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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Water disinfection byproducts (Sodium chlorate)
CASRN: ="7775-09-9"
Study Number: C96010A
Exposure Route: DOSED WATER
TDMS Number: 9601004
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
201 Untreated Control Eye Abnormality 09/21/2000 09/30/98 723.00 No
201 Untreated Control Eye Abnormality 10/03/2000 09/30/98 735.00 Yes
203 Untreated Control Mass Torso/Ventral, Medium (6mm-15mm) 1 09/21/2000 09/30/98 723.00 No
203 Untreated Control Mass Torso/Ventral, Large (16mm And Larger) 1 10/03/2000 09/30/98 735.00 Yes
205 Untreated Control Mass Torso/Dorsal, Large (16mm And Larger) 1 05/04/2000 09/30/98 583.00 No
205 Untreated Control Ulcer/Abscess Torso/Dorsal 1 05/04/2000 09/30/98 583.00 No
205 Untreated Control Thin 05/12/2000 09/30/98 591.00 Yes
205 Untreated Control Mass Torso/Dorsal, Large (16mm And Larger) 1 05/12/2000 09/30/98 591.00 Yes
205 Untreated Control Ulcer/Abscess Torso/Dorsal 1 05/12/2000 09/30/98 591.00 Yes
214 Untreated Control Eye Abnormality 06/29/2000 09/30/98 639.00 No
214 Untreated Control Eye Abnormality 07/27/2000 09/30/98 667.00 No
214 Untreated Control Eye Abnormality 08/24/2000 09/30/98 695.00 No
214 Untreated Control Eye Abnormality 09/21/2000 09/30/98 723.00 No
214 Untreated Control Eye Abnormality 10/03/2000 09/30/98 735.00 Yes
216 Untreated Control Eye Abnormality 10/03/2000 09/30/98 735.00 Yes
223 Untreated Control Mass Torso/Lateral, Medium (6mm-15mm) 1 09/21/2000 09/30/98 723.00 No
223 Untreated Control Mass Torso/Lateral, Medium (6mm-15mm) 1 10/04/2000 09/30/98 736.00 Yes
227 Untreated Control Abnormal Breathing 04/27/2000 09/30/98 576.00 Yes
227 Untreated Control Thin 04/27/2000 09/30/98 576.00 Yes
227 Untreated Control Lethargic 04/27/2000 09/30/98 576.00 Yes
227 Untreated Control Ruffled Fur 04/27/2000 09/30/98 576.00 Yes
246 Untreated Control Mass Head, Medium (6mm-15mm) 1 05/04/2000 09/30/98 583.00 No
246 Untreated Control Abnormal Breathing 05/04/2000 09/30/98 583.00 No
246 Untreated Control Thin 05/12/2000 09/30/98 591.00 Yes
246 Untreated Control Mass Head, Large (16mm And Larger) 1 05/12/2000 09/30/98 591.00 Yes
247 Untreated Control Mass Appendage, Small (1mm-5mm) 1 06/29/2000 09/30/98 639.00 No
247 Untreated Control Mass Appendage, Small (1mm-5mm) 1 07/27/2000 09/30/98 667.00 No
247 Untreated Control Mass Appendage, Small (1mm-5mm) 1 08/24/2000 09/30/98 695.00 No
247 Untreated Control Mass Appendage, Small (1mm-5mm) 1 09/21/2000 09/30/98 723.00 No
247 Untreated Control Mass Appendage, Small (1mm-5mm) 1 10/03/2000 09/30/98 735.00 Yes
257 500 MG/L Lethargic 10/01/2000 09/30/98 733.00 Yes
257 500 MG/L Abnormal Breathing 10/01/2000 09/30/98 733.00 Yes
264 500 MG/L Mass Head, Small (1mm-5mm) 1 06/29/2000 09/30/98 639.00 No
264 500 MG/L Mass Head, Small (1mm-5mm) 1 07/27/2000 09/30/98 667.00 No
276 500 MG/L Mass Torso/Ventral, Small (1mm-5mm) 1 09/21/2000 09/30/98 723.00 No
282 500 MG/L Eye Abnormality 06/29/2000 09/30/98 639.00 No
282 500 MG/L Eye Abnormality 07/27/2000 09/30/98 667.00 No
282 500 MG/L Eye Abnormality 08/24/2000 09/30/98 695.00 No
282 500 MG/L Eye Abnormality 09/21/2000 09/30/98 723.00 No
282 500 MG/L Eye Abnormality 10/03/2000 09/30/98 735.00 Yes
285 500 MG/L Lethargic 09/04/2000 09/30/98 706.00 Yes
285 500 MG/L Tremors 09/04/2000 09/30/98 706.00 Yes
290 500 MG/L Thin 09/21/2000 09/30/98 723.00 No
290 500 MG/L Lethargic 09/21/2000 09/30/98 723.00 No
292 500 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 08/24/2000 09/30/98 695.00 No
292 500 MG/L Ulcer/Abscess Torso/Lateral 1 08/24/2000 09/30/98 695.00 No
292 500 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 09/11/2000 09/30/98 713.00 Yes
292 500 MG/L Mass Torso/Lateral, Medium (6mm-15mm) 1 09/11/2000 09/30/98 713.00 Yes
292 500 MG/L Ulcer/Abscess Torso/Lateral 1 09/11/2000 09/30/98 713.00 Yes
293 500 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 12/16/1999 09/30/98 443.00 No
293 500 MG/L Ulcer/Abscess Torso/Lateral 1 01/03/2000 09/30/98 461.00 Yes
293 500 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 01/03/2000 09/30/98 461.00 Yes
296 500 MG/L Mass Torso/Lateral, Medium (6mm-15mm) 1 02/10/2000 09/30/98 499.00 No
296 500 MG/L Thin 02/10/2000 09/30/98 499.00 No
296 500 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 02/24/2000 09/30/98 513.00 Yes
297 500 MG/L Eye Abnormality 05/04/2000 09/30/98 583.00 No
297 500 MG/L Eye Abnormality 06/01/2000 09/30/98 611.00 No
297 500 MG/L Eye Abnormality 06/29/2000 09/30/98 639.00 No
297 500 MG/L Eye Abnormality 07/27/2000 09/30/98 667.00 No
297 500 MG/L Eye Abnormality 08/24/2000 09/30/98 695.00 No
298 500 MG/L Mass Torso/Lateral, Medium (6mm-15mm) 1 10/02/2000 09/30/98 734.00 Yes
299 500 MG/L Mass Torso/Ventral, Large (16mm And Larger) 1 04/06/2000 09/30/98 555.00 No
299 500 MG/L Mass Torso/Ventral, Large (16mm And Larger) 1 04/12/2000 09/30/98 561.00 Yes
300 500 MG/L Eye Abnormality 06/29/2000 09/30/98 639.00 No
300 500 MG/L Eye Abnormality 07/27/2000 09/30/98 667.00 No
300 500 MG/L Thin 07/27/2000 09/30/98 667.00 No
300 500 MG/L Ruffled Fur 07/27/2000 09/30/98 667.00 No
300 500 MG/L Thin 08/02/2000 09/30/98 673.00 Yes
300 500 MG/L Eye Abnormality 08/02/2000 09/30/98 673.00 Yes
300 500 MG/L Ruffled Fur 08/02/2000 09/30/98 673.00 Yes
301 1000 MG/L Ataxia 04/06/2000 09/30/98 555.00 No
301 1000 MG/L Lethargic 04/25/2000 09/30/98 574.00 Yes
304 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 12/16/1999 09/30/98 443.00 No
304 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 01/13/2000 09/30/98 471.00 No
304 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 02/10/2000 09/30/98 499.00 No
304 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 03/09/2000 09/30/98 527.00 No
304 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 04/06/2000 09/30/98 555.00 No
304 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 05/04/2000 09/30/98 583.00 No
304 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 06/01/2000 09/30/98 611.00 No
309 1000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 10/04/2000 09/30/98 736.00 Yes
311 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 05/04/2000 09/30/98 583.00 No
311 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 06/01/2000 09/30/98 611.00 No
311 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 06/29/2000 09/30/98 639.00 No
311 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 07/27/2000 09/30/98 667.00 No
311 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 08/24/2000 09/30/98 695.00 No
311 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 09/21/2000 09/30/98 723.00 No
311 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 10/03/2000 09/30/98 735.00 Yes
316 1000 MG/L Mass Torso/Ventral, Medium (6mm-15mm) 1 06/01/2000 09/30/98 611.00 No
316 1000 MG/L Mass Torso/Ventral, Large (16mm And Larger) 1 06/12/2000 09/30/98 622.00 Yes
319 1000 MG/L Mass Torso/Lateral, Medium (6mm-15mm) 1 09/21/2000 09/30/98 723.00 No
319 1000 MG/L Mass Torso/Lateral, Medium (6mm-15mm) 1 10/05/2000 09/30/98 737.00 Yes
324 1000 MG/L Head Tilt 01/28/2000 09/30/98 486.00 Yes
325 1000 MG/L Abnormal Breathing 07/22/2000 09/30/98 662.00 Yes
325 1000 MG/L Lethargic 07/22/2000 09/30/98 662.00 Yes
325 1000 MG/L Tremors 07/22/2000 09/30/98 662.00 Yes
326 1000 MG/L Thin 01/13/2000 09/30/98 471.00 No
326 1000 MG/L Mass Torso/Ventral, Small (1mm-5mm) 2 02/10/2000 09/30/98 499.00 No
326 1000 MG/L Mass Torso/Lateral, Small (1mm-5mm) 1 02/10/2000 09/30/98 499.00 No
326 1000 MG/L Mass Torso/Lateral, Small (1mm-5mm) 1 02/14/2000 09/30/98 503.00 Yes
326 1000 MG/L Mass Torso/Ventral, Small (1mm-5mm) 2 02/14/2000 09/30/98 503.00 Yes
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 12/16/1999 09/30/98 443.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 01/13/2000 09/30/98 471.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 02/10/2000 09/30/98 499.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 03/09/2000 09/30/98 527.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 04/06/2000 09/30/98 555.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 05/04/2000 09/30/98 583.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 06/01/2000 09/30/98 611.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 06/29/2000 09/30/98 639.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 07/27/2000 09/30/98 667.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 08/24/2000 09/30/98 695.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 09/21/2000 09/30/98 723.00 No
327 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 10/02/2000 09/30/98 734.00 Yes
330 1000 MG/L Mass Torso/Dorsal, Medium (6mm-15mm) 1 09/21/2000 09/30/98 723.00 No
330 1000 MG/L Mass Torso/Lateral, Medium (6mm-15mm) 1 10/02/2000 09/30/98 734.00 Yes
333 1000 MG/L Lethargic 09/18/2000 09/30/98 720.00 Yes
338 1000 MG/L Mass Torso/Lateral, Medium (6mm-15mm) 1 09/21/2000 09/30/98 723.00 No
343 1000 MG/L Thin 06/01/2000 09/30/98 611.00 No
343 1000 MG/L Thin 06/08/2000 09/30/98 618.00 Yes
349 1000 MG/L Thin 06/01/2000 09/30/98 611.00 No
349 1000 MG/L Thin 06/08/2000 09/30/98 618.00 Yes
352 2000 MG/L Lethargic 02/18/1999 09/30/98 142.00 Yes
353 2000 MG/L Mass Torso/Lateral, Medium (6mm-15mm) 1 09/21/2000 09/30/98 723.00 No
353 2000 MG/L Ulcer/Abscess Torso/Lateral 1 09/21/2000 09/30/98 723.00 No
353 2000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 09/27/2000 09/30/98 729.00 Yes
353 2000 MG/L Ulcer/Abscess Torso/Lateral 1 09/27/2000 09/30/98 729.00 Yes
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 01/13/2000 09/30/98 471.00 No
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 02/10/2000 09/30/98 499.00 No
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 03/09/2000 09/30/98 527.00 No
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 04/06/2000 09/30/98 555.00 No
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 05/04/2000 09/30/98 583.00 No
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 06/01/2000 09/30/98 611.00 No
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 06/29/2000 09/30/98 639.00 No
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 07/27/2000 09/30/98 667.00 No
355 2000 MG/L Mass Torso/Ventral, Large (16mm And Larger) 1 08/24/2000 09/30/98 695.00 No
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 08/24/2000 09/30/98 695.00 No
355 2000 MG/L Mass Torso/Dorsal, Medium (6mm-15mm) 1 09/21/2000 09/30/98 723.00 No
355 2000 MG/L Mass Torso/Ventral, Large (16mm And Larger) 1 09/21/2000 09/30/98 723.00 No
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 09/21/2000 09/30/98 723.00 No
355 2000 MG/L Mass Torso/Ventral, Large (16mm And Larger) 1 09/27/2000 09/30/98 729.00 Yes
355 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 09/27/2000 09/30/98 729.00 Yes
355 2000 MG/L Mass Torso/Dorsal, Medium (6mm-15mm) 1 09/27/2000 09/30/98 729.00 Yes
359 2000 MG/L Ulcer/Abscess Torso/Lateral 1 12/16/1999 09/30/98 443.00 No
359 2000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 12/16/1999 09/30/98 443.00 No
359 2000 MG/L Ulcer/Abscess Torso/Lateral 1 12/20/1999 09/30/98 447.00 Yes
359 2000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 12/20/1999 09/30/98 447.00 Yes
359 2000 MG/L Thin 12/20/1999 09/30/98 447.00 Yes
360 2000 MG/L Ulcer/Abscess Torso/Lateral 1 06/01/2000 09/30/98 611.00 No
360 2000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 06/01/2000 09/30/98 611.00 No
360 2000 MG/L Thin 06/08/2000 09/30/98 618.00 Yes
360 2000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 06/08/2000 09/30/98 618.00 Yes
361 2000 MG/L Thin 08/17/2000 09/30/98 688.00 Yes
361 2000 MG/L Ataxia 08/17/2000 09/30/98 688.00 Yes
363 2000 MG/L Lethargic 07/27/2000 09/30/98 667.00 No
363 2000 MG/L Ataxia 07/27/2000 09/30/98 667.00 Yes
363 2000 MG/L Lethargic 07/27/2000 09/30/98 667.00 Yes
363 2000 MG/L Thin 07/27/2000 09/30/98 667.00 No
363 2000 MG/L Thin 07/27/2000 09/30/98 667.00 Yes
363 2000 MG/L Ataxia 07/27/2000 09/30/98 667.00 No
368 2000 MG/L Mass Torso/Ventral, Medium (6mm-15mm) 1 09/27/2000 09/30/98 729.00 Yes
372 2000 MG/L Mass Torso/Lateral, Small (1mm-5mm) 4 09/21/2000 09/30/98 723.00 No
372 2000 MG/L Mass Torso/Lateral, Small (1mm-5mm) 4 10/05/2000 09/30/98 737.00 Yes
374 2000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 09/21/2000 09/30/98 723.00 No
374 2000 MG/L Mass Torso/Dorsal, Small (1mm-5mm) 1 09/21/2000 09/30/98 723.00 No
374 2000 MG/L Ulcer/Abscess Torso/Lateral 1 10/05/2000 09/30/98 737.00 Yes
374 2000 MG/L Mass Torso/Dorsal, Small (1mm-5mm) 1 10/05/2000 09/30/98 737.00 Yes
374 2000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 10/05/2000 09/30/98 737.00 Yes
379 2000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 07/27/2000 09/30/98 667.00 No
379 2000 MG/L Ulcer/Abscess Torso/Lateral 1 07/27/2000 09/30/98 667.00 No
379 2000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 08/14/2000 09/30/98 685.00 Yes
379 2000 MG/L Thin 08/14/2000 09/30/98 685.00 Yes
379 2000 MG/L Ulcer/Abscess Torso/Lateral 1 08/14/2000 09/30/98 685.00 Yes
380 2000 MG/L Lethargic 08/14/2000 09/30/98 685.00 Yes
392 2000 MG/L Thin 12/16/1999 09/30/98 443.00 No
392 2000 MG/L Abnormal Breathing 12/28/1999 09/30/98 455.00 Yes
392 2000 MG/L Lethargic 12/28/1999 09/30/98 455.00 Yes
392 2000 MG/L Thin 12/28/1999 09/30/98 455.00 Yes
393 2000 MG/L Eye Abnormality 10/04/2000 09/30/98 736.00 Yes