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Chemical Properties

CAS Registry Number: 1319-77-3

Selected information from two of the National Library of Medicine's databases: ChemIDPlus2 and HSDB3.

Names 1

  • Cresol
  • Cresols (Mixed Isomers Of Ortho, Meta, Para)
  • Cryslol
  • Hydroxytoluene
  • Meta/Para-Cresol
  • Methylphenol (9ci)
  • Tricresol


Chemical Structure for Chemical Abstracts Service Registry Number 1319-77-3 from NLM

Synonyms (Sources: NTP,HSDB,RTECS,MESH)2

  • 4-06-00-02035 (Beilstein Handbook Reference)
  • Acede cresylique [French]
  • Acide cresylique [French]
  • BRN 0506719
  • Bacillol
  • Cresoli [Italian]
  • Cresolum crudum
  • Cresylic acid
  • HSDB 250
  • Hydroxymethylbenzene
  • Hydroxytoluole [German]
  • Kresole [German]
  • Kresolen [Dutch]
  • Kresolum venale
  • Krezol [Polish]
  • Methyl phenol
  • Methylphenol
  • Phenol, methyl-
  • RCRA waste number U052
  • Tekresol
  • Tricresol
  • Tricresolum
  • Trikresolum
  • ar-Toluenol

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Other Registry Numbers2

  • 116804-25-2
  • 52037-47-5
  • 8003-33-6
  • 8006-62-0
  • 8026-94-6
  • 8027-16-5

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Chemical Properties3

Property Description
Boiling Point
  • 191-203 deg C
  • Colorless, yellowish, brownish-yellow or pinkish liquid
  • None Found
Critical Temperature & Pressure
  • Critical temperature: 424.4-432.6 deg C; 4.56-5.15 mPa /individual isomers/
Density/Specific Gravity
  • 1.030-1.038 at 25 deg C/25 deg C
Dissociation Constants
  • The pKa for the cresol isomers range from approximately 10.1 to 10.3.
Heat Of Combustion
  • -3696 to -3706 kJ/mol at 25 deg C /individual isomers/
Heat Of Vaporization
  • 45.222 to 47.581 kJ/mol at the boiling point /individual isomers/
Melting Point
  • 11-35 deg C
Molecular Weight
  • 108.14
  • Phenolic odor
  • Sweet, tarry
Other Chemical/Physical Properties
  • A solution in water is neutral to bromocresol purple; not less than 90% by volume
  • Wt/gal = 8.66-8.68 lb
Relative Evaporation Rate
  • None Found
  • Miscible with alcohol, benzene, ether, glycerol, petroleum ether; also soluble in solutions of fixed alkali hydroxides
  • Soluble in about 50 parts water
  • Soluble in vegetable oils
Spectral Properties
  • ... In the direct-reading infrared analyzers, cresol reportedly absorbs at the 8.6 um wavelength, with a sensitivity of 0.3 ppm.
  • Index of refraction: 1.5312 to 1.5401 at 20-35 deg C /individual isomers/
Surface Tension
  • 33.4-34.4 mN/m at 50 deg C /individual isomers/
  • Pungent
Vapor Density
  • 3.72 (Air = 1)
Vapor Pressure
  • 0.11 to 0.299 mm Hg at 25 deg C
  • Varies from 4.49 to 7.0 cP at 40 deg C depending on isomer
log P (octanol-water)
  • The log octanol-water partition coefficients of the cresol isomers range from 1.94-1.96.
  • Saturated solutions are neutral or slightly acid to litmus

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  • ... Used in ore flotation and fiber treatment, as metal degreasing and cutting oils, as extracting solvents, and as agents for removing carbonization deposits from internal combustion engines. **PEER REVIEWED**
  • ...In photographic developers, and in explosives. **PEER REVIEWED**
  • Crude cresols are used as wood preservatives. ...Cresol mixtures condensed with formaldehyde are important for modifying phenolic resins. However, the m-isomer content is critical to the mixture because m-cresol is the most reactive of the three isomers. Cresols are also used in paints and textiles. Mixtures of cresols are used as solvents for synthetic resin coatings such as wire enamels, metal degreasers, cutting oils, and agents to remove carbon deposits from combustion engines. Other uses of cresol mixtures include ore flotation and fiber treatment. **PEER REVIEWED**
  • Disinfectant, phenolic resins, tricresyl phosphate, ore flotation, textile scouring agent, organic intermediate, manufacture of salicylaldehyde, coumarin, and herbicides, surfactant, synthetic food flavors (para isomer only). **PEER REVIEWED**
  • For cresol (USEPA/OPP Pesticide Code: 022101) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ **PEER REVIEWED**
  • For making synthetic resins; in disinfectants and fumigants; as industrial solvent. **PEER REVIEWED**
  • Inert pesticide ingredient, Approved for Nonfood Use Only **PEER REVIEWED**
  • Mixtures of cresols are used as solvents for synthetic paints and textiles for ore flotation and in fiber treatment. They are also used as intermediates for the production of resins, antioxidants and fire retardant plasticizers for PVCs. **PEER REVIEWED**
  • The active ingredient is no longer contained in any registered products ... "cancelled." **PEER REVIEWED**
  • The higher boiling cresylic acids are mixtures of cresols ... Their main uses are in phenol-formaldehyde resins, solvents for wire-coating enamels, as metal-degreasing agents, froth-flotation agents, and synthetic tanning agents. **PEER REVIEWED**
  • The largest part of cresols are used as intermediates in chemical processes for the production of e.g. antioxidants, arylphosphates, synthetic Vitamin E and pesticides. m/p-Cresol isomeric mixture is used as a process solvent for the production of wire enamels. Direct uses of cresols are as bactericide in biotechnological processing, pesticide and other minor, wide dispersive uses (< 1 % of worldwide production). **PEER REVIEWED**

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Notes (Sources: NTP,HSDB,RTECS,MESH)2

  • None Found.

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Superlist Classes2

  • 2007 CERCLA Priority List, Rank: 227
  • 2011 CERCLA Priority List, Rank: 240
  • Reportable Quantity (RQ) = 1000 lb
  • TWA (5 ppm); skin
  • TWA 5 ppm (22 mg/m3); skin

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Links to Additional Information2

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1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's ChemIDPlus, 02/28/2017.

3 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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