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Chemical Properties

CAS Registry Number: 99-66-1

Selected information from two of the National Library of Medicine's databases: ChemIDPlus2 and HSDB3.

Names 1

  • Valeric Acid, 2-Propyl
  • Valproic acid

Structure

Chemical Structure for Chemical Abstracts Service Registry Number 99-66-1 from NLM

Synonyms (Sources: NTP,HSDB,RTECS,MESH)2

  • 2-Propylpentanoic acid
  • 2-Propylvaleric acid
  • 3-02-00-00807 (Beilstein Handbook Reference)
  • Abbott 44090
  • Acetic acid, dipropyl-
  • BRN 1750447
  • Depakine
  • Di-n-propylacetic acid
  • Di-n-propylessigsaure [German]
  • Dipropylacetic acid
  • Ergenyl
  • HSDB 3582
  • Kyselina 2-propylvalerova [Czech]
  • Mylproin
  • Valproate
  • Valproic acid
  • Vupral

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Other Registry Numbers2

  • None Found

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Chemical Properties3

Property Description
Boiling Point
  • 219.5 deg C
Color/Form
  • Colorless liquid
Corrosivity
  • None Found
Critical Temperature & Pressure
  • None Found
Density/Specific Gravity
  • 0.904 g/cu cm at 25 deg C
Dissociation Constants
  • pKa = 4.6
Heat Of Combustion
  • None Found
Heat Of Vaporization
  • None Found
Melting Point
  • None Found
Molecular Weight
  • 144.21
Odor
  • Characteristic odor
Other Chemical/Physical Properties
  • BP: 219 to 220 deg C
  • Henry's Law constant = 3.0X10-6 atm-cu m/mol at 25 deg C (est)
  • Hydroxyl radical reaction rate constant = 8.18X10-12 cu cm/molec-sec at 25 deg C (est)
  • White, odorless, crystalline, deliquescent powder. pKa 4.8. Hygroscopic. One gram is soluble in 0.4 mL water; 1.5 mL ethanol; 5 mL methanol. Practically insoluble in common organic solvents /Valproic acid sodium salt (1:1)/
Relative Evaporation Rate
  • None Found
Solubilities
  • Freely soluble in 1N sodium hydroxide, methanol, alcohol, acetone, chloroform, benzene, ether, n-heptane; slightly soluble in 0.1 N hydrochloric acid
  • In water, 2.0X10+3 mg/L at 20 deg C
  • Very soluble in organic solvents
Spectral Properties
  • Index of refraction = 1.425 at 24.5 deg C/D
Surface Tension
  • None Found
Taste
  • None Found
Vapor Density
  • None Found
Vapor Pressure
  • 8.47X10-2 mm Hg at 25 deg C (est)
Viscosity
  • None Found
log P (octanol-water)
  • log Kow = 2.75
pH
  • None Found

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Uses3

  • Anticonvulsants; Antimanic Agents; Enzyme Inhibitors; GABA Agents **PEER REVIEWED**
  • Indicated as monotherapy and adjunctive therapy in the treatment of patients with complex partial seizures that occur in either isolation or association with other types of seizures **PEER REVIEWED**
  • MEDICATION **PEER REVIEWED**
  • THERAPEUTIC CATEGORY (VETERINARY): Anticonvulsant **PEER REVIEWED**

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Notes (Sources: NTP,HSDB,RTECS,MESH)2

  • A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.

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Superlist Classes2

  • None Found

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Links to Additional Information2

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's ChemIDPlus, 02/28/2017.

3 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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