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Toxicity Effects

CAS Registry Number: 110-02-1

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • Thiophene
  • Thiotetrole

Human Toxicity Excerpts

  • In man, tiophene has caused skin irritation and may induce sensitization responses. Nausea, itching and jaundice were seen in a woman repeatedly taking thiophene in suppositories.[BIBRA Working Group; Toxicity Profile. The British Industrial Biological Research Association (1989)] **PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • ALBINO RATS GIVEN DAILY SC INJECTION OF 0.4 ML HAD LONGER MITOCHONDRIA AND DENSITY OF MITOCHONDRIA WAS REDUCED FROM NORMAL VALUE OF 140.4 TO 105.8 IN PURKINJE CELLS.[ALBRECHTSEN R ET AL; ACT PATHOL MICROBIOL SCAND SECT A PATHOL 82(6) 791 (1974)] **PEER REVIEWED**
  • ALTERATIONS WERE OBSERVED IN DENDRITIC ORGANIZATION OF PURKINJE CELLS IN CEREBELLUM OF ADULT RAT FOLLOWING ADMIN OF DEGRANULATING AGENT. PURKINJE CELL DENDRITIC TREES WERE REDUCED IN SIZE WHEN COMPARED WITH CONTROL CELLS.[BRADLEY P, BERRY M; NEUROPATHOL APPL NEUROBIOL 5(1) 9 (1979)] **PEER REVIEWED**
  • EXPOSURE OF RATS TO THIOPHENE @ 0.1 L FOR 4 HR DAILY FOR 1-9 MO CAUSED INFLAMMATION IN LUNGS & BRONCHI, WEAK /NECROTIC/ CHANGES IN MYOCARDIUM & LIVER, & INCR IN LEVELS OF LIPIDS IN ADRENAL GLANDS.[VALIAKHMETOV AF; KHIM SERAORG SOEDIN, SODERZH NEFTYAKH NEFTEPROD 9 566 (1972)] **PEER REVIEWED**
  • FOLLOWING ADMIN OF THIOPHENE (0.4 ML/DAY FOR 5 & 9 DAYS) TO RATS, NADH-TETRAZOLIUM REDUCTASE ACTIVITY IN PURKINJE CELLS WAS DECR BY 70% BUT THAT IN GLOMERULI REMAINED UNCHANGED.[ALBRECHTSEN R, JENSEN H; IRCS LIBR COMPEND 1(1) (1974)] **PEER REVIEWED**
  • INHALATION OF 3 OR 20 MG/CU M OF THIOPHENE BY RATS OVER 80 DAY PERIOD DECR ADRENAL, KIDNEY, LIVER, & BRAIN ASCORBIC ACID (VITAMIN C) LEVELS. ACCOMPANIED BY DEHYDROASCORBIC ACID & DIKETOGULONIC ACID ACCUMULATION IN LIVER & INCR URINARY EXCRETION OF 17-KETO STEROIDS.[PUSHKINA NN ET AL; GIG SANIT 32 (10): 103 (1967)] **PEER REVIEWED**
  • SELECTIVE NECROSIS OF GRANULAR LAYER OF CEREBELLUM WAS INDUCED IN 14 OR 25 RATS BY SC INJECTION OF THIOPHEN. PYKNOSIS OF GRANULAR CELL NUCLEI WAS SEEN BEFORE ANY ALTERATION IN ENZYMES IN CYTOPLASM.[ALBRECHTSEN R, JENSEN H; ACTA NEUROPATHOL 26(3) 217 (1973)] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • None found

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Absorption, Distribution And Excretion

  • (35)S-LABELED THIOPHENE (250 MUCI) ADMIN ONCE SC TO RATS WAS RAPIDLY ABSORBED INTO BLOOD STREAM, DEPOSITED IN MAJOR ORGANS, & EXCRETED WITH URINE. URINE ANAL SHOWED 61.1% OF ISOTOPE WAS EXCRETED WITHIN 34 HR & 74.4% WITHIN 3 DAYS.[BIKBULATOV NT, NIGMATULLINA GN; SB NAUCHN TR BASHK GOS MED INST 19:114 (1976)] **PEER REVIEWED**
  • (35)S-LABELED THIOPHENE APPLIED TO RABBIT SKIN OR INJECTED IP INTO RATS WAS IMMEDIATELY INCORPORATED INTO SKIN.[BIKBULATOVA LI ET AL; VOPR REAKT ORG NORME PATOL, MATER NAUCHN KONF 23 (1974)] **PEER REVIEWED**
  • FOLLOWING RECTAL & ORAL ADMIN OF (14)C-LABELED THIOPHENE (33 MG/KG), PULMONARY EXCRETION WAS 40% & 5%, RESPECTIVELY.[CHANAL JL ET AL; EUR J MED CHEM -CHIM THER 9(6) 641 (1974)] **PEER REVIEWED**
  • RABBITS FED THIOPHEN 150 MG/KG EXCRETED ABOUT 35% OF DOSE UNCHANGED IN EXPIRED AIR & 0.5% IN FECES.[BRAY HG ET AL; BIOCHEM J 109(2) 11 (1968)] **PEER REVIEWED**

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Metabolism/Metabolites

  • MAJOR METABOLITE OF THIOPHENE (200-300 MG/KG, ORALLY) IN RATS & RABBITS WAS 3-HYDROXY-2,3-DIHYDRO-2-THIENYLMERCAPTURIC ACID & 2-THIENYLMERCAPTURIC ACID WAS MINOR METABOLITE. IN RAT 32% OF THIOPHENE EXCRETED UNCHANGED IN EXPIRED AIR & 40% EXCRETED IN URINE AS MERCAPTURIC ACIDS.[BRAY HG ET AL; XENOBIOTICA 1(2) 157 (1971)] **PEER REVIEWED**
  • RABBITS FED THIOPHEN 150 MG/KG EXCRETED 40% OF DOSE IN URINE IN FORM OF 2 MERCAPTURIC ACIDS, BELIEVED TO BE THIENYL 3-MERCAPTURIC ACID & THIENYL 2-MERCAPTURIC ACID.[BRAY HG ET AL; BIOCHEM J 109(2) 11 (1968)] **PEER REVIEWED**
  • THIOPHEN IS METABOLIZED IN VIVO TO PREMERCAPTURIC ACID AND 2-THIENYL-MERCAPTURIC ACID.[The Chemical Society. Foreign Compound Metabolism in Mammals. Volume 2: A Review of the Literature Published Between 1970 and 1971. London: The Chemical Society, 1972., p. 386] **PEER REVIEWED**

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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