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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: alpha-Methylstyrene
CASRN: ="98-83-9"
Study Number: C88006B
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 8800604
Sex: Female
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
101 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 05/09/2003 07/30/01 649.00 No
101 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 05/23/2003 07/30/01 663.00 No
101 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 05/30/2003 07/30/01 670.00 Yes
101 Vehicle Control Lethargic 05/30/2003 07/30/01 670.00 Yes
101 Vehicle Control Thin 05/30/2003 07/30/01 670.00 Yes
105 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/31/2003 07/30/01 732.00 Yes
106 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 08/01/2003 07/30/01 733.00 Yes
110 Vehicle Control Abnormal Breathing 04/24/2003 07/30/01 634.00 Yes
110 Vehicle Control Lethargic 04/24/2003 07/30/01 634.00 Yes
114 Vehicle Control Abnormal Breathing 06/18/2003 07/30/01 689.00 Yes
114 Vehicle Control Lethargic 06/18/2003 07/30/01 689.00 Yes
115 Vehicle Control Lethargic 12/21/2001 07/30/01 145.00 No
115 Vehicle Control Abnormal Breathing 12/21/2001 07/30/01 145.00 No
115 Vehicle Control Abnormal Breathing 12/25/2001 07/30/01 149.00 Yes
115 Vehicle Control Lethargic 12/25/2001 07/30/01 149.00 Yes
125 Vehicle Control Impaired Gait 07/04/2003 07/30/01 705.00 No
125 Vehicle Control Lethargic 07/04/2003 07/30/01 705.00 No
125 Vehicle Control Thin 07/04/2003 07/30/01 705.00 No
125 Vehicle Control Mass Torso/Lateral, Medium (6mm-15mm) 1 07/06/2003 07/30/01 707.00 Yes
125 Vehicle Control Lethargic 07/06/2003 07/30/01 707.00 Yes
125 Vehicle Control Thin 07/06/2003 07/30/01 707.00 Yes
125 Vehicle Control Impaired Gait 07/06/2003 07/30/01 707.00 Yes
127 Vehicle Control Mass Torso/Lateral, Small (1mm-5mm) 1 07/04/2003 07/30/01 705.00 No
127 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/18/2003 07/30/01 719.00 No
127 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/31/2003 07/30/01 732.00 Yes
128 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 06/20/2003 07/30/01 691.00 No
128 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 07/04/2003 07/30/01 705.00 No
128 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 07/18/2003 07/30/01 719.00 No
128 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 07/30/2003 07/30/01 731.00 Yes
134 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 06/06/2003 07/30/01 677.00 No
134 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 06/20/2003 07/30/01 691.00 No
134 Vehicle Control Mass Torso/Lateral, Large (16mm And Larger) 1 07/04/2003 07/30/01 705.00 Yes
136 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/05/2002 07/30/01 341.00 No
136 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 08/02/2002 07/30/01 369.00 No
136 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 08/30/2002 07/30/01 397.00 No
136 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 09/27/2002 07/30/01 425.00 No
136 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 10/25/2002 07/30/01 453.00 No
136 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 11/22/2002 07/30/01 481.00 No
136 Vehicle Control Thin 11/22/2002 07/30/01 481.00 No
136 Vehicle Control Mass Torso/Ventral, Large (16mm And Larger) 1 11/22/2002 07/30/01 481.00 Yes
136 Vehicle Control Thin 11/22/2002 07/30/01 481.00 Yes
138 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 07/04/2003 07/30/01 705.00 No
138 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 07/18/2003 07/30/01 719.00 No
138 Vehicle Control Mass Torso/Ventral, Medium (6mm-15mm) 1 07/24/2003 07/30/01 725.00 Yes
146 Vehicle Control Lethargic 04/23/2003 07/30/01 633.00 Yes
146 Vehicle Control Thin 04/23/2003 07/30/01 633.00 Yes
148 Vehicle Control Eye Abnormality 06/20/2003 07/30/01 691.00 No
148 Vehicle Control Mass Torso/Dorsal, Medium (6mm-15mm) 1 07/04/2003 07/30/01 705.00 No
148 Vehicle Control Eye Abnormality 07/04/2003 07/30/01 705.00 No
148 Vehicle Control Eye Abnormality 07/18/2003 07/30/01 719.00 No
148 Vehicle Control Mass Torso/Dorsal, Large (16mm And Larger) 1 07/18/2003 07/30/01 719.00 No
148 Vehicle Control Mass Torso/Dorsal, Large (16mm And Larger) 1 07/31/2003 07/30/01 732.00 Yes
148 Vehicle Control Eye Abnormality 07/31/2003 07/30/01 732.00 Yes
304 100 PPM Thin 04/12/2002 07/30/01 257.00 No
304 100 PPM Lethargic 12/20/2002 07/30/01 509.00 Yes
304 100 PPM Lethargic 12/20/2002 07/30/01 509.00 No
304 100 PPM Thin 12/20/2002 07/30/01 509.00 Yes
304 100 PPM Thin 12/20/2002 07/30/01 509.00 No
307 100 PPM Ataxia 04/24/2002 07/30/01 269.00 Yes
310 100 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 05/09/2003 07/30/01 649.00 No
310 100 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 05/23/2003 07/30/01 663.00 No
310 100 PPM Thin 05/30/2003 07/30/01 670.00 Yes
310 100 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 05/30/2003 07/30/01 670.00 Yes
311 100 PPM Mass Torso/Ventral, Small (1mm-5mm) 1 03/14/2003 07/30/01 593.00 No
311 100 PPM Mass Torso/Ventral, Large (16mm And Larger) 1 04/11/2003 07/30/01 621.00 No
311 100 PPM Mass Torso/Ventral, Large (16mm And Larger) 1 04/30/2003 07/30/01 640.00 Yes
314 100 PPM Hindlimb Splay 01/03/2003 07/30/01 523.00 Yes
316 100 PPM Eye Abnormality 11/22/2002 07/30/01 481.00 No
316 100 PPM Eye Abnormality 12/20/2002 07/30/01 509.00 No
316 100 PPM Eye Abnormality 01/17/2003 07/30/01 537.00 No
316 100 PPM Eye Abnormality 02/14/2003 07/30/01 565.00 No
316 100 PPM Eye Abnormality 03/14/2003 07/30/01 593.00 No
316 100 PPM Eye Abnormality 04/11/2003 07/30/01 621.00 No
316 100 PPM Eye Abnormality 05/09/2003 07/30/01 649.00 No
316 100 PPM Eye Abnormality 05/23/2003 07/30/01 663.00 No
316 100 PPM Eye Abnormality 06/06/2003 07/30/01 677.00 No
316 100 PPM Eye Abnormality 06/20/2003 07/30/01 691.00 No
316 100 PPM Abnormal Breathing 07/04/2003 07/30/01 705.00 No
316 100 PPM Eye Abnormality 07/04/2003 07/30/01 705.00 No
316 100 PPM Abnormal Breathing 07/04/2003 07/30/01 705.00 Yes
316 100 PPM Eye Abnormality 07/04/2003 07/30/01 705.00 Yes
324 100 PPM Mass Torso/Ventral, Small (1mm-5mm) 1 07/18/2003 07/30/01 719.00 No
324 100 PPM Mass Torso/Ventral, Small (1mm-5mm) 1 07/31/2003 07/30/01 732.00 Yes
331 100 PPM Ulcer/Abscess Torso/Dorsal 1 08/01/2003 07/30/01 733.00 Yes
333 100 PPM Thin 06/06/2003 07/30/01 677.00 No
333 100 PPM Thin 06/20/2003 07/30/01 691.00 No
333 100 PPM Thin 07/04/2003 07/30/01 705.00 No
333 100 PPM Thin 07/18/2003 07/30/01 719.00 No
333 100 PPM Abnormal Breathing 07/24/2003 07/30/01 725.00 Yes
333 100 PPM Thin 07/24/2003 07/30/01 725.00 Yes
334 100 PPM Abnormal Breathing 07/25/2003 07/30/01 726.00 Yes
334 100 PPM Thin 07/25/2003 07/30/01 726.00 Yes
342 100 PPM Thin 01/17/2003 07/30/01 537.00 No
342 100 PPM Thin 02/05/2003 07/30/01 556.00 Yes
342 100 PPM Abnormal Breathing 02/05/2003 07/30/01 556.00 Yes
510 300 PPM Lethargic 07/01/2003 07/30/01 702.00 Yes
510 300 PPM Abnormal Breathing 07/01/2003 07/30/01 702.00 Yes
516 300 PPM Abnormal Breathing 05/16/2003 07/30/01 656.00 Yes
520 300 PPM Thin 07/04/2003 07/30/01 705.00 No
520 300 PPM Abnormal Breathing 07/18/2003 07/30/01 719.00 Yes
520 300 PPM Thin 07/18/2003 07/30/01 719.00 No
520 300 PPM Thin 07/18/2003 07/30/01 719.00 Yes
525 300 PPM Thin 05/23/2003 07/30/01 663.00 Yes
525 300 PPM Thin 05/23/2003 07/30/01 663.00 No
526 300 PPM Thin 07/18/2003 07/30/01 719.00 No
526 300 PPM Thin 07/31/2003 07/30/01 732.00 Yes
532 300 PPM Thin 07/04/2003 07/30/01 705.00 Yes
532 300 PPM Thin 07/04/2003 07/30/01 705.00 No
538 300 PPM Thin 09/28/2001 07/30/01 61.00 No
538 300 PPM Thin 05/09/2003 07/30/01 649.00 No
538 300 PPM Thin 05/09/2003 07/30/01 649.00 Yes
538 300 PPM Mass Torso/Ventral, Large (16mm And Larger) 1 05/09/2003 07/30/01 649.00 Yes
538 300 PPM Mass Torso/Ventral, Large (16mm And Larger) 1 05/09/2003 07/30/01 649.00 No
539 300 PPM Abnormal Breathing 07/18/2003 07/30/01 719.00 Yes
539 300 PPM Abnormal Breathing 07/18/2003 07/30/01 719.00 No
539 300 PPM Thin 07/18/2003 07/30/01 719.00 Yes
539 300 PPM Thin 07/18/2003 07/30/01 719.00 No
539 300 PPM Lethargic 07/18/2003 07/30/01 719.00 Yes
539 300 PPM Lethargic 07/18/2003 07/30/01 719.00 No
540 300 PPM Lethargic 06/03/2002 07/30/01 309.00 Yes
540 300 PPM Abnormal Breathing 06/03/2002 07/30/01 309.00 Yes
547 300 PPM Eye Abnormality 07/04/2003 07/30/01 705.00 No
547 300 PPM Eye Abnormality 07/18/2003 07/30/01 719.00 No
547 300 PPM Eye Abnormality 07/30/2003 07/30/01 731.00 Yes
548 300 PPM Thin 05/23/2003 07/30/01 663.00 No
548 300 PPM Impaired Gait 05/30/2003 07/30/01 670.00 Yes
548 300 PPM Thin 05/30/2003 07/30/01 670.00 Yes
702 600 PPM Thin 07/08/2003 07/30/01 709.00 Yes
711 600 PPM Eye Abnormality 03/14/2003 07/30/01 593.00 No
711 600 PPM Eye Abnormality 04/11/2003 07/30/01 621.00 No
711 600 PPM Eye Abnormality 05/09/2003 07/30/01 649.00 No
711 600 PPM Eye Abnormality 05/23/2003 07/30/01 663.00 No
711 600 PPM Eye Abnormality 06/06/2003 07/30/01 677.00 No
711 600 PPM Eye Abnormality 06/20/2003 07/30/01 691.00 No
711 600 PPM Eye Abnormality 07/04/2003 07/30/01 705.00 No
711 600 PPM Eye Abnormality 07/18/2003 07/30/01 719.00 No
711 600 PPM Eye Abnormality 07/31/2003 07/30/01 732.00 Yes
712 600 PPM Thin 07/31/2003 07/30/01 732.00 Yes
713 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 06/20/2003 07/30/01 691.00 No
713 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 07/04/2003 07/30/01 705.00 No
713 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 07/11/2003 07/30/01 712.00 Yes
713 600 PPM Mass Head, Medium (6mm-15mm) 1 07/11/2003 07/30/01 712.00 Yes
713 600 PPM Thin 07/11/2003 07/30/01 712.00 Yes
723 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 07/18/2003 07/30/01 719.00 No
723 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 07/31/2003 07/30/01 732.00 Yes
727 600 PPM Abnormal Breathing 04/02/2003 07/30/01 612.00 Yes
727 600 PPM Thin 04/02/2003 07/30/01 612.00 Yes
729 600 PPM Abnormal Breathing 06/06/2003 07/30/01 677.00 No
729 600 PPM Abnormal Breathing 06/06/2003 07/30/01 677.00 Yes
734 600 PPM Lethargic 11/05/2002 07/30/01 464.00 Yes
734 600 PPM Abnormal Breathing 11/05/2002 07/30/01 464.00 Yes
737 600 PPM Thin 05/05/2003 07/30/01 645.00 Yes
737 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 05/05/2003 07/30/01 645.00 Yes
737 600 PPM Impaired Gait 05/05/2003 07/30/01 645.00 Yes
739 600 PPM Mass Torso/Lateral, Small (1mm-5mm) 1 06/06/2003 07/30/01 677.00 No
739 600 PPM Mass Torso/Ventral, Small (1mm-5mm) 1 06/20/2003 07/30/01 691.00 No
739 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 06/20/2003 07/30/01 691.00 No
739 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 06/23/2003 07/30/01 694.00 Yes
739 600 PPM Mass Torso/Ventral, Small (1mm-5mm) 1 06/23/2003 07/30/01 694.00 Yes
740 600 PPM Thin 07/31/2003 07/30/01 732.00 Yes
743 600 PPM Lethargic 06/13/2003 07/30/01 684.00 Yes
743 600 PPM Abnormal Breathing 06/13/2003 07/30/01 684.00 Yes
744 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 06/06/2003 07/30/01 677.00 No
744 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 06/20/2003 07/30/01 691.00 No
744 600 PPM Mass Torso/Lateral, Large (16mm And Larger) 1 06/23/2003 07/30/01 694.00 Yes
744 600 PPM Thin 06/23/2003 07/30/01 694.00 Yes
746 600 PPM Nasal/Eye Discharge 01/07/2003 07/30/01 527.00 Yes
746 600 PPM Lethargic 01/07/2003 07/30/01 527.00 Yes
749 600 PPM Thin 06/12/2003 07/30/01 683.00 Yes