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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Water disinfection byproducts (Sodium chlorate)
CASRN: ="7775-09-9"
Study Number: C96010A
Exposure Route: DOSED WATER
TDMS Number: 9601004
Sex: Male
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
9 Untreated Control Mass Appendage, Small (1mm-5mm) 1 01/14/2000 09/30/98 472.00 No
9 Untreated Control Mass Appendage, Small (1mm-5mm) 1 02/11/2000 09/30/98 500.00 No
9 Untreated Control Mass Appendage, Small (1mm-5mm) 1 03/10/2000 09/30/98 528.00 No
9 Untreated Control Mass Torso/Ventral, Small (1mm-5mm) 1 04/07/2000 09/30/98 556.00 No
9 Untreated Control Mass Appendage, Small (1mm-5mm) 1 04/07/2000 09/30/98 556.00 No
9 Untreated Control Mass Torso/Ventral, Small (1mm-5mm) 1 05/05/2000 09/30/98 584.00 No
9 Untreated Control Mass Appendage, Small (1mm-5mm) 1 05/05/2000 09/30/98 584.00 No
9 Untreated Control Mass Appendage, Small (1mm-5mm) 1 06/02/2000 09/30/98 612.00 No
9 Untreated Control Lethargic 06/28/2000 09/30/98 638.00 Yes
9 Untreated Control Thin 06/28/2000 09/30/98 638.00 Yes
9 Untreated Control Mass Appendage, Small (1mm-5mm) 1 06/28/2000 09/30/98 638.00 Yes
12 Untreated Control Ulcer/Abscess Torso/Dorsal 1 06/30/2000 09/30/98 640.00 No
12 Untreated Control Ulcer/Abscess Torso/Dorsal 1 07/28/2000 09/30/98 668.00 No
12 Untreated Control Ulcer/Abscess Torso/Dorsal 1 08/25/2000 09/30/98 696.00 No
12 Untreated Control Ulcer/Abscess Torso/Lateral 3 08/25/2000 09/30/98 696.00 No
12 Untreated Control Ulcer/Abscess Torso/Dorsal 1 09/22/2000 09/30/98 724.00 No
12 Untreated Control Ulcer/Abscess Torso/Dorsal 1 09/29/2000 09/30/98 731.00 Yes
14 Untreated Control Lethargic 04/12/2000 09/30/98 561.00 Yes
15 Untreated Control Eye Abnormality 01/14/2000 09/30/98 472.00 No
15 Untreated Control Eye Abnormality 02/11/2000 09/30/98 500.00 No
15 Untreated Control Eye Abnormality 03/10/2000 09/30/98 528.00 No
15 Untreated Control Eye Abnormality 04/07/2000 09/30/98 556.00 No
15 Untreated Control Thin 04/07/2000 09/30/98 556.00 No
23 Untreated Control Mass Torso/Ventral, Small (1mm-5mm) 1 09/22/2000 09/30/98 724.00 No
23 Untreated Control Mass Torso/Ventral, Small (1mm-5mm) 1 09/28/2000 09/30/98 730.00 Yes
24 Untreated Control Mass Torso/Ventral, Small (1mm-5mm) 1 09/22/2000 09/30/98 724.00 No
24 Untreated Control Mass Torso/Ventral, Small (1mm-5mm) 1 10/02/2000 09/30/98 734.00 Yes
30 Untreated Control Ulcer/Abscess Torso/Dorsal 1 08/25/2000 09/30/98 696.00 No
30 Untreated Control Ulcer/Abscess Torso/Dorsal 2 09/22/2000 09/30/98 724.00 No
30 Untreated Control Ulcer/Abscess Torso/Dorsal 1 10/02/2000 09/30/98 734.00 Yes
31 Untreated Control Thin 07/21/2000 09/30/98 661.00 Yes
31 Untreated Control Lethargic 07/21/2000 09/30/98 661.00 Yes
32 Untreated Control Mass Torso/Ventral, Small (1mm-5mm) 2 04/07/2000 09/30/98 556.00 No
32 Untreated Control Mass Torso/Ventral, Small (1mm-5mm) 2 05/05/2000 09/30/98 584.00 No
38 Untreated Control Thin 04/07/2000 09/30/98 556.00 No
38 Untreated Control Thin 04/12/2000 09/30/98 561.00 Yes
42 Untreated Control Mass Appendage, Small (1mm-5mm) 1 05/05/2000 09/30/98 584.00 No
42 Untreated Control Mass Appendage, Small (1mm-5mm) 1 06/02/2000 09/30/98 612.00 No
42 Untreated Control Mass Appendage, Small (1mm-5mm) 1 06/30/2000 09/30/98 640.00 No
42 Untreated Control Mass Appendage, Small (1mm-5mm) 1 08/25/2000 09/30/98 696.00 No
42 Untreated Control Mass Appendage, Small (1mm-5mm) 1 09/22/2000 09/30/98 724.00 No
42 Untreated Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 09/27/2000 09/30/98 729.00 Yes
42 Untreated Control Mass Appendage, Small (1mm-5mm) 1 09/27/2000 09/30/98 729.00 Yes
45 Untreated Control Ulcer/Abscess Head 06/02/2000 09/30/98 612.00 No
45 Untreated Control Ruffled Fur 08/25/2000 09/30/98 696.00 No
50 Untreated Control Lethargic 01/26/2000 09/30/98 484.00 Yes
56 500 MG/L Ruffled Fur 05/05/2000 09/30/98 584.00 No
59 500 MG/L Lethargic 09/19/2000 09/30/98 721.00 Yes
59 500 MG/L Thin 09/19/2000 09/30/98 721.00 Yes
67 500 MG/L Mass Appendage, Small (1mm-5mm) 1 08/25/2000 09/30/98 696.00 No
67 500 MG/L Ulcer/Abscess Appendage 1 10/02/2000 09/30/98 734.00 Yes
71 500 MG/L Eye Abnormality 05/05/2000 09/30/98 584.00 No
71 500 MG/L Eye Abnormality 06/02/2000 09/30/98 612.00 No
71 500 MG/L Eye Abnormality 06/30/2000 09/30/98 640.00 No
71 500 MG/L Nasal/Eye Discharge 07/28/2000 09/30/98 668.00 No
71 500 MG/L Eye Abnormality 07/28/2000 09/30/98 668.00 No
71 500 MG/L Nasal/Eye Discharge 08/25/2000 09/30/98 696.00 No
71 500 MG/L Eye Abnormality 08/25/2000 09/30/98 696.00 No
71 500 MG/L Eye Abnormality 09/22/2000 09/30/98 724.00 No
71 500 MG/L Eye Abnormality 09/29/2000 09/30/98 731.00 Yes
80 500 MG/L Mass Torso/Ventral, Small (1mm-5mm) 1 09/29/2000 09/30/98 731.00 Yes
83 500 MG/L Lethargic 09/11/2000 09/30/98 713.00 Yes
83 500 MG/L Abnormal Breathing 09/11/2000 09/30/98 713.00 Yes
85 500 MG/L Lethargic 04/25/2000 09/30/98 574.00 Yes
90 500 MG/L Ulcer/Abscess Appendage 1 07/28/2000 09/30/98 668.00 No
90 500 MG/L Ulcer/Abscess Appendage 1 08/25/2000 09/30/98 696.00 No
92 500 MG/L Lethargic 04/28/2000 09/30/98 577.00 Yes
92 500 MG/L Abnormal Breathing 04/28/2000 09/30/98 577.00 Yes
92 500 MG/L Ruffled Fur 04/28/2000 09/30/98 577.00 Yes
99 500 MG/L Ruffled Fur 05/25/2000 09/30/98 604.00 Yes
99 500 MG/L Lethargic 05/25/2000 09/30/98 604.00 Yes
99 500 MG/L Ataxia 05/25/2000 09/30/98 604.00 Yes
100 500 MG/L Thin 08/25/2000 09/30/98 696.00 No
100 500 MG/L Ruffled Fur 08/25/2000 09/30/98 696.00 No
100 500 MG/L Thin 09/22/2000 09/30/98 724.00 No
100 500 MG/L Thin 09/28/2000 09/30/98 730.00 Yes
100 500 MG/L Lethargic 09/28/2000 09/30/98 730.00 Yes
100 500 MG/L Ruffled Fur 09/28/2000 09/30/98 730.00 Yes
103 1000 MG/L Ulcer/Abscess Appendage 1 07/28/2000 09/30/98 668.00 No
103 1000 MG/L Thin 08/02/2000 09/30/98 673.00 Yes
103 1000 MG/L Lethargic 08/02/2000 09/30/98 673.00 Yes
103 1000 MG/L Abnormal Breathing 08/02/2000 09/30/98 673.00 Yes
103 1000 MG/L Ruffled Fur 08/02/2000 09/30/98 673.00 Yes
107 1000 MG/L Tremors 08/27/1999 09/30/98 332.00 No
111 1000 MG/L Eye Abnormality 09/24/1999 09/30/98 360.00 No
111 1000 MG/L Eye Abnormality 10/22/1999 09/30/98 388.00 No
111 1000 MG/L Eye Abnormality 11/19/1999 09/30/98 416.00 No
111 1000 MG/L Eye Abnormality 12/17/1999 09/30/98 444.00 No
111 1000 MG/L Eye Abnormality 01/14/2000 09/30/98 472.00 No
111 1000 MG/L Mass Head, Small (1mm-5mm) 1 02/11/2000 09/30/98 500.00 No
111 1000 MG/L Eye Abnormality 02/11/2000 09/30/98 500.00 No
111 1000 MG/L Mass Head, Small (1mm-5mm) 1 03/10/2000 09/30/98 528.00 No
111 1000 MG/L Eye Abnormality 03/10/2000 09/30/98 528.00 No
111 1000 MG/L Eye Abnormality 04/07/2000 09/30/98 556.00 No
111 1000 MG/L Mass Head, Small (1mm-5mm) 1 04/07/2000 09/30/98 556.00 No
111 1000 MG/L Mass Head, Small (1mm-5mm) 1 05/05/2000 09/30/98 584.00 No
111 1000 MG/L Eye Abnormality 05/05/2000 09/30/98 584.00 No
111 1000 MG/L Nasal/Eye Discharge 05/05/2000 09/30/98 584.00 No
111 1000 MG/L Eye Abnormality 06/02/2000 09/30/98 612.00 No
111 1000 MG/L Nasal/Eye Discharge 06/02/2000 09/30/98 612.00 No
111 1000 MG/L Mass Head, Small (1mm-5mm) 1 06/02/2000 09/30/98 612.00 No
111 1000 MG/L Eye Abnormality 06/30/2000 09/30/98 640.00 No
111 1000 MG/L Nasal/Eye Discharge 06/30/2000 09/30/98 640.00 No
111 1000 MG/L Mass Head, Small (1mm-5mm) 1 06/30/2000 09/30/98 640.00 No
111 1000 MG/L Mass Head, Medium (6mm-15mm) 1 07/28/2000 09/30/98 668.00 No
111 1000 MG/L Eye Abnormality 07/28/2000 09/30/98 668.00 No
111 1000 MG/L Nasal/Eye Discharge 07/28/2000 09/30/98 668.00 No
111 1000 MG/L Eye Abnormality 08/25/2000 09/30/98 696.00 No
111 1000 MG/L Mass Head, Medium (6mm-15mm) 1 08/25/2000 09/30/98 696.00 No
111 1000 MG/L Mass Head, Medium (6mm-15mm) 1 09/22/2000 09/30/98 724.00 No
111 1000 MG/L Mass Head, Medium (6mm-15mm) 1 09/29/2000 09/30/98 731.00 Yes
117 1000 MG/L Abnormal Breathing 05/28/2000 09/30/98 607.00 Yes
117 1000 MG/L Lethargic 05/28/2000 09/30/98 607.00 Yes
117 1000 MG/L Tremors 05/28/2000 09/30/98 607.00 Yes
121 1000 MG/L Ruffled Fur 10/02/2000 09/30/98 734.00 Yes
126 1000 MG/L Thin 09/27/2000 09/30/98 729.00 Yes
127 1000 MG/L Abnormal Breathing 07/28/2000 09/30/98 668.00 No
127 1000 MG/L Ruffled Fur 07/28/2000 09/30/98 668.00 Yes
127 1000 MG/L Ruffled Fur 07/28/2000 09/30/98 668.00 No
127 1000 MG/L Lethargic 07/28/2000 09/30/98 668.00 No
127 1000 MG/L Abnormal Breathing 07/28/2000 09/30/98 668.00 Yes
127 1000 MG/L Ataxia 07/28/2000 09/30/98 668.00 Yes
127 1000 MG/L Ataxia 07/28/2000 09/30/98 668.00 No
127 1000 MG/L Lethargic 07/28/2000 09/30/98 668.00 Yes
128 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 02/11/2000 09/30/98 500.00 No
128 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 03/10/2000 09/30/98 528.00 No
128 1000 MG/L Thin 04/07/2000 09/30/98 556.00 No
128 1000 MG/L Ruffled Fur 04/07/2000 09/30/98 556.00 No
128 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 04/07/2000 09/30/98 556.00 No
128 1000 MG/L Ruffled Fur 04/13/2000 09/30/98 562.00 Yes
128 1000 MG/L Thin 04/13/2000 09/30/98 562.00 Yes
128 1000 MG/L Mass Appendage, Small (1mm-5mm) 1 04/13/2000 09/30/98 562.00 Yes
149 1000 MG/L Mass Torso/Lateral, Small (1mm-5mm) 1 06/02/2000 09/30/98 612.00 No
149 1000 MG/L Mass Torso/Lateral, Medium (6mm-15mm) 1 06/30/2000 09/30/98 640.00 No
149 1000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 07/28/2000 09/30/98 668.00 No
149 1000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 08/25/2000 09/30/98 696.00 No
149 1000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 09/22/2000 09/30/98 724.00 No
149 1000 MG/L Mass Torso/Lateral, Large (16mm And Larger) 1 09/29/2000 09/30/98 731.00 Yes
152 2000 MG/L Abnormal Breathing 07/28/2000 09/30/98 668.00 No
154 2000 MG/L Abnormal Breathing 07/17/2000 09/30/98 657.00 Yes
154 2000 MG/L Lethargic 07/17/2000 09/30/98 657.00 Yes
156 2000 MG/L Head Tilt 07/14/1999 09/30/98 288.00 Yes
157 2000 MG/L Tremors 08/27/1999 09/30/98 332.00 No
158 2000 MG/L Lethargic 09/19/2000 09/30/98 721.00 Yes
158 2000 MG/L Abnormal Breathing 09/19/2000 09/30/98 721.00 Yes
158 2000 MG/L Ruffled Fur 09/19/2000 09/30/98 721.00 Yes
158 2000 MG/L Thin 09/19/2000 09/30/98 721.00 Yes
160 2000 MG/L Ulcer/Abscess Torso/Dorsal 3 05/05/2000 09/30/98 584.00 No
160 2000 MG/L Ulcer/Abscess Torso/Dorsal 2 06/02/2000 09/30/98 612.00 No
161 2000 MG/L Mass Torso/Ventral, Small (1mm-5mm) 1 09/22/2000 09/30/98 724.00 No
161 2000 MG/L Mass Torso/Ventral, Small (1mm-5mm) 1 09/28/2000 09/30/98 730.00 Yes
163 2000 MG/L Thin 06/30/2000 09/30/98 640.00 No
163 2000 MG/L Thin 06/30/2000 09/30/98 640.00 Yes
163 2000 MG/L Lethargic 06/30/2000 09/30/98 640.00 Yes
163 2000 MG/L Lethargic 06/30/2000 09/30/98 640.00 No
171 2000 MG/L Lethargic 06/08/2000 09/30/98 618.00 Yes
171 2000 MG/L Abnormal Breathing 06/08/2000 09/30/98 618.00 Yes
176 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 01/14/2000 09/30/98 472.00 No
176 2000 MG/L Thin 09/09/2000 09/30/98 711.00 Yes
176 2000 MG/L Lethargic 09/09/2000 09/30/98 711.00 Yes
176 2000 MG/L Ruffled Fur 09/09/2000 09/30/98 711.00 Yes
177 2000 MG/L Lethargic 01/07/2000 09/30/98 465.00 Yes
177 2000 MG/L Thin 01/07/2000 09/30/98 465.00 Yes
179 2000 MG/L Mass Torso/Ventral, Small (1mm-5mm) 1 09/22/2000 09/30/98 724.00 No
179 2000 MG/L Mass Torso/Ventral, Small (1mm-5mm) 1 09/29/2000 09/30/98 731.00 Yes
184 2000 MG/L Eye Abnormality 06/02/2000 09/30/98 612.00 No
184 2000 MG/L Eye Abnormality 06/30/2000 09/30/98 640.00 No
184 2000 MG/L Nasal/Eye Discharge 06/30/2000 09/30/98 640.00 No
186 2000 MG/L Mass Torso/Ventral, Large (16mm And Larger) 1 09/22/2000 09/30/98 724.00 No
188 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 04/07/2000 09/30/98 556.00 No
188 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 05/05/2000 09/30/98 584.00 No
188 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 06/02/2000 09/30/98 612.00 No
188 2000 MG/L Ulcer/Abscess Appendage 1 07/28/2000 09/30/98 668.00 No
188 2000 MG/L Ulcer/Abscess Appendage 1 08/25/2000 09/30/98 696.00 No
188 2000 MG/L Ulcer/Abscess Appendage 1 09/22/2000 09/30/98 724.00 No
188 2000 MG/L Ulcer/Abscess Appendage 1 09/29/2000 09/30/98 731.00 Yes
191 2000 MG/L Mass Torso/Dorsal, Large (16mm And Larger) 1 03/10/2000 09/30/98 528.00 No
191 2000 MG/L Mass Torso/Dorsal, Large (16mm And Larger) 1 03/17/2000 09/30/98 535.00 Yes
191 2000 MG/L Thin 03/17/2000 09/30/98 535.00 Yes
192 2000 MG/L Abnormal Breathing 07/28/2000 09/30/98 668.00 No
195 2000 MG/L Mass Torso/Ventral, Small (1mm-5mm) 1 09/28/2000 09/30/98 730.00 Yes
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 08/27/1999 09/30/98 332.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 09/24/1999 09/30/98 360.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 10/22/1999 09/30/98 388.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 11/19/1999 09/30/98 416.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 12/17/1999 09/30/98 444.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 01/14/2000 09/30/98 472.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 02/11/2000 09/30/98 500.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 03/10/2000 09/30/98 528.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 04/07/2000 09/30/98 556.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 05/05/2000 09/30/98 584.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 06/02/2000 09/30/98 612.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 06/30/2000 09/30/98 640.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 07/28/2000 09/30/98 668.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 08/25/2000 09/30/98 696.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 09/22/2000 09/30/98 724.00 No
196 2000 MG/L Mass Appendage, Small (1mm-5mm) 1 09/27/2000 09/30/98 729.00 Yes
198 2000 MG/L Abnormal Breathing 05/05/2000 09/30/98 584.00 No
198 2000 MG/L Abnormal Breathing 06/02/2000 09/30/98 612.00 No
198 2000 MG/L Lethargic 06/30/2000 09/30/98 640.00 No
198 2000 MG/L Lethargic 06/30/2000 09/30/98 640.00 Yes
198 2000 MG/L Thin 06/30/2000 09/30/98 640.00 No
198 2000 MG/L Thin 06/30/2000 09/30/98 640.00 Yes
198 2000 MG/L Abnormal Breathing 06/30/2000 09/30/98 640.00 No
199 2000 MG/L Ruffled Fur 04/21/2000 09/30/98 570.00 Yes
200 2000 MG/L Eye Abnormality 01/14/2000 09/30/98 472.00 No
200 2000 MG/L Eye Abnormality 02/11/2000 09/30/98 500.00 No
200 2000 MG/L Eye Abnormality 03/10/2000 09/30/98 528.00 No
200 2000 MG/L Mass Head, Small (1mm-5mm) 1 04/07/2000 09/30/98 556.00 No
200 2000 MG/L Eye Abnormality 04/07/2000 09/30/98 556.00 No
200 2000 MG/L Eye Abnormality 05/05/2000 09/30/98 584.00 No
200 2000 MG/L Mass Head, Small (1mm-5mm) 1 05/05/2000 09/30/98 584.00 No
200 2000 MG/L Mass Head, Small (1mm-5mm) 1 05/16/2000 09/30/98 595.00 Yes