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Toxicity Effects

CAS Registry Number: 108-68-9

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • 1-Hydroxy-3,5-Dimethylbenzene
  • 3,5-Dimethyl phenol
  • 3,5-Dimethylphenol

Human Toxicity Excerpts

  • TOXIC BY INGESTION AND SKIN ABSORPTION. /COMMERCIAL MIXTURES/[Sax, N.I. and R.J. Lewis, Sr. (eds.). Hawley's Condensed Chemical Dictionary. 11th ed. New York: Van Nostrand Reinhold Co., 1987., p. 1244] **PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • ... DIMETHYLPHENOLS WERE AS POTENT IN PROMOTING PAPILLOMAS AS PHENOL ITSELF (WITH THE EXCEPTION OF 2,6-DIMETHYLPHENOL, WHICH WAS INACTIVE) ... IT APPEARS THAT THERE MUST BE AT LEAST ONE UNSUBSTITUTED POSITION ORTHO TO THE PHENOLIC GROUP FOR PAPILLOMA-PROMOTING ACTIVITY /IN MICE/. /DIMETHYLPHENOLS/[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2583] **PEER REVIEWED**
  • ACUTE AND CHRONIC TOXICITY STUDIES ON 3,5- AND 2,4-DIMETHYLPHENOL ARE DESCRIBED. THE TWO PHENOLS AT RESPECTIVE CONCENTRATIONS OF 4 MG/CU M AND 26-30 MG/CU M SHOWED NO LETHALITY BUT CAUSED IRRITATION OF THE MUCOUS MEMBRANE OF MICE.[UZHDAVINI ER ET AL; GIG TR PROF ZABOL 10: 52-3 (1979)] **PEER REVIEWED** PubMed Abstract
  • Phenol, three cresols, and 2,5-, 2,4-, 3,5-, and 3,4-dimethylphenols were detected in ether extract of black fermented tea. ... Six of the 15 mice of Group 1 developed epithelial-cell carcinoma in the neck region after one painting of 3,4-benzopyrene followed by 55 paintings of brewed tea /over 110 days/. All other mice in this group developed pre-carcinogenic or carcinogenic stages of squamous-cell tumors. The mice of Group 2 after one painting of 3,4-benzopyrene only, developed no pathologic legions.[KAISER HE; CANCER (PHILADELPHIA) 20 (5): 614-6 (1967)] **PEER REVIEWED**
  • SEVERAL SUBSTITUTED PHENOLS WITH ANTIOXIDANT PROPERTIES WERE POTENT REVERSIBLE INHIBITORS OF PROSTAGLANDIN SYNTHESIS IN 3T3 CELL CULTURES. THE ID50 FOR PROSTAGLANDIN E2 SYNTHESIS IN THESE CELLS WAS 15 UMOL FOR 3,5-XYLENOL.[LINDGREN JA ET AL; PROSTAGLANDINS 13 (6): 1093-102 (1977)] **PEER REVIEWED** PubMed Abstract
  • THE CILIOTOXICITY OF COMPOUNDS (INCLUDING 3,5-DIMETHYLPHENOL) REPRESENTATIVE OF THE GASEOUS AND SEMIVOLATILE PHASES OF TOBACCO SMOKE WAS INVESTIGATED USING CHICKEN TRACHEAL ORGAN CULTURES. THE ALKYLATED PHENOLS EXHIBITED GREATER CILIOSTATIC EFFECTS THAN PHENOL ITSELF.[PETTERSSON B ET AL; TOXICOLOGY 23 (1): 41-55 (1982)] **PEER REVIEWED** PubMed Abstract
  • TO ENSURE LONG TERM SURVIVAL OF SALMONIDS IN PRESENCE OF PHENOLIC WASTES, THE CONCN OF XYLENOLS SHOULD NOT EXCEED 1.9 MG/L, EITHER SINGLY OR COLLECTIVELY. /XYLENOLS/[FAO; WATER RES 7 (6): 929-41 (1973)] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • LD50 Mouse ip 156 mg/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 3406] **PEER REVIEWED**
  • LD50 Mouse oral 477 mg/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 3406] **PEER REVIEWED**
  • LD50 Rabbit oral 1313 mg/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 3406] **PEER REVIEWED**
  • LD50 Rat oral 608 mg/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 3406] **PEER REVIEWED**

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Absorption, Distribution And Excretion

  • Associations between o-cresol, p-cresol, m-cresol, 2,4-xylenol, 2,5-xylenol, 3,4-xylenol, and 3,5-xylenol exposure levels and urinary phenol excretion were examined in the coke facility industry. The subjects consisted of 76 exposed workers employed in the tar distillation process and 34 controls. ... Urinary metabolite levels were corrected for specific gravity and creatinine. The time weighted average exposure concentrations in the breathing zones of the tar distillation workers were ... 0.02 to 0.04 mg/cu m for xylenols. ... The urinary xylenol levels of exposed workers ranged from 0.12 to 0.97 mg/l with specific gravity correction. In control urine samples, the specific gravity corrected xylenol concentrations ranged from 25 x 10(-3) to 43 x 10(-3) mg/l. Significant correlations were observed between the ambient levels and urinary concentrations of phenol, o-cresol, and the xylenols, with coefficients ranging from 0.45 to 0.82. The author concludes that the biological monitoring of urinary xylenols may be used as a means of measuring xylenol exposure in coke facility workers.[Bieniek G; International Archives of Occupational and Environmental Health 70 (5): 334-40 (1997)] **PEER REVIEWED** PubMed Abstract

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Metabolism/Metabolites

  • 3,5-DIMETHYLPHENOL (SYM-M-XYLENOL) YIELDS 3,5-DIMETHYL PHENYL-BETA-DELTA-GLUCURONIDE, 3,5-DIMETHYLPHENYL SULFATE, & 2,6-DIMETHYLQUINOL IN RABBIT. /FROM TABLE/[Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. D-93] **PEER REVIEWED**
  • 3,5-DIMETHYLPHENOL (SYM-M-XYLENOL) YIELDS 3,5-DIMETHYLCATECHOL IN RABBITS. /FROM TABLE/[Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. D-93] **PEER REVIEWED**
  • 3,5-DIMETHYLPHENOL (SYM-M-XYLENOL) YIELDS 3-HYDROXY-5-METHYLBENZOIC ACID IN PSEUDOMONAS. /FROM TABLE/[Goodwin, B.L. Handbook of Intermediary Metabolism of Aromatic Compounds. New York: Wiley, 1976., p. D-93] **PEER REVIEWED**

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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