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Toxicity Effects

CAS Registry Number: 100-37-8

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • (Diethylamino)ethanol
  • Benzenediazonium, 4-(Diethylamino)-, Trichlorozincate(1-)
  • Diethylethanolamine
  • N,N-Diethylethanolamine

Human Toxicity Excerpts

  • Diethylaminoethanol: can also produce nausea and vomiting.[Sullivan, J.B. Jr., G.R. Krieger (eds.). Hazardous Materials Toxicology-Clinical Principles of Environmental Health. Baltimore, MD: Williams and Wilkins, 1992., p. 1106] **PEER REVIEWED**
  • An attempt by a laboratory worker to remove animals from an inhalation chamber containing approx 100 ppm resulted in nausea and vomiting within 5 min after a fleeting exposure; no irritation of the eyes or throat was noted during this brief exposure. Other persons in the same room also complained of a nauseating odor but showed no ill effects.[American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 462] **PEER REVIEWED**
  • Environmental samples were analyzed for diethylaminoethanol at the Johnson Museum, Cornell University, Ithaca, New York in January 1983. The survey was requested by the 40 employees because of eye irritation and dermatitis. Diethylaminoethanol was used to humidify the air in the museum. Air samples and bulk samples were analyzed for diethylaminoethanol. Medical interviews were conducted. Of the 14 samples taken, only 2 had detectable amounts of diethylaminoethanol. The two concentrations were 0.05 and 0.04 mg/cu m. This was below the OSHA standard of 50 mg/cu m. The two bulk samples contained about 30 mg per square meter of exposed area. A total of 46% of the employees complained of eye irritation, 37% complained of skin irritation, and 17% complained of headache, nose and throat irritation, or dizziness. Six females reported gynecological problems. /It was/ concluded that contact with surfaces coated with condensed diethylaminoethanol may be responsible for some of the irritant effects. It is recommended that diethylaminoethanol be wiped from surfaces, or the use of diethylaminoethanol be discontinued.[NIOSH/ Hazard Evaluations and Technical Assistance Branch; Report No. HETA-83-020-1351, 11 pp (1983)] **PEER REVIEWED**
  • In response to a request from a management representative an evaluation was made of an outbreak of illness at a /electronics manufacturing plant/ located in Cincinnati, Ohio. The company manufactured electrical circuit boards and electrical equipment for the commercial and defense industries. In September of 1988 two boilers were prepared for operation by adding corrosion inhibitinq chemicals, diethylaminoethanol and cyclohexylamine. Steam produced by the boilers was used for humidity in the work area. Symptoms consistent with acute toxic effects of diethylaminoethanol and cyclohexylamine were noted in 65 of the employees. These included nausea, dizziness, vomiting, and eye, nose, and throat irritation. A significantly higher risk of having several symptoms was noted among the employees in the areas humidified with boiler steam than among employees in the nonboiler steam humidified areas. Employee exposures to metals from solder fumes and methyl-ethyl-ketone were all below established-limits. There was friable asbestos insulation exposed on one boiler. /It was/ concluded that the exposures to the two corrosion inhibiting chemica1s were responsible for the workers' symptoms.[NIOSH; Health Hazard Evaluation Report HETA 89-057-2003 (1991)] **PEER REVIEWED**
  • On March 23, 1981, the National Institute for Occupational Safety and Health (NIOSH) received a request for a Health Hazard Evaluation from Boehring Ingelheim, Ltd, Ridgefield, Connecticut. The request stated that approximately 15 employees in the office support area of a production building had been experiencing rashes since the beginning of March 1981. Environmental samplinq did not reveal any diethylaminoethanol in air samples. However, results of sampling suggested the presence of a conjugated amine which possesses acidic properties. The specific agent could not be identified. Skin examinations revealed an irritant-type rash on the exposed areas of the face neck and hands. The distribution of the rash was consistent with and suggestive of a phototoxic skin reaction. Both the environmental and medical evaluations indicated the source of the dermatitis to be the air-handling system. However, no specific etiologic agent has been identified. The information in the body of the fu11 report suggests that a condensation or reaction product of diethylaminoethanol was likely responsible for the reported symptoms.[NIOSH; Health Hazard Evaluation Report No. HETA-81-247-958 (1983)] **PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • ... EXPOSURES @ 200 PPM (+ OR - 5%) RESULTED IN WEIGHT LOSS & EVENTUAL DEATH OF 7 OF THE 50 RATS EXPOSED BY ONE MONTH. BRONCHOPNEUMONIA WAS APPARENT CAUSE OF DEATH. AT THE END OF THREE MONTHS, APPARENT ADAPTATION OCCURRED, AS NO CLINICAL VARIABLES THAT WERE MEASURED DIFFERED FROM THE CONTROLS; SIMILAR FINDINGS WERE MADE AT THE END OF SIX MONTHS. HISTOPATHOLOGIC EXAMINATION REVEALED THAT CONTROL AND EXPOSED ANIMAL TISSUES WERE NOT SIGNIFICANTLY DIFFERENT.[American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 462] **PEER REVIEWED**
  • ... EYE INJURY FROM THE FLUID /IS/ VERY SEVERE IN RABBIT FROM 0.005 ML UNDILUTED, SEVERE FROM 15% OR MORE IN GLYCOL & NOT SEVERE FROM 5% IN GLYCOL.[American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values, 4th ed., 1980. Cincinnati, Ohio: American Conference of Governmmental Industrial Hygienists, Inc., 1980., p. 141] **PEER REVIEWED**
  • ... REPEATED, DAILY INHALATION EXPOSURES OF RATS @ 500 PPM (+ OR -10%) REVEALED MARKED EYE & NASAL IRRITATION ON THE FIRST EXPOSURE DAY. MILD TREMORS OF THE HEAD & FORELEGS CONTINUED THROUGHOUT THE 5-DAY EXPOSURE PERIOD. CORNEAL OPACITY WAS OBSERVABLE IN A NUMBER OF THE RATS BY THE THIRD DAY, & BY THE FIFTH EXPOSURE 4 OF 20 ANIMALS HAD DIED. ALL ANIMALS LOST 40 TO 80 G. AUTOPSY SHOWED ACUTE PURULENT BRONCHITIS, AND BRONCHOPNEUMONIA BUT NO OTHER ORGAN INVOLVEMENT.[American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 462] **PEER REVIEWED**
  • AS PRIMARY IRRITANT, IT CAN BE COMPARED TO MORPHOLINE, & ITS ACTION REGARDING EYE INJURY CAN BE COMPARED TO AMMONIUM HYDROXIDE.[American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 462] **PEER REVIEWED**
  • DIETHYLAMINOETHANOL BLOCKED IMPULSE CONDUCTION IN FROG SCIATIC NERVES, BUT HAD NO LOCAL ANESTHETIC EFFECT ON RABBIT CORNEA.[GUERRERO S ET AL; ARZNEIM- FORSCH; 23 (7): 951 (1973)] **PEER REVIEWED**
  • Diethylaminoethanol was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by the National Toxicology Program. Diethylaminoethanol was tested at doses of 0, 33, 100, 333, 1000, 2500, and 3333 ug/plate in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. Diethylaminoethanol was negative in these tests and the highest ineffective dose level tested without total or slight clearing of the background lawn in any Salmonella tester strain was 1000 ug/plate.[Zeiger E et al; Environ Mutagen 9: 1-110 (1987)] **PEER REVIEWED**
  • Diethylaminoethanol, a neutralizing amine used to prevent corrosion of steam condensate lines, caused chlorosis in younq leaves of chrysanthemum (Chrysanthemum morifolium), tomato (Lycopersicon esculentum), corn (Zea mays) and bean (Phaseolus vulgaris). Sensitivity of corn and chrysanthemum to diethylaminoethanol was cultivar-dependent; Indianapolis White chrysanthemum was sensitive to low concentrations of diethylaminoethanol, while Bonnie Jean, Velvet Ridge and Mistletoe were less so, and '3XD50' corn was sensitive to diethylaminoethanol while Ohio 28 was not. The presence of latent chrysanthemum chlorotic mottle viroid (ChCMV-L) increased the sensitivity of Bonnie Jean and Velvet Ridge to diethylaminoethanol. Infection of tomatoes with mild or severe strains of potato spindle tuber viroid (PSTV) resulted in increased sensitivity to diethylaminoethanol under conditions of environmental stress. Leaves of chrysanthemum exhibiting diethylaminoethanol induced chlorosis contained higher, but non-toxic, levels of iron and other minerals than those from non-diethylaminoethanol treated plants.[Horst RK et al; Sci Hortic 19 (1-2): 1-8 (1983)] **PEER REVIEWED**
  • Diethylethanolamine is a strongly alkaline liquid which has the same severity of injurious effect on rabbit eyes as ammonium hydroxide, judged at 24 hr.[Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 337] **PEER REVIEWED**
  • Exposure of plants via treated steam containing 2-diethylaminoethanol has resulted in chlorosis in several plant species, including corn (Zea mays), tomato (Lycopersicon esculentum), bean (Phaseolus vulgaris), and Chrysanthemum (Chrysanthemum morifolium). Elevated (nontoxic) iron levels were also noted in the leaves of these plants.[Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 414] **PEER REVIEWED**
  • In a 2 week study, male and female Fischer 344 rats were exposed to 0, 11, 56, and 301 ppm diethylethanolamine vapor for 6 hr/day, for 9 days. For the subchronic study, rats were exposed to 0, 11, 25, and 75 ppm diethylethanolamine vapor for 6 hr/day, 5 days/wk for up to 14 wk in inhalation chambers. Rats of both groups were studied for body weight changes, clinical symptoms, urinalysis, and blood analysis, and internal organs were examined logically. The nasal cavity and turbinates were examined for signs of toxicity. In the 2 wk study, the 30l ppm group was severely affected, and the high mortality rate limited the meaningful use of data. The principal histopathological findings from the 0, 10, and 56 ppm groups showed dose related changes of the nasal cavity and turbinates, with mononuclear inflammatory cell infiltrates and squamous metaplasia. In the subchronic study, signs of respiratory and ocular irritation appeared in the 76 ppm group during the second week, and similar symptoms appeared later in the 10 and 25 ppm groups. Corneal opacities, and metaplasia, hyperplasia and inflammatory cell infiltrations of the nasal mucosa, were noted. Hypertrophic goblet cells, focal necrosis, and exudate in the nasal lumen, were also evident. The lesions were still present at 4 wk postexposure. The ll ppm and control rats were free of these lesions. /It was/ concluded that the no observed effect level for diethylethanolamine is 10 ppm.[Hinz JP et al; Fundam and Appl Toxicol 18 (3): 418-24 (1992)] **PEER REVIEWED**
  • Inhalation toxicity (rats): Saturated vapor time for 0 deaths = 4 hr.[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 3147] **PEER REVIEWED**
  • Rats were administered 50 and 100 ppm 2-diethylaminoethanol orally for six months, with resulting weight loss and increased kidney/body weight ratios occurring in the 100 ppm group.[Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 413] **PEER REVIEWED**
  • The liquid is a severe skin irritant; in the guinea pig it is a skin sensitizer.[Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981.] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • LD50 Guinea pig skin 1,000 mg/kg[Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984., p. 1015] **PEER REVIEWED**
  • LD50 Mouse im 416 mg/kg[Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 413] **PEER REVIEWED**
  • LD50 Mouse ip 308 mg/kg[Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 413] **PEER REVIEWED**
  • LD50 Mouse sc 1561 mg/kg[Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 413] **PEER REVIEWED**
  • LD50 Rabbit skin 1,260 mg/kg[Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984., p. 1015] **PEER REVIEWED**
  • LD50 Rat ip 1,220 mg/kg[Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984., p. 1015] **PEER REVIEWED**
  • LD50 Rat oral 1,300 mg/kg[Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984., p. 1015] **PEER REVIEWED**

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Absorption, Distribution And Excretion

  • ORALLY ADMIN TO RATS, WAS MAINLY EXCRETED VIA KIDNEYS. ELIMINATED WITHIN FIRST 24 HR. AFTER 48 HR EXCRETED INDEPENDENTLY OF DOSE. AFTER 40 DAYS STILL BEING ELIMINATED. UP TO 60% ACCUMULATED IN LIVER. CNS & SPINAL CORD SHOWED HIGHEST CONCN AFTER 7 DAYS.[SCHULTE KE ET AL; ARZNEIM- FORSCH 22 (8): 1381 (1972)] **PEER REVIEWED**
  • The absorption of 2-diethylaminoethanol (administered orally as 2-diethylaminoethanol acid malate or 'Cerebrol') in healthy adult rats is very rapid, reaching a peak plasma level in 30 min. The biological half-life is 3.5 hr with 39% of the excreted product appearing in the urine after 48 hr.[Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990., p. 412] **PEER REVIEWED**

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Metabolism/Metabolites

  • CHRONIC ORAL ADMIN ... TO RATS RESULTS IN LIVER ACCUM OF UP TO 60% OF THE DRUG. ... METABOLITES PRODUCED WERE DIETHYLAMINOETHANOL N-OXIDE, DIETHYLAMINOACETIC ACID & ETHYLAMINOETHANOL ... .[The Chemical Society. Foreign Compound Metabolism in Mammals Volume 3. London: The Chemical Society, 1975., p. 272] **PEER REVIEWED**

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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