2383 500 MG/KG, 120 MG/KG Lethargic 09/01/1992 10/08/90 695.00 Yes
2384 500 MG/KG, 120 MG/KG Thin 10/18/1991 10/08/90 376.00 Yes
2384 500 MG/KG, 120 MG/KG Lethargic 10/18/1991 10/08/90 376.00 Yes
2387 500 MG/KG, 120 MG/KG Abnormal Posture 10/07/1992 10/08/90 731.00 Yes
2390 500 MG/KG, 120 MG/KG Lethargic 09/28/1992 10/08/90 722.00 Yes
2390 500 MG/KG, 120 MG/KG Abnormal Breathing 09/28/1992 10/08/90 722.00 Yes
2390 500 MG/KG, 120 MG/KG Abnormal Posture 09/28/1992 10/08/90 722.00 Yes
2390 500 MG/KG, 120 MG/KG Thin 09/28/1992 10/08/90 722.00 Yes
2393 500 MG/KG, 120 MG/KG Abnormal Posture 11/08/1990 10/08/90 32.00 Yes
2398 500 MG/KG, 120 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 05/21/1992 10/08/90 592.00 No
2398 500 MG/KG, 120 MG/KG Abnormal Posture 06/01/1992 10/08/90 603.00 Yes
2398 500 MG/KG, 120 MG/KG Ulcer/Abscess Torso/Dorsal 06/01/1992 10/08/90 603.00 Yes
2398 500 MG/KG, 120 MG/KG Abnormal Breathing 06/01/1992 10/08/90 603.00 Yes
2400 500 MG/KG, 120 MG/KG Ulcer/Abscess Torso/Ventral 05/21/1992 10/08/90 592.00 No
2400 500 MG/KG, 120 MG/KG Ulcer/Abscess Torso/Ventral 06/18/1992 10/08/90 620.00 No
2400 500 MG/KG, 120 MG/KG Ulcer/Abscess Torso/Ventral 07/16/1992 10/08/90 648.00 No
2400 500 MG/KG, 120 MG/KG Ulcer/Abscess Torso/Ventral 08/13/1992 10/08/90 676.00 No
2400 500 MG/KG, 120 MG/KG Ulcer/Abscess Torso/Ventral 09/11/1992 10/08/90 705.00 Yes
2400 500 MG/KG, 120 MG/KG Mass Torso/Ventral, Medium (6mm-15mm) 1 09/11/1992 10/08/90 705.00 Yes