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Current Search Critera

Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Sodium nitrite
CASRN: ="7632-00-0"
Study Number: C88007B
Exposure Route: DOSED WATER
TDMS Number: 8800706
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
201 Vehicle Control Lethargic 07/18/1997 08/03/95 716.00 Yes
201 Vehicle Control Abnormal Breathing 07/18/1997 08/03/95 716.00 Yes
201 Vehicle Control Ataxia 07/18/1997 08/03/95 716.00 Yes
202 Vehicle Control Ulcer/Abscess Head 2 03/04/1997 08/03/95 580.00 Yes
210 Vehicle Control Paralysis 08/08/1996 08/03/95 372.00 No
210 Vehicle Control Paralysis 09/05/1996 08/03/95 400.00 No
210 Vehicle Control Paralysis 10/03/1996 08/03/95 428.00 No
210 Vehicle Control Paralysis 10/31/1996 08/03/95 456.00 No
210 Vehicle Control Paralysis 11/28/1996 08/03/95 484.00 No
210 Vehicle Control Paralysis 12/24/1996 08/03/95 510.00 No
210 Vehicle Control Paralysis 01/23/1997 08/03/95 540.00 No
217 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 10/03/1996 08/03/95 428.00 No
217 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 10/31/1996 08/03/95 456.00 No
218 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 03/10/1997 08/03/95 586.00 Yes
234 Vehicle Control Head Tilt 10/03/1996 08/03/95 428.00 No
234 Vehicle Control Head Tilt 10/31/1996 08/03/95 456.00 No
234 Vehicle Control Head Tilt 11/28/1996 08/03/95 484.00 No
234 Vehicle Control Head Tilt 12/24/1996 08/03/95 510.00 No
234 Vehicle Control Head Tilt 01/23/1997 08/03/95 540.00 No
234 Vehicle Control Head Tilt 02/20/1997 08/03/95 568.00 No
234 Vehicle Control Head Tilt 03/20/1997 08/03/95 596.00 No
234 Vehicle Control Head Tilt 04/17/1997 08/03/95 624.00 No
234 Vehicle Control Head Tilt 05/15/1997 08/03/95 652.00 No
234 Vehicle Control Head Tilt 06/12/1997 08/03/95 680.00 No
234 Vehicle Control Head Tilt 07/10/1997 08/03/95 708.00 No
234 Vehicle Control Head Tilt 07/31/1997 08/03/95 729.00 Yes
236 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 11/28/1996 08/03/95 484.00 No
236 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 12/24/1996 08/03/95 510.00 No
238 Vehicle Control Thin 06/12/1997 08/03/95 680.00 No
238 Vehicle Control Thin 07/10/1997 08/03/95 708.00 No
238 Vehicle Control Thin 08/01/1997 08/03/95 730.00 Yes
264 0.075 % Mass Torso/Ventral, Small (1mm-5mm) 1 11/28/1996 08/03/95 484.00 No
267 0.075 % Mass Torso/Ventral, Small (1mm-5mm) 1 11/28/1996 08/03/95 484.00 No
267 0.075 % Mass Torso/Ventral, Medium (6mm-15mm) 1 12/24/1996 08/03/95 510.00 No
268 0.075 % Mass Torso/Lateral, Medium (6mm-15mm) 2 05/15/1997 08/03/95 652.00 No
268 0.075 % Mass Torso/Lateral, Medium (6mm-15mm) 1 06/05/1997 08/03/95 673.00 Yes
271 0.075 % Mass Torso/Lateral, Large (16mm And Larger) 1 06/12/1997 08/03/95 680.00 No
271 0.075 % Mass Torso/Lateral, Medium (6mm-15mm) 1 06/15/1997 08/03/95 683.00 Yes
272 0.075 % Ulcer/Abscess Torso/Lateral 1 05/15/1997 08/03/95 652.00 No
272 0.075 % Ulcer/Abscess Torso/Lateral 1 05/22/1997 08/03/95 659.00 Yes
275 0.075 % Mass Torso/Lateral, Large (16mm And Larger) 1 05/15/1997 08/03/95 652.00 No
275 0.075 % Lethargic 05/30/1997 08/03/95 667.00 Yes
275 0.075 % Ulcer/Abscess Torso/Lateral 1 05/30/1997 08/03/95 667.00 Yes
275 0.075 % Mass Torso/Lateral, Large (16mm And Larger) 1 05/30/1997 08/03/95 667.00 Yes
275 0.075 % Abnormal Breathing 05/30/1997 08/03/95 667.00 Yes
277 0.075 % Abnormal Breathing 05/06/1997 08/03/95 643.00 Yes
277 0.075 % Head Tilt 05/06/1997 08/03/95 643.00 Yes
277 0.075 % Lethargic 05/06/1997 08/03/95 643.00 Yes
277 0.075 % Thin 05/06/1997 08/03/95 643.00 Yes
280 0.075 % Thin 06/12/1997 08/03/95 680.00 No
280 0.075 % Thin 07/10/1997 08/03/95 708.00 No
280 0.075 % Ataxia 07/10/1997 08/03/95 708.00 No
280 0.075 % Thin 07/11/1997 08/03/95 709.00 Yes
280 0.075 % Ataxia 07/11/1997 08/03/95 709.00 Yes
288 0.075 % Mass Torso/Lateral, Large (16mm And Larger) 1 05/14/1997 08/03/95 651.00 Yes
289 0.075 % Eye Abnormality 04/17/1997 08/03/95 624.00 No
289 0.075 % Eye Abnormality 05/15/1997 08/03/95 652.00 No
289 0.075 % Lethargic 05/22/1997 08/03/95 659.00 Yes
293 0.075 % Thin 05/15/1997 08/03/95 652.00 No
293 0.075 % Thin 06/05/1997 08/03/95 673.00 Yes
293 0.075 % Abnormal Breathing 06/05/1997 08/03/95 673.00 Yes
293 0.075 % Lethargic 06/05/1997 08/03/95 673.00 Yes
294 0.075 % Thin 07/08/1997 08/03/95 706.00 Yes
294 0.075 % Abnormal Breathing 07/08/1997 08/03/95 706.00 Yes
294 0.075 % Lethargic 07/08/1997 08/03/95 706.00 Yes
296 0.075 % Thin 07/10/1997 08/03/95 708.00 No
299 0.075 % Mass Torso/Lateral, Medium (6mm-15mm) 1 07/31/1997 08/03/95 729.00 Yes
302 0.15 % Thin 06/09/1997 08/03/95 677.00 Yes
310 0.15 % Mass Torso/Ventral, Large (16mm And Larger) 1 10/31/1996 08/03/95 456.00 No
310 0.15 % Mass Torso/Ventral, Large (16mm And Larger) 2 11/21/1996 08/03/95 477.00 Yes
311 0.15 % Eye Abnormality 09/05/1996 08/03/95 400.00 No
311 0.15 % Nasal/Eye Discharge 09/05/1996 08/03/95 400.00 No
311 0.15 % Mass Head, Small (1mm-5mm) 1 09/05/1996 08/03/95 400.00 No
311 0.15 % Mass Head, Small (1mm-5mm) 1 10/03/1996 08/03/95 428.00 No
311 0.15 % Eye Abnormality 10/03/1996 08/03/95 428.00 No
311 0.15 % Nasal/Eye Discharge 10/03/1996 08/03/95 428.00 No
311 0.15 % Mass Head, Small (1mm-5mm) 1 10/31/1996 08/03/95 456.00 No
311 0.15 % Eye Abnormality 10/31/1996 08/03/95 456.00 No
311 0.15 % Nasal/Eye Discharge 11/28/1996 08/03/95 484.00 No
311 0.15 % Eye Abnormality 11/28/1996 08/03/95 484.00 No
311 0.15 % Mass Head, Small (1mm-5mm) 1 11/28/1996 08/03/95 484.00 No
311 0.15 % Eye Abnormality 12/24/1996 08/03/95 510.00 No
311 0.15 % Nasal/Eye Discharge 12/24/1996 08/03/95 510.00 No
311 0.15 % Mass Head, Small (1mm-5mm) 1 12/24/1996 08/03/95 510.00 No
311 0.15 % Mass Head, Medium (6mm-15mm) 1 01/23/1997 08/03/95 540.00 No
311 0.15 % Eye Abnormality 01/23/1997 08/03/95 540.00 No
311 0.15 % Nasal/Eye Discharge 01/23/1997 08/03/95 540.00 No
311 0.15 % Nasal/Eye Discharge 02/20/1997 08/03/95 568.00 No
311 0.15 % Mass Head, Medium (6mm-15mm) 1 02/20/1997 08/03/95 568.00 No
311 0.15 % Eye Abnormality 02/20/1997 08/03/95 568.00 No
311 0.15 % Nasal/Eye Discharge 03/20/1997 08/03/95 596.00 No
311 0.15 % Mass Head, Medium (6mm-15mm) 1 03/20/1997 08/03/95 596.00 No
311 0.15 % Eye Abnormality 03/20/1997 08/03/95 596.00 No
311 0.15 % Eye Abnormality 04/17/1997 08/03/95 624.00 No
311 0.15 % Mass Head, Medium (6mm-15mm) 1 04/17/1997 08/03/95 624.00 No
311 0.15 % Nasal/Eye Discharge 04/17/1997 08/03/95 624.00 No
311 0.15 % Mass Head, Small (1mm-5mm) 1 05/15/1997 08/03/95 652.00 No
311 0.15 % Eye Abnormality 05/15/1997 08/03/95 652.00 No
311 0.15 % Nasal/Eye Discharge 05/15/1997 08/03/95 652.00 No
311 0.15 % Eye Abnormality 06/12/1997 08/03/95 680.00 No
311 0.15 % Mass Head, Medium (6mm-15mm) 1 06/12/1997 08/03/95 680.00 No
311 0.15 % Ulcer/Abscess Head 1 06/12/1997 08/03/95 680.00 No
311 0.15 % Nasal/Eye Discharge 06/12/1997 08/03/95 680.00 No
311 0.15 % Ulcer/Abscess Head 2 07/10/1997 08/03/95 708.00 No
311 0.15 % Eye Abnormality 07/10/1997 08/03/95 708.00 No
311 0.15 % Nasal/Eye Discharge 07/10/1997 08/03/95 708.00 No
311 0.15 % Mass Head, Medium (6mm-15mm) 1 07/10/1997 08/03/95 708.00 No
311 0.15 % Nasal/Eye Discharge 07/30/1997 08/03/95 728.00 Yes
311 0.15 % Mass Head, Medium (6mm-15mm) 1 07/30/1997 08/03/95 728.00 Yes
311 0.15 % Ulcer/Abscess Head 2 07/30/1997 08/03/95 728.00 Yes
311 0.15 % Eye Abnormality 07/30/1997 08/03/95 728.00 Yes
313 0.15 % Lethargic 01/07/1997 08/03/95 524.00 Yes
313 0.15 % Ataxia 01/07/1997 08/03/95 524.00 Yes
313 0.15 % Abnormal Breathing 01/07/1997 08/03/95 524.00 Yes
313 0.15 % Mass Head, Medium (6mm-15mm) 1 01/07/1997 08/03/95 524.00 Yes
314 0.15 % Abnormal Breathing 07/18/1997 08/03/95 716.00 Yes
314 0.15 % Ataxia 07/18/1997 08/03/95 716.00 Yes
314 0.15 % Lethargic 07/18/1997 08/03/95 716.00 Yes
324 0.15 % Thin 07/10/1997 08/03/95 708.00 No
324 0.15 % Thin 07/30/1997 08/03/95 728.00 Yes
345 0.15 % Mass Torso/Lateral, Large (16mm And Larger) 1 06/12/1997 08/03/95 680.00 No
345 0.15 % Mass Torso/Lateral, Large (16mm And Larger) 1 07/08/1997 08/03/95 706.00 Yes
352 0.30 % Thin 07/31/1997 08/03/95 729.00 Yes
358 0.30 % Ataxia 06/12/1997 08/03/95 680.00 No
358 0.30 % Lethargic 06/12/1997 08/03/95 680.00 No
359 0.30 % Mass Torso/Lateral, Medium (6mm-15mm) 1 12/24/1996 08/03/95 510.00 No
359 0.30 % Mass Head, Medium (6mm-15mm) 1 12/24/1996 08/03/95 510.00 No
359 0.30 % Eye Abnormality 01/03/1997 08/03/95 520.00 Yes
359 0.30 % Mass Head, Large (16mm And Larger) 1 01/03/1997 08/03/95 520.00 Yes
359 0.30 % Thin 01/03/1997 08/03/95 520.00 Yes
359 0.30 % Nasal/Eye Discharge 01/03/1997 08/03/95 520.00 Yes
359 0.30 % Lethargic 01/03/1997 08/03/95 520.00 Yes
359 0.30 % Abnormal Breathing 01/03/1997 08/03/95 520.00 Yes
361 0.30 % Mass Torso/Lateral, Small (1mm-5mm) 1 07/30/1997 08/03/95 728.00 Yes
366 0.30 % Thin 05/15/1997 08/03/95 652.00 No
366 0.30 % Thin 05/22/1997 08/03/95 659.00 Yes
370 0.30 % Mass Torso/Lateral, Large (16mm And Larger) 1 07/10/1997 08/03/95 708.00 No
379 0.30 % Thin 06/12/1997 08/03/95 680.00 No
379 0.30 % Thin 07/10/1997 08/03/95 708.00 No
379 0.30 % Ataxia 07/10/1997 08/03/95 708.00 No
379 0.30 % Thin 07/31/1997 08/03/95 729.00 Yes
379 0.30 % Ataxia 07/31/1997 08/03/95 729.00 Yes
379 0.30 % Paralysis 07/31/1997 08/03/95 729.00 Yes
380 0.30 % Thin 12/24/1996 08/03/95 510.00 No
380 0.30 % Thin 01/23/1997 08/03/95 540.00 No
380 0.30 % Paralysis 02/19/1997 08/03/95 567.00 Yes
380 0.30 % Thin 02/19/1997 08/03/95 567.00 Yes
385 0.30 % Mass Torso/Ventral, Small (1mm-5mm) 1 11/28/1996 08/03/95 484.00 No
390 0.30 % Mass Head, Small (1mm-5mm) 1 07/10/1997 08/03/95 708.00 No
390 0.30 % Eye Abnormality 07/10/1997 08/03/95 708.00 No
390 0.30 % Nasal/Eye Discharge 07/10/1997 08/03/95 708.00 No
390 0.30 % Mass Head, Small (1mm-5mm) 1 07/31/1997 08/03/95 729.00 Yes
390 0.30 % Eye Abnormality 07/31/1997 08/03/95 729.00 Yes
390 0.30 % Nasal/Eye Discharge 07/31/1997 08/03/95 729.00 Yes
392 0.30 % Mass Torso/Dorsal, Large (16mm And Larger) 1 06/12/1997 08/03/95 680.00 No
392 0.30 % Thin 07/07/1997 08/03/95 705.00 Yes
392 0.30 % Mass Torso/Lateral, Large (16mm And Larger) 1 07/07/1997 08/03/95 705.00 Yes
394 0.30 % Paralysis 09/05/1996 08/03/95 400.00 No
394 0.30 % Paralysis 09/06/1996 08/03/95 401.00 Yes