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Short-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Pentachlorobenzene
CASRN: ="608-93-5"
Study Number: C61847A
Exposure Route:
TDMS Number: 0513903
Sex: Male
Strain and Species: F 344/N Rats

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
2 Untreated Control Reddened Eye 03/02/1987 01/12/87 50.00 No
2 Untreated Control Reddened Eye 03/09/1987 01/12/87 57.00 No
2 Untreated Control Reddened Eye 03/16/1987 01/12/87 64.00 No
2 Untreated Control Reddened Eye 03/23/1987 01/12/87 71.00 No
2 Untreated Control Reddened Eye 03/30/1987 01/12/87 78.00 No
7 Untreated Control Reddened Eye 03/31/1987 01/12/87 78.00 No
7 Untreated Control Reddened Eye 04/07/1987 01/12/87 85.00 No
7 Untreated Control Reddened Eye 04/14/1987 01/12/87 92.00 No
11 Untreated Control Reddened Eye 01/19/1987 01/12/87 8.00 No
11 Untreated Control Reddened Eye 01/26/1987 01/12/87 15.00 No
11 Untreated Control Opacity Right Eye 02/16/1987 01/12/87 36.00 No
11 Untreated Control Opacity Right Eye 02/23/1987 01/12/87 43.00 No
11 Untreated Control Opacity Right Eye 03/02/1987 01/12/87 50.00 No
11 Untreated Control Discoloration Right Eye, White 03/09/1987 01/12/87 57.00 No
11 Untreated Control Discoloration Right Eye, White 03/16/1987 01/12/87 64.00 No
11 Untreated Control Micro-Ophthalmia 03/23/1987 01/12/87 71.00 No
11 Untreated Control Discoloration Right Eye, White 03/23/1987 01/12/87 71.00 No
11 Untreated Control Micro-Ophthalmia 03/30/1987 01/12/87 78.00 No
11 Untreated Control Discoloration Right Eye, White 03/30/1987 01/12/87 78.00 No
11 Untreated Control Micro-Ophthalmia 04/06/1987 01/12/87 85.00 No
11 Untreated Control Discoloration Right Eye, White 04/06/1987 01/12/87 85.00 No
11 Untreated Control Discoloration Right Eye, White 04/12/1987 01/12/87 91.00 No
11 Untreated Control Micro-Ophthalmia 04/12/1987 01/12/87 91.00 No
11 Untreated Control Discoloration Right Eye, White 04/13/1987 01/12/87 92.00 Yes
14 Untreated Control Reddened Eye 01/19/1987 01/12/87 8.00 No
15 Untreated Control Reddened Eye 01/19/1987 01/12/87 8.00 No
15 Untreated Control Reddened Eye 01/26/1987 01/12/87 15.00 No
15 Untreated Control Reddened Eye 02/02/1987 01/12/87 22.00 No
15 Untreated Control Discoloration Left Eye, White 02/10/1987 01/12/87 30.00 No
15 Untreated Control Micro-Ophthalmia 02/16/1987 01/12/87 36.00 No
15 Untreated Control Opacity Left Eye 02/16/1987 01/12/87 36.00 No
15 Untreated Control Micro-Ophthalmia 02/23/1987 01/12/87 43.00 No
15 Untreated Control Opacity Left Eye 02/23/1987 01/12/87 43.00 No
15 Untreated Control Opacity Left Eye 03/02/1987 01/12/87 50.00 No
15 Untreated Control Micro-Ophthalmia 03/02/1987 01/12/87 50.00 No
15 Untreated Control Discoloration Left Eye, White 03/09/1987 01/12/87 57.00 No
15 Untreated Control Micro-Ophthalmia 03/09/1987 01/12/87 57.00 No
15 Untreated Control Micro-Ophthalmia 03/16/1987 01/12/87 64.00 No
15 Untreated Control Discoloration Left Eye, White 03/16/1987 01/12/87 64.00 No
15 Untreated Control Micro-Ophthalmia 03/23/1987 01/12/87 71.00 No
15 Untreated Control Discoloration Left Eye, White 03/23/1987 01/12/87 71.00 No
15 Untreated Control Discoloration Left Eye, White 03/30/1987 01/12/87 78.00 No
15 Untreated Control Micro-Ophthalmia 03/30/1987 01/12/87 78.00 No
15 Untreated Control Micro-Ophthalmia 04/06/1987 01/12/87 85.00 No
15 Untreated Control Discoloration Left Eye, White 04/06/1987 01/12/87 85.00 No
15 Untreated Control Micro-Ophthalmia 04/12/1987 01/12/87 91.00 No
15 Untreated Control Discoloration Left Eye, White 04/12/1987 01/12/87 91.00 No
15 Untreated Control Discoloration Left Eye, White 04/13/1987 01/12/87 92.00 Yes
15 Untreated Control Micro-Ophthalmia 04/13/1987 01/12/87 92.00 Yes
18 Untreated Control Discoloration Right Eye, Opaque 01/27/1987 01/12/87 15.00 No
18 Untreated Control Discoloration Right Eye, Opaque 02/03/1987 01/12/87 22.00 No
18 Untreated Control Discoloration Right Eye, White 02/10/1987 01/12/87 29.00 No
18 Untreated Control Micro-Ophthalmia 02/17/1987 01/12/87 36.00 No
18 Untreated Control Opacity Right Eye 02/17/1987 01/12/87 36.00 No
18 Untreated Control Opacity Right Eye 02/24/1987 01/12/87 43.00 No
18 Untreated Control Micro-Ophthalmia 02/24/1987 01/12/87 43.00 No
18 Untreated Control Micro-Ophthalmia 03/03/1987 01/12/87 50.00 No
18 Untreated Control Discoloration Right Eye, White 03/03/1987 01/12/87 50.00 No
18 Untreated Control Micro-Ophthalmia 03/17/1987 01/12/87 64.00 No
18 Untreated Control Discoloration Right Eye, White 03/17/1987 01/12/87 64.00 No
18 Untreated Control Micro-Ophthalmia 03/24/1987 01/12/87 71.00 No
18 Untreated Control Discoloration Right Eye, White 03/24/1987 01/12/87 71.00 No
18 Untreated Control Discoloration Right Eye, White 03/31/1987 01/12/87 78.00 No
18 Untreated Control Micro-Ophthalmia 03/31/1987 01/12/87 78.00 No
18 Untreated Control Micro-Ophthalmia 04/07/1987 01/12/87 85.00 No
18 Untreated Control Discoloration Right Eye, White 04/07/1987 01/12/87 85.00 No
18 Untreated Control Micro-Ophthalmia 04/13/1987 01/12/87 91.00 No
18 Untreated Control Discoloration Right Eye, White 04/13/1987 01/12/87 91.00 No
18 Untreated Control Discoloration Right Eye, White 04/14/1987 01/12/87 92.00 Yes
18 Untreated Control Micro-Ophthalmia 04/14/1987 01/12/87 92.00 Yes
19 Untreated Control Reddened Eye 01/27/1987 01/12/87 15.00 No
19 Untreated Control Reddened Eye 02/03/1987 01/12/87 22.00 No
20 Untreated Control Discoloration Right Eye, White 03/24/1987 01/12/87 71.00 No
20 Untreated Control Micro-Ophthalmia 03/24/1987 01/12/87 71.00 No
20 Untreated Control Discoloration Right Eye, White 03/31/1987 01/12/87 78.00 No
20 Untreated Control Discoloration Right Eye, White 04/07/1987 01/12/87 85.00 No
20 Untreated Control Micro-Ophthalmia 04/07/1987 01/12/87 85.00 No
20 Untreated Control Discoloration Right Eye, White 04/13/1987 01/12/87 91.00 No
20 Untreated Control Micro-Ophthalmia 04/13/1987 01/12/87 91.00 No
20 Untreated Control Micro-Ophthalmia 04/14/1987 01/12/87 92.00 Yes
20 Untreated Control Discoloration Right Eye, White 04/14/1987 01/12/87 92.00 Yes
35 33 PPM Reddened Eye 01/19/1987 01/12/87 8.00 No
35 33 PPM Sore Mouth, Red 01/19/1987 01/12/87 8.00 No
35 33 PPM Sore Mouth, Red 01/26/1987 01/12/87 15.00 No
35 33 PPM Reddened Eye 01/26/1987 01/12/87 15.00 No
35 33 PPM Sore Mouth, Red 02/02/1987 01/12/87 22.00 No
38 33 PPM Reddened Eye 03/10/1987 01/12/87 57.00 No
51 100 PPM Reddened Eye 01/19/1987 01/12/87 8.00 No
51 100 PPM Reddened Eye 01/26/1987 01/12/87 15.00 No
51 100 PPM Reddened Eye 02/02/1987 01/12/87 22.00 No
51 100 PPM Micro-Ophthalmia 02/16/1987 01/12/87 36.00 No
51 100 PPM Micro-Ophthalmia 03/02/1987 01/12/87 50.00 No
51 100 PPM Micro-Ophthalmia 03/09/1987 01/12/87 57.00 No
51 100 PPM Micro-Ophthalmia 03/16/1987 01/12/87 64.00 No
51 100 PPM Micro-Ophthalmia 03/30/1987 01/12/87 78.00 No
51 100 PPM Micro-Ophthalmia 04/06/1987 01/12/87 85.00 No
51 100 PPM Micro-Ophthalmia 04/12/1987 01/12/87 91.00 No
52 100 PPM Reddened Eye 01/19/1987 01/12/87 8.00 No
52 100 PPM Reddened Eye 01/26/1987 01/12/87 15.00 No
52 100 PPM Micro-Ophthalmia 04/06/1987 01/12/87 85.00 No
52 100 PPM Micro-Ophthalmia 04/12/1987 01/12/87 91.00 No
57 100 PPM Head Tilted 01/20/1987 01/12/87 8.00 No
57 100 PPM Opacity Right Eye 01/20/1987 01/12/87 8.00 No
57 100 PPM Discoloration Right Eye, White 01/27/1987 01/12/87 15.00 No
57 100 PPM Discoloration Right Eye, White 02/03/1987 01/12/87 22.00 No
57 100 PPM Discoloration Right Eye, White 02/10/1987 01/12/87 29.00 No
57 100 PPM Opacity Right Eye 02/17/1987 01/12/87 36.00 No
57 100 PPM Micro-Ophthalmia 02/17/1987 01/12/87 36.00 No
57 100 PPM Opacity Right Eye 02/24/1987 01/12/87 43.00 No
57 100 PPM Micro-Ophthalmia 02/24/1987 01/12/87 43.00 No
57 100 PPM Micro-Ophthalmia 03/03/1987 01/12/87 50.00 No
57 100 PPM Discoloration Right Eye, White 03/03/1987 01/12/87 50.00 No
57 100 PPM Missing Anatomy Right Eye 03/10/1987 01/12/87 57.00 No
57 100 PPM Missing Anatomy Right Eye 03/17/1987 01/12/87 64.00 No
57 100 PPM Missing Anatomy Right Eye 03/24/1987 01/12/87 71.00 No
57 100 PPM Missing Anatomy Right Eye 03/31/1987 01/12/87 78.00 No
57 100 PPM Missing Anatomy Right Eye 04/07/1987 01/12/87 85.00 No
57 100 PPM Missing Anatomy Right Eye 04/13/1987 01/12/87 91.00 No
57 100 PPM Opacity Right Eye 04/14/1987 01/12/87 92.00 Yes
57 100 PPM Micro-Ophthalmia 04/14/1987 01/12/87 92.00 Yes
60 100 PPM Micro-Ophthalmia 02/17/1987 01/12/87 36.00 No
60 100 PPM Micro-Ophthalmia 02/24/1987 01/12/87 43.00 No
60 100 PPM Micro-Ophthalmia 03/31/1987 01/12/87 78.00 No
60 100 PPM Micro-Ophthalmia 04/07/1987 01/12/87 85.00 No
60 100 PPM Micro-Ophthalmia 04/13/1987 01/12/87 91.00 No
72 330 PPM Reddened Eye 02/02/1987 01/12/87 22.00 No
73 330 PPM Reddened Eye 01/19/1987 01/12/87 8.00 No
73 330 PPM Reddened Eye 01/26/1987 01/12/87 15.00 No
73 330 PPM Micro-Ophthalmia 03/02/1987 01/12/87 50.00 No
73 330 PPM Micro-Ophthalmia 03/09/1987 01/12/87 57.00 No
73 330 PPM Micro-Ophthalmia 03/16/1987 01/12/87 64.00 No
73 330 PPM Micro-Ophthalmia 03/23/1987 01/12/87 71.00 No
73 330 PPM Micro-Ophthalmia 04/06/1987 01/12/87 85.00 No
73 330 PPM Micro-Ophthalmia 04/12/1987 01/12/87 91.00 No
76 330 PPM Reddened Eye 02/03/1987 01/12/87 22.00 No
76 330 PPM Reddened Eye 03/03/1987 01/12/87 50.00 No
76 330 PPM Swelling Right Eye 03/10/1987 01/12/87 57.00 No
76 330 PPM Exophthalmos 03/10/1987 01/12/87 57.00 No
76 330 PPM Exophthalmos 03/17/1987 01/12/87 64.00 No
76 330 PPM Swelling Right Eye 03/17/1987 01/12/87 64.00 No
76 330 PPM Exophthalmos 03/24/1987 01/12/87 71.00 No
76 330 PPM Swelling Right Eye 03/24/1987 01/12/87 71.00 No
76 330 PPM Swelling Right Eye 03/31/1987 01/12/87 78.00 No
76 330 PPM Exophthalmos 03/31/1987 01/12/87 78.00 No
76 330 PPM Exophthalmos 04/07/1987 01/12/87 85.00 No
76 330 PPM Swelling Right Eye 04/07/1987 01/12/87 85.00 No
76 330 PPM Reddened Eye 04/13/1987 01/12/87 91.00 No
76 330 PPM Exophthalmos 04/13/1987 01/12/87 91.00 No
76 330 PPM Reddened Eye 04/14/1987 01/12/87 92.00 Yes
76 330 PPM Exophthalmos 04/14/1987 01/12/87 92.00 Yes
77 330 PPM Sore Mouth, Red 01/27/1987 01/12/87 15.00 No
77 330 PPM Sore Mouth, Red 02/03/1987 01/12/87 22.00 No
80 330 PPM Discoloration Right Eye, White 03/03/1987 01/12/87 50.00 No
80 330 PPM Discoloration Right Eye, White 03/10/1987 01/12/87 57.00 No
80 330 PPM Discoloration Right Eye, White 03/17/1987 01/12/87 64.00 No
80 330 PPM Discoloration Right Eye, White 03/24/1987 01/12/87 71.00 No
80 330 PPM Discoloration Right Eye, White 03/31/1987 01/12/87 78.00 No
80 330 PPM Micro-Ophthalmia 03/31/1987 01/12/87 78.00 No
80 330 PPM Discoloration Right Eye, White 04/07/1987 01/12/87 85.00 No
80 330 PPM Micro-Ophthalmia 04/07/1987 01/12/87 85.00 No
80 330 PPM Micro-Ophthalmia 04/13/1987 01/12/87 91.00 No
80 330 PPM Discoloration Right Eye, White 04/13/1987 01/12/87 91.00 No
80 330 PPM Micro-Ophthalmia 04/14/1987 01/12/87 92.00 Yes
80 330 PPM Opacity Right Eye 04/14/1987 01/12/87 92.00 Yes
81 1000 PPM Reddened Eye 04/06/1987 01/12/87 85.00 No
81 1000 PPM Reddened Eye 04/13/1987 01/12/87 92.00 No
93 1000 PPM Discoloration Right Eye, White 02/02/1987 01/12/87 22.00 No
93 1000 PPM Micro-Ophthalmia 02/16/1987 01/12/87 36.00 No
93 1000 PPM Micro-Ophthalmia 02/23/1987 01/12/87 43.00 No
93 1000 PPM Micro-Ophthalmia 03/02/1987 01/12/87 50.00 No
93 1000 PPM Opacity Right Eye 03/02/1987 01/12/87 50.00 No
93 1000 PPM Micro-Ophthalmia 03/09/1987 01/12/87 57.00 No
93 1000 PPM Discoloration Right Eye, White 03/09/1987 01/12/87 57.00 No
93 1000 PPM Micro-Ophthalmia 03/16/1987 01/12/87 64.00 No
93 1000 PPM Discoloration Right Eye, White 03/16/1987 01/12/87 64.00 No
93 1000 PPM Micro-Ophthalmia 03/23/1987 01/12/87 71.00 No
93 1000 PPM Discoloration Right Eye, White 03/23/1987 01/12/87 71.00 No
93 1000 PPM Micro-Ophthalmia 03/30/1987 01/12/87 78.00 No
93 1000 PPM Discoloration Right Eye, White 03/30/1987 01/12/87 78.00 No
93 1000 PPM Discoloration Right Eye, White 04/06/1987 01/12/87 85.00 No
93 1000 PPM Micro-Ophthalmia 04/06/1987 01/12/87 85.00 No
93 1000 PPM Discoloration Right Eye, White 04/12/1987 01/12/87 91.00 No
93 1000 PPM Micro-Ophthalmia 04/12/1987 01/12/87 91.00 No
93 1000 PPM Micro-Ophthalmia 04/13/1987 01/12/87 92.00 Yes
93 1000 PPM Reddened Eye 04/13/1987 01/12/87 92.00 Yes
97 1000 PPM Discoloration Right Eye, White 01/27/1987 01/12/87 15.00 No
97 1000 PPM Discoloration Right Eye, White 02/03/1987 01/12/87 22.00 No
97 1000 PPM Discoloration Right Eye, White 02/10/1987 01/12/87 29.00 No
97 1000 PPM Opacity Right Eye 02/17/1987 01/12/87 36.00 No
97 1000 PPM Micro-Ophthalmia 02/17/1987 01/12/87 36.00 No
97 1000 PPM Micro-Ophthalmia 02/24/1987 01/12/87 43.00 No
97 1000 PPM Opacity Right Eye 02/24/1987 01/12/87 43.00 No
97 1000 PPM Missing Anatomy Right Eye 03/03/1987 01/12/87 50.00 No
97 1000 PPM Micro-Ophthalmia 03/10/1987 01/12/87 57.00 No
97 1000 PPM Discoloration Right Eye, White 03/10/1987 01/12/87 57.00 No
97 1000 PPM Micro-Ophthalmia 03/17/1987 01/12/87 64.00 No
97 1000 PPM Discoloration Right Eye, White 03/17/1987 01/12/87 64.00 No
97 1000 PPM Micro-Ophthalmia 03/24/1987 01/12/87 71.00 No
97 1000 PPM Discoloration Right Eye, White 03/24/1987 01/12/87 71.00 No
97 1000 PPM Micro-Ophthalmia 03/31/1987 01/12/87 78.00 No
97 1000 PPM Discoloration Right Eye, White 03/31/1987 01/12/87 78.00 No
97 1000 PPM Micro-Ophthalmia 04/13/1987 01/12/87 91.00 No
97 1000 PPM Discoloration Right Eye, White 04/13/1987 01/12/87 91.00 No
97 1000 PPM Opacity Right Eye 04/14/1987 01/12/87 92.00 Yes
97 1000 PPM Micro-Ophthalmia 04/14/1987 01/12/87 92.00 Yes
111 2000 PPM Reddened Eye 03/16/1987 01/12/87 64.00 No
111 2000 PPM Reddened Eye 03/23/1987 01/12/87 71.00 No
111 2000 PPM Reddened Eye 03/30/1987 01/12/87 78.00 No
111 2000 PPM Reddened Eye 04/06/1987 01/12/87 85.00 No
111 2000 PPM Micro-Ophthalmia 04/12/1987 01/12/87 91.00 No
111 2000 PPM Reddened Eye 04/12/1987 01/12/87 91.00 No
111 2000 PPM Reddened Eye 04/13/1987 01/12/87 92.00 Yes
117 2000 PPM Micro-Ophthalmia 02/24/1987 01/12/87 43.00 No
117 2000 PPM Micro-Ophthalmia 03/03/1987 01/12/87 50.00 No
117 2000 PPM Micro-Ophthalmia 03/10/1987 01/12/87 57.00 No
117 2000 PPM Micro-Ophthalmia 03/17/1987 01/12/87 64.00 No
117 2000 PPM Discoloration Right Eye, White 03/24/1987 01/12/87 71.00 No
117 2000 PPM Micro-Ophthalmia 03/24/1987 01/12/87 71.00 No
117 2000 PPM Discoloration Right Eye, White 03/31/1987 01/12/87 78.00 No
117 2000 PPM Micro-Ophthalmia 03/31/1987 01/12/87 78.00 No
117 2000 PPM Discoloration Right Eye, White 04/07/1987 01/12/87 85.00 No
117 2000 PPM Micro-Ophthalmia 04/07/1987 01/12/87 85.00 No
117 2000 PPM Micro-Ophthalmia 04/13/1987 01/12/87 91.00 No
117 2000 PPM Discoloration Right Eye, White 04/13/1987 01/12/87 91.00 No
117 2000 PPM Discoloration Right Eye, White 04/14/1987 01/12/87 92.00 Yes
119 2000 PPM Reddened Eye 01/20/1987 01/12/87 8.00 No
119 2000 PPM Reddened Eye 01/27/1987 01/12/87 15.00 No
119 2000 PPM Reddened Eye 02/03/1987 01/12/87 22.00 No
119 2000 PPM Micro-Ophthalmia 02/10/1987 01/12/87 29.00 No
119 2000 PPM Micro-Ophthalmia 02/17/1987 01/12/87 36.00 No
119 2000 PPM Opacity Right Eye 02/17/1987 01/12/87 36.00 No
119 2000 PPM Micro-Ophthalmia 02/24/1987 01/12/87 43.00 No
119 2000 PPM Opacity Right Eye 02/24/1987 01/12/87 43.00 No
119 2000 PPM Micro-Ophthalmia 03/03/1987 01/12/87 50.00 No
119 2000 PPM Discoloration Right Eye, White 03/03/1987 01/12/87 50.00 No
119 2000 PPM Discoloration Right Eye, White 03/10/1987 01/12/87 57.00 No
119 2000 PPM Micro-Ophthalmia 03/10/1987 01/12/87 57.00 No
119 2000 PPM Micro-Ophthalmia 03/17/1987 01/12/87 64.00 No
119 2000 PPM Discoloration Right Eye, White 03/17/1987 01/12/87 64.00 No
119 2000 PPM Micro-Ophthalmia 03/24/1987 01/12/87 71.00 No
119 2000 PPM Discoloration Right Eye, White 03/24/1987 01/12/87 71.00 No
119 2000 PPM Discoloration Right Eye, White 03/31/1987 01/12/87 78.00 No
119 2000 PPM Micro-Ophthalmia 03/31/1987 01/12/87 78.00 No
119 2000 PPM Micro-Ophthalmia 04/07/1987 01/12/87 85.00 No
119 2000 PPM Discoloration Right Eye, White 04/07/1987 01/12/87 85.00 No
119 2000 PPM Micro-Ophthalmia 04/13/1987 01/12/87 91.00 No
119 2000 PPM Discoloration Right Eye, White 04/13/1987 01/12/87 91.00 No
119 2000 PPM Micro-Ophthalmia 04/14/1987 01/12/87 92.00 Yes
119 2000 PPM Discoloration Right Eye, White 04/14/1987 01/12/87 92.00 Yes