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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative)
CASRN: ="INTAZTCOMB"
Study Number: C89006
Exposure Route: GAVAGE
TDMS Number: 8900604
Sex: Male
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
3003 Vehicle Control Abnormal Breathing 08/11/1992 01/14/91 576.00 Yes
3003 Vehicle Control Lethargic 08/11/1992 01/14/91 576.00 Yes
3005 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 01/13/1993 01/14/91 731.00 Yes
3010 Vehicle Control Lethargic 12/04/1992 01/14/91 691.00 Yes
3010 Vehicle Control Abnormal Breathing 12/04/1992 01/14/91 691.00 Yes
3015 Vehicle Control Ataxia 02/10/1992 01/14/91 393.00 Yes
3015 Vehicle Control Abnormal Posture 02/10/1992 01/14/91 393.00 Yes
3019 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 07/28/1992 01/14/91 562.00 No
3019 Vehicle Control Mass Head, Small (1mm-5mm) 1 07/28/1992 01/14/91 562.00 No
3019 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 08/25/1992 01/14/91 590.00 No
3019 Vehicle Control Mass Head, Small (1mm-5mm) 1 08/25/1992 01/14/91 590.00 No
3019 Vehicle Control Mass Appendage, Small (1mm-5mm) 1 09/17/1992 01/14/91 613.00 Yes
3019 Vehicle Control Mass Head, Medium (6mm-15mm) 1 09/17/1992 01/14/91 613.00 Yes
3029 Vehicle Control Abnormal Breathing 12/10/1992 01/14/91 697.00 Yes
3029 Vehicle Control Abnormal Posture 12/10/1992 01/14/91 697.00 Yes
3029 Vehicle Control Lethargic 12/10/1992 01/14/91 697.00 Yes
3036 Vehicle Control Mass Torso/Dorsal, Large (16mm And Larger) 1 01/11/1993 01/14/91 729.00 Yes
3038 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 01/13/1993 01/14/91 731.00 Yes
3040 Vehicle Control Lethargic 01/06/1993 01/14/91 724.00 Yes
3040 Vehicle Control Abnormal Breathing 01/06/1993 01/14/91 724.00 Yes
3040 Vehicle Control Abnormal Posture 01/06/1993 01/14/91 724.00 Yes
3046 Vehicle Control Lethargic 11/19/1992 01/14/91 676.00 Yes
3046 Vehicle Control Abnormal Posture 11/19/1992 01/14/91 676.00 Yes
3046 Vehicle Control Abnormal Breathing 11/19/1992 01/14/91 676.00 Yes
3047 Vehicle Control Abnormal Posture 11/13/1992 01/14/91 670.00 Yes
3047 Vehicle Control Hyperactive 11/13/1992 01/14/91 670.00 Yes
3049 Vehicle Control Tremors 12/07/1992 01/14/91 694.00 Yes
3051 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 09/22/1992 01/14/91 618.00 No
3051 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 10/20/1992 01/14/91 646.00 No
3051 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 11/17/1992 01/14/91 674.00 No
3051 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 12/15/1992 01/14/91 702.00 No
3051 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 01/13/1993 01/14/91 731.00 Yes
3052 5000 MG/KG, 30 MG/KG Ulcer/Abscess Torso/Dorsal 01/11/1993 01/14/91 729.00 Yes
3055 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 07/28/1992 01/14/91 562.00 No
3055 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 08/25/1992 01/14/91 590.00 No
3055 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 09/22/1992 01/14/91 618.00 No
3055 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 10/20/1992 01/14/91 646.00 No
3055 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 11/17/1992 01/14/91 674.00 No
3055 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 12/15/1992 01/14/91 702.00 No
3055 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 01/11/1993 01/14/91 729.00 Yes
3056 5000 MG/KG, 30 MG/KG Lethargic 01/11/1992 01/14/91 363.00 Yes
3056 5000 MG/KG, 30 MG/KG Ataxia 01/11/1992 01/14/91 363.00 Yes
3056 5000 MG/KG, 30 MG/KG Abnormal Breathing 01/11/1992 01/14/91 363.00 Yes
3057 5000 MG/KG, 30 MG/KG Lethargic 12/28/1992 01/14/91 715.00 Yes
3057 5000 MG/KG, 30 MG/KG Abnormal Posture 12/28/1992 01/14/91 715.00 Yes
3057 5000 MG/KG, 30 MG/KG Tremors 12/28/1992 01/14/91 715.00 Yes
3057 5000 MG/KG, 30 MG/KG Abnormal Breathing 12/28/1992 01/14/91 715.00 Yes
3062 5000 MG/KG, 30 MG/KG Lethargic 04/30/1992 01/14/91 473.00 Yes
3062 5000 MG/KG, 30 MG/KG Thin 04/30/1992 01/14/91 473.00 Yes
3062 5000 MG/KG, 30 MG/KG Ulcer/Abscess Torso/Dorsal 04/30/1992 01/14/91 473.00 Yes
3063 5000 MG/KG, 30 MG/KG Mass Torso/Dorsal, Small (1mm-5mm) 1 06/30/1992 01/14/91 534.00 No
3063 5000 MG/KG, 30 MG/KG Abnormal Posture 07/20/1992 01/14/91 554.00 Yes
3063 5000 MG/KG, 30 MG/KG Mass Torso/Dorsal, Large (16mm And Larger) 1 07/20/1992 01/14/91 554.00 Yes
3067 5000 MG/KG, 30 MG/KG Mass Torso/Dorsal, Small (1mm-5mm) 1 03/27/1992 01/14/91 439.00 Yes
3067 5000 MG/KG, 30 MG/KG Mass Torso/Dorsal, Medium (6mm-15mm) 1 03/27/1992 01/14/91 439.00 Yes
3068 5000 MG/KG, 30 MG/KG Abnormal Breathing 12/18/1991 01/14/91 339.00 Yes
3068 5000 MG/KG, 30 MG/KG Abnormal Posture 12/18/1991 01/14/91 339.00 Yes
3070 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 06/30/1992 01/14/91 534.00 No
3070 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 07/28/1992 01/14/91 562.00 No
3070 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 08/25/1992 01/14/91 590.00 No
3070 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 01/13/1993 01/14/91 731.00 Yes
3072 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 05/05/1992 01/14/91 478.00 No
3072 5000 MG/KG, 30 MG/KG Mass Head, Large (16mm And Larger) 1 07/23/1992 01/14/91 557.00 Yes
3072 5000 MG/KG, 30 MG/KG Ruffled Fur 07/23/1992 01/14/91 557.00 Yes
3075 5000 MG/KG, 30 MG/KG Abnormal Breathing 11/23/1992 01/14/91 680.00 Yes
3075 5000 MG/KG, 30 MG/KG Mass Torso/Lateral, Large (16mm And Larger) 1 11/23/1992 01/14/91 680.00 Yes
3080 5000 MG/KG, 30 MG/KG Abnormal Breathing 07/23/1992 01/14/91 557.00 Yes
3080 5000 MG/KG, 30 MG/KG Abnormal Posture 07/23/1992 01/14/91 557.00 Yes
3084 5000 MG/KG, 30 MG/KG Abnormal Posture 11/04/1992 01/14/91 661.00 Yes
3084 5000 MG/KG, 30 MG/KG Abnormal Breathing 11/04/1992 01/14/91 661.00 Yes
3084 5000 MG/KG, 30 MG/KG Tremors 11/04/1992 01/14/91 661.00 Yes
3087 5000 MG/KG, 30 MG/KG Mass Torso/Ventral, Small (1mm-5mm) 1 10/20/1992 01/14/91 646.00 No
3087 5000 MG/KG, 30 MG/KG Tremors 12/01/1992 01/14/91 688.00 Yes
3087 5000 MG/KG, 30 MG/KG Abnormal Breathing 12/01/1992 01/14/91 688.00 Yes
3087 5000 MG/KG, 30 MG/KG Lethargic 12/01/1992 01/14/91 688.00 Yes
3090 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 12/15/1992 01/14/91 702.00 No
3090 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 01/13/1993 01/14/91 731.00 Yes
3097 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 10/20/1992 01/14/91 646.00 No
3097 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 11/17/1992 01/14/91 674.00 No
3097 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 12/15/1992 01/14/91 702.00 No
3097 5000 MG/KG, 30 MG/KG Mass Head, Small (1mm-5mm) 1 01/11/1993 01/14/91 729.00 Yes
3100 5000 MG/KG, 30 MG/KG Mass Head, Medium (6mm-15mm) 1 12/28/1992 01/14/91 715.00 Yes
3100 5000 MG/KG, 30 MG/KG Lethargic 12/28/1992 01/14/91 715.00 Yes
3100 5000 MG/KG, 30 MG/KG Abnormal Posture 12/28/1992 01/14/91 715.00 Yes
3107 5000 MG/KG, 60 MG/KG Thin 05/15/1992 01/14/91 488.00 Yes
3107 5000 MG/KG, 60 MG/KG Lethargic 05/15/1992 01/14/91 488.00 Yes
3110 5000 MG/KG, 60 MG/KG Lethargic 07/01/1991 01/14/91 169.00 Yes
3110 5000 MG/KG, 60 MG/KG Thin 07/01/1991 01/14/91 169.00 Yes
3110 5000 MG/KG, 60 MG/KG Abnormal Posture 07/01/1991 01/14/91 169.00 Yes
3110 5000 MG/KG, 60 MG/KG Swelling Body Ventral 07/01/1991 01/14/91 169.00 Yes
3113 5000 MG/KG, 60 MG/KG Abnormal Posture 05/07/1992 01/14/91 480.00 Yes
3114 5000 MG/KG, 60 MG/KG Lethargic 02/03/1992 01/14/91 386.00 Yes
3119 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 06/30/1992 01/14/91 534.00 No
3119 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 07/28/1992 01/14/91 562.00 No
3119 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 08/25/1992 01/14/91 590.00 No
3119 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 09/09/1992 01/14/91 605.00 Yes
3129 5000 MG/KG, 60 MG/KG Abnormal Posture 07/28/1992 01/14/91 562.00 Yes
3129 5000 MG/KG, 60 MG/KG Lethargic 07/28/1992 01/14/91 562.00 Yes
3132 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 01/12/1993 01/14/91 730.00 Yes
3136 5000 MG/KG, 60 MG/KG Lethargic 10/20/1992 01/14/91 646.00 Yes
3142 5000 MG/KG, 60 MG/KG Nasal/Eye Discharge 10/26/1992 01/14/91 652.00 Yes
3142 5000 MG/KG, 60 MG/KG Abnormal Breathing 10/26/1992 01/14/91 652.00 Yes
3142 5000 MG/KG, 60 MG/KG Tremors 10/26/1992 01/14/91 652.00 Yes
3143 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 06/30/1992 01/14/91 534.00 No
3143 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 07/28/1992 01/14/91 562.00 No
3143 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 08/25/1992 01/14/91 590.00 No
3143 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 09/22/1992 01/14/91 618.00 No
3143 5000 MG/KG, 60 MG/KG Mass Head, Small (1mm-5mm) 1 10/20/1992 01/14/91 646.00 No
3143 5000 MG/KG, 60 MG/KG Mass Head, Medium (6mm-15mm) 1 11/08/1992 01/14/91 665.00 Yes
3144 5000 MG/KG, 60 MG/KG Nasal/Eye Discharge 08/16/1991 01/14/91 215.00 Yes
3144 5000 MG/KG, 60 MG/KG Lethargic 08/16/1991 01/14/91 215.00 Yes
3144 5000 MG/KG, 60 MG/KG Abnormal Breathing 08/16/1991 01/14/91 215.00 Yes
3147 5000 MG/KG, 60 MG/KG Abnormal Breathing 12/30/1992 01/14/91 717.00 Yes
3147 5000 MG/KG, 60 MG/KG Lethargic 12/30/1992 01/14/91 717.00 Yes
3150 5000 MG/KG, 60 MG/KG Abnormal Posture 12/19/1991 01/14/91 340.00 Yes
3150 5000 MG/KG, 60 MG/KG Lethargic 12/19/1991 01/14/91 340.00 Yes
3150 5000 MG/KG, 60 MG/KG Abnormal Breathing 12/19/1991 01/14/91 340.00 Yes
3151 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 06/30/1992 01/14/91 534.00 No
3151 5000 MG/KG, 120 MG/KG Lethargic 01/08/1993 01/14/91 726.00 Yes
3151 5000 MG/KG, 120 MG/KG Abnormal Breathing 01/08/1993 01/14/91 726.00 Yes
3151 5000 MG/KG, 120 MG/KG Abnormal Posture 01/08/1993 01/14/91 726.00 Yes
3161 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 07/28/1992 01/14/91 562.00 No
3161 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 08/25/1992 01/14/91 590.00 No
3161 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 09/22/1992 01/14/91 618.00 No
3161 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 10/20/1992 01/14/91 646.00 No
3161 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 11/17/1992 01/14/91 674.00 No
3161 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 12/15/1992 01/14/91 702.00 No
3161 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 01/12/1993 01/14/91 730.00 Yes
3163 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 06/30/1992 01/14/91 534.00 No
3163 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 07/28/1992 01/14/91 562.00 No
3163 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 08/25/1992 01/14/91 590.00 No
3163 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 09/22/1992 01/14/91 618.00 No
3163 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 10/20/1992 01/14/91 646.00 No
3163 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 11/17/1992 01/14/91 674.00 No
3163 5000 MG/KG, 120 MG/KG Mass Head, Small (1mm-5mm) 1 12/15/1992 01/14/91 702.00 No
3163 5000 MG/KG, 120 MG/KG Mass Head, Medium (6mm-15mm) 1 01/12/1993 01/14/91 730.00 Yes
3172 5000 MG/KG, 120 MG/KG Abnormal Breathing 01/07/1993 01/14/91 725.00 Yes
3172 5000 MG/KG, 120 MG/KG Lethargic 01/07/1993 01/14/91 725.00 Yes
3176 5000 MG/KG, 120 MG/KG Abnormal Posture 09/29/1992 01/14/91 625.00 Yes
3176 5000 MG/KG, 120 MG/KG Abnormal Breathing 09/29/1992 01/14/91 625.00 Yes
3189 5000 MG/KG, 120 MG/KG Lethargic 09/04/1992 01/14/91 600.00 Yes
3189 5000 MG/KG, 120 MG/KG Abnormal Breathing 09/04/1992 01/14/91 600.00 Yes
3191 5000 MG/KG, 120 MG/KG Abnormal Breathing 10/06/1992 01/14/91 632.00 Yes
3191 5000 MG/KG, 120 MG/KG Lethargic 10/06/1992 01/14/91 632.00 Yes
3198 5000 MG/KG, 120 MG/KG Abnormal Posture 07/23/1992 01/14/91 557.00 Yes
3198 5000 MG/KG, 120 MG/KG Thin 07/23/1992 01/14/91 557.00 Yes