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Current Search Critera

Short-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Isobutyl nitrite
CASRN: ="542-56-3"
Study Number: C61052B
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 0518502
Sex: Male
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
1 Vehicle Control Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
3 Vehicle Control Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
3 Vehicle Control Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
3 Vehicle Control Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
3 Vehicle Control Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
3 Vehicle Control Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
4 Vehicle Control Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
5 Vehicle Control Wound Tail 06/26/1987 04/17/87 71.00 No
5 Vehicle Control Wound Tail 07/02/1987 04/17/87 77.00 No
5 Vehicle Control Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
5 Vehicle Control Wound Tail 07/10/1987 04/17/87 85.00 No
5 Vehicle Control Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
5 Vehicle Control Wound Tail 07/17/1987 04/17/87 92.00 No
5 Vehicle Control Wound Tail 07/23/1987 04/17/87 98.00 Yes
6 Vehicle Control Ruffled Fur 07/02/1987 04/17/87 77.00 No
8 Vehicle Control Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
8 Vehicle Control Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
8 Vehicle Control Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
8 Vehicle Control Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
8 Vehicle Control Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
9 Vehicle Control Ruffled Fur 07/02/1987 04/17/87 77.00 No
10 Vehicle Control Wound Tail 05/22/1987 04/17/87 36.00 No
10 Vehicle Control Wound Tail 05/29/1987 04/17/87 43.00 No
10 Vehicle Control Wound Tail 06/05/1987 04/17/87 50.00 No
10 Vehicle Control Reddened Tail 06/05/1987 04/17/87 50.00 No
10 Vehicle Control Wound Tail 06/12/1987 04/17/87 57.00 No
10 Vehicle Control Wound Tail 06/19/1987 04/17/87 64.00 No
10 Vehicle Control Wound Tail 06/26/1987 04/17/87 71.00 No
10 Vehicle Control Wound Tail 07/02/1987 04/17/87 77.00 No
10 Vehicle Control Wound Tail 07/10/1987 04/17/87 85.00 No
10 Vehicle Control Wound Tail 07/17/1987 04/17/87 92.00 No
10 Vehicle Control Wound Tail 07/23/1987 04/17/87 98.00 Yes
21 10 PPM Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
21 10 PPM Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
21 10 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
21 10 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
21 10 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
22 10 PPM Ruffled Fur 05/01/1987 04/17/87 15.00 No
22 10 PPM Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
22 10 PPM Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
22 10 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
22 10 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
22 10 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
23 10 PPM Wound Tail 05/29/1987 04/17/87 43.00 No
23 10 PPM Wound Tail 06/05/1987 04/17/87 50.00 No
23 10 PPM Wound Tail 06/12/1987 04/17/87 57.00 No
23 10 PPM Wound Tail 07/10/1987 04/17/87 85.00 No
23 10 PPM Wound Tail 07/17/1987 04/17/87 92.00 No
23 10 PPM Wound Tail 07/23/1987 04/17/87 98.00 Yes
24 10 PPM Alopecia Body Ventral 05/15/1987 04/17/87 29.00 No
24 10 PPM Alopecia Body Ventral 05/22/1987 04/17/87 36.00 No
24 10 PPM Alopecia Body Ventral 05/29/1987 04/17/87 43.00 No
24 10 PPM Alopecia Body Ventral 06/05/1987 04/17/87 50.00 No
24 10 PPM Alopecia Body Ventral 06/12/1987 04/17/87 57.00 No
24 10 PPM Alopecia Body Ventral 06/19/1987 04/17/87 64.00 No
24 10 PPM Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
24 10 PPM Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
24 10 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
24 10 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
24 10 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
26 10 PPM Ruffled Fur 04/24/1987 04/17/87 8.00 No
28 10 PPM Reddened Penis 04/24/1987 04/17/87 8.00 No
28 10 PPM Ruffled Fur 04/24/1987 04/17/87 8.00 No
28 10 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
29 10 PPM Ruffled Fur 04/24/1987 04/17/87 8.00 No
29 10 PPM Ruffled Fur 07/02/1987 04/17/87 77.00 No
30 10 PPM Alopecia Body Ventral 05/22/1987 04/17/87 36.00 No
30 10 PPM Alopecia Body Ventral 05/29/1987 04/17/87 43.00 No
30 10 PPM Alopecia Body Ventral 06/05/1987 04/17/87 50.00 No
30 10 PPM Alopecia Body Ventral 06/12/1987 04/17/87 57.00 No
30 10 PPM Alopecia Body Ventral 06/19/1987 04/17/87 64.00 No
30 10 PPM Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
30 10 PPM Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
30 10 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
30 10 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
30 10 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
41 25 PPM Ruffled Fur 04/24/1987 04/17/87 8.00 No
42 25 PPM Alopecia Body Ventral 05/29/1987 04/17/87 43.00 No
42 25 PPM Alopecia Body Ventral 06/05/1987 04/17/87 50.00 No
42 25 PPM Alopecia Body Ventral 06/12/1987 04/17/87 57.00 No
42 25 PPM Alopecia Body Ventral 06/19/1987 04/17/87 64.00 No
42 25 PPM Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
42 25 PPM Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
42 25 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
42 25 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
42 25 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
43 25 PPM Alopecia Neck 05/22/1987 04/17/87 36.00 No
43 25 PPM Ruffled Fur 06/19/1987 04/17/87 64.00 No
44 25 PPM Alopecia Neck 05/15/1987 04/17/87 29.00 No
44 25 PPM Alopecia Neck 05/22/1987 04/17/87 36.00 No
44 25 PPM Alopecia Body Ventral 05/29/1987 04/17/87 43.00 No
44 25 PPM Alopecia Body Ventral 06/05/1987 04/17/87 50.00 No
44 25 PPM Alopecia Body Ventral 06/12/1987 04/17/87 57.00 No
44 25 PPM Alopecia Body Ventral 06/19/1987 04/17/87 64.00 No
44 25 PPM Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
44 25 PPM Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
44 25 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
44 25 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
44 25 PPM Wound Tail 07/17/1987 04/17/87 92.00 No
44 25 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
44 25 PPM Wound Tail 07/23/1987 04/17/87 98.00 Yes
45 25 PPM Alopecia Body Ventral 06/19/1987 04/17/87 64.00 No
45 25 PPM Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
45 25 PPM Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
45 25 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
45 25 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
45 25 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
46 25 PPM Ruffled Fur 06/19/1987 04/17/87 64.00 No
46 25 PPM Ruffled Fur 07/02/1987 04/17/87 77.00 No
47 25 PPM Wound Tail 06/12/1987 04/17/87 57.00 No
47 25 PPM Wound Tail 07/10/1987 04/17/87 85.00 No
47 25 PPM Wound Tail 07/23/1987 04/17/87 98.00 Yes
49 25 PPM Alopecia Neck 05/15/1987 04/17/87 29.00 No
49 25 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
63 75 PPM Ruffled Fur 04/24/1987 04/17/87 8.00 No
63 75 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
63 75 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
64 75 PPM Wound Tail 07/23/1987 04/17/87 98.00 Yes
65 75 PPM Abnormal Posture 04/21/1987 04/17/87 5.00 No
65 75 PPM Hypoactivity 04/21/1987 04/17/87 5.00 No
65 75 PPM Ruffled Fur 04/22/1987 04/17/87 6.00 No
65 75 PPM Abnormal Posture 04/22/1987 04/17/87 6.00 No
65 75 PPM Ruffled Fur 06/19/1987 04/17/87 64.00 No
65 75 PPM Ruffled Fur 07/02/1987 04/17/87 77.00 No
65 75 PPM Ruffled Fur 07/23/1987 04/17/87 98.00 Yes
67 75 PPM Ruffled Fur 04/24/1987 04/17/87 8.00 No
67 75 PPM Ruffled Fur 07/02/1987 04/17/87 77.00 No
68 75 PPM Ruffled Fur 06/19/1987 04/17/87 64.00 No
68 75 PPM Ruffled Fur 06/26/1987 04/17/87 71.00 No
68 75 PPM Ruffled Fur 07/02/1987 04/17/87 77.00 No
68 75 PPM Ruffled Fur 07/23/1987 04/17/87 98.00 Yes
70 75 PPM Ruffled Fur 04/24/1987 04/17/87 8.00 No
81 150 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
82 150 PPM Ruffled Fur 04/22/1987 04/17/87 6.00 No
82 150 PPM Ruffled Fur 06/19/1987 04/17/87 64.00 No
82 150 PPM Ruffled Fur 07/02/1987 04/17/87 77.00 No
84 150 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
85 150 PPM Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
85 150 PPM Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
85 150 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
85 150 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
85 150 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
87 150 PPM Ruffled Fur 04/24/1987 04/17/87 8.00 No
87 150 PPM Ruffled Fur 06/26/1987 04/17/87 71.00 No
87 150 PPM Ruffled Fur 07/02/1987 04/17/87 77.00 No
87 150 PPM Ruffled Fur 07/10/1987 04/17/87 85.00 No
87 150 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
87 150 PPM Ruffled Fur 07/23/1987 04/17/87 98.00 Yes
89 150 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
90 150 PPM Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
90 150 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
90 150 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
90 150 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
104 300 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
104 300 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
106 300 PPM Reddened Penis 06/19/1987 04/17/87 64.00 No
107 300 PPM Ruffled Fur 06/19/1987 04/17/87 64.00 No
107 300 PPM Ruffled Fur 07/02/1987 04/17/87 77.00 No
108 300 PPM Alopecia Body Ventral 06/26/1987 04/17/87 71.00 No
108 300 PPM Alopecia Body Ventral 07/02/1987 04/17/87 77.00 No
108 300 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No
108 300 PPM Alopecia Body Ventral 07/17/1987 04/17/87 92.00 No
108 300 PPM Alopecia Body Ventral 07/23/1987 04/17/87 98.00 Yes
109 300 PPM Alopecia Body Ventral 07/10/1987 04/17/87 85.00 No