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Current Search Critera

Short-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Isoprene
CASRN: ="78-79-5"
Study Number: C61825C
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 0513505
Sex: Male
Strain and Species: F 344/N Rats

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
11 Vehicle Control Urine Stain 10/27/1988 03/07/88 235.00 No
15 Vehicle Control Urine Stain 08/04/1988 03/07/88 151.00 No
15 Vehicle Control Urine Stain 10/27/1988 03/07/88 235.00 No
15 Vehicle Control Sore Penis, 3- 5 Mm 01/19/1989 03/07/88 319.00 No
15 Vehicle Control Sore Penis, 0- 2 Mm 03/09/1989 03/07/88 368.00 Yes
21 Vehicle Control Urine Stain 08/04/1988 03/07/88 151.00 No
21 Vehicle Control Urine Stain 10/27/1988 03/07/88 235.00 No
33 Vehicle Control Discharge Right Eye 11/23/1988 03/07/88 262.00 No
33 Vehicle Control Discharge Right Eye 12/22/1988 03/07/88 291.00 No
33 Vehicle Control Discharge Right Eye 01/19/1989 03/07/88 319.00 No
33 Vehicle Control Discharge Left Eye 03/09/1989 03/07/88 368.00 Yes
38 Vehicle Control Urine Stain 09/02/1988 03/07/88 180.00 No
39 Vehicle Control Sore Penis, 3- 5 Mm 01/19/1989 03/07/88 319.00 No
40 Vehicle Control Urine Stain 09/22/1988 03/07/88 200.00 No
40 Vehicle Control Urine Stain 10/27/1988 03/07/88 235.00 No
40 Vehicle Control Urine Stain 01/19/1989 03/07/88 319.00 No
40 Vehicle Control Urine Stain 03/09/1989 03/07/88 368.00 Yes
41 Vehicle Control Urine Stain 08/04/1988 03/07/88 151.00 No
42 Vehicle Control Urine Stain 10/27/1988 03/07/88 235.00 No
46 Vehicle Control Urine Stain 08/04/1988 03/07/88 151.00 No
46 Vehicle Control Urine Stain 09/22/1988 03/07/88 200.00 No
46 Vehicle Control Urine Stain 10/27/1988 03/07/88 235.00 No
47 Vehicle Control Discharge Left Eye 05/05/1988 03/07/88 60.00 No
49 Vehicle Control Urine Stain 10/27/1988 03/07/88 235.00 No
214 70 PPM Emaciated 03/17/1988 03/07/88 11.00 No
237 70 PPM Urine Stain 08/04/1988 03/07/88 151.00 No
237 70 PPM Urine Stain 09/22/1988 03/07/88 200.00 No
237 70 PPM Urine Stain 10/27/1988 03/07/88 235.00 No
416 220 PPM Urine Stain 02/16/1989 03/07/88 347.00 No
420 220 PPM Urine Stain 01/19/1989 03/07/88 319.00 No
420 220 PPM Tissue Mass Body Ventral, 6-10 Mm 03/08/1989 03/07/88 367.00 Yes
421 220 PPM Swelling Right Eye 10/27/1988 03/07/88 235.00 No
421 220 PPM Discharge Right Eye 10/27/1988 03/07/88 235.00 No
421 220 PPM Discharge Right Eye 11/23/1988 03/07/88 262.00 No
421 220 PPM Discharge Right Eye 12/22/1988 03/07/88 291.00 No
421 220 PPM Discharge Right Eye 01/19/1989 03/07/88 319.00 No
421 220 PPM Discharge Right Eye 02/16/1989 03/07/88 347.00 No
421 220 PPM Discharge Right Eye, Red 03/08/1989 03/07/88 367.00 Yes
425 220 PPM Discharge Nose, Red 08/16/1988 03/07/88 163.00 Yes
425 220 PPM Discharge Mouth, Red 08/16/1988 03/07/88 163.00 Yes
442 220 PPM Urine Stain 09/22/1988 03/07/88 200.00 No
611 700 PPM Urine Stain 08/04/1988 03/07/88 151.00 No
612 700 PPM Discharge Right Eye 05/05/1988 03/07/88 60.00 No
614 700 PPM Sore Penis, 3- 5 Mm 01/19/1989 03/07/88 319.00 No
619 700 PPM Swelling Scrotum 05/05/1988 03/07/88 60.00 No
619 700 PPM Sore Scrotum, 6-10 Mm 05/05/1988 03/07/88 60.00 No
623 700 PPM Tissue Mass Body Ventral, 26 Or Gr 02/16/1989 03/07/88 347.00 No
623 700 PPM Tissue Mass Body (Trunk), 26 Or Gr 03/08/1989 03/07/88 367.00 Yes
623 700 PPM Tachypnea 03/08/1989 03/07/88 367.00 Yes
628 700 PPM Urine Stain 08/04/1988 03/07/88 151.00 No
628 700 PPM Urine Stain 09/22/1988 03/07/88 200.00 No
636 700 PPM Sore Groin, 6-10 Mm 01/19/1989 03/07/88 319.00 No
636 700 PPM Tissue Mass Body Ventral, 21-45 Mm 03/08/1989 03/07/88 367.00 Yes
637 700 PPM Opacity Right Eye 02/16/1989 03/07/88 347.00 No
637 700 PPM Opacity Right Eye 03/08/1989 03/07/88 367.00 Yes
640 700 PPM Discharge Right Eye 05/05/1988 03/07/88 60.00 No
641 700 PPM Sore Penis, 0- 2 Mm 10/27/1988 03/07/88 235.00 No
642 700 PPM Discharge Left Eye 07/07/1988 03/07/88 123.00 No
643 700 PPM Urine Stain 10/27/1988 03/07/88 235.00 No
643 700 PPM Tissue Mass Body Ventral, 11-15 Mm 03/08/1989 03/07/88 367.00 Yes
819 2200 PPM Sore Penis, 3- 5 Mm 01/19/1989 03/07/88 319.00 No
829 2200 PPM Urine Stain 09/02/1988 03/07/88 180.00 No
833 2200 PPM Opacity Left Eye 12/22/1988 03/07/88 291.00 No
833 2200 PPM Opacity Left Eye 01/19/1989 03/07/88 319.00 No
833 2200 PPM Opacity Left Eye 02/16/1989 03/07/88 347.00 No
833 2200 PPM Opacity Left Eye 03/07/1989 03/07/88 366.00 Yes
837 2200 PPM Discharge Nose 11/23/1988 03/07/88 262.00 No
837 2200 PPM Swelling Left Front Leg 11/23/1988 03/07/88 262.00 No
840 2200 PPM Urine Stain 07/07/1988 03/07/88 123.00 No
850 2200 PPM Urine Stain 08/04/1988 03/07/88 151.00 No
850 2200 PPM Urine Stain 09/22/1988 03/07/88 200.00 No
1014 7000 PPM Urine Stain 08/04/1988 03/07/88 151.00 No
1014 7000 PPM Urine Stain 09/22/1988 03/07/88 200.00 No
1014 7000 PPM Discharge Right Eye 02/16/1989 03/07/88 347.00 No
1025 7000 PPM Urine Stain 08/04/1988 03/07/88 151.00 No
1025 7000 PPM Urine Stain 09/22/1988 03/07/88 200.00 No
1025 7000 PPM Urine Stain 10/27/1988 03/07/88 235.00 No
1026 7000 PPM Diarrhea 08/04/1988 03/07/88 151.00 No
1032 7000 PPM Discharge Right Eye 06/02/1988 03/07/88 88.00 No
1040 7000 PPM Opacity Left Eye 02/16/1989 03/07/88 347.00 No
1040 7000 PPM Opacity Left Eye 03/07/1989 03/07/88 366.00 Yes
1046 7000 PPM Urine Stain 10/27/1988 03/07/88 235.00 No