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Toxicity Effects

CAS Registry Number: 123-11-5

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • 4-Methoxybenzaldehyde
  • P-Methoxybenzaldehyde
  • p-Anisaldehyde

Human Toxicity Excerpts

  • TESTED @ 10% IN PETROLATUM, IT PRODUCED NO IRRITATION AFTER A 48 HR CLOSED-PATCH TEST ON HUMAN SUBJECTS.[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979., p. 100] **PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • ANISIC ALDEHYDE APPLIED FULL STRENGTH TO INTACT OR ABRADED RABBIT SKIN FOR 24 HR UNDER OCCLUSION WAS MODERATELY IRRITATING.[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979., p. 100] **PEER REVIEWED**
  • THE INTERACTION OF THE AROMATIC ALDEHYDE, P-ANISALDEHYDE, WITH RAT LIVER MITOCHONDRIA WAS EXAMINED IN VITRO. BOTH PYRUVATE/MALATE- AND SUCCINATE-MEDIATED RESPIRATION WAS INHIBITED BY THE AROMATIC ALDEHYDE (0.5-1.0 MMOLAR). CYTOCHROME C OXIDASE WAS NOT INHIBITED. SEVERAL SITES OF INHIBITION, POSSIBLY BOTH AT THE SITE OF TRANSPORT OF SUBSTRATES AND THE ACTIVE ENZYMES MAY EXIST.[WOLF CR ET AL; INTERACTION OF AROMATIC ALDEHYDES WITH ISOLATED RAT LIVER MITOCHONDRIA; BIOCHEM PHARMACOL 31(11) 2025 (1982)] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • None found

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Absorption, Distribution And Excretion

  • None found

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Metabolism/Metabolites

  • ANISIC ALDEHYDE UNDERGOES A VERY SLIGHT DEGREE OF DEMETHYLATION WITH OXIDATION OF ITS ALDEHYDE GROUP TO AN ACID GROUP, THE MAJOR METABOLITE EXCRETED BEING ANISIC ACID.[Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979., p. 100] **PEER REVIEWED**

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Tsca Test Submissions

  • None found

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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