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Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: alpha-Methylstyrene
CASRN: ="98-83-9"
Study Number: C88006B
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 8800604
Sex: Male
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
7 Vehicle Control Eye Abnormality 01/17/2003 07/30/01 537.00 No
7 Vehicle Control Eye Abnormality 02/14/2003 07/30/01 565.00 No
7 Vehicle Control Eye Abnormality 03/14/2003 07/30/01 593.00 No
7 Vehicle Control Eye Abnormality 04/11/2003 07/30/01 621.00 No
7 Vehicle Control Eye Abnormality 05/09/2003 07/30/01 649.00 No
7 Vehicle Control Eye Abnormality 05/23/2003 07/30/01 663.00 No
7 Vehicle Control Eye Abnormality 06/06/2003 07/30/01 677.00 No
7 Vehicle Control Eye Abnormality 06/20/2003 07/30/01 691.00 No
7 Vehicle Control Eye Abnormality 07/04/2003 07/30/01 705.00 No
7 Vehicle Control Eye Abnormality 07/18/2003 07/30/01 719.00 No
7 Vehicle Control Eye Abnormality 07/29/2003 07/30/01 730.00 Yes
8 Vehicle Control Thin 06/19/2003 07/30/01 690.00 Yes
13 Vehicle Control Eye Abnormality 01/17/2003 07/30/01 537.00 No
13 Vehicle Control Eye Abnormality 02/14/2003 07/30/01 565.00 No
13 Vehicle Control Eye Abnormality 03/14/2003 07/30/01 593.00 No
13 Vehicle Control Eye Abnormality 04/11/2003 07/30/01 621.00 No
13 Vehicle Control Eye Abnormality 05/09/2003 07/30/01 649.00 No
13 Vehicle Control Ulcer/Abscess Torso/Lateral 1 05/23/2003 07/30/01 663.00 No
13 Vehicle Control Eye Abnormality 05/23/2003 07/30/01 663.00 No
13 Vehicle Control Ulcer/Abscess Torso/Lateral 1 06/06/2003 07/30/01 677.00 No
13 Vehicle Control Eye Abnormality 06/06/2003 07/30/01 677.00 No
13 Vehicle Control Eye Abnormality 06/13/2003 07/30/01 684.00 Yes
13 Vehicle Control Ulcer/Abscess Torso/Lateral 1 06/13/2003 07/30/01 684.00 Yes
17 Vehicle Control Head Tilt 02/14/2003 07/30/01 565.00 No
17 Vehicle Control Head Tilt 02/28/2003 07/30/01 579.00 Yes
17 Vehicle Control Ulcer/Abscess Torso/Ventral 1 02/28/2003 07/30/01 579.00 Yes
22 Vehicle Control Eye Abnormality 09/27/2002 07/30/01 425.00 No
22 Vehicle Control Eye Abnormality 10/25/2002 07/30/01 453.00 No
22 Vehicle Control Eye Abnormality 11/22/2002 07/30/01 481.00 No
22 Vehicle Control Eye Abnormality 12/20/2002 07/30/01 509.00 No
22 Vehicle Control Eye Abnormality 01/17/2003 07/30/01 537.00 No
22 Vehicle Control Eye Abnormality 02/04/2003 07/30/01 555.00 Yes
28 Vehicle Control Eye Abnormality 11/22/2002 07/30/01 481.00 No
28 Vehicle Control Eye Abnormality 12/20/2002 07/30/01 509.00 No
28 Vehicle Control Eye Abnormality 01/17/2003 07/30/01 537.00 No
28 Vehicle Control Eye Abnormality 02/14/2003 07/30/01 565.00 No
28 Vehicle Control Eye Abnormality 03/14/2003 07/30/01 593.00 No
28 Vehicle Control Eye Abnormality 04/11/2003 07/30/01 621.00 No
28 Vehicle Control Eye Abnormality 05/09/2003 07/30/01 649.00 No
28 Vehicle Control Eye Abnormality 05/23/2003 07/30/01 663.00 No
28 Vehicle Control Eye Abnormality 06/06/2003 07/30/01 677.00 No
28 Vehicle Control Eye Abnormality 06/20/2003 07/30/01 691.00 No
28 Vehicle Control Eye Abnormality 07/04/2003 07/30/01 705.00 No
28 Vehicle Control Eye Abnormality 07/18/2003 07/30/01 719.00 No
28 Vehicle Control Eye Abnormality 07/30/2003 07/30/01 731.00 Yes
32 Vehicle Control Ulcer/Abscess Torso/Ventral 1 03/14/2003 07/30/01 593.00 No
32 Vehicle Control Ulcer/Abscess Torso/Ventral 1 04/11/2003 07/30/01 621.00 No
32 Vehicle Control Ulcer/Abscess Torso/Ventral 1 05/09/2003 07/30/01 649.00 No
32 Vehicle Control Ulcer/Abscess Torso/Ventral 1 05/19/2003 07/30/01 659.00 Yes
33 Vehicle Control Ulcer/Abscess Torso/Ventral 1 02/14/2003 07/30/01 565.00 No
33 Vehicle Control Ulcer/Abscess Torso/Ventral 1 03/14/2003 07/30/01 593.00 No
33 Vehicle Control Ulcer/Abscess Torso/Ventral 1 04/11/2003 07/30/01 621.00 No
33 Vehicle Control Ulcer/Abscess Torso/Ventral 1 05/09/2003 07/30/01 649.00 No
33 Vehicle Control Ulcer/Abscess Torso/Ventral 1 05/23/2003 07/30/01 663.00 No
33 Vehicle Control Ulcer/Abscess Torso/Ventral 1 06/06/2003 07/30/01 677.00 No
33 Vehicle Control Ulcer/Abscess Torso/Ventral 1 06/20/2003 07/30/01 691.00 No
33 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
33 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
33 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/28/2003 07/30/01 729.00 Yes
36 Vehicle Control Ulcer/Abscess Torso/Ventral 1 02/14/2003 07/30/01 565.00 No
36 Vehicle Control Lethargic 02/19/2003 07/30/01 570.00 Yes
36 Vehicle Control Ulcer/Abscess Torso/Ventral 1 02/19/2003 07/30/01 570.00 Yes
37 Vehicle Control Ulcer/Abscess Torso/Ventral 1 11/23/2001 07/30/01 117.00 No
38 Vehicle Control Eye Abnormality 05/09/2003 07/30/01 649.00 No
38 Vehicle Control Eye Abnormality 05/23/2003 07/30/01 663.00 No
38 Vehicle Control Eye Abnormality 06/06/2003 07/30/01 677.00 No
38 Vehicle Control Eye Abnormality 06/20/2003 07/30/01 691.00 No
38 Vehicle Control Eye Abnormality 07/04/2003 07/30/01 705.00 No
38 Vehicle Control Eye Abnormality 07/18/2003 07/30/01 719.00 No
38 Vehicle Control Eye Abnormality 07/29/2003 07/30/01 730.00 Yes
39 Vehicle Control Ulcer/Abscess Torso/Ventral 1 06/20/2003 07/30/01 691.00 No
39 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
39 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
39 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/29/2003 07/30/01 730.00 Yes
42 Vehicle Control Ulcer/Abscess Torso/Ventral 1 05/09/2003 07/30/01 649.00 No
42 Vehicle Control Ulcer/Abscess Torso/Ventral 1 05/23/2003 07/30/01 663.00 No
42 Vehicle Control Ulcer/Abscess Torso/Ventral 1 06/06/2003 07/30/01 677.00 No
42 Vehicle Control Ulcer/Abscess Torso/Ventral 1 06/20/2003 07/30/01 691.00 No
42 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
42 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
42 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/29/2003 07/30/01 730.00 Yes
43 Vehicle Control Ulcer/Abscess Torso/Ventral 1 06/06/2003 07/30/01 677.00 No
43 Vehicle Control Ulcer/Abscess Torso/Ventral 1 06/20/2003 07/30/01 691.00 No
43 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
43 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
43 Vehicle Control Ulcer/Abscess Torso/Ventral 1 07/23/2003 07/30/01 724.00 Yes
44 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 12/20/2002 07/30/01 509.00 No
44 Vehicle Control Mass Torso/Ventral, Small (1mm-5mm) 1 01/17/2003 07/30/01 537.00 No
44 Vehicle Control Thin 07/09/2003 07/30/01 710.00 Yes
46 Vehicle Control Ulcer/Abscess Torso/Ventral 1 11/22/2002 07/30/01 481.00 No
46 Vehicle Control Ulcer/Abscess Torso/Ventral 1 11/27/2002 07/30/01 486.00 Yes
46 Vehicle Control Lethargic 11/27/2002 07/30/01 486.00 Yes
49 Vehicle Control Ulcer/Abscess Torso/Ventral 1 02/14/2003 07/30/01 565.00 No
49 Vehicle Control Ulcer/Abscess Torso/Ventral 1 03/14/2003 07/30/01 593.00 No
49 Vehicle Control Ulcer/Abscess Torso/Ventral 1 04/11/2003 07/30/01 621.00 No
49 Vehicle Control Ulcer/Abscess Torso/Ventral 1 04/25/2003 07/30/01 635.00 Yes
204 100 PPM Thin 07/05/2002 07/30/01 341.00 No
204 100 PPM Nasal/Eye Discharge 07/12/2002 07/30/01 348.00 Yes
204 100 PPM Abnormal Breathing 07/12/2002 07/30/01 348.00 Yes
204 100 PPM Lethargic 07/12/2002 07/30/01 348.00 Yes
207 100 PPM Abnormal Breathing 08/31/2001 07/30/01 33.00 No
207 100 PPM Thin 11/22/2002 07/30/01 481.00 No
207 100 PPM Abnormal Breathing 11/22/2002 07/30/01 481.00 No
207 100 PPM Abnormal Breathing 11/22/2002 07/30/01 481.00 Yes
207 100 PPM Thin 11/22/2002 07/30/01 481.00 Yes
209 100 PPM Lethargic 07/09/2003 07/30/01 710.00 Yes
218 100 PPM Mass Torso/Dorsal, Medium (6mm-15mm) 1 07/04/2003 07/30/01 705.00 No
218 100 PPM Mass Torso/Dorsal, Medium (6mm-15mm) 1 07/18/2003 07/30/01 719.00 No
230 100 PPM Lethargic 07/09/2002 07/30/01 345.00 Yes
237 100 PPM Ulcer/Abscess Torso/Ventral 1 04/11/2003 07/30/01 621.00 No
237 100 PPM Ulcer/Abscess Torso/Ventral 1 05/09/2003 07/30/01 649.00 No
237 100 PPM Ulcer/Abscess Torso/Ventral 1 05/23/2003 07/30/01 663.00 No
237 100 PPM Ulcer/Abscess Torso/Ventral 1 06/06/2003 07/30/01 677.00 No
237 100 PPM Ulcer/Abscess Torso/Ventral 1 06/20/2003 07/30/01 691.00 No
237 100 PPM Abnormal Breathing 07/04/2003 07/30/01 705.00 No
237 100 PPM Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
237 100 PPM Thin 07/04/2003 07/30/01 705.00 No
237 100 PPM Ulcer/Abscess Torso/Ventral 1 07/10/2003 07/30/01 711.00 Yes
237 100 PPM Thin 07/10/2003 07/30/01 711.00 Yes
239 100 PPM Abnormal Breathing 06/04/2003 07/30/01 675.00 Yes
242 100 PPM Abnormal Breathing 01/12/2003 07/30/01 532.00 Yes
242 100 PPM Lethargic 01/12/2003 07/30/01 532.00 Yes
243 100 PPM Ulcer/Abscess Torso/Lateral 1 07/18/2003 07/30/01 719.00 No
243 100 PPM Ulcer/Abscess Torso/Lateral 1 07/29/2003 07/30/01 730.00 Yes
243 100 PPM Thin 07/29/2003 07/30/01 730.00 Yes
246 100 PPM Ulcer/Abscess Torso/Ventral 1 06/20/2003 07/30/01 691.00 No
246 100 PPM Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
246 100 PPM Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
246 100 PPM Ulcer/Abscess Torso/Ventral 1 07/28/2003 07/30/01 729.00 Yes
247 100 PPM Lethargic 07/25/2003 07/30/01 726.00 Yes
247 100 PPM Thin 07/25/2003 07/30/01 726.00 Yes
247 100 PPM Abnormal Breathing 07/25/2003 07/30/01 726.00 Yes
248 100 PPM Abnormal Breathing 07/29/2003 07/30/01 730.00 Yes
248 100 PPM Thin 07/29/2003 07/30/01 730.00 Yes
249 100 PPM Lethargic 07/27/2003 07/30/01 728.00 Yes
404 300 PPM Abnormal Breathing 03/29/2003 07/30/01 608.00 Yes
404 300 PPM Lethargic 03/29/2003 07/30/01 608.00 Yes
410 300 PPM Eye Abnormality 07/04/2003 07/30/01 705.00 No
410 300 PPM Eye Abnormality 07/18/2003 07/30/01 719.00 No
410 300 PPM Eye Abnormality 07/29/2003 07/30/01 730.00 Yes
419 300 PPM Eye Abnormality 06/06/2003 07/30/01 677.00 No
419 300 PPM Eye Abnormality 06/20/2003 07/30/01 691.00 No
419 300 PPM Eye Abnormality 07/04/2003 07/30/01 705.00 No
419 300 PPM Ulcer/Abscess Torso/Dorsal 2 07/18/2003 07/30/01 719.00 No
419 300 PPM Eye Abnormality 07/18/2003 07/30/01 719.00 No
419 300 PPM Ulcer/Abscess Torso/Dorsal 1 07/29/2003 07/30/01 730.00 Yes
419 300 PPM Ulcer/Abscess Torso/Lateral 1 07/29/2003 07/30/01 730.00 Yes
419 300 PPM Eye Abnormality 07/29/2003 07/30/01 730.00 Yes
420 300 PPM Thin 06/27/2003 07/30/01 698.00 Yes
420 300 PPM Abnormal Breathing 06/27/2003 07/30/01 698.00 Yes
423 300 PPM Ulcer/Abscess Torso/Ventral 1 07/05/2002 07/30/01 341.00 No
423 300 PPM Ulcer/Abscess Torso/Ventral 1 04/11/2003 07/30/01 621.00 No
423 300 PPM Ulcer/Abscess Torso/Ventral 1 05/09/2003 07/30/01 649.00 No
423 300 PPM Ulcer/Abscess Torso/Ventral 1 05/23/2003 07/30/01 663.00 No
423 300 PPM Ulcer/Abscess Torso/Ventral 1 06/06/2003 07/30/01 677.00 No
423 300 PPM Ulcer/Abscess Torso/Ventral 1 06/20/2003 07/30/01 691.00 No
423 300 PPM Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
423 300 PPM Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
423 300 PPM Ulcer/Abscess Torso/Ventral 1 07/29/2003 07/30/01 730.00 Yes
426 300 PPM Lethargic 07/09/2003 07/30/01 710.00 Yes
427 300 PPM Abnormal Breathing 07/27/2003 07/30/01 728.00 Yes
427 300 PPM Lethargic 07/27/2003 07/30/01 728.00 Yes
427 300 PPM Ulcer/Abscess Torso/Dorsal 1 07/27/2003 07/30/01 728.00 Yes
429 300 PPM Abnormal Breathing 06/27/2003 07/30/01 698.00 Yes
429 300 PPM Thin 06/27/2003 07/30/01 698.00 Yes
438 300 PPM Ulcer/Abscess Torso/Ventral 1 05/09/2003 07/30/01 649.00 No
438 300 PPM Ulcer/Abscess Torso/Ventral 1 05/23/2003 07/30/01 663.00 No
438 300 PPM Ulcer/Abscess Torso/Ventral 1 06/06/2003 07/30/01 677.00 No
438 300 PPM Ulcer/Abscess Torso/Ventral 1 06/20/2003 07/30/01 691.00 No
438 300 PPM Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
438 300 PPM Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
438 300 PPM Ulcer/Abscess Torso/Ventral 1 07/29/2003 07/30/01 730.00 Yes
440 300 PPM Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
440 300 PPM Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
440 300 PPM Ulcer/Abscess Torso/Ventral 1 07/25/2003 07/30/01 726.00 Yes
440 300 PPM Thin 07/25/2003 07/30/01 726.00 Yes
440 300 PPM Lethargic 07/25/2003 07/30/01 726.00 Yes
450 300 PPM Thin 02/14/2003 07/30/01 565.00 Yes
450 300 PPM Abnormal Breathing 02/14/2003 07/30/01 565.00 Yes
450 300 PPM Lethargic 02/14/2003 07/30/01 565.00 Yes
450 300 PPM Thin 02/14/2003 07/30/01 565.00 No
450 300 PPM Abnormal Breathing 02/14/2003 07/30/01 565.00 No
450 300 PPM Lethargic 02/14/2003 07/30/01 565.00 No
605 600 PPM Abnormal Breathing 06/21/2002 07/30/01 327.00 Yes
605 600 PPM Lethargic 06/21/2002 07/30/01 327.00 Yes
606 600 PPM Eye Abnormality 03/14/2003 07/30/01 593.00 No
606 600 PPM Eye Abnormality 04/11/2003 07/30/01 621.00 No
606 600 PPM Eye Abnormality 05/09/2003 07/30/01 649.00 No
606 600 PPM Eye Abnormality 05/23/2003 07/30/01 663.00 No
606 600 PPM Eye Abnormality 06/06/2003 07/30/01 677.00 No
606 600 PPM Eye Abnormality 06/20/2003 07/30/01 691.00 No
606 600 PPM Eye Abnormality 07/04/2003 07/30/01 705.00 No
606 600 PPM Eye Abnormality 07/18/2003 07/30/01 719.00 No
606 600 PPM Eye Abnormality 07/28/2003 07/30/01 729.00 Yes
607 600 PPM Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
607 600 PPM Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
607 600 PPM Ulcer/Abscess Torso/Ventral 1 07/28/2003 07/30/01 729.00 Yes
611 600 PPM Lethargic 02/17/2003 07/30/01 568.00 Yes
616 600 PPM Ulcer/Abscess Torso/Ventral 1 09/27/2002 07/30/01 425.00 No
616 600 PPM Ulcer/Abscess Torso/Ventral 1 10/25/2002 07/30/01 453.00 No
616 600 PPM Ulcer/Abscess Torso/Ventral 1 11/22/2002 07/30/01 481.00 No
619 600 PPM Lethargic 11/01/2002 07/30/01 460.00 Yes
619 600 PPM Abnormal Breathing 11/01/2002 07/30/01 460.00 Yes
621 600 PPM Thin 01/02/2003 07/30/01 522.00 Yes
623 600 PPM Thin 09/27/2002 07/30/01 425.00 No
623 600 PPM Thin 10/25/2002 07/30/01 453.00 No
624 600 PPM Lethargic 10/04/2002 07/30/01 432.00 Yes
626 600 PPM Lethargic 10/01/2002 07/30/01 429.00 Yes
626 600 PPM Abnormal Breathing 10/01/2002 07/30/01 429.00 Yes
628 600 PPM Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
628 600 PPM Ulcer/Abscess Torso/Ventral 1 07/28/2003 07/30/01 729.00 Yes
634 600 PPM Ulcer/Abscess Torso/Ventral 1 06/20/2003 07/30/01 691.00 No
634 600 PPM Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
634 600 PPM Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 11/22/2002 07/30/01 481.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 12/20/2002 07/30/01 509.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 01/17/2003 07/30/01 537.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 02/14/2003 07/30/01 565.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 03/14/2003 07/30/01 593.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 04/11/2003 07/30/01 621.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 05/09/2003 07/30/01 649.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 05/23/2003 07/30/01 663.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 06/06/2003 07/30/01 677.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 06/20/2003 07/30/01 691.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 07/04/2003 07/30/01 705.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 07/18/2003 07/30/01 719.00 No
635 600 PPM Ulcer/Abscess Torso/Ventral 1 07/28/2003 07/30/01 729.00 Yes
643 600 PPM Thin 01/17/2003 07/30/01 537.00 No
643 600 PPM Thin 01/17/2003 07/30/01 537.00 Yes
643 600 PPM Abnormal Breathing 01/17/2003 07/30/01 537.00 Yes
643 600 PPM Abnormal Breathing 01/17/2003 07/30/01 537.00 No
645 600 PPM Ulcer/Abscess Torso/Ventral 1 09/27/2002 07/30/01 425.00 No
645 600 PPM Abnormal Breathing 03/30/2003 07/30/01 609.00 Yes
645 600 PPM Lethargic 03/30/2003 07/30/01 609.00 Yes
647 600 PPM Abnormal Breathing 07/04/2003 07/30/01 705.00 No
647 600 PPM Abnormal Breathing 07/04/2003 07/30/01 705.00 Yes
650 600 PPM Ulcer/Abscess Torso/Ventral 1 11/22/2002 07/30/01 481.00 No
650 600 PPM Ulcer/Abscess Torso/Ventral 1 12/20/2002 07/30/01 509.00 No
650 600 PPM Ulcer/Abscess Torso/Ventral 1 01/17/2003 07/30/01 537.00 No
650 600 PPM Ulcer/Abscess Torso/Ventral 1 02/14/2003 07/30/01 565.00 No