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Chemical Properties

CAS Registry Number: 58-15-1

Selected information from two of the National Library of Medicine's databases: ChemIDPlus2 and HSDB3.

Names 1

  • 4-Dimethylamino-2,3-Dimethyl-1-Phenyl-5-Pyrazolone
  • 4-Dimethylaminoantipyrine
  • Aminopyrine

Structure

Chemical Structure for Chemical Abstracts Service Registry Number 58-15-1 from NLM

Synonyms (Sources: NTP,HSDB,RTECS,MESH)2

  • 1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone
  • 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one
  • 2,3-Dimethyl-4-dimethylamino-1-phenyl-5-pyrazolone
  • 3-Keto-1,5-dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole
  • 3-Pyrazolin-5-one, 4-(dimethylamino)-2,3-dimethyl-1-phenyl-
  • 3H-Pyrazol-3-one, 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-
  • 4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
  • 4-(Dimethylamino)antipyrine
  • 4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone
  • 4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
  • 4-Dimethylamino-2,3-dimethyl-1-phenyl-5-pyrazolone
  • 4-Dimethylaminophenazone
  • Amidazophen
  • Amidazophene
  • Amidofebrin
  • Amidofen
  • Amidophen
  • Amidophenazone
  • Amidopyrazoline
  • Amidopyrin
  • Amidopyrine
  • Aminofenazone [Italian]
  • Aminophenazon [German]
  • Aminophenazone
  • Aminopyrine
  • Anafebrina
  • Brufaneuxol
  • Dereuma
  • Dimapyrin
  • Dimethylamino-analgesine
  • Dimethylaminoantipyrine
  • Dimethylaminoazophene
  • Dimethylaminophenazon [German]
  • Dimethylaminophenazone
  • Dimethylaminophenyldimethylpyrazolin
  • Dimethylaminophenyldimethylpyrazolone
  • Dipirin
  • Dipyrin
  • Dipyrine
  • Febrinina
  • Febron
  • HSDB 2135
  • Itamidone
  • Mamallet-A
  • Netsusarin
  • Novamidon
  • Piramidon
  • Piridol
  • Piromidina
  • Polinalin
  • Pyradone
  • Pyramidon
  • Pyramidone

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Other Registry Numbers2

  • 144574-10-7

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Chemical Properties3

Property Description
Boiling Point
  • None Found
Color/Form
  • COLORLESS LEAFLETS
  • LEAFLETS FROM LIGROIN
  • PRISM OR PLATELETS FROM PETROLEUM ETHER OR ETHYL ACETATE
Corrosivity
  • None Found
Critical Temperature & Pressure
  • None Found
Density/Specific Gravity
  • None Found
Dissociation Constants
  • 5.00
Heat Of Combustion
  • None Found
Heat Of Vaporization
  • None Found
Melting Point
  • 107-109 DEG C
Molecular Weight
  • 231.29
Odor
  • ODORLESS
Other Chemical/Physical Properties
  • FORMS EUTECTIC MIXT WITH ACETYLSALICYLIC ACID, PHENYL SALICYLATE, PHENOL, & CITRIC, TARTARIC & SALICYLIC ACIDS
  • IN PRESENCE OF WATER, READILY ATTACKED BY MILD OXIDIZING AGENTS; ADDITION OF SODIUM BENZOATE TO WATER INCR SOLUBILITY
Relative Evaporation Rate
  • None Found
Solubilities
  • 1 G SOL IN 1.5 ML ALC, 12 ML BENZENE, 1 ML CHLOROFORM, 13 ML ETHER, 18 ML WATER
  • SOL IN PETROLEUM ETHER
Spectral Properties
  • INDEX OF REFRACTION: ALPHA 1.520, GAMMA 1.732
  • IR: 8478 (Sadtler Research Laboratories IR Grating Collection)
  • Intense mass spectral peaks: 56 m/z, 97 m/z, 123 m/z, 231 m/z
  • MASS: 1563 (National Bureau of Standards EPA-NIH Mass Spectra Data Base, NSRDS-NBS-63)
  • MAX ABSORPTION (0.1 N HCL): 224 NM (A= 409, 1%, 1 CM)
  • MAX ABSORPTION (0.1 N NAOH): 226 NM, 263 NM
  • NMR: 615 (Varian Associates NMR Spectra Catalogue)
  • UV: 2547 (Sadtler Research Laboratories Spectral Collection)
Surface Tension
  • None Found
Taste
  • None Found
Vapor Density
  • None Found
Vapor Pressure
  • None Found
Viscosity
  • None Found
log P (octanol-water)
  • None Found
pH
  • AQ SOLN IS SLIGHTLY ALKALINE TO LITMUS

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Uses3

  • MEDICATION (VET) **PEER REVIEWED**
  • MEDICATION **PEER REVIEWED**

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Notes (Sources: NTP,HSDB,RTECS,MESH)2

  • A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.

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Superlist Classes2

  • None Found

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Links to Additional Information2

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's ChemIDPlus, 02/28/2017.

3 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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