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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Interferon A (AIDS Initiative)
CASRN: ="76543-88-9"
Study Number: C89001
Exposure Route: SUBCUTANEOUS
TDMS Number: 8900608
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
1204 Vehicle Control Abnormal Breathing 07/20/1992 09/05/90 685.00 Yes
1204 Vehicle Control Abnormal Posture 07/20/1992 09/05/90 685.00 Yes
1206 Vehicle Control Lethargic 06/19/1992 09/05/90 654.00 Yes
1206 Vehicle Control Abnormal Breathing 06/19/1992 09/05/90 654.00 Yes
1206 Vehicle Control Tremors 06/19/1992 09/05/90 654.00 Yes
1206 Vehicle Control Abnormal Posture 06/19/1992 09/05/90 654.00 Yes
1208 Vehicle Control Mass Head, Small (1mm-5mm) 1 02/20/1992 09/05/90 534.00 No
1208 Vehicle Control Mass Head, Small (1mm-5mm) 1 03/19/1992 09/05/90 562.00 No
1208 Vehicle Control Mass Head, Small (1mm-5mm) 1 04/16/1992 09/05/90 590.00 No
1208 Vehicle Control Mass Head, Small (1mm-5mm) 1 05/14/1992 09/05/90 618.00 No
1208 Vehicle Control Mass Head, Small (1mm-5mm) 1 06/11/1992 09/05/90 646.00 No
1208 Vehicle Control Mass Head, Medium (6mm-15mm) 1 07/09/1992 09/05/90 674.00 No
1208 Vehicle Control Mass Head, Small (1mm-5mm) 1 07/16/1992 09/05/90 681.00 Yes
1213 Vehicle Control Mass Head, Small (1mm-5mm) 1 04/16/1992 09/05/90 590.00 No
1213 Vehicle Control Mass Head, Small (1mm-5mm) 1 05/14/1992 09/05/90 618.00 No
1213 Vehicle Control Mass Head, Small (1mm-5mm) 1 06/11/1992 09/05/90 646.00 No
1213 Vehicle Control Mass Head, Small (1mm-5mm) 1 07/09/1992 09/05/90 674.00 No
1213 Vehicle Control Mass Head, Small (1mm-5mm) 1 08/06/1992 09/05/90 702.00 No
1213 Vehicle Control Mass Head, Small (1mm-5mm) 1 09/02/1992 09/05/90 729.00 Yes
1218 Vehicle Control Abnormal Breathing 08/03/1992 09/05/90 699.00 Yes
1218 Vehicle Control Lethargic 08/03/1992 09/05/90 699.00 Yes
1218 Vehicle Control Abnormal Posture 08/03/1992 09/05/90 699.00 Yes
1221 Vehicle Control Abnormal Breathing 07/08/1992 09/05/90 673.00 Yes
1221 Vehicle Control Abnormal Posture 07/08/1992 09/05/90 673.00 Yes
1222 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 01/23/1992 09/05/90 506.00 No
1222 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 02/20/1992 09/05/90 534.00 No
1222 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 03/19/1992 09/05/90 562.00 No
1222 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 04/16/1992 09/05/90 590.00 No
1222 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 05/14/1992 09/05/90 618.00 No
1222 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 06/11/1992 09/05/90 646.00 No
1222 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 06/20/1992 09/05/90 655.00 Yes
1223 Vehicle Control Abnormal Breathing 08/25/1992 09/05/90 721.00 Yes
1223 Vehicle Control Ataxia 08/25/1992 09/05/90 721.00 Yes
1223 Vehicle Control Abnormal Posture 08/25/1992 09/05/90 721.00 Yes
1226 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 06/11/1992 09/05/90 646.00 No
1226 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/06/1992 09/05/90 671.00 Yes
1227 Vehicle Control Lethargic 07/24/1992 09/05/90 689.00 Yes
1227 Vehicle Control Mass Torso/Lateral, Small (1mm-5mm) 2 07/24/1992 09/05/90 689.00 Yes
1227 Vehicle Control Mass Head, Medium (6mm-15mm) 1 07/24/1992 09/05/90 689.00 Yes
1228 Vehicle Control Mass Torso/Ventral, 0- 2 Mm 07/11/1991 09/05/90 310.00 No
1228 Vehicle Control Mass Torso/Ventral, 0- 2 Mm 08/08/1991 09/05/90 338.00 No
1228 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 09/05/1991 09/05/90 366.00 No
1228 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 10/03/1991 09/05/90 394.00 No
1228 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 10/31/1991 09/05/90 422.00 No
1228 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 11/27/1991 09/05/90 449.00 No
1228 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 12/26/1991 09/05/90 478.00 No
1228 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 01/23/1992 09/05/90 506.00 No
1228 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 02/20/1992 09/05/90 534.00 No
1228 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 03/19/1992 09/05/90 562.00 No
1228 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 03/24/1992 09/05/90 567.00 Yes
1230 Vehicle Control Thin 02/19/1992 09/05/90 533.00 Yes
1234 Vehicle Control Abnormal Breathing 04/23/1992 09/05/90 597.00 Yes
1234 Vehicle Control Lethargic 04/23/1992 09/05/90 597.00 Yes
1236 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 06/11/1992 09/05/90 646.00 No
1236 Vehicle Control Ulcer/Abscess Torso/Ventral 06/11/1992 09/05/90 646.00 No
1236 Vehicle Control Ulcer/Abscess Torso/Lateral 07/09/1992 09/05/90 674.00 No
1236 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/09/1992 09/05/90 674.00 No
1236 Vehicle Control Thin 07/10/1992 09/05/90 675.00 Yes
1236 Vehicle Control Ulcer/Abscess Torso/Lateral 07/10/1992 09/05/90 675.00 Yes
1236 Vehicle Control Lethargic 07/10/1992 09/05/90 675.00 Yes
1236 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/10/1992 09/05/90 675.00 Yes
1242 Vehicle Control Tremors 09/04/1991 09/05/90 365.00 Yes
1242 Vehicle Control Abnormal Posture 09/04/1991 09/05/90 365.00 Yes
1242 Vehicle Control Ruffled Fur 09/04/1991 09/05/90 365.00 Yes
1242 Vehicle Control Thin 09/04/1991 09/05/90 365.00 Yes
1242 Vehicle Control Abnormal Breathing 09/04/1991 09/05/90 365.00 Yes
1247 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 04/16/1992 09/05/90 590.00 No
1247 Vehicle Control Mass Torso/Dorsal, Large (16mm And Larger) 1 05/14/1992 09/05/90 618.00 No
1247 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 06/11/1992 09/05/90 646.00 No
1247 Vehicle Control Abnormal Breathing 07/08/1992 09/05/90 673.00 Yes
1247 Vehicle Control Abnormal Posture 07/08/1992 09/05/90 673.00 Yes
1247 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/08/1992 09/05/90 673.00 Yes
1252 500 500 U Abnormal Breathing 05/19/1992 09/05/90 623.00 Yes
1252 500 500 U Abnormal Posture 05/19/1992 09/05/90 623.00 Yes
1252 500 500 U Lethargic 05/19/1992 09/05/90 623.00 Yes
1255 500 500 U Abnormal Breathing 07/20/1992 09/05/90 685.00 Yes
1255 500 500 U Abnormal Posture 07/20/1992 09/05/90 685.00 Yes
1261 500 500 U Mass Head, Small (1mm-5mm) 1 09/04/1992 09/05/90 731.00 Yes
1262 500 500 U Lethargic 08/19/1992 09/05/90 715.00 Yes
1262 500 500 U Abnormal Posture 08/19/1992 09/05/90 715.00 Yes
1262 500 500 U Abnormal Breathing 08/19/1992 09/05/90 715.00 Yes
1264 500 500 U Mass Head, Small (1mm-5mm) 1 03/19/1992 09/05/90 562.00 No
1264 500 500 U Mass Head, Small (1mm-5mm) 1 04/16/1992 09/05/90 590.00 No
1264 500 500 U Mass Head, Small (1mm-5mm) 1 05/14/1992 09/05/90 618.00 No
1264 500 500 U Mass Head, Small (1mm-5mm) 1 06/11/1992 09/05/90 646.00 No
1264 500 500 U Mass Head, Small (1mm-5mm) 1 07/09/1992 09/05/90 674.00 No
1264 500 500 U Mass Head, Small (1mm-5mm) 1 08/06/1992 09/05/90 702.00 No
1264 500 500 U Mass Head, Small (1mm-5mm) 1 09/04/1992 09/05/90 731.00 Yes
1267 500 500 U Mass Torso/Ventral, Small (1mm-5mm) 1 07/09/1992 09/05/90 674.00 No
1267 500 500 U Mass Torso/Ventral, Medium (6mm-15mm) 1 08/06/1992 09/05/90 702.00 No
1267 500 500 U Mass Torso/Ventral, Medium (6mm-15mm) 1 08/26/1992 09/05/90 722.00 Yes
1267 500 500 U Thin 08/26/1992 09/05/90 722.00 Yes
1267 500 500 U Ataxia 08/26/1992 09/05/90 722.00 Yes
1270 500 500 U Lethargic 08/24/1992 09/05/90 720.00 Yes
1270 500 500 U Ruffled Fur 08/24/1992 09/05/90 720.00 Yes
1270 500 500 U Mass Appendage, Medium (6mm-15mm) 1 08/24/1992 09/05/90 720.00 Yes
1270 500 500 U Abnormal Breathing 08/24/1992 09/05/90 720.00 Yes
1270 500 500 U Abnormal Posture 08/24/1992 09/05/90 720.00 Yes
1270 500 500 U Thin 08/24/1992 09/05/90 720.00 Yes
1277 500 500 U Mass Torso/Lateral, Large (16mm And Larger) 1 07/09/1992 09/05/90 674.00 No
1277 500 500 U Mass Torso/Lateral, Large (16mm And Larger) 1 08/06/1992 09/05/90 702.00 No
1277 500 500 U Ulcer/Abscess Torso/Lateral 08/06/1992 09/05/90 702.00 No
1277 500 500 U Mass Torso/Lateral, Large (16mm And Larger) 1 08/08/1992 09/05/90 704.00 Yes
1277 500 500 U Ulcer/Abscess Torso/Lateral 08/08/1992 09/05/90 704.00 Yes
1277 500 500 U Abnormal Posture 08/08/1992 09/05/90 704.00 Yes
1279 500 500 U Abnormal Breathing 07/22/1992 09/05/90 687.00 Yes
1279 500 500 U Ataxia 07/22/1992 09/05/90 687.00 Yes
1279 500 500 U Abnormal Posture 07/22/1992 09/05/90 687.00 Yes
1283 500 500 U Mass Torso/Ventral, Medium (6mm-15mm) 1 10/03/1991 09/05/90 394.00 No
1286 500 500 U Abnormal Breathing 06/23/1992 09/05/90 658.00 Yes
1286 500 500 U Abnormal Posture 06/23/1992 09/05/90 658.00 Yes
1291 500 500 U Nasal/Eye Discharge 06/10/1992 09/05/90 645.00 Yes
1291 500 500 U Abnormal Breathing 06/10/1992 09/05/90 645.00 Yes
1291 500 500 U Abnormal Posture 06/10/1992 09/05/90 645.00 Yes
1291 500 500 U Tremors 06/10/1992 09/05/90 645.00 Yes
1291 500 500 U Lethargic 06/10/1992 09/05/90 645.00 Yes
1291 500 500 U Thin 06/10/1992 09/05/90 645.00 Yes
1292 500 500 U Lethargic 08/05/1992 09/05/90 701.00 Yes
1292 500 500 U Abnormal Breathing 08/05/1992 09/05/90 701.00 Yes
1296 500 500 U Thin 12/31/1991 09/05/90 483.00 Yes
1296 500 500 U Abnormal Posture 12/31/1991 09/05/90 483.00 Yes
1296 500 500 U Abnormal Breathing 12/31/1991 09/05/90 483.00 Yes
1297 500 500 U Abnormal Breathing 03/10/1992 09/05/90 553.00 Yes
1297 500 500 U Lethargic 03/10/1992 09/05/90 553.00 Yes
1297 500 500 U Nasal/Eye Discharge 03/10/1992 09/05/90 553.00 Yes
1300 500 500 U Mass Head, Small (1mm-5mm) 1 03/19/1992 09/05/90 562.00 No
1300 500 500 U Mass Head, Small (1mm-5mm) 1 04/16/1992 09/05/90 590.00 No
1300 500 500 U Nasal/Eye Discharge 05/06/1992 09/05/90 610.00 Yes
1300 500 500 U Mass Head, Medium (6mm-15mm) 1 05/06/1992 09/05/90 610.00 Yes
1301 5000 5000 U Lethargic 06/24/1992 09/05/90 659.00 Yes
1301 5000 5000 U Abnormal Breathing 06/24/1992 09/05/90 659.00 Yes
1309 5000 5000 U Nasal/Eye Discharge 07/20/1992 09/05/90 685.00 Yes
1311 5000 5000 U Mass Head, Small (1mm-5mm) 1 07/09/1992 09/05/90 674.00 No
1311 5000 5000 U Mass Head, Small (1mm-5mm) 1 08/06/1992 09/05/90 702.00 No
1311 5000 5000 U Mass Head, Small (1mm-5mm) 1 09/03/1992 09/05/90 730.00 Yes
1312 5000 5000 U Tremors 06/24/1992 09/05/90 659.00 Yes
1312 5000 5000 U Abnormal Posture 06/24/1992 09/05/90 659.00 Yes
1312 5000 5000 U Abnormal Breathing 06/24/1992 09/05/90 659.00 Yes
1314 5000 5000 U Mass Appendage, Small (1mm-5mm) 1 10/03/1991 09/05/90 394.00 No
1314 5000 5000 U Mass Appendage, Small (1mm-5mm) 1 02/20/1992 09/05/90 534.00 No
1318 5000 5000 U Mass Head, Small (1mm-5mm) 1 01/23/1992 09/05/90 506.00 No
1318 5000 5000 U Mass Head, Small (1mm-5mm) 1 01/23/1992 09/05/90 506.00 Yes
1320 5000 5000 U Abnormal Breathing 09/05/1990 09/05/90 1.00 Yes
1320 5000 5000 U Abnormal Posture 09/05/1990 09/05/90 1.00 Yes
1329 5000 5000 U Abnormal Breathing 08/19/1992 09/05/90 715.00 Yes
1329 5000 5000 U Abnormal Posture 08/19/1992 09/05/90 715.00 Yes
1329 5000 5000 U Lethargic 08/19/1992 09/05/90 715.00 Yes
1332 5000 5000 U Nasal/Eye Discharge 07/13/1992 09/05/90 678.00 Yes
1332 5000 5000 U Abnormal Posture 07/13/1992 09/05/90 678.00 Yes
1333 5000 5000 U Abnormal Posture 05/20/1992 09/05/90 624.00 Yes
1333 5000 5000 U Nasal/Eye Discharge 05/20/1992 09/05/90 624.00 Yes
1333 5000 5000 U Lethargic 05/20/1992 09/05/90 624.00 Yes
1333 5000 5000 U Abnormal Breathing 05/20/1992 09/05/90 624.00 Yes
1334 5000 5000 U Abnormal Breathing 03/21/1992 09/05/90 564.00 Yes
1334 5000 5000 U Abnormal Posture 03/21/1992 09/05/90 564.00 Yes
1343 5000 5000 U Lethargic 06/25/1992 09/05/90 660.00 Yes
1343 5000 5000 U Abnormal Posture 06/25/1992 09/05/90 660.00 Yes
1343 5000 5000 U Nasal/Eye Discharge 06/25/1992 09/05/90 660.00 Yes
1343 5000 5000 U Abnormal Breathing 06/25/1992 09/05/90 660.00 Yes
1344 5000 5000 U Abnormal Breathing 06/17/1992 09/05/90 652.00 Yes
1344 5000 5000 U Abnormal Posture 06/17/1992 09/05/90 652.00 Yes
1344 5000 5000 U Lethargic 06/17/1992 09/05/90 652.00 Yes
1353 5000 5000 U Thin 03/24/1992 09/05/90 567.00 Yes
1354 5000 5000 U Lethargic 08/12/1992 09/05/90 708.00 Yes
1354 5000 5000 U Abnormal Posture 08/12/1992 09/05/90 708.00 Yes
1354 5000 5000 U Abnormal Breathing 08/12/1992 09/05/90 708.00 Yes
1356 5000 5000 U Hyperactive 08/06/1992 09/05/90 702.00 Yes
1356 5000 5000 U Ataxia 08/06/1992 09/05/90 702.00 Yes
1356 5000 5000 U Tremors 08/06/1992 09/05/90 702.00 Yes
1356 5000 5000 U Abnormal Breathing 08/06/1992 09/05/90 702.00 Yes
1360 5000 5000 U Abnormal Breathing 11/04/1991 09/05/90 426.00 Yes
1360 5000 5000 U Ataxia 11/04/1991 09/05/90 426.00 Yes
1360 5000 5000 U Abnormal Posture 11/04/1991 09/05/90 426.00 Yes
1365 5000 5000 U Abnormal Breathing 05/08/1992 09/05/90 612.00 Yes
1365 5000 5000 U Abnormal Posture 05/08/1992 09/05/90 612.00 Yes
1365 5000 5000 U Lethargic 05/08/1992 09/05/90 612.00 Yes
1366 5000 5000 U Ulcer/Abscess Torso/Lateral 08/06/1992 09/05/90 702.00 No
1366 5000 5000 U Mass Torso/Lateral, Large (16mm And Larger) 1 08/06/1992 09/05/90 702.00 No
1366 5000 5000 U Ulcer/Abscess Torso/Lateral 08/24/1992 09/05/90 720.00 Yes
1366 5000 5000 U Mass Torso/Lateral, Large (16mm And Larger) 1 08/24/1992 09/05/90 720.00 Yes
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 10/03/1991 09/05/90 394.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 10/31/1991 09/05/90 422.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 11/27/1991 09/05/90 449.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 12/26/1991 09/05/90 478.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 01/23/1992 09/05/90 506.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 02/20/1992 09/05/90 534.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 03/19/1992 09/05/90 562.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 04/16/1992 09/05/90 590.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 05/14/1992 09/05/90 618.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 06/11/1992 09/05/90 646.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 07/09/1992 09/05/90 674.00 No
1378 5000 5000 U Mass Head, Small (1mm-5mm) 1 08/06/1992 09/05/90 702.00 No
1378 5000 5000 U Mass Head, Medium (6mm-15mm) 1 09/02/1992 09/05/90 729.00 Yes
1383 5000 5000 U Mass Head, Small (1mm-5mm) 1 07/09/1992 09/05/90 674.00 No
1383 5000 5000 U Mass Head, Small (1mm-5mm) 1 08/06/1992 09/05/90 702.00 No
1383 5000 5000 U Mass Head, Small (1mm-5mm) 1 09/04/1992 09/05/90 731.00 Yes
1385 5000 5000 U Mass Torso/Ventral, Medium (6mm-15mm) 1 08/06/1992 09/05/90 702.00 No
1385 5000 5000 U Mass Torso/Ventral, Large (16mm And Larger) 1 09/04/1992 09/05/90 731.00 Yes
1385 5000 5000 U Abnormal Posture 09/04/1992 09/05/90 731.00 Yes
1387 5000 5000 U Abnormal Breathing 03/20/1992 09/05/90 563.00 Yes
1387 5000 5000 U Tremors 03/20/1992 09/05/90 563.00 Yes
1387 5000 5000 U Ruffled Fur 03/20/1992 09/05/90 563.00 Yes
1389 5000 5000 U Abnormal Breathing 01/31/1991 09/05/90 149.00 Yes
1389 5000 5000 U Lethargic 01/31/1991 09/05/90 149.00 Yes
1397 5000 5000 U Abnormal Breathing 08/12/1992 09/05/90 708.00 Yes
1397 5000 5000 U Abnormal Posture 08/12/1992 09/05/90 708.00 Yes
1399 5000 5000 U Mass Head, Small (1mm-5mm) 1 04/16/1992 09/05/90 590.00 No
1399 5000 5000 U Mass Head, Small (1mm-5mm) 1 05/14/1992 09/05/90 618.00 No
1399 5000 5000 U Abnormal Breathing 06/07/1992 09/05/90 642.00 Yes
1399 5000 5000 U Nasal/Eye Discharge 06/07/1992 09/05/90 642.00 Yes
1399 5000 5000 U Lethargic 06/07/1992 09/05/90 642.00 Yes
1399 5000 5000 U Abnormal Posture 06/07/1992 09/05/90 642.00 Yes
1399 5000 5000 U Mass Head, Small (1mm-5mm) 1 06/07/1992 09/05/90 642.00 Yes