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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative)
CASRN: ="INTAZTCOMB"
Study Number: C89006
Exposure Route: GAVAGE
TDMS Number: 8900604
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
3202 Vehicle Control Mass Head, Small (1mm-5mm) 1 09/24/1992 01/14/91 620.00 No
3202 Vehicle Control Mass Head, Small (1mm-5mm) 1 10/22/1992 01/14/91 648.00 No
3202 Vehicle Control Mass Head, Medium (6mm-15mm) 1 11/19/1992 01/14/91 676.00 No
3202 Vehicle Control Mass Head, Small (1mm-5mm) 1 12/17/1992 01/14/91 704.00 No
3202 Vehicle Control Mass Head, Small (1mm-5mm) 1 01/12/1993 01/14/91 730.00 Yes
3204 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 01/12/1993 01/14/91 730.00 Yes
3208 Vehicle Control Abnormal Breathing 08/24/1992 01/14/91 589.00 Yes
3211 Vehicle Control Mass Head, Small (1mm-5mm) 1 12/17/1992 01/14/91 704.00 No
3211 Vehicle Control Mass Head, Large (16mm And Larger) 1 01/15/1993 01/14/91 733.00 Yes
3213 Vehicle Control Abnormal Posture 08/21/1992 01/14/91 586.00 Yes
3213 Vehicle Control Tremors 08/21/1992 01/14/91 586.00 Yes
3215 Vehicle Control Abnormal Posture 05/07/1992 01/14/91 480.00 Yes
3218 Vehicle Control Hyperactive 12/14/1992 01/14/91 701.00 Yes
3218 Vehicle Control Tremors 12/14/1992 01/14/91 701.00 Yes
3230 Vehicle Control Abnormal Posture 11/25/1992 01/14/91 682.00 Yes
3230 Vehicle Control Abnormal Breathing 11/25/1992 01/14/91 682.00 Yes
3235 Vehicle Control Abnormal Breathing 11/15/1992 01/14/91 672.00 Yes
3235 Vehicle Control Abnormal Posture 11/15/1992 01/14/91 672.00 Yes
3242 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 08/27/1992 01/14/91 592.00 No
3242 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 09/24/1992 01/14/91 620.00 No
3242 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 10/22/1992 01/14/91 648.00 No
3242 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 11/04/1992 01/14/91 661.00 Yes
3246 Vehicle Control Abnormal Breathing 12/23/1992 01/14/91 710.00 Yes
3246 Vehicle Control Abnormal Posture 12/23/1992 01/14/91 710.00 Yes
3249 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 09/24/1992 01/14/91 620.00 No
3249 Vehicle Control Ulcer/Abscess Torso/Ventral 09/29/1992 01/14/91 625.00 Yes
3249 Vehicle Control Abnormal Breathing 09/29/1992 01/14/91 625.00 Yes
3249 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 09/29/1992 01/14/91 625.00 Yes
3249 Vehicle Control Abnormal Posture 09/29/1992 01/14/91 625.00 Yes
3249 Vehicle Control Lethargic 09/29/1992 01/14/91 625.00 Yes
3256 5000 MG/KG, 30 MG/KG Mass Appendage, Medium (6mm-15mm) 1 12/17/1992 01/14/91 704.00 No
3266 5000 MG/KG, 30 MG/KG Thin 07/23/1992 01/14/91 557.00 Yes
3266 5000 MG/KG, 30 MG/KG Abnormal Posture 07/23/1992 01/14/91 557.00 Yes
3272 5000 MG/KG, 30 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 08/27/1992 01/14/91 592.00 Yes
3275 5000 MG/KG, 30 MG/KG Abnormal Breathing 09/02/1992 01/14/91 598.00 Yes
3283 5000 MG/KG, 30 MG/KG Mass Torso/Ventral, Medium (6mm-15mm) 1 09/24/1992 01/14/91 620.00 No
3283 5000 MG/KG, 30 MG/KG Mass Torso/Ventral, Medium (6mm-15mm) 1 10/22/1992 01/14/91 648.00 No
3283 5000 MG/KG, 30 MG/KG Mass Torso/Ventral, Large (16mm And Larger) 1 10/30/1992 01/14/91 656.00 Yes
3285 5000 MG/KG, 30 MG/KG Lethargic 10/12/1992 01/14/91 638.00 Yes
3285 5000 MG/KG, 30 MG/KG Abnormal Breathing 10/12/1992 01/14/91 638.00 Yes
3289 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 12/17/1992 01/14/91 704.00 No
3297 5000 MG/KG, 30 MG/KG Mass Torso/Lateral, Medium (6mm-15mm) 1 11/19/1992 01/14/91 676.00 No
3297 5000 MG/KG, 30 MG/KG Ulcer/Abscess Torso/Lateral 12/17/1992 01/14/91 704.00 No
3297 5000 MG/KG, 30 MG/KG Mass Torso/Lateral, Medium (6mm-15mm) 1 12/17/1992 01/14/91 704.00 No
3297 5000 MG/KG, 30 MG/KG Mass Torso/Lateral, Medium (6mm-15mm) 2 01/15/1993 01/14/91 733.00 Yes
3298 5000 MG/KG, 30 MG/KG Ruffled Fur 07/20/1992 01/14/91 554.00 Yes
3298 5000 MG/KG, 30 MG/KG Thin 07/20/1992 01/14/91 554.00 Yes
3298 5000 MG/KG, 30 MG/KG Abnormal Posture 07/20/1992 01/14/91 554.00 Yes
3300 5000 MG/KG, 30 MG/KG Abnormal Posture 08/21/1992 01/14/91 586.00 Yes
3303 5000 MG/KG, 60 MG/KG Lethargic 09/24/1992 01/14/91 620.00 Yes
3303 5000 MG/KG, 60 MG/KG Abnormal Posture 09/24/1992 01/14/91 620.00 Yes
3303 5000 MG/KG, 60 MG/KG Abnormal Breathing 09/24/1992 01/14/91 620.00 Yes
3304 5000 MG/KG, 60 MG/KG Mass Torso/Dorsal, Small (1mm-5mm) 1 10/22/1992 01/14/91 648.00 Yes
3307 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 07/30/1992 01/14/91 564.00 No
3307 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 08/27/1992 01/14/91 592.00 No
3307 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 09/24/1992 01/14/91 620.00 No
3307 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 10/22/1992 01/14/91 648.00 No
3307 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 11/19/1992 01/14/91 676.00 No
3307 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 12/17/1992 01/14/91 704.00 No
3307 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 01/14/1993 01/14/91 732.00 Yes
3312 5000 MG/KG, 60 MG/KG Abnormal Breathing 12/23/1991 01/14/91 344.00 Yes
3312 5000 MG/KG, 60 MG/KG Thin 12/23/1991 01/14/91 344.00 Yes
3313 5000 MG/KG, 60 MG/KG Lethargic 07/31/1991 01/14/91 199.00 Yes
3313 5000 MG/KG, 60 MG/KG Nasal/Eye Discharge 07/31/1991 01/14/91 199.00 Yes
3320 5000 MG/KG, 60 MG/KG Abnormal Posture 05/21/1992 01/14/91 494.00 Yes
3322 5000 MG/KG, 60 MG/KG Lethargic 11/27/1991 01/14/91 318.00 Yes
3334 5000 MG/KG, 60 MG/KG Lethargic 05/15/1992 01/14/91 488.00 Yes
3334 5000 MG/KG, 60 MG/KG Thin 05/15/1992 01/14/91 488.00 Yes
3342 5000 MG/KG, 60 MG/KG Ataxia 01/16/1991 01/14/91 3.00 Yes
3342 5000 MG/KG, 60 MG/KG Convulsions 01/16/1991 01/14/91 3.00 Yes
3342 5000 MG/KG, 60 MG/KG Emaciated 01/16/1991 01/14/91 3.00 Yes
3344 5000 MG/KG, 60 MG/KG Mass Torso/Ventral, Small (1mm-5mm) 1 01/14/1993 01/14/91 732.00 Yes
3345 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 09/24/1992 01/14/91 620.00 No
3345 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 10/22/1992 01/14/91 648.00 No
3345 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 11/19/1992 01/14/91 676.00 No
3345 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 12/17/1992 01/14/91 704.00 No
3345 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 01/14/1993 01/14/91 732.00 Yes
3348 5000 MG/KG, 60 MG/KG Abnormal Breathing 09/08/1992 01/14/91 604.00 Yes
3350 5000 MG/KG, 60 MG/KG Mass Torso/Lateral, Medium (6mm-15mm) 1 11/19/1992 01/14/91 676.00 No
3350 5000 MG/KG, 60 MG/KG Mass Torso/Lateral, Large (16mm And Larger) 1 12/17/1992 01/14/91 704.00 No
3350 5000 MG/KG, 60 MG/KG Ulcer/Abscess Torso/Lateral 01/15/1993 01/14/91 733.00 Yes
3350 5000 MG/KG, 60 MG/KG Mass Torso/Lateral, Large (16mm And Larger) 1 01/15/1993 01/14/91 733.00 Yes
3351 5000 MG/KG, 120 MG/KG Abnormal Breathing 11/25/1992 01/14/91 682.00 Yes
3351 5000 MG/KG, 120 MG/KG Abnormal Posture 11/25/1992 01/14/91 682.00 Yes
3360 5000 MG/KG, 120 MG/KG Abnormal Posture 08/06/1992 01/14/91 571.00 Yes
3360 5000 MG/KG, 120 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 08/06/1992 01/14/91 571.00 Yes
3361 5000 MG/KG, 120 MG/KG Abnormal Posture 11/04/1992 01/14/91 661.00 Yes
3361 5000 MG/KG, 120 MG/KG Ataxia 11/04/1992 01/14/91 661.00 Yes
3364 5000 MG/KG, 120 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 01/15/1993 01/14/91 733.00 Yes
3365 5000 MG/KG, 120 MG/KG Abnormal Posture 08/28/1992 01/14/91 593.00 Yes
3365 5000 MG/KG, 120 MG/KG Abnormal Breathing 08/28/1992 01/14/91 593.00 Yes
3368 5000 MG/KG, 120 MG/KG Abnormal Posture 07/23/1992 01/14/91 557.00 Yes
3368 5000 MG/KG, 120 MG/KG Ataxia 07/23/1992 01/14/91 557.00 Yes
3368 5000 MG/KG, 120 MG/KG Ruffled Fur 07/23/1992 01/14/91 557.00 Yes
3374 5000 MG/KG, 120 MG/KG Abnormal Breathing 10/04/1992 01/14/91 630.00 Yes
3374 5000 MG/KG, 120 MG/KG Lethargic 10/04/1992 01/14/91 630.00 Yes
3379 5000 MG/KG, 120 MG/KG Mass Torso/Ventral, Small (1mm-5mm) 1 05/07/1992 01/14/91 480.00 No
3379 5000 MG/KG, 120 MG/KG Mass Torso/Ventral, Medium (6mm-15mm) 1 05/28/1992 01/14/91 501.00 Yes
3386 5000 MG/KG, 120 MG/KG Ulcer/Abscess Torso/Dorsal 11/30/1992 01/14/91 687.00 Yes
3386 5000 MG/KG, 120 MG/KG Abnormal Posture 11/30/1992 01/14/91 687.00 Yes
3390 5000 MG/KG, 120 MG/KG Ulcer/Abscess Torso/Ventral 01/14/1993 01/14/91 732.00 Yes