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Toxicity Effects

CAS Registry Number: 112-56-1

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • 2-(2-Butoxyethoxy)ethyl thiocyanate
  • Lethane 384
  • Thiocyanic Acid, 2-(2-Butoxyethoxy)Ethyl Ester

Human Toxicity Excerpts

  • OF COMMON THIOCYANATE INSECTICIDES, LETHANE 384 HAS HIGHEST ACUTE TOXICITY; BASED ON VARIOUS ANIMAL SPECIES, LETHAL ORAL DOSE IN AN ADULT PERSON MAY LIE ANYWHERE BETWEEN 1 TEASPOONFUL AND 1 OZ OF CONCENTRATED COMMERCIAL SOLN (50% ACTIVE INGREDIENT).[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-15] **PEER REVIEWED**
  • ONLY HUMAN FATALITIES KNOWN TO US INVOLVED AN ADULT WHO DRANK A MIXT CONTAINING NO MORE THAN 3.5 G OF LETHANE 384 & 10 G OF LAURYL THIOCYANATE & A 2 YR OLD BOY WHO SWALLOWED ... A MIXT OF LETHANE 384 (CONCN ABOUT 6%) & LETHANE 60 (CONCN ABOUT 18%) IN PETROLEUM SOLVENT.[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-15] **PEER REVIEWED**
  • SIGNS AND SYMPTOMS OF KEROSENE POISONING ARE OFTEN DOMINANT AFTER EXPOSURE TO DIL SOLN OF THIOCYANATE INSECTICIDES. /LETHANE 384 IS APPROX 50% KEROSENE BY VOLUME./ /ALIPHATIC THIOCYANATES/[Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-188] **PEER REVIEWED**
  • SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 1. INGESTION OF CONCENTRATED SOLN MAY LEAD TO VOMITING BECAUSE OF MUCOSAL IRRITATION. /ALIPHATIC THIOCYANATES/[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-16] **PEER REVIEWED**
  • SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 2. PRINCIPAL SYSTEMIC REACTION IS PROBABLY ... CENTRAL NERVOUS DEPRESSION, INTERRUPTED BY PERIODS OF RESTLESSNESS, HYPERPNEA, TONIC CONVULSIONS. AS JUDGED FROM ANIMAL TESTS, DEPRESSION MAY LAST FOR MANY DAYS. /ALIPHATIC THIOCYANATES/[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-16] **PEER REVIEWED**
  • SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 4. DEATH IS USUALLY DUE TO RESPIRATORY ARREST FROM PARALYSIS OF MEDULLARY CENTERS. ... 5. MASSIVE SKIN CONTAMINATION WITH ORG THIOCYANATES SOLN MAY PRODUCE SYSTEMIC POISONING ... & ... LOCAL IRRITATION & DERMATITIS. /ALIPHATIC THIOCYANATES/[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-16] **PEER REVIEWED**
  • SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 6. IN NONFATAL CASES EVIDENCE OF INJURIES TO LIVER AND KIDNEYS MAY APPEAR. /ALIPHATIC THIOCYANATES/[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-16] **PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • ... METHYL, ETHYL & ISOPROPYL THIOCYANATES & LETHANE 384 ARE RAPIDLY ACTING POISONS ... THEY PRODUCE CENTRAL NERVOUS DEPRESSION, USUALLY WITH TRANSIENT PERIOD OF RESP STIMULATION, PROGRESSING PROMPTLY TO DEATH FROM RESP FAILURE.[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-16] **PEER REVIEWED**
  • ... TREMORS, PARALYSIS, SPASTICITY, AND EVEN OPISTHOTONOS HAVE BEEN DESCRIBED ... IN RABBITS GIVEN LETHANE 384 BY VARIOUS ROUTES ... .[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-16] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • LD50 Rat oral 90 mg/kg[Matsumura, F. Toxicology of Insecticides. 2nd ed. New York, NY: Plenum Press, 1985., p. 86] **PEER REVIEWED**

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Absorption, Distribution And Excretion

  • ABSORBED THROUGH INTACT SKIN.[Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 857] **PEER REVIEWED**

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Metabolism/Metabolites

  • ENZYMES IN LIVER AND PERHAPS OTHER ORGANS ARE KNOWN TO LIBERATE CYANIDE ION FROM ... LETHANE 384. GLUTATHIONE S-TRANSFERASE CATALYZES ATTACK OF REDUCED GLUTATHIONE @ THIOCYANATE SULFUR, RESULTING IN LIBERATION OF HCN, OXIDIZED GLUTATHIONE & MERCAPTAN MOIETY OF THE ORGANOTHIOCYANATE.[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-16] **PEER REVIEWED**

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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