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Current Search Critera

Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Milk thistle extract
CASRN: ="84604-20-6"
Study Number: C20008
Exposure Route:
TDMS Number: 2000804
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
202 Untreated Control Thin 10/04/2004 03/25/03 560.00 Yes
202 Untreated Control Ataxia 10/04/2004 03/25/03 560.00 Yes
206 Untreated Control Head Tilt 11/02/2004 03/25/03 589.00 No
206 Untreated Control Thin 11/30/2004 03/25/03 617.00 No
206 Untreated Control Head Tilt 11/30/2004 03/25/03 617.00 No
206 Untreated Control Lethargic 12/01/2004 03/25/03 618.00 Yes
206 Untreated Control Thin 12/01/2004 03/25/03 618.00 Yes
206 Untreated Control Head Tilt 12/01/2004 03/25/03 618.00 Yes
229 Untreated Control Lethargic 10/26/2004 03/25/03 582.00 Yes
229 Untreated Control Paralysis 10/26/2004 03/25/03 582.00 Yes
229 Untreated Control Hindlimb Splay 10/26/2004 03/25/03 582.00 Yes
234 Untreated Control Nasal/Eye Discharge 12/28/2004 03/25/03 645.00 No
234 Untreated Control Head Tilt 12/28/2004 03/25/03 645.00 No
234 Untreated Control Mass Head, Small (1mm-5mm) 1 12/28/2004 03/25/03 645.00 No
234 Untreated Control Eye Abnormality 12/28/2004 03/25/03 645.00 No
234 Untreated Control Nasal/Eye Discharge 01/25/2005 03/25/03 673.00 No
234 Untreated Control Head Tilt 01/25/2005 03/25/03 673.00 No
234 Untreated Control Mass Head, Small (1mm-5mm) 1 01/25/2005 03/25/03 673.00 No
234 Untreated Control Mass Head, Small (1mm-5mm) 1 02/22/2005 03/25/03 701.00 No
234 Untreated Control Head Tilt 02/22/2005 03/25/03 701.00 No
234 Untreated Control Nasal/Eye Discharge 02/22/2005 03/25/03 701.00 No
234 Untreated Control Mass Head, Small (1mm-5mm) 1 03/25/2005 03/25/03 732.00 Yes
234 Untreated Control Eye Abnormality 03/25/2005 03/25/03 732.00 Yes
241 Untreated Control Mass Torso/Ventral, Small (1mm-5mm) 1 09/07/2004 03/25/03 533.00 No
241 Untreated Control Thin 09/07/2004 03/25/03 533.00 No
241 Untreated Control Mass Torso/Ventral, Large (16mm And Larger) 1 09/23/2004 03/25/03 549.00 Yes
242 Untreated Control Mass Torso/Dorsal, Medium (6mm-15mm) 2 01/25/2005 03/25/03 673.00 No
242 Untreated Control Ulcer/Abscess Torso/Dorsal 1 01/25/2005 03/25/03 673.00 No
242 Untreated Control Mass Torso/Dorsal, Large (16mm And Larger) 1 02/22/2005 03/25/03 701.00 No
242 Untreated Control Ulcer/Abscess Torso/Dorsal 1 02/22/2005 03/25/03 701.00 No
242 Untreated Control Mass Torso/Dorsal, Large (16mm And Larger) 1 02/26/2005 03/25/03 705.00 Yes
245 Untreated Control Eye Abnormality 11/02/2004 03/25/03 589.00 No
245 Untreated Control Nasal/Eye Discharge 11/02/2004 03/25/03 589.00 No
245 Untreated Control Nasal/Eye Discharge 11/30/2004 03/25/03 617.00 No
245 Untreated Control Mass Head, Small (1mm-5mm) 1 11/30/2004 03/25/03 617.00 No
245 Untreated Control Eye Abnormality 11/30/2004 03/25/03 617.00 No
245 Untreated Control Nasal/Eye Discharge 12/28/2004 03/25/03 645.00 No
245 Untreated Control Head Tilt 12/28/2004 03/25/03 645.00 No
245 Untreated Control Eye Abnormality 12/28/2004 03/25/03 645.00 No
245 Untreated Control Mass Head, Small (1mm-5mm) 1 01/25/2005 03/25/03 673.00 No
245 Untreated Control Mass Head, Small (1mm-5mm) 1 02/22/2005 03/25/03 701.00 No
245 Untreated Control Mass Head, Small (1mm-5mm) 1 03/25/2005 03/25/03 732.00 Yes
257 12500 PPM Thin 05/20/2003 03/25/03 57.00 No
258 12500 PPM Thin 05/20/2003 03/25/03 57.00 No
262 12500 PPM Mass Torso/Lateral, Medium (6mm-15mm) 1 09/07/2004 03/25/03 533.00 No
262 12500 PPM Mass Torso/Lateral, Medium (6mm-15mm) 1 10/05/2004 03/25/03 561.00 No
262 12500 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 11/02/2004 03/25/03 589.00 No
262 12500 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 11/30/2004 03/25/03 617.00 No
262 12500 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 12/28/2004 03/25/03 645.00 No
262 12500 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 01/25/2005 03/25/03 673.00 No
262 12500 PPM Ulcer/Abscess Torso/Lateral 1 01/25/2005 03/25/03 673.00 No
262 12500 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 01/27/2005 03/25/03 675.00 Yes
262 12500 PPM Ulcer/Abscess Torso/Lateral 1 01/27/2005 03/25/03 675.00 Yes
263 12500 PPM Abnormal Breathing 06/15/2004 03/25/03 449.00 No
263 12500 PPM Thin 06/16/2004 03/25/03 450.00 Yes
263 12500 PPM Abnormal Breathing 06/16/2004 03/25/03 450.00 Yes
276 12500 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 05/03/2004 03/25/03 406.00 Yes
277 12500 PPM Thin 12/28/2004 03/25/03 645.00 No
282 12500 PPM Eye Abnormality 07/13/2004 03/25/03 477.00 No
282 12500 PPM Nasal/Eye Discharge 08/10/2004 03/25/03 505.00 No
282 12500 PPM Eye Abnormality 09/07/2004 03/25/03 533.00 No
282 12500 PPM Nasal/Eye Discharge 09/07/2004 03/25/03 533.00 No
282 12500 PPM Nasal/Eye Discharge 10/05/2004 03/25/03 561.00 No
282 12500 PPM Eye Abnormality 10/05/2004 03/25/03 561.00 No
282 12500 PPM Eye Abnormality 11/02/2004 03/25/03 589.00 No
282 12500 PPM Nasal/Eye Discharge 11/02/2004 03/25/03 589.00 No
282 12500 PPM Mass Head, Small (1mm-5mm) 1 11/02/2004 03/25/03 589.00 No
282 12500 PPM Nasal/Eye Discharge 11/30/2004 03/25/03 617.00 No
282 12500 PPM Mass Head, Small (1mm-5mm) 1 11/30/2004 03/25/03 617.00 No
282 12500 PPM Eye Abnormality 11/30/2004 03/25/03 617.00 No
282 12500 PPM Mass Head, Small (1mm-5mm) 1 12/28/2004 03/25/03 645.00 No
282 12500 PPM Eye Abnormality 12/28/2004 03/25/03 645.00 No
282 12500 PPM Head Tilt 12/28/2004 03/25/03 645.00 No
282 12500 PPM Nasal/Eye Discharge 12/28/2004 03/25/03 645.00 No
282 12500 PPM Mass Head, Medium (6mm-15mm) 1 01/25/2005 03/25/03 673.00 No
282 12500 PPM Nasal/Eye Discharge 01/25/2005 03/25/03 673.00 No
282 12500 PPM Nasal/Eye Discharge 02/22/2005 03/25/03 701.00 No
282 12500 PPM Mass Head, Medium (6mm-15mm) 1 02/22/2005 03/25/03 701.00 No
282 12500 PPM Mass Head, Medium (6mm-15mm) 1 03/25/2005 03/25/03 732.00 Yes
282 12500 PPM Eye Abnormality 03/25/2005 03/25/03 732.00 Yes
287 12500 PPM Head Tilt 03/29/2004 03/25/03 371.00 Yes
288 12500 PPM Thin 03/26/2005 03/25/03 733.00 Yes
288 12500 PPM Nasal/Eye Discharge 03/26/2005 03/25/03 733.00 Yes
288 12500 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 03/26/2005 03/25/03 733.00 Yes
288 12500 PPM Lethargic 03/26/2005 03/25/03 733.00 Yes
289 12500 PPM Mass Torso/Lateral, Medium (6mm-15mm) 1 12/28/2004 03/25/03 645.00 No
289 12500 PPM Mass Torso/Lateral, Medium (6mm-15mm) 1 01/25/2005 03/25/03 673.00 No
289 12500 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 02/22/2005 03/25/03 701.00 No
289 12500 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 03/18/2005 03/25/03 725.00 Yes
302 25000 PPM Mass Torso/Dorsal, Small (1mm-5mm) 1 02/22/2005 03/25/03 701.00 No
302 25000 PPM Mass Torso/Dorsal, Large (16mm And Larger) 1 03/29/2005 03/25/03 736.00 Yes
302 25000 PPM Ulcer/Abscess Torso/Dorsal 1 03/29/2005 03/25/03 736.00 Yes
305 25000 PPM Nasal/Eye Discharge 11/02/2004 03/25/03 589.00 No
305 25000 PPM Nasal/Eye Discharge 11/30/2004 03/25/03 617.00 No
306 25000 PPM Thin 07/13/2004 03/25/03 477.00 No
306 25000 PPM Thin 08/10/2004 03/25/03 505.00 No
306 25000 PPM Thin 09/07/2004 03/25/03 533.00 No
306 25000 PPM Thin 10/05/2004 03/25/03 561.00 No
306 25000 PPM Thin 11/02/2004 03/25/03 589.00 No
306 25000 PPM Thin 11/30/2004 03/25/03 617.00 No
306 25000 PPM Thin 12/28/2004 03/25/03 645.00 No
306 25000 PPM Lethargic 12/28/2004 03/25/03 645.00 No
306 25000 PPM Lethargic 01/11/2005 03/25/03 659.00 Yes
306 25000 PPM Thin 01/11/2005 03/25/03 659.00 Yes
312 25000 PPM Eye Abnormality 11/02/2004 03/25/03 589.00 No
312 25000 PPM Mass Head, Small (1mm-5mm) 1 11/02/2004 03/25/03 589.00 No
312 25000 PPM Eye Abnormality 11/30/2004 03/25/03 617.00 No
312 25000 PPM Mass Head, Small (1mm-5mm) 1 11/30/2004 03/25/03 617.00 No
312 25000 PPM Nasal/Eye Discharge 12/28/2004 03/25/03 645.00 No
312 25000 PPM Mass Head, Small (1mm-5mm) 1 12/28/2004 03/25/03 645.00 No
312 25000 PPM Head Tilt 12/28/2004 03/25/03 645.00 No
312 25000 PPM Eye Abnormality 12/28/2004 03/25/03 645.00 No
312 25000 PPM Nasal/Eye Discharge 01/25/2005 03/25/03 673.00 No
312 25000 PPM Mass Head, Small (1mm-5mm) 1 01/25/2005 03/25/03 673.00 No
312 25000 PPM Mass Head, Small (1mm-5mm) 1 02/22/2005 03/25/03 701.00 No
312 25000 PPM Nasal/Eye Discharge 02/22/2005 03/25/03 701.00 No
312 25000 PPM Eye Abnormality 03/29/2005 03/25/03 736.00 Yes
312 25000 PPM Mass Head, Small (1mm-5mm) 1 03/29/2005 03/25/03 736.00 Yes
317 25000 PPM Mass Torso/Ventral, Large (16mm And Larger) 1 12/28/2004 03/25/03 645.00 No
317 25000 PPM Ulcer/Abscess Torso/Ventral 1 01/25/2005 03/25/03 673.00 No
317 25000 PPM Mass Torso/Ventral, Large (16mm And Larger) 1 01/25/2005 03/25/03 673.00 No
317 25000 PPM Ruffled Fur 01/25/2005 03/25/03 673.00 No
317 25000 PPM Thin 02/09/2005 03/25/03 688.00 Yes
317 25000 PPM Ulcer/Abscess Torso/Ventral 1 02/09/2005 03/25/03 688.00 Yes
317 25000 PPM Mass Torso/Ventral, Large (16mm And Larger) 1 02/09/2005 03/25/03 688.00 Yes
342 25000 PPM Mass Head, Small (1mm-5mm) 1 01/25/2005 03/25/03 673.00 No
342 25000 PPM Nasal/Eye Discharge 01/25/2005 03/25/03 673.00 No
342 25000 PPM Nasal/Eye Discharge 02/22/2005 03/25/03 701.00 No
342 25000 PPM Mass Head, Small (1mm-5mm) 1 02/22/2005 03/25/03 701.00 No
342 25000 PPM Mass Head, Small (1mm-5mm) 1 03/28/2005 03/25/03 735.00 Yes
342 25000 PPM Eye Abnormality 03/28/2005 03/25/03 735.00 Yes
354 50000 PPM Mass Torso/Dorsal, Medium (6mm-15mm) 1 11/30/2004 03/25/03 617.00 No
354 50000 PPM Mass Torso/Dorsal, Large (16mm And Larger) 1 12/15/2004 03/25/03 632.00 Yes
355 50000 PPM Lethargic 03/14/2005 03/25/03 721.00 Yes
355 50000 PPM Mass Torso/Ventral, Large (16mm And Larger) 1 03/14/2005 03/25/03 721.00 Yes
355 50000 PPM Ulcer/Abscess Torso/Ventral 1 03/14/2005 03/25/03 721.00 Yes
355 50000 PPM Thin 03/14/2005 03/25/03 721.00 Yes
368 50000 PPM Mass Torso/Lateral, Medium (6mm-15mm) 1 01/25/2005 03/25/03 673.00 No
368 50000 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 02/09/2005 03/25/03 688.00 Yes
368 50000 PPM Lethargic 02/09/2005 03/25/03 688.00 Yes
368 50000 PPM Thin 02/09/2005 03/25/03 688.00 Yes
370 50000 PPM Mass Torso/Ventral, Large (16mm And Larger) 1 12/28/2004 03/25/03 645.00 No
370 50000 PPM Mass Torso/Ventral, Large (16mm And Larger) 1 01/11/2005 03/25/03 659.00 Yes
370 50000 PPM Lethargic 01/11/2005 03/25/03 659.00 Yes
370 50000 PPM Thin 01/11/2005 03/25/03 659.00 Yes
392 50000 PPM Mass Appendage, Small (1mm-5mm) 1 03/29/2005 03/25/03 736.00 Yes