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Short-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: alpha/beta Thujone mixture
CASRN: ="76231-76-0"
Study Number: C99037B
Exposure Route: GAVAGE
TDMS Number: 9903703
Sex: Female
Strain and Species: F 344/N Rats

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
66 Vehicle Control Eye Abnormality 08/22/2002 08/12/02 11.00 No
66 Vehicle Control Eye Abnormality 08/29/2002 08/12/02 18.00 No
66 Vehicle Control Eye Abnormality 09/05/2002 08/12/02 25.00 No
66 Vehicle Control Eye Abnormality 09/12/2002 08/12/02 32.00 No
66 Vehicle Control Eye Abnormality 09/19/2002 08/12/02 39.00 No
66 Vehicle Control Head Tilt 10/03/2002 08/12/02 53.00 No
66 Vehicle Control Eye Abnormality 10/03/2002 08/12/02 53.00 No
66 Vehicle Control Head Tilt 10/10/2002 08/12/02 60.00 No
66 Vehicle Control Eye Abnormality 10/10/2002 08/12/02 60.00 No
66 Vehicle Control Eye Abnormality 10/17/2002 08/12/02 67.00 No
66 Vehicle Control Head Tilt 10/17/2002 08/12/02 67.00 No
66 Vehicle Control Eye Abnormality 10/24/2002 08/12/02 74.00 No
66 Vehicle Control Head Tilt 10/24/2002 08/12/02 74.00 No
66 Vehicle Control Head Tilt 10/31/2002 08/12/02 81.00 No
66 Vehicle Control Eye Abnormality 10/31/2002 08/12/02 81.00 No
66 Vehicle Control Eye Abnormality 11/07/2002 08/12/02 88.00 No
66 Vehicle Control Head Tilt 11/07/2002 08/12/02 88.00 No
66 Vehicle Control Head Tilt 11/12/2002 08/12/02 93.00 Yes
66 Vehicle Control Eye Abnormality 11/12/2002 08/12/02 93.00 Yes
83 25 MG/KG Tonic Seizures 10/10/2002 08/12/02 60.00 No
88 25 MG/KG Abnormal Breathing 10/24/2002 08/12/02 74.00 No
90 25 MG/KG Eye Abnormality 11/12/2002 08/12/02 93.00 Yes
91 50 MG/KG Clonic Seizures 09/27/2002 08/12/02 47.00 No
91 50 MG/KG Clonic Seizures 09/30/2002 08/12/02 50.00 No
91 50 MG/KG Clonic Seizures 10/11/2002 08/12/02 61.00 No
91 50 MG/KG Clonic Seizures 10/22/2002 08/12/02 72.00 No
91 50 MG/KG Clonic Seizures 10/24/2002 08/12/02 74.00 No
91 50 MG/KG Clonic Seizures 11/01/2002 08/12/02 82.00 No
91 50 MG/KG Clonic Seizures 11/04/2002 08/12/02 85.00 No
92 50 MG/KG Clonic Seizures 10/01/2002 08/12/02 51.00 No
92 50 MG/KG Clonic Seizures 10/24/2002 08/12/02 74.00 No
92 50 MG/KG Tonic Seizures 10/30/2002 08/12/02 80.00 No
92 50 MG/KG Tonic Seizures 11/08/2002 08/12/02 89.00 No
94 50 MG/KG Tonic Seizures 10/22/2002 08/12/02 72.00 No
94 50 MG/KG Clonic Seizures 11/04/2002 08/12/02 85.00 No
94 50 MG/KG Clonic Seizures 11/07/2002 08/12/02 88.00 No
96 50 MG/KG Tonic Seizures 10/15/2002 08/12/02 65.00 No
96 50 MG/KG Ruffled Fur 10/31/2002 08/12/02 81.00 No
96 50 MG/KG Nasal/Eye Discharge 10/31/2002 08/12/02 81.00 No
97 50 MG/KG Ruffled Fur 10/31/2002 08/12/02 81.00 No
97 50 MG/KG Clonic Seizures 11/07/2002 08/12/02 88.00 No
98 50 MG/KG Tonic Seizures 10/15/2002 08/12/02 65.00 No
99 50 MG/KG Clonic Seizures 10/03/2002 08/12/02 53.00 No
99 50 MG/KG Tonic Seizures 10/15/2002 08/12/02 65.00 No
99 50 MG/KG Ulcer/Abscess Appendage 1 10/24/2002 08/12/02 74.00 No
99 50 MG/KG Clonic Seizures 10/30/2002 08/12/02 80.00 No
99 50 MG/KG Ulcer/Abscess Appendage 1 10/31/2002 08/12/02 81.00 No
100 50 MG/KG Eye Abnormality 09/12/2002 08/12/02 32.00 No
100 50 MG/KG Eye Abnormality 09/19/2002 08/12/02 39.00 No
100 50 MG/KG Clonic Seizures 09/24/2002 08/12/02 44.00 No
100 50 MG/KG Eye Abnormality 09/26/2002 08/12/02 46.00 No
100 50 MG/KG Eye Abnormality 10/03/2002 08/12/02 53.00 No
100 50 MG/KG Eye Abnormality 10/10/2002 08/12/02 60.00 No
100 50 MG/KG Tonic Seizures 10/14/2002 08/12/02 64.00 No
100 50 MG/KG Eye Abnormality 10/17/2002 08/12/02 67.00 No
100 50 MG/KG Eye Abnormality 10/24/2002 08/12/02 74.00 No
100 50 MG/KG Eye Abnormality 10/31/2002 08/12/02 81.00 No
100 50 MG/KG Eye Abnormality 11/07/2002 08/12/02 88.00 No
100 50 MG/KG Eye Abnormality 11/12/2002 08/12/02 93.00 Yes
101 75 MG/KG Clonic Seizures 09/10/2002 08/12/02 30.00 No
101 75 MG/KG Clonic Seizures 09/23/2002 08/12/02 43.00 No
102 75 MG/KG Clonic Seizures 09/10/2002 08/12/02 30.00 No
102 75 MG/KG Clonic Seizures 09/16/2002 08/12/02 36.00 No
102 75 MG/KG Clonic Seizures 09/17/2002 08/12/02 37.00 No
102 75 MG/KG Clonic Seizures 09/23/2002 08/12/02 43.00 No
102 75 MG/KG Clonic Seizures 10/07/2002 08/12/02 57.00 No
103 75 MG/KG Tonic Seizures 10/14/2002 08/12/02 64.00 No
104 75 MG/KG Clonic Seizures 09/16/2002 08/12/02 36.00 No
104 75 MG/KG Clonic Seizures 09/30/2002 08/12/02 50.00 No
104 75 MG/KG Clonic Seizures 10/10/2002 08/12/02 60.00 No
104 75 MG/KG Clonic Seizures 10/18/2002 08/12/02 68.00 No
104 75 MG/KG Clonic Seizures 10/22/2002 08/12/02 72.00 No
104 75 MG/KG Clonic Seizures 10/25/2002 08/12/02 75.00 No
104 75 MG/KG Excitability 10/31/2002 08/12/02 81.00 No
104 75 MG/KG Clonic Seizures 10/31/2002 08/12/02 81.00 No
104 75 MG/KG Clonic Seizures 11/07/2002 08/12/02 88.00 No
104 75 MG/KG Excitability 11/07/2002 08/12/02 88.00 No
105 75 MG/KG Clonic Seizures 09/16/2002 08/12/02 36.00 No
105 75 MG/KG Clonic Seizures 09/23/2002 08/12/02 43.00 No
105 75 MG/KG Clonic Seizures 10/07/2002 08/12/02 57.00 No
105 75 MG/KG Clonic Seizures 10/08/2002 08/12/02 58.00 No
106 75 MG/KG Clonic Seizures 09/10/2002 08/12/02 30.00 No
106 75 MG/KG Clonic Seizures 09/17/2002 08/12/02 37.00 No
106 75 MG/KG Clonic Seizures 09/23/2002 08/12/02 43.00 No
106 75 MG/KG Tonic Seizures 09/24/2002 08/12/02 44.00 No
107 75 MG/KG Clonic Seizures 09/17/2002 08/12/02 37.00 No
107 75 MG/KG Clonic Seizures 09/24/2002 08/12/02 44.00 No
107 75 MG/KG Clonic Seizures 10/01/2002 08/12/02 51.00 No
107 75 MG/KG Clonic Seizures 10/03/2002 08/12/02 53.00 No
107 75 MG/KG Clonic Seizures 10/14/2002 08/12/02 64.00 No
107 75 MG/KG Clonic Seizures 10/16/2002 08/12/02 66.00 No
107 75 MG/KG Clonic Seizures 10/21/2002 08/12/02 71.00 No
107 75 MG/KG Clonic Seizures 10/25/2002 08/12/02 75.00 No
107 75 MG/KG Clonic Seizures 10/28/2002 08/12/02 78.00 No
107 75 MG/KG Clonic Seizures 11/06/2002 08/12/02 87.00 No
107 75 MG/KG Clonic Seizures 11/08/2002 08/12/02 89.00 No
108 75 MG/KG Clonic Seizures 09/13/2002 08/12/02 33.00 No
108 75 MG/KG Clonic Seizures 09/23/2002 08/12/02 43.00 No
109 75 MG/KG Clonic Seizures 09/13/2002 08/12/02 33.00 No
109 75 MG/KG Clonic Seizures 09/23/2002 08/12/02 43.00 No
109 75 MG/KG Clonic Seizures 09/30/2002 08/12/02 50.00 No
109 75 MG/KG Tonic Seizures 10/15/2002 08/12/02 65.00 No
109 75 MG/KG Tonic Seizures 10/22/2002 08/12/02 72.00 No
109 75 MG/KG Clonic Seizures 11/04/2002 08/12/02 85.00 No
109 75 MG/KG Clonic Seizures 11/05/2002 08/12/02 86.00 No
110 75 MG/KG Clonic Seizures 09/10/2002 08/12/02 30.00 No
110 75 MG/KG Clonic Seizures 09/19/2002 08/12/02 39.00 No
110 75 MG/KG Clonic Seizures 09/23/2002 08/12/02 43.00 No
111 100 MG/KG Clonic Seizures 09/13/2002 08/12/02 33.00 No
111 100 MG/KG Clonic Seizures 09/19/2002 08/12/02 39.00 No
111 100 MG/KG Lethargic 09/19/2002 08/12/02 39.00 No
111 100 MG/KG Clonic Seizures 09/24/2002 08/12/02 44.00 No
111 100 MG/KG Clonic Seizures 10/01/2002 08/12/02 51.00 No
111 100 MG/KG Clonic Seizures 10/07/2002 08/12/02 57.00 No
111 100 MG/KG Clonic Seizures 10/22/2002 08/12/02 72.00 No
111 100 MG/KG Clonic Seizures 10/29/2002 08/12/02 79.00 No
111 100 MG/KG Clonic Seizures 10/31/2002 08/12/02 81.00 No
111 100 MG/KG Ruffled Fur 10/31/2002 08/12/02 81.00 No
111 100 MG/KG Clonic Seizures 11/06/2002 08/12/02 87.00 No
112 100 MG/KG Clonic Seizures 09/13/2002 08/12/02 33.00 No
112 100 MG/KG Clonic Seizures 09/19/2002 08/12/02 39.00 No
112 100 MG/KG Clonic Seizures 09/30/2002 08/12/02 50.00 No
112 100 MG/KG Clonic Seizures 10/08/2002 08/12/02 58.00 No
112 100 MG/KG Clonic Seizures 10/11/2002 08/12/02 61.00 No
112 100 MG/KG Clonic Seizures 10/17/2002 08/12/02 67.00 No
112 100 MG/KG Clonic Seizures 10/23/2002 08/12/02 73.00 No
112 100 MG/KG Clonic Seizures 10/28/2002 08/12/02 78.00 No
112 100 MG/KG Clonic Seizures 11/04/2002 08/12/02 85.00 No
112 100 MG/KG Ruffled Fur 11/07/2002 08/12/02 88.00 No
113 100 MG/KG Clonic Seizures 09/09/2002 08/12/02 29.00 No
113 100 MG/KG Clonic Seizures 09/11/2002 08/12/02 31.00 No
113 100 MG/KG Clonic Seizures 09/13/2002 08/12/02 33.00 No
113 100 MG/KG Clonic Seizures 09/24/2002 08/12/02 44.00 No
113 100 MG/KG Clonic Seizures 10/14/2002 08/12/02 64.00 No
113 100 MG/KG Clonic Seizures 10/18/2002 08/12/02 68.00 No
113 100 MG/KG Tonic Seizures 10/28/2002 08/12/02 78.00 No
114 100 MG/KG Clonic Seizures 09/10/2002 08/12/02 30.00 No
114 100 MG/KG Clonic Seizures 09/16/2002 08/12/02 36.00 No
114 100 MG/KG Clonic Seizures 09/17/2002 08/12/02 37.00 No
114 100 MG/KG Clonic Seizures 09/20/2002 08/12/02 40.00 No
114 100 MG/KG Clonic Seizures 09/24/2002 08/12/02 44.00 No
114 100 MG/KG Clonic Seizures 09/30/2002 08/12/02 50.00 No
114 100 MG/KG Clonic Seizures 10/08/2002 08/12/02 58.00 No
114 100 MG/KG Clonic Seizures 10/11/2002 08/12/02 61.00 No
114 100 MG/KG Tonic Seizures 10/22/2002 08/12/02 72.00 No
114 100 MG/KG Clonic Seizures 10/29/2002 08/12/02 79.00 No
114 100 MG/KG Clonic Seizures 11/04/2002 08/12/02 85.00 No
114 100 MG/KG Clonic Seizures 11/05/2002 08/12/02 86.00 No
115 100 MG/KG Clonic Seizures 09/10/2002 08/12/02 30.00 No
115 100 MG/KG Clonic Seizures 09/16/2002 08/12/02 36.00 No
115 100 MG/KG Clonic Seizures 09/17/2002 08/12/02 37.00 No
116 100 MG/KG Clonic Seizures 09/11/2002 08/12/02 31.00 No
116 100 MG/KG Clonic Seizures 09/16/2002 08/12/02 36.00 No
117 100 MG/KG Clonic Seizures 09/09/2002 08/12/02 29.00 No
117 100 MG/KG Clonic Seizures 09/16/2002 08/12/02 36.00 No
117 100 MG/KG Clonic Seizures 09/17/2002 08/12/02 37.00 No
118 100 MG/KG Clonic Seizures 09/09/2002 08/12/02 29.00 No
119 100 MG/KG Clonic Seizures 09/09/2002 08/12/02 29.00 No
119 100 MG/KG Clonic Seizures 09/17/2002 08/12/02 37.00 No
119 100 MG/KG Clonic Seizures 09/27/2002 08/12/02 47.00 No
119 100 MG/KG Excitability 10/10/2002 08/12/02 60.00 No
119 100 MG/KG Tonic Seizures 10/10/2002 08/12/02 60.00 No
119 100 MG/KG Clonic Seizures 10/14/2002 08/12/02 64.00 No
119 100 MG/KG Ruffled Fur 10/17/2002 08/12/02 67.00 No
119 100 MG/KG Tonic Seizures 10/23/2002 08/12/02 73.00 No
119 100 MG/KG Clonic Seizures 10/30/2002 08/12/02 80.00 No
119 100 MG/KG Clonic Seizures 10/31/2002 08/12/02 81.00 No