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Toxicity Effects

CAS Registry Number: 108-21-4

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • Acetic Acid, 1-Methylethyl Ester (9ci)
  • Isopropyl acetate

Human Toxicity Excerpts

  • AMONGST WORKERS OCCUPATIONALLY EXPOSED TO ... /ISOPROPYL ACETATE/, THERE HAVE BEEN CASES OF CONJUNCTIVAL IRRITATION & REPORTS OF A FEELING OF CONSTRICTION OF CHEST & COUGHING; HOWEVER, NO CASES OF PERMANENT OR SYSTEMIC EFFECTS HAVE BEEN FOUND IN EXPOSED WORKERS. REPEATED CONTACT OF THE LIQ WITH THE SKIN MAY LEAD TO DEFATTING AND CRACKING.[International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 782] **PEER REVIEWED**
  • Humans exposed to 200 ppm (0.8 mg/l) isopropyl acetate developed eye irritation. /From table/[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 2982] **PEER REVIEWED**
  • ISOPROPYL ACETATE IS AN IRRITANT OF MUCOUS MEMBRANES BUT ONLY TO SLIGHT EXTENT; IT IS ALSO /SRP: CNS DEPRESSANT/ ... BUT LESS SO THAN N-ISOMER. ... NO SYSTEMIC INJURY HAS BEEN REPORTED ... .[Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 536] **PEER REVIEWED**
  • In man, concentrations of 200 ppm cause irritation of the eyes and greater concentrations give rise to irritation of the nose and larynx. Amongst workers occupationally exposed to these esters, there have been cases of conjunctival irritation and reports of a feeling of constriction of the chest and coughing; however, no cases of permanent or systemic effects have been found in exposed workers. Repeated contact of the liquid with the skin may lead to defatting and cracking.[International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 782] **PEER REVIEWED**
  • Isopropyl acetate irritates the eyes and upper respiratory tract. ... No chronic systemic effects have been reported in humans.[Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 1] **PEER REVIEWED**
  • Overexposure to isopropyl acetate may cause irritation of the eyes, nose and throat. Severe overexposure may cause weakness, drowsiness, and unconsciousness.[Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 1] **PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • ... /IT WAS/ FOUND THAT 32000 PPM WAS FATAL TO 5 OF 6 RATS IN 4 HR, WHEREAS 16000 PPM WAS FATAL TO 1 OF 6.[American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 826] **PEER REVIEWED**
  • ... It may produce /CNS depression/ at high concentrations approaching the lethal level in animals. ...[Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 1] **PEER REVIEWED**
  • FROM EXPT ON ISOLATED FROG'S HEART IT APPEARS TO BE MORE TOXIC ... THAN ETHYL OR METHYL ACETATE. ... MODERATE EYE IRRITATION; NO SKIN IRRITATION; /SRP: CNS DEPRESSION/ ... PRECEDING DEATH.[Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 536] **PEER REVIEWED**
  • In vivo anesthetic activity of alkyl acetates in mice was studied in relation to hydrophobicity and the in vivo effect on membrane fluidity. The anesthetic potency (AD50) of alkyl acetates was determined; Ad50 shows the ip dose required to anesthetize 50% of mice from the treated group. We used log P (n-octanol/water partition coefficient) as an operational definition of hydrophobicity. Membrane fluidity was determined using 1,6-diphenyl-1,3,5-hexatriene as fluorescence probe. Log (1/AD50) was a parabolic function of log P, and the value of log P that corresponds to the minimum AD50 was estimated to be 2.08. Brain synaptosomal membranes were prepared from mice 30 min after dosing with each of the three alkyl acetates applied at 1.5 fold AD50: n-butyl, n-amyl, and n-hexyl acetate. In each alkyl acetate group, most of the animals were anesthetized (> 68%). Decreased membrane fluidity was observed for the animals that were anesthetized while no change in the fluidity was seen for the animals that were not anesthetized. The results suggest an involvement of decreased DPH fluidity in alkyl acetate induced anesthesia.[Tanii H et al; Archives of Toxicology 71 (10): 622-26 (1997)] **PEER REVIEWED** PubMed Abstract
  • Mice were exposed during 4 hr to isopropyl acetate. After exposure, measurements were made on duration of immobility developed in a behavioral despair swimming test. The chemical reduced the total duration of immobility measured over 3 min in a concn-related manner.[De Ceaurriz J et al; Toxicol Appl Pharmacol 67 (3): 383-9 (1983)] **PEER REVIEWED** PubMed Abstract
  • Toxicity Rating: 2. Like other simple esters, mild irritant and central depressant actions. Although n-propanol is about 3-fold more acutely toxic than isopropanol, the simple esters of each are about equi-toxic with n-propyl acetate 6.6 g/kg, isopropyl acetate 6.9 g/kg, n-propyl, n-butyrate 5.7 g/kg and n-propyl isovalerate 8.2 g/kg. The ratio of the narcotic to the lethal dose is smaller for the esters than for the parent alcohols.[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-203] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • LD50 RABBIT SKIN PENETRATION 20000 PPM[Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 536] **PEER REVIEWED**
  • LD50 Rabbit oral 6.95 g/kg /From table/[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 2980] **PEER REVIEWED**
  • LD50 Rat oral 3.0 g/kg /From table/[Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 2980] **PEER REVIEWED**
  • LD50 Rat oral 6.75 g/kg[Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 889] **PEER REVIEWED**

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Absorption, Distribution And Excretion

  • IT IS ABSORBED THROUGH LUNG, GASTRO-INTESTINAL TRACT & SKIN OF ANIMALS.[Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 536] **PEER REVIEWED**

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Metabolism/Metabolites

  • None found

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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