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Toxicity Effects

CAS Registry Number: 142-84-7

Selected toxicity information from HSDB, one of the National Library of Medicine's databases. 2.

Names 1

  • 1-Propanamine, N-Propyl-
  • Dipropylamine

Human Toxicity Excerpts

  • OTHER TOXICITY INFORMATION: Moderately toxic by skin contact and inhalation.[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1415] **PEER REVIEWED**
  • OTHER TOXICITY INFORMATION: Since the amines are bases and may form strongly alkaline solutions, they can be damaging if splashed in the eye or if allowed to contaminate the skin. Otherwise they have no specific toxic properties, and the lower aliphatic amines are normal constituents of body tissues, so that they occur in a large number of foods, particularly fish, to which they impart a characteristic odor. One area of concern at present is the possibility that some aliphatic amines may react with nitrate or nitrite in vivo to form nitroso compounds, many of which are known to be potent carcinogens in animals ... . /Aliphatic amines/[ILO; Amines, Aliphatic. In Encyclopedia of Occupational Health and Safety, Vol IV, Part XVII. Guides. Guide 104. Guide to Chemicals. JM Stellman et al; Chapter Eds. Available from, as of July 28, 2007: http://www.ilo.org/encyclopaedia/] **PEER REVIEWED**
  • SIGNS AND SYMPTOMS: Inhalation causes severe coughing and chest pain due to irritation of air passages; can cause lung edema; may also cause headache, nausea, faintness, and anxiety. Ingestion causes irritation and burning of mouth and stomach. Contact with eyes causes severe irritation and edema of the cornea. Contact with skin causes severe irritation.[U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.] **PEER REVIEWED**

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Non-Human Toxicity Excerpts

  • GENOTOXICITY: Di-n-propylamine (DPA) was evaluated for mutagenicity in the Salmonella/microsome preincubation assay using a standard protocol approved by the National Toxicology Program. DPA was tested at doses of 0, 33, 100, 333, 1000, and 3333 ug/plate in four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) in the presence and absence of Aroclor-induced rat or hamster liver S9. DPA was negative in these tests and the highest ineffective dose level tested in any Salmonella tester strain was 3333 ug/plate.[Zeiger E et al; Environ Mutagen 9:1-110 (1987)] **PEER REVIEWED**
  • GENOTOXICITY: The inhibition of the DNA synthesis was determined by autoradiographic methods. Dipropylamine was negative.[European Chemicals Bureau; IUCLID Dataset, Dipropylamine (142-84-7) (2000 CD-ROM edition). Available from, as of July 16, 2007: http://esis.jrc.ec.europa.eu/] **PEER REVIEWED**
  • LABORATORY ANIMALS: Acute Exposure: Death resulted in two of six rats exposed to dipropylamine at 1000 ppm/4 min. /from table/[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 4:697] **PEER REVIEWED**
  • LABORATORY ANIMALS: Acute Exposure: N-Propylamine ... and di-n-propylamine show approximately same degree of acute toxicity in animals. Approximate oral LD50 for each is 0.2 g/kg in rats and 0.8 to 1.6 g/kg in mice (10% solution of base). Both cause severe injury to rabbit eye and guinea pig skin.[Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 3154] **PEER REVIEWED**
  • LABORATORY ANIMALS: Acute Exposure: Not sensitizing to guinea pig.[European Chemicals Bureau; IUCLID Dataset, Dipropylamine (142-84-7) (2000 CD-ROM edition). Available from, as of July 16, 2007: http://esis.jrc.ec.europa.eu/] **PEER REVIEWED**
  • LABORATORY ANIMALS: Acute Exposure: Rabbit and guinea pig; corrosive when applied to skin; necrosis, causes severe burns[European Chemicals Bureau; IUCLID Dataset, Dipropylamine (142-84-7) (2000 CD-ROM edition). Available from, as of July 16, 2007: http://esis.jrc.ec.europa.eu/] **PEER REVIEWED**
  • LABORATORY ANIMALS: Acute Exposure: Rabbit eye irritation test: risk of serious damage to eyes. A 5% solution caused severe damage to the cornea; 1% solution caused minor damage. In another rabbit eye irritation test 1 drop caused corneal damage[European Chemicals Bureau; IUCLID Dataset, Dipropylamine (142-84-7) (2000 CD-ROM edition). Available from, as of July 16, 2007: http://esis.jrc.ec.europa.eu/] **PEER REVIEWED**
  • LABORATORY ANIMALS: Acute Exposure: When administered ip to rats, dipropylamine was a moderate inhibitor of liver monoamine oxidase activity. ...[Valiev AG; Vopr Biokhim Immunol Chel Zhivotn 33 (1974)] **PEER REVIEWED**

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Human Toxicity Values

  • None found

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Non-Human Toxicity Values

  • LC50 Mouse inhalation 3070 mg/cu m/2 hr[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1415] **PEER REVIEWED**
  • LC50 Rat inhalation 4400 mg/cu m/4 hr[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1415] **PEER REVIEWED**
  • LC50 Rat inhalation >8.22 mg/cu m/1 hr[European Chemicals Bureau; IUCLID Dataset, Dipropylamine (142-84-7) p.31 (2000 CD-ROM edition). Available from, as of July 16, 2007: http://esis.jrc.ec.europa.eu/] **PEER REVIEWED**
  • LD50 Mouse ip <50 mg/kg bw[European Chemicals Bureau; IUCLID Dataset, Dipropylamine (142-84-7) p.23 (2000 CD-ROM edition). Available from, as of July 16, 2007: http://esis.jrc.ec.europa.eu/] **PEER REVIEWED**
  • LD50 Rabbit dermal 1250 mg/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1415] **PEER REVIEWED**
  • LD50 Rabbit dermal 925 mg/kg bw[European Chemicals Bureau; IUCLID Dataset, Dipropylamine (142-84-7) p.34 (2000 CD-ROM edition). Available from, as of July 16, 2007: http://esis.jrc.ec.europa.eu/] **PEER REVIEWED**
  • LD50 Rabbit sc 1250 mg/kg bw[European Chemicals Bureau; IUCLID Dataset, Dipropylamine (142-84-7) p.37 (2000 CD-ROM edition). Available from, as of July 16, 2007: http://esis.jrc.ec.europa.eu/] **PEER REVIEWED**
  • LD50 Rat oral 460 mg/kg[Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1415] **PEER REVIEWED**
  • LD50 Rat oral 930 mg/kg[Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 4:723] **PEER REVIEWED**

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Absorption, Distribution And Excretion

  • None found

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Metabolism/Metabolites

  • None found

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Tsca Test Submissions

  • Acute systemic toxicity was evaluated in groups of mice (5/group, strain unspecified) administered a gavaged oral dose of 10% di-n-propylamine (CAS # 142-84-7) in corn oil at doses ranging from 100-1600 mg/kg. An LD50 was 800-1600 mg/kg, with time to death of a solitary high-dose mouse occurring at 13 minutes post-gavage. Symptoms of toxicity exhibited during 2 weeks' post-treatment observation included weakness, ataxia, and convulsions at the highest dosage.[Eastman Kodak Co; Toxicological Investigation of: Di-n-Propylamine with Cover Letter Dated 082492; 03/16/92; EPA Document No. 88-920007825; Fiche No. OTS0545970] **UNREVIEWED**
  • Acute systemic toxicity was evaluated in groups of mice (5/group, strain unspecified) administered a single intraperitoneal injection of 10% di-n-propylamine (CAS # 142-84-7) in corn oil at doses ranging from 50-800 mg/kg. An LD50 was less than 50 mg/kg, with all mice succumbing from 12 minutes to 11 days post-injection. Symptoms of toxicity exhibited during 2 weeks' post-treatment observation included weakness, ataxia, and convulsions.[Eastman Kodak Co; Toxicological Investigation of: Di-n-Propylamine with Cover Letter Dated 082492; 03/16/92; EPA Document No. 88-920007825; Fiche No. OTS0545970] **UNREVIEWED**
  • Acute systemic toxicity was evaluated in groups of rats (5/group, strain unspecified) administered a single intraperitoneal injection of undiluted di-n-propylamine (CAS # 142-84-7) at doses ranging from 100-1600 mg/kg. An LD50 was 100-200 mg/kg with time to death occurring 2-1/4 hours to 1 day post-injection. Symptoms of toxicity exhibited during a 2-week post-treatment observation period included weakness, ataxia, shaking, and convulsions.[Eastman Kodak Co; Toxicological Investigation of: Di-n-Propylamine with Cover Letter Dated 082492; 03/16/92; EPA Document No. 88-920007825; Fiche No. OTS0545970] **UNREVIEWED**
  • An acute dermal toxicity study was conducted in 3 groups of male albino New Zealand strain rabbits (4/group) administered 24-hour occluded dermal exposure upon clipped skin of the trunk to undiluted di-n-propylamine (CAS # 142-84-7) at doses of 0.625, 1.25, and 2.50 ml/kg respectively. A dermal LD50 calculated by moving average method was 1.25 ml/kg. Following 14-day post-treatment observation necrosis characterized sites of application. Gross necropsy revealed pale or opaque internal organs which study reviewers attributed speculatively to corrosive action of the test material. Among the 6 decedent rabbits, one exhibited a single hemorrhagic lung.[Mellon Institute; Range Finding Tests on Di-N-Propylamine; 12/31/57; EPA Document No. 878216452; Fiche No. OTS0510380] **UNREVIEWED**
  • An acute inhalation toxicity study was conducted with 4 Sprague-Dawley rats (sex not reported) receiving whole body exposure to a saturated atmosphere of di-n-propylamine in a gas environment chamber for 15 minutes. The saturated atmosphere was generated by passing air at 1 liter/minute through a bubbler containing the test material, resulting in an average concentration of 110 mg/l. The exposure was run at room temperature. Ten to twelve minutes into the exposure, all rats were observed with labored breathing to the point of gasping, loss of equilibrium, and forced movements. After 15 minutes of exposure, some of the animals became prostrate and the exposure was terminated. All animals survived the exposure and subsequent 14 day observation period. Necropsy did not revealed any gross alterations.[Dow Industrial Medicine and Toxicology Department; Acute Inhalation Toxicity Study, (1973), EPA Document No. 868600036, Fiche No. OTS0510188] **UNREVIEWED**
  • An acute oral toxicity study was conducted with non-fasted male albino Carworth Farm-Nelson rats (5/group) receiving di-n-propylamine, undiluted and as a 5% dilution in corn oil, once orally by gavage. Animals were observed for 14 days post dosing. The administration of the undiluted test material was lethal to all rats at a dose level of 0.125 ml/kg. However, groups of animals receiving the test material, diluted in corn oil, at doses of 0.25, 0.5, 1 or 2 g/kg, resulted in the following mortality data (no. animals dead/no. animals treated): 0/5, 0/5, 3/5 and 5/5, respectively. Deaths occurred within 1 day of dosing. Necropsy of animals found dead revealed congestion in all internal organs. The oral LD50 was calculated by the moving average method to be 0.933 g/kg (0.669 - 1.30 g/kg).[Mellon Institute; Range Finding Tests on Di-N-Propylamine, (1957), EPA Document No. 878216452, Fiche No. OTS0510380] **UNREVIEWED**
  • An acute oral toxicity was conducted with groups of fasted female Sprague-Dawley rats (4/group) receiving di-n-propylamine (vehicle use not reported) once orally by gavage. Groups of animals were administered the test material at doses of 0.125, 0.25, 0.50, 1, or 2 g/kg, resulting in the following mortality data (no. animals dead/no. animals tested): 0/4, 0/4, 2/4, 4/4 and 4/4, respectively. Time of deaths were not reported. The acute oral LD50 of di-n-propylamine was calculated to be 0.5 g/kg (95% confidence limits of 0.335 - 0.746 g/kg).[Dow Industrial Medicine and Toxicology Department; Acute Oral Toxicity, (1973), EPA Document No. 868600036, Fiche No. OTS0510188] **UNREVIEWED**
  • Dermal irritation and corrosivity of di-n-propylamine (142-84-7) was evaluated in 3 New Zealand White rabbits each administered 0.5 ml undiluted doses upon a single intact site of the right flank under semi-occluded patch. After 3 minutes, all patches were removed and the application sites cleansed of any residual test material for grading of signs of irritation and corrosion at 3 minutes, 1, 24, 48, 72 hours, and 7 days after initiation of the exposure. Initial necrosis that was noted in all animals at the 3-minute evaluation progressed to eschar documented in 2/3 upon the 1-hour examination and 3/3 rabbits upon the 24-hour examination. Slight to moderate edema, persisting in all animals, had diminished by 7th day study conclusion.[Hoechst Celanese Corp; Dermal Corrosivity Study of C1328 Di-n-Propylamine in Rabbits with Cover Letter; 04/20/90; EPA Document No. 86-900000427; Fiche No. OTS0526008] **UNREVIEWED**
  • Subchronic oral toxicity was evaluated in 3 groups of albino Sprague-Dawley CR rats (10/sex/group) exposed to di-n-propylamine (CAS # 142-84-7) by dietary inclusion at doses of 0, 75, 150, and 300 mg/kg bodyweight/day for 2 weeks. All animals survived the 2-week study and no outward physical or behavioral abnormalities were noted. Subsequent gross necropsy and microscopic examination of kidney and liver likewise revealed no tissue-based evidence of toxicity in any treated group. A 20% reduced weight gain in high-dose males as well as slight dose-related reduced weight gain during Week 1 appeared to coincide with reduced mean food consumption as compared to the control groups. The authors suggested that changes in food consumption may have reflected a palatability threshold rather than systemic effects.[Hoescht Celanese Corp; Two-Week Dietary Administration Study in Rats - Di-n-Propylamine Final Report with Cover Letter and Attachments; 04/20/90; EPA Document No. 86-900000426; Fiche No. OTS0526006] **UNREVIEWED**
  • The eye irritation potential of di-n-propylamine (142-84-7) was evaluated in 4 rabbits (strain unspecified) administered 0.1 ml undiluted doses (manner unspecified) into right eyes, the left eyes serving as negative control. The treated eyes remained unrinsed and were evaluated for signs of irritation up to 7 days post-instillation. Responses were profound and included corneal opacity, stippling and ulceration to prevent grading of iritis in 3 rabbits at 24th hour evaluation. Severe conjunctival irritation in all 4 animals was characterized by redness, chemosis, discharge, and/or ulceration. Humane intervention terminated study for the 3 worst effected animals after 24th hour evaluation. Upon Day 7 examination, the remaining rabbit continued to exhibit corneal opacity, stippling, and pannous with moderate-severe conjunctival irritation and iridic changes.[Hoechst Celanese Corp; Acute Toxicity and Irritation Studies C-896 with Cover Letter; 04/20/90; EPA Document No. 86-900000427; Fiche No. OTS0526007] **UNREVIEWED**

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Footnotes

1 Source: the NTP's CEBS database.

2 Source: the National Library of Medicine's Hazardous Substance Database, 02/28/2017.

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