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Short-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Tetrachlorophthalic anhydride
CASRN: ="117-08-8"
Study Number: C61585
Exposure Route: GAVAGE
TDMS Number: 0511301
Sex: Female
Strain and Species: F 344/N Rats

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
71 Vehicle Control Opacity Right Eye 06/19/1987 06/05/87 14.00 No
71 Vehicle Control Micro-Ophthalmia 06/19/1987 06/05/87 14.00 No
71 Vehicle Control Missing Anatomy Right Eye 06/26/1987 06/05/87 21.00 No
71 Vehicle Control Missing Anatomy Right Eye 07/03/1987 06/05/87 28.00 No
71 Vehicle Control Missing Anatomy Right Eye 07/10/1987 06/05/87 35.00 No
71 Vehicle Control Missing Anatomy Right Eye 07/17/1987 06/05/87 42.00 No
71 Vehicle Control Missing Anatomy Right Eye 07/24/1987 06/05/87 49.00 No
71 Vehicle Control Missing Anatomy Right Eye 07/31/1987 06/05/87 56.00 No
71 Vehicle Control Missing Anatomy Right Eye 08/07/1987 06/05/87 63.00 No
71 Vehicle Control Missing Anatomy Right Eye 08/14/1987 06/05/87 70.00 No
71 Vehicle Control Missing Anatomy Right Eye 08/21/1987 06/05/87 77.00 No
71 Vehicle Control Missing Anatomy Right Eye 08/28/1987 06/05/87 84.00 No
71 Vehicle Control Missing Anatomy Right Eye 09/03/1987 06/05/87 90.00 No
84 94 MG/KG Reddened Eye 06/26/1987 06/05/87 21.00 No
85 94 MG/KG Micro-Ophthalmia 06/26/1987 06/05/87 21.00 No
85 94 MG/KG Micro-Ophthalmia 07/03/1987 06/05/87 28.00 No
85 94 MG/KG Opacity Right Eye 07/10/1987 06/05/87 35.00 No
85 94 MG/KG Micro-Ophthalmia 07/10/1987 06/05/87 35.00 No
85 94 MG/KG Micro-Ophthalmia 07/17/1987 06/05/87 42.00 No
85 94 MG/KG Opacity Right Eye 07/17/1987 06/05/87 42.00 No
85 94 MG/KG Opacity Right Eye 07/24/1987 06/05/87 49.00 No
85 94 MG/KG Micro-Ophthalmia 07/24/1987 06/05/87 49.00 No
85 94 MG/KG Micro-Ophthalmia 07/31/1987 06/05/87 56.00 No
85 94 MG/KG Opacity Right Eye 07/31/1987 06/05/87 56.00 No
85 94 MG/KG Micro-Ophthalmia 08/07/1987 06/05/87 63.00 No
85 94 MG/KG Opacity Right Eye 08/07/1987 06/05/87 63.00 No
85 94 MG/KG Opacity Right Eye 08/14/1987 06/05/87 70.00 No
85 94 MG/KG Micro-Ophthalmia 08/14/1987 06/05/87 70.00 No
85 94 MG/KG Micro-Ophthalmia 08/21/1987 06/05/87 77.00 No
85 94 MG/KG Opacity Right Eye 08/21/1987 06/05/87 77.00 No
85 94 MG/KG Opacity Right Eye 08/28/1987 06/05/87 84.00 No
85 94 MG/KG Micro-Ophthalmia 08/28/1987 06/05/87 84.00 No
85 94 MG/KG Micro-Ophthalmia 09/03/1987 06/05/87 90.00 No
85 94 MG/KG Opacity Right Eye 09/03/1987 06/05/87 90.00 No
85 94 MG/KG Discoloration Right Eye, Opaque 09/04/1987 06/05/87 91.00 Yes
85 94 MG/KG Urine Stain 09/04/1987 06/05/87 91.00 Yes
86 187 MG/KG Rales 08/28/1987 06/05/87 85.00 No
89 187 MG/KG Rales 08/21/1987 06/05/87 78.00 No
89 187 MG/KG Rales 09/03/1987 06/05/87 91.00 No
91 187 MG/KG Rales 08/21/1987 06/05/87 77.00 No
91 187 MG/KG Rales 09/03/1987 06/05/87 90.00 No
94 187 MG/KG Rales 08/14/1987 06/05/87 70.00 No
97 375 MG/KG Opacity Right Eye 08/28/1987 06/05/87 85.00 No
97 375 MG/KG Discoloration Right Eye, Opaque 09/03/1987 06/05/87 91.00 Yes
97 375 MG/KG Opacity Right Eye 09/03/1987 06/05/87 91.00 No
104 375 MG/KG Urine Stain 08/21/1987 06/05/87 77.00 No
105 375 MG/KG Exophthalmos 06/26/1987 06/05/87 21.00 No
105 375 MG/KG Exophthalmos 07/03/1987 06/05/87 28.00 No
107 750 MG/KG Urine Stain 07/31/1987 06/05/87 57.00 No
107 750 MG/KG Urine Stain 08/28/1987 06/05/87 85.00 No
108 750 MG/KG Urine Stain 08/21/1987 06/05/87 78.00 No
109 750 MG/KG Urine Stain 08/28/1987 06/05/87 85.00 No
110 750 MG/KG Urine Stain 07/31/1987 06/05/87 57.00 No
110 750 MG/KG Urine Stain 08/28/1987 06/05/87 85.00 No
111 750 MG/KG Urine Stain 08/07/1987 06/05/87 63.00 No
112 750 MG/KG Urine Stain 07/31/1987 06/05/87 56.00 No
112 750 MG/KG Urine Stain 08/28/1987 06/05/87 84.00 No
113 750 MG/KG Urine Stain 08/07/1987 06/05/87 63.00 No
113 750 MG/KG Urine Stain 08/21/1987 06/05/87 77.00 No
114 750 MG/KG Urine Stain 07/31/1987 06/05/87 56.00 No
114 750 MG/KG Urine Stain 08/07/1987 06/05/87 63.00 No
114 750 MG/KG Urine Stain 08/21/1987 06/05/87 77.00 No
114 750 MG/KG Urine Stain 08/28/1987 06/05/87 84.00 No
114 750 MG/KG Urine Stain 09/03/1987 06/05/87 90.00 No
116 1500 MG/KG Diarrhea 06/12/1987 06/05/87 8.00 No
116 1500 MG/KG Ruffled Fur 06/12/1987 06/05/87 8.00 No
116 1500 MG/KG Discoloration Groin, Yellow 06/26/1987 06/05/87 22.00 No
116 1500 MG/KG Discoloration Groin, Yellow 07/03/1987 06/05/87 29.00 No
116 1500 MG/KG Discoloration Groin, Yellow 07/10/1987 06/05/87 36.00 No
116 1500 MG/KG Discoloration Groin, Yellow 07/17/1987 06/05/87 43.00 No
116 1500 MG/KG Urine Stain 07/31/1987 06/05/87 57.00 No
116 1500 MG/KG Urine Stain 08/07/1987 06/05/87 64.00 No
116 1500 MG/KG Urine Stain 08/14/1987 06/05/87 71.00 No
116 1500 MG/KG Urine Stain 09/03/1987 06/05/87 91.00 No
116 1500 MG/KG Urine Stain 09/03/1987 06/05/87 91.00 Yes
117 1500 MG/KG Ruffled Fur 06/12/1987 06/05/87 8.00 No
117 1500 MG/KG Diarrhea 06/12/1987 06/05/87 8.00 No
117 1500 MG/KG Discoloration Groin, Yellow 06/26/1987 06/05/87 22.00 No
117 1500 MG/KG Missing Anatomy Right Eye 07/03/1987 06/05/87 29.00 No
117 1500 MG/KG Sore Right Eye, Yellow 07/03/1987 06/05/87 29.00 No
117 1500 MG/KG Discoloration Groin, Yellow 07/03/1987 06/05/87 29.00 No
117 1500 MG/KG Missing Anatomy Right Eye 07/10/1987 06/05/87 36.00 No
117 1500 MG/KG Sore Right Eye, Red 07/10/1987 06/05/87 36.00 No
117 1500 MG/KG Missing Anatomy Right Eye 07/17/1987 06/05/87 43.00 No
117 1500 MG/KG Discoloration Groin, Yellow 07/17/1987 06/05/87 43.00 No
117 1500 MG/KG Urine Stain 07/24/1987 06/05/87 50.00 No
117 1500 MG/KG Missing Anatomy Right Eye 07/24/1987 06/05/87 50.00 No
117 1500 MG/KG Missing Anatomy Right Eye 07/31/1987 06/05/87 57.00 No
117 1500 MG/KG Urine Stain 07/31/1987 06/05/87 57.00 No
117 1500 MG/KG Missing Anatomy Right Eye 08/07/1987 06/05/87 64.00 No
117 1500 MG/KG Urine Stain 08/07/1987 06/05/87 64.00 No
117 1500 MG/KG Rales 08/14/1987 06/05/87 71.00 No
117 1500 MG/KG Missing Anatomy Right Eye 08/14/1987 06/05/87 71.00 No
117 1500 MG/KG Missing Anatomy Right Eye 08/21/1987 06/05/87 78.00 No
117 1500 MG/KG Urine Stain 08/28/1987 06/05/87 85.00 No
117 1500 MG/KG Urine Stain 09/03/1987 06/05/87 91.00 No
117 1500 MG/KG Missing Anatomy Right Eye 09/03/1987 06/05/87 91.00 No
118 1500 MG/KG Ruffled Fur 06/12/1987 06/05/87 8.00 No
118 1500 MG/KG Diarrhea 06/12/1987 06/05/87 8.00 No
118 1500 MG/KG Discoloration Groin, Yellow 06/26/1987 06/05/87 22.00 No
118 1500 MG/KG Discoloration Groin, Yellow 07/03/1987 06/05/87 29.00 No
118 1500 MG/KG Diarrhea 07/03/1987 06/05/87 29.00 No
118 1500 MG/KG Discoloration Groin, Yellow 07/10/1987 06/05/87 36.00 No
118 1500 MG/KG Discoloration Groin, Yellow 07/17/1987 06/05/87 43.00 No
118 1500 MG/KG Urine Stain 07/31/1987 06/05/87 57.00 No
118 1500 MG/KG Urine Stain 08/07/1987 06/05/87 64.00 No
118 1500 MG/KG Urine Stain 08/14/1987 06/05/87 71.00 No
118 1500 MG/KG Urine Stain 08/21/1987 06/05/87 78.00 No
118 1500 MG/KG Urine Stain 08/28/1987 06/05/87 85.00 No
118 1500 MG/KG Urine Stain 09/03/1987 06/05/87 91.00 No
119 1500 MG/KG Ruffled Fur 06/12/1987 06/05/87 8.00 No
119 1500 MG/KG Diarrhea 06/12/1987 06/05/87 8.00 No
119 1500 MG/KG Discoloration Groin, Yellow 06/26/1987 06/05/87 22.00 No
119 1500 MG/KG Discoloration Groin, Yellow 07/03/1987 06/05/87 29.00 No
119 1500 MG/KG Discoloration Groin, Yellow 07/17/1987 06/05/87 43.00 No
119 1500 MG/KG Urine Stain 07/31/1987 06/05/87 57.00 No
119 1500 MG/KG Urine Stain 08/21/1987 06/05/87 78.00 No
119 1500 MG/KG Urine Stain 08/28/1987 06/05/87 85.00 No
119 1500 MG/KG Opacity Right Eye 09/03/1987 06/05/87 91.00 No
119 1500 MG/KG Urine Stain 09/03/1987 06/05/87 91.00 No
119 1500 MG/KG Discoloration Right Eye, Opaque 09/03/1987 06/05/87 91.00 Yes
120 1500 MG/KG Diarrhea 06/12/1987 06/05/87 8.00 No
120 1500 MG/KG Ruffled Fur 06/12/1987 06/05/87 8.00 No
120 1500 MG/KG Discoloration Groin, Yellow 06/26/1987 06/05/87 22.00 No
120 1500 MG/KG Discoloration Groin, Yellow 07/03/1987 06/05/87 29.00 No
120 1500 MG/KG Discoloration Groin, Yellow 07/17/1987 06/05/87 43.00 No
120 1500 MG/KG Urine Stain 07/31/1987 06/05/87 57.00 No
120 1500 MG/KG Urine Stain 08/14/1987 06/05/87 71.00 No
120 1500 MG/KG Urine Stain 08/21/1987 06/05/87 78.00 No
120 1500 MG/KG Urine Stain 08/28/1987 06/05/87 85.00 No
120 1500 MG/KG Urine Stain 09/03/1987 06/05/87 91.00 No
121 1500 MG/KG Ruffled Fur 06/12/1987 06/05/87 7.00 No
121 1500 MG/KG Diarrhea 06/12/1987 06/05/87 7.00 No
121 1500 MG/KG Ruffled Fur 06/26/1987 06/05/87 21.00 No
121 1500 MG/KG Discoloration Groin, Yellow 06/26/1987 06/05/87 21.00 No
121 1500 MG/KG Discoloration Groin, Yellow 07/03/1987 06/05/87 28.00 No
121 1500 MG/KG Reddened Eye 07/10/1987 06/05/87 35.00 No
121 1500 MG/KG Discoloration Groin, Yellow 07/17/1987 06/05/87 42.00 No
121 1500 MG/KG Urine Stain 08/28/1987 06/05/87 84.00 No
121 1500 MG/KG Urine Stain 09/03/1987 06/05/87 90.00 No
122 1500 MG/KG Diarrhea 06/12/1987 06/05/87 7.00 No
122 1500 MG/KG Ruffled Fur 06/12/1987 06/05/87 7.00 No
122 1500 MG/KG Discoloration Groin, Yellow 06/19/1987 06/05/87 14.00 No
122 1500 MG/KG Discoloration Groin, Yellow 06/26/1987 06/05/87 21.00 No
122 1500 MG/KG Discoloration Groin, Yellow 07/03/1987 06/05/87 28.00 No
122 1500 MG/KG Discoloration Groin, Yellow 07/10/1987 06/05/87 35.00 No
122 1500 MG/KG Missing Anatomy Left Front Leg 07/12/1987 06/05/87 37.00 Yes
123 1500 MG/KG Diarrhea 06/12/1987 06/05/87 7.00 No
123 1500 MG/KG Ruffled Fur 06/12/1987 06/05/87 7.00 No
123 1500 MG/KG Discoloration Groin, Yellow 06/19/1987 06/05/87 14.00 No
123 1500 MG/KG Colored Urine Yellow 06/19/1987 06/05/87 14.00 No
123 1500 MG/KG Discoloration Groin, Yellow 06/26/1987 06/05/87 21.00 No
123 1500 MG/KG Discoloration Groin, Yellow 07/17/1987 06/05/87 42.00 No
123 1500 MG/KG Urine Stain 08/07/1987 06/05/87 63.00 No
123 1500 MG/KG Urine Stain 08/21/1987 06/05/87 77.00 No
123 1500 MG/KG Urine Stain 08/28/1987 06/05/87 84.00 No
123 1500 MG/KG Urine Stain 09/03/1987 06/05/87 90.00 No
124 1500 MG/KG Diarrhea 06/12/1987 06/05/87 7.00 No
124 1500 MG/KG Ruffled Fur 06/12/1987 06/05/87 7.00 No
124 1500 MG/KG Discoloration Groin, Yellow 06/19/1987 06/05/87 14.00 No
124 1500 MG/KG Discoloration Groin, Yellow 06/26/1987 06/05/87 21.00 No
124 1500 MG/KG Discoloration Groin, Yellow 07/03/1987 06/05/87 28.00 No
124 1500 MG/KG Discoloration Groin, Yellow 07/10/1987 06/05/87 35.00 No
124 1500 MG/KG Discoloration Groin, Yellow 07/17/1987 06/05/87 42.00 No
124 1500 MG/KG Urine Stain 07/31/1987 06/05/87 56.00 No
124 1500 MG/KG Rales 08/14/1987 06/05/87 70.00 No
124 1500 MG/KG Urine Stain 08/14/1987 06/05/87 70.00 No
124 1500 MG/KG Urine Stain 08/28/1987 06/05/87 84.00 No
125 1500 MG/KG Diarrhea 06/12/1987 06/05/87 7.00 No
125 1500 MG/KG Ruffled Fur 06/12/1987 06/05/87 7.00 No
125 1500 MG/KG Rales 06/19/1987 06/05/87 14.00 No
125 1500 MG/KG Abnormal Posture 06/19/1987 06/05/87 14.00 No
125 1500 MG/KG Discoloration Groin, Yellow 06/26/1987 06/05/87 21.00 No
125 1500 MG/KG Discoloration Groin, Yellow 07/03/1987 06/05/87 28.00 No
125 1500 MG/KG Discoloration Groin, Yellow 07/10/1987 06/05/87 35.00 No
125 1500 MG/KG Discoloration Groin, Yellow 07/17/1987 06/05/87 42.00 No
125 1500 MG/KG Urine Stain 07/31/1987 06/05/87 56.00 No
125 1500 MG/KG Urine Stain 08/07/1987 06/05/87 63.00 No
125 1500 MG/KG Urine Stain 08/14/1987 06/05/87 70.00 No
125 1500 MG/KG Urine Stain 08/21/1987 06/05/87 77.00 No
125 1500 MG/KG Urine Stain 08/28/1987 06/05/87 84.00 No
125 1500 MG/KG Urine Stain 09/03/1987 06/05/87 90.00 No