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Current Search Critera

Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: 5-(Hydroxymethyl)-2-furfural
CASRN: ="67-47-0"
Study Number: C95011B
Exposure Route: GAVAGE
TDMS Number: 9501106
Sex: Male
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
2 Vehicle Control Thin 03/11/2003 08/09/01 580.00 Yes
2 Vehicle Control Ruffled Fur 03/11/2003 08/09/01 580.00 Yes
8 Vehicle Control Ulcer/Abscess Head 1 06/12/2003 08/09/01 673.00 No
8 Vehicle Control Ulcer/Abscess Torso/Dorsal 2 07/01/2003 08/09/01 692.00 Yes
8 Vehicle Control Thin 07/01/2003 08/09/01 692.00 Yes
8 Vehicle Control Ruffled Fur 07/01/2003 08/09/01 692.00 Yes
9 Vehicle Control Eye Abnormality 03/20/2003 08/09/01 589.00 No
9 Vehicle Control Nasal/Eye Discharge 03/20/2003 08/09/01 589.00 No
9 Vehicle Control Eye Abnormality 04/17/2003 08/09/01 617.00 No
9 Vehicle Control Eye Abnormality 05/15/2003 08/09/01 645.00 No
9 Vehicle Control Nasal/Eye Discharge 05/15/2003 08/09/01 645.00 No
9 Vehicle Control Nasal/Eye Discharge 06/12/2003 08/09/01 673.00 No
9 Vehicle Control Eye Abnormality 06/12/2003 08/09/01 673.00 No
9 Vehicle Control Mass Head, Small (1mm-5mm) 1 06/12/2003 08/09/01 673.00 No
9 Vehicle Control Mass Head, Small (1mm-5mm) 1 07/10/2003 08/09/01 701.00 No
9 Vehicle Control Nasal/Eye Discharge 07/10/2003 08/09/01 701.00 No
9 Vehicle Control Eye Abnormality 07/10/2003 08/09/01 701.00 No
9 Vehicle Control Eye Abnormality 08/08/2003 08/09/01 730.00 Yes
9 Vehicle Control Mass Head, Small (1mm-5mm) 1 08/08/2003 08/09/01 730.00 Yes
9 Vehicle Control Nasal/Eye Discharge 08/08/2003 08/09/01 730.00 Yes
10 Vehicle Control Nasal/Eye Discharge 06/12/2003 08/09/01 673.00 No
10 Vehicle Control Nasal/Eye Discharge 07/10/2003 08/09/01 701.00 No
10 Vehicle Control Nasal/Eye Discharge 08/06/2003 08/09/01 728.00 Yes
10 Vehicle Control Eye Abnormality 08/06/2003 08/09/01 728.00 Yes
11 Vehicle Control Tremors 07/22/2003 08/09/01 713.00 Yes
11 Vehicle Control Lethargic 07/22/2003 08/09/01 713.00 Yes
22 Vehicle Control Eye Abnormality 02/20/2003 08/09/01 561.00 No
22 Vehicle Control Eye Abnormality 03/20/2003 08/09/01 589.00 No
22 Vehicle Control Eye Abnormality 04/02/2003 08/09/01 602.00 Yes
29 Vehicle Control Abnormal Breathing 03/19/2003 08/09/01 588.00 Yes
29 Vehicle Control Thin 03/19/2003 08/09/01 588.00 Yes
29 Vehicle Control Lethargic 03/19/2003 08/09/01 588.00 Yes
32 Vehicle Control Nasal/Eye Discharge 05/15/2003 08/09/01 645.00 No
32 Vehicle Control Mass Head, Small (1mm-5mm) 1 06/12/2003 08/09/01 673.00 No
32 Vehicle Control Eye Abnormality 06/12/2003 08/09/01 673.00 No
32 Vehicle Control Mass Head, Small (1mm-5mm) 1 07/08/2003 08/09/01 699.00 Yes
32 Vehicle Control Eye Abnormality 07/08/2003 08/09/01 699.00 Yes
34 Vehicle Control Abnormal Breathing 05/21/2003 08/09/01 651.00 Yes
34 Vehicle Control Ruffled Fur 05/21/2003 08/09/01 651.00 Yes
34 Vehicle Control Thin 05/21/2003 08/09/01 651.00 Yes
35 Vehicle Control Ruffled Fur 07/11/2002 08/09/01 337.00 No
35 Vehicle Control Ruffled Fur 08/07/2003 08/09/01 729.00 Yes
39 Vehicle Control Ulcer/Abscess Torso/Dorsal 1 08/08/2003 08/09/01 730.00 Yes
40 Vehicle Control Nasal/Eye Discharge 03/20/2003 08/09/01 589.00 No
40 Vehicle Control Nasal/Eye Discharge 04/17/2003 08/09/01 617.00 No
40 Vehicle Control Nasal/Eye Discharge 05/15/2003 08/09/01 645.00 No
40 Vehicle Control Mass Head, Small (1mm-5mm) 1 06/12/2003 08/09/01 673.00 No
40 Vehicle Control Nasal/Eye Discharge 06/12/2003 08/09/01 673.00 No
40 Vehicle Control Mass Head, Small (1mm-5mm) 1 07/10/2003 08/09/01 701.00 No
40 Vehicle Control Nasal/Eye Discharge 07/10/2003 08/09/01 701.00 No
40 Vehicle Control Eye Abnormality 07/10/2003 08/09/01 701.00 No
40 Vehicle Control Nasal/Eye Discharge 08/07/2003 08/09/01 729.00 Yes
40 Vehicle Control Mass Head, Small (1mm-5mm) 1 08/07/2003 08/09/01 729.00 Yes
42 Vehicle Control Ruffled Fur 07/10/2003 08/09/01 701.00 No
43 Vehicle Control Nasal/Eye Discharge 02/20/2003 08/09/01 561.00 No
43 Vehicle Control Eye Abnormality 03/20/2003 08/09/01 589.00 No
43 Vehicle Control Nasal/Eye Discharge 03/20/2003 08/09/01 589.00 No
43 Vehicle Control Eye Abnormality 04/17/2003 08/09/01 617.00 No
43 Vehicle Control Nasal/Eye Discharge 04/17/2003 08/09/01 617.00 No
43 Vehicle Control Eye Abnormality 05/15/2003 08/09/01 645.00 No
43 Vehicle Control Nasal/Eye Discharge 05/15/2003 08/09/01 645.00 No
43 Vehicle Control Mass Head, Small (1mm-5mm) 1 06/12/2003 08/09/01 673.00 No
43 Vehicle Control Nasal/Eye Discharge 06/12/2003 08/09/01 673.00 No
43 Vehicle Control Eye Abnormality 06/12/2003 08/09/01 673.00 No
43 Vehicle Control Nasal/Eye Discharge 07/10/2003 08/09/01 701.00 No
43 Vehicle Control Eye Abnormality 07/10/2003 08/09/01 701.00 No
43 Vehicle Control Mass Head, Small (1mm-5mm) 1 07/10/2003 08/09/01 701.00 No
43 Vehicle Control Eye Abnormality 08/08/2003 08/09/01 730.00 Yes
43 Vehicle Control Mass Head, Small (1mm-5mm) 1 08/08/2003 08/09/01 730.00 Yes
43 Vehicle Control Nasal/Eye Discharge 08/08/2003 08/09/01 730.00 Yes
58 188 MG/KG Mass Torso/Ventral, Medium (6mm-15mm) 1 09/05/2002 08/09/01 393.00 No
58 188 MG/KG Thin 06/12/2003 08/09/01 673.00 No
58 188 MG/KG Ruffled Fur 06/12/2003 08/09/01 673.00 No
58 188 MG/KG Ruffled Fur 07/10/2003 08/09/01 701.00 No
59 188 MG/KG Nasal/Eye Discharge 07/10/2003 08/09/01 701.00 No
59 188 MG/KG Nasal/Eye Discharge 08/07/2003 08/09/01 729.00 Yes
62 188 MG/KG Ruffled Fur 02/14/2003 08/09/01 555.00 Yes
62 188 MG/KG Thin 02/14/2003 08/09/01 555.00 Yes
64 188 MG/KG Ataxia 04/29/2003 08/09/01 629.00 Yes
64 188 MG/KG Ruffled Fur 04/29/2003 08/09/01 629.00 Yes
64 188 MG/KG Lethargic 04/29/2003 08/09/01 629.00 Yes
69 188 MG/KG Eye Abnormality 02/10/2003 08/09/01 551.00 Yes
72 188 MG/KG Ulcer/Abscess Torso/Lateral 1 08/08/2003 08/09/01 730.00 Yes
72 188 MG/KG Ulcer/Abscess Torso/Dorsal 2 08/08/2003 08/09/01 730.00 Yes
73 188 MG/KG Ruffled Fur 04/03/2003 08/09/01 603.00 Yes
73 188 MG/KG Lethargic 04/03/2003 08/09/01 603.00 Yes
73 188 MG/KG Thin 04/03/2003 08/09/01 603.00 Yes
74 188 MG/KG Abnormal Breathing 01/08/2003 08/09/01 518.00 Yes
74 188 MG/KG Ruffled Fur 01/08/2003 08/09/01 518.00 Yes
74 188 MG/KG Thin 01/08/2003 08/09/01 518.00 Yes
90 188 MG/KG Ruffled Fur 05/15/2003 08/09/01 645.00 No
92 188 MG/KG Lethargic 03/03/2003 08/09/01 572.00 Yes
92 188 MG/KG Ulcer/Abscess Torso/Lateral 1 03/03/2003 08/09/01 572.00 Yes
93 188 MG/KG Ulcer/Abscess Torso/Dorsal 1 05/15/2003 08/09/01 645.00 No
93 188 MG/KG Ulcer/Abscess Torso/Dorsal 1 06/12/2003 08/09/01 673.00 No
93 188 MG/KG Ulcer/Abscess Torso/Dorsal 1 07/08/2003 08/09/01 699.00 Yes
95 188 MG/KG Nasal/Eye Discharge 04/17/2003 08/09/01 617.00 No
95 188 MG/KG Eye Abnormality 05/15/2003 08/09/01 645.00 No
95 188 MG/KG Nasal/Eye Discharge 05/15/2003 08/09/01 645.00 No
95 188 MG/KG Nasal/Eye Discharge 06/12/2003 08/09/01 673.00 No
95 188 MG/KG Eye Abnormality 06/12/2003 08/09/01 673.00 No
95 188 MG/KG Eye Abnormality 07/10/2003 08/09/01 701.00 No
95 188 MG/KG Mass Head, Small (1mm-5mm) 1 07/10/2003 08/09/01 701.00 No
95 188 MG/KG Nasal/Eye Discharge 07/10/2003 08/09/01 701.00 No
95 188 MG/KG Nasal/Eye Discharge 08/08/2003 08/09/01 730.00 Yes
95 188 MG/KG Mass Head, Small (1mm-5mm) 1 08/08/2003 08/09/01 730.00 Yes
98 188 MG/KG Lethargic 04/25/2003 08/09/01 625.00 Yes
98 188 MG/KG Ruffled Fur 04/25/2003 08/09/01 625.00 Yes
98 188 MG/KG Thin 04/25/2003 08/09/01 625.00 Yes
99 188 MG/KG Lethargic 08/23/2002 08/09/01 380.00 Yes
99 188 MG/KG Ruffled Fur 08/23/2002 08/09/01 380.00 Yes
99 188 MG/KG Ataxia 08/23/2002 08/09/01 380.00 Yes
103 375 MG/KG Nasal/Eye Discharge 03/20/2003 08/09/01 589.00 No
103 375 MG/KG Nasal/Eye Discharge 04/17/2003 08/09/01 617.00 No
103 375 MG/KG Nasal/Eye Discharge 05/15/2003 08/09/01 645.00 No
103 375 MG/KG Nasal/Eye Discharge 06/12/2003 08/09/01 673.00 No
103 375 MG/KG Nasal/Eye Discharge 07/10/2003 08/09/01 701.00 No
103 375 MG/KG Nasal/Eye Discharge 08/06/2003 08/09/01 728.00 Yes
107 375 MG/KG Ulcer/Abscess Torso/Lateral 1 08/08/2003 08/09/01 730.00 Yes
112 375 MG/KG Thin 05/15/2003 08/09/01 645.00 No
112 375 MG/KG Ruffled Fur 05/15/2003 08/09/01 645.00 No
112 375 MG/KG Ruffled Fur 05/22/2003 08/09/01 652.00 Yes
112 375 MG/KG Thin 05/22/2003 08/09/01 652.00 Yes
112 375 MG/KG Lethargic 05/22/2003 08/09/01 652.00 Yes
114 375 MG/KG Nasal/Eye Discharge 04/17/2003 08/09/01 617.00 No
114 375 MG/KG Nasal/Eye Discharge 05/15/2003 08/09/01 645.00 No
114 375 MG/KG Nasal/Eye Discharge 06/12/2003 08/09/01 673.00 No
114 375 MG/KG Ruffled Fur 06/12/2003 08/09/01 673.00 No
114 375 MG/KG Ruffled Fur 07/10/2003 08/09/01 701.00 No
114 375 MG/KG Nasal/Eye Discharge 07/10/2003 08/09/01 701.00 No
119 375 MG/KG Lethargic 01/17/2003 08/09/01 527.00 Yes
119 375 MG/KG Thin 01/17/2003 08/09/01 527.00 Yes
119 375 MG/KG Ruffled Fur 01/17/2003 08/09/01 527.00 Yes
119 375 MG/KG Abnormal Breathing 01/17/2003 08/09/01 527.00 Yes
123 375 MG/KG Thin 12/06/2002 08/09/01 485.00 Yes
123 375 MG/KG Lethargic 12/06/2002 08/09/01 485.00 Yes
124 375 MG/KG Ruffled Fur 07/11/2002 08/09/01 337.00 No
125 375 MG/KG Nasal/Eye Discharge 07/10/2003 08/09/01 701.00 No
125 375 MG/KG Nasal/Eye Discharge 08/07/2003 08/09/01 729.00 Yes
129 375 MG/KG Ruffled Fur 05/15/2003 08/09/01 645.00 No
132 375 MG/KG Mass Head, Small (1mm-5mm) 1 06/12/2003 08/09/01 673.00 No
132 375 MG/KG Mass Head, Small (1mm-5mm) 1 07/10/2003 08/09/01 701.00 No
132 375 MG/KG Mass Head, Small (1mm-5mm) 1 08/08/2003 08/09/01 730.00 Yes
140 375 MG/KG Ruffled Fur 09/05/2002 08/09/01 393.00 No
140 375 MG/KG Thin 09/05/2002 08/09/01 393.00 No
140 375 MG/KG Thin 09/06/2002 08/09/01 394.00 Yes
140 375 MG/KG Abnormal Breathing 09/06/2002 08/09/01 394.00 Yes
140 375 MG/KG Ruffled Fur 09/06/2002 08/09/01 394.00 Yes
142 375 MG/KG Thin 07/10/2003 08/09/01 701.00 No
142 375 MG/KG Ulcer/Abscess Torso/Dorsal 1 07/10/2003 08/09/01 701.00 No
142 375 MG/KG Ruffled Fur 07/10/2003 08/09/01 701.00 No
142 375 MG/KG Thin 07/12/2003 08/09/01 703.00 Yes
142 375 MG/KG Ulcer/Abscess Torso/Dorsal 1 07/12/2003 08/09/01 703.00 Yes
158 750 MG/KG Ruffled Fur 06/12/2003 08/09/01 673.00 No
170 750 MG/KG Thin 08/08/2003 08/09/01 730.00 Yes
171 750 MG/KG Excitability 09/06/2001 08/09/01 29.00 No
175 750 MG/KG Lethargic 06/17/2003 08/09/01 678.00 Yes
175 750 MG/KG Abnormal Breathing 06/17/2003 08/09/01 678.00 Yes
182 750 MG/KG Nasal/Eye Discharge 08/08/2003 08/09/01 730.00 Yes